Abstract：
BACKGROUND & AIMS:Data on acute exacerbation and reactivation of chronic hepatitis C virus (HCV) infection following chemotherapy are very limited. We sought to characterize the episodes of acute exacerbation and viral reactivation of HCV infection in cancer patients. METHODS:The medical records of HCV-infected patients seen at our institution (2008-2009) were analyzed retrospectively. Acute exacerbation was defined as greater than 3-fold increase in serum level of alanine aminotransferase, and viral reactivation as ≥ 1 log(10) IU/ml increase of HCV viral load following chemotherapy. RESULTS:Acute exacerbation occurred in 33 (11%) of 308 patients with proven HCV infection. Patients with acute exacerbation more often had underlying hematological malignancies (73% vs. 29%; p<0.001) and lymphopenia (6% vs. 0%; p=0.01) than patients without it. In multivariate analysis, underlying hematological malignancies (p=0.02; odds ratio, 3.2; 95% confidence interval, 1.2-8.7) and use of rituximab (p=0.004; odds ratio, 4.2; 95% confidence interval, 1.6-10.9) were associated with acute exacerbation. Patients with acute exacerbation received higher median cumulative dose of rituximab than those without exacerbation. Discontinuation of chemotherapy due to liver dysfunction was more common in patients with acute exacerbation than in patients without it (45% vs. 11%; p<0.001). Eight (36%) of 22 patients with known pre- and post-chemotherapy viral load had viral reactivation. CONCLUSIONS:Acute exacerbation and reactivation of chronic HCV infection occur often after chemotherapy. Liver dysfunction can lead to discontinuation of potentially life-saving chemotherapy in nearly one-half of the patients with exacerbation of HCV infection.
journal_name
J Hepatoljournal_title
Journal of hepatologyauthors
Mahale P,Kontoyiannis DP,Chemaly RF,Jiang Y,Hwang JP,Davila M,Torres HAdoi
10.1016/j.jhep.2012.07.031subject
Has Abstractpub_date
2012-12-01 00:00:00pages
1177-85issue
6eissn
0168-8278issn
1600-0641pii
S0168-8278(12)00607-1journal_volume
57pub_type
杂志文章abstract：BACKGROUND/AIMS:The ability to transfer foreign genes into the biliary tract would be useful for the treatment of biliary tract diseases, including cancer, cystic fibrosis and other genetic diseases. To introduce a foreign gene precisely into the rat biliary epithelial cells, we developed a new technique, inserting a p...
journal_title：Journal of hepatology
pub_type： 杂志文章
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journal_title：Journal of hepatology
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abstract：BACKGROUND & AIMS:Aceruloplasminemia is a rare autosomal recessive neurodegenerative disease associated with brain and liver iron accumulation which typically presents with movement disorders, retinal degeneration, and diabetes mellitus. Ceruloplasmin is a multi-copper ferroxidase that is secreted into plasma and facil...
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abstract：BACKGROUND/AIMS:Venous hyporesponsiveness in portal hypertension has been reported previously by us. The present study was undertaken to investigate possible changes of phosphoinositide signal transduction pathway in the portal veins from portal hypertensive rats METHODS:Portal hypertension was induced by partial port...
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abstract：BACKGROUND/AIMS:The endogenous low molecular weight iron chelator, citrate, is considered to be an important contributor to iron transport and the liver the main site of uptake of iron citrate in subjects suffering from diseases of iron overload. Moreover, the citrate-metabolising enzyme, aconitase, is implicated in th...
journal_title：Journal of hepatology
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pub_type： 杂志文章,评审
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journal_title：Journal of hepatology
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更新日期：1997-07-01 00:00:00
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journal_title：Journal of hepatology
pub_type： 临床试验,杂志文章
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更新日期：1996-02-01 00:00:00
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journal_title：Journal of hepatology
pub_type： 杂志文章
doi：10.1016/s0168-8278(97)80091-8
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abstract：:This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...
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doi：10.1016/j.jhep.2015.01.037
更新日期：2015-02-10 00:00:00
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pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1987-04-01 00:00:00
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pub_type： 杂志文章,多中心研究
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journal_title：Journal of hepatology
pub_type： 杂志文章
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pub_type： 杂志文章,多中心研究,随机对照试验
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更新日期：2012-01-01 00:00:00
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journal_title：Journal of hepatology
pub_type： 杂志文章
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更新日期：2012-06-01 00:00:00
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journal_title：Journal of hepatology
pub_type： 临床试验,杂志文章
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journal_title：Journal of hepatology
pub_type： 杂志文章
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更新日期：1991-07-01 00:00:00
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doi：10.1016/s0168-8278(00)00098-2
更新日期：2001-04-01 00:00:00
abstract：BACKGROUND & AIMS:Low levels of toll-like receptor 3 (TLR3) in patients with hepatocellular carcinoma (HCC) are associated with poor prognosis, primarily owing to the loss of inflammatory signaling and subsequent lack of immune cell recruitment to the liver. Herein, we explore the role of TLR3-triggered apoptosis in HC...
journal_title：Journal of hepatology
pub_type： 杂志文章
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更新日期：2019-10-01 00:00:00
