In vitro and in vivo tumour localisation with a monoclonal antibody directed against a membrane antigen on the human hepatocellular carcinoma cell line PLC/PRF/5.

abstract：BACKGROUND/AIMS:No study has compared the liver fibrosis progression rates among chronic liver diseases and the risk factors in order to better organize screening strategies. METHODS:A total of 4852 patients were retrospectively studied (chronic hepatitis C (HCV) [n=2313], human immunodeficiency virus (HIV)-HCV co-inf...

journal_title：Journal of hepatology

authors： Poynard T,Mathurin P,Lai CL,Guyader D,Poupon R,Tainturier MH,Myers RP,Muntenau M,Ratziu V,Manns M,Vogel A,Capron F,Chedid A,Bedossa P,PANFIBROSIS Group.

更新日期：2003-03-01 00:00:00

abstract：AIM/METHODS:To elucidate the metabolic effect of interferon alpha, the following tests were performed on 14 patients with chronic active hepatitis C before and after interferon therapy (6 million units/day for 2 weeks): (1) oral glucose tolerance tests to measure insulin secretion; (2) euglycemic hyperinsulinemic clamp...

journal_title：Journal of hepatology

authors： Imano E,Kanda T,Ishigami Y,Kubota M,Ikeda M,Matsuhisa M,Kawamori R,Yamasaki Y

更新日期：1998-02-01 00:00:00

abstract：:Infection with the hepatitis C virus (HCV) is the major cause of nonA-nonB hepatitis worldwide. Although this virus cannot be cultivated in vitro, several of its key features have been elucidated in the past few years. The viral genome is a positive-sense, single-stranded, 9.6 kb long RNA molecule. The viral genome is...

journal_title：Journal of hepatology

authors： De Francesco R

更新日期：1999-01-01 00:00:00

abstract：:The purpose of the present study was to determine the effects of chronic portal diversion on antioxidant levels in the rat liver. Male Sprague-Dawley rats (n = 32) were used for these studies. An end-to-side portacaval anastomosis was constructed in 17 of the rats. Sham-operated rats (n = 15) served as controls. Two w...

journal_title：Journal of hepatology

authors： Benoit JN,Grisham MB,Mesh CL,Korthuis RJ,Granger DN

更新日期：1992-03-01 00:00:00

abstract：BACKGROUND/AIMS:Gadolinium chloride inactivates Kupffer cells and alleviates alcohol-induced liver lesions. We investigated the mechanism of gadolinium chloride protection after oral ethanol feeding. METHODS:Rats were maintained ethanol-intoxicated for 6 weeks by feeding ethanol in a low-carbohydrate/high-fat liquid d...

journal_title：Journal of hepatology

authors： Järveläinen HA,Fang C,Ingelman-Sundberg M,Lukkari TA,Sippel H,Lindros KO

更新日期：2000-06-01 00:00:00

abstract：BACKGROUND & AIMS:Hepatitis B virus (HBV) and D virus (HDV) co-infections cause the most severe form of viral hepatitis. HDV induces an innate immune response, but it is unknown how the host cell senses HDV and if this defense affects HDV replication. We aim to characterize interferon (IFN) activation by HDV, identify ...

journal_title：Journal of hepatology

authors： Zhang Z,Filzmayer C,Ni Y,Sültmann H,Mutz P,Hiet MS,Vondran FWR,Bartenschlager R,Urban S

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND/AIMS:Circulatory abnormalities with activation of vasoconstrictor systems after large-volume paracentesis are generally considered secondary to an increased extravasation of fluid from the intravascular compartment to the extravascular space with subsequent reduction in plasma volume. To test this hypothesis...

journal_title：Journal of hepatology

authors： Saló J,Ginès A,Ginès P,Piera C,Jiménez W,Guevara M,Fernández-Esparrach G,Sort P,Bataller R,Arroyo V,Rodés J

更新日期：1997-10-01 00:00:00

abstract：BACKGROUND/AIMS:The applicability of adult-to-adult living donor liver transplantation has not been established yet. We report the first data in a European center of the process leading to this procedure from the first moment the patients were informed about it. METHODS:In phase 1 of the process, 121 adult patients en...

journal_title：Journal of hepatology

authors： Rimola A,Llovet JM,Navasa M,Bruix J,Londoño MC,Fuster J,García-Valdecasas JC

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND & AIMS:Myeloperoxidase exocytosis and production of hydrogen peroxide via the neutrophil superoxide-generating nicotinamide adenine dinucleotide phosphate (NADPH) oxidase contribute to efficient elimination of bacteria. Cirrhosis impairs immune functions and increases susceptibility to bacterial infection. W...

journal_title：Journal of hepatology

authors： Boussif A,Rolas L,Weiss E,Bouriche H,Moreau R,Périanin A

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND & AIMS:Recent studies have suggested that insulin resistance exerts a strong influence on chronic hepatitis C virus (HCV) infection. We analyzed pretreatment factors useful for predicting sustained virological response (SVR), especially interleukin (IL) 28B polymorphism and Homeostasis Model Assessment of In...

journal_title：Journal of hepatology

authors： Ogawa E,Furusyo N,Murata M,Ikezaki H,Ihara T,Hayashi T,Toyoda K,Taniai H,Okada K,Kainuma M,Hayashi J

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND & AIMS:Virus-specific T cells capable of controlling HBV and eliminating hepatocellular carcinoma (HCC) expressing HBV antigens are deleted or dysfunctional in patients with chronic HBV or HBV-related HCC. The goal of this study was to determine if T cell receptor (TCR) gene transfer can reconstitute HBV-spe...

journal_title：Journal of hepatology

authors： Gehring AJ,Xue SA,Ho ZZ,Teoh D,Ruedl C,Chia A,Koh S,Lim SG,Maini MK,Stauss H,Bertoletti A

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND/AIMS:Hepatitis C virus (HCV) has been recognized as a major cause of liver disease, but little is known about its diffusion at population level. To estimate the prevalence and incidence of HCV infection and to explore potential risk factors at population level, an epidemiologic study was carried out. METHOD...

journal_title：Journal of hepatology

authors： Osella AR,Misciagna G,Leone A,Di Leo A,Fiore G

更新日期：1997-07-01 00:00:00

abstract：BACKGROUND/AIMS:Rats with long-term cholestasis have reduced ketosis of unknown origin. METHODS:Fatty acid metabolism was studied in starved rats with biliary obstruction for 4 weeks (bile duct ligated rats = BDL rats), and 3, 7, 14, 28 and 84 days after reversal of biliary obstruction by Roux-en-Y anastomosis (RY rat...

journal_title：Journal of hepatology

authors： Lang C,Berardi S,Schäfer M,Serra D,Hegardt FG,Krähenbühl L,Krähenbühl S

更新日期：2002-11-01 00:00:00

abstract：:We describe a PFIC2 patient with a good response to ursodeoxycholic acid for 9 years. We found two novel ABCB11 gene mutations in the patient, i.e. I498T and 2098delA. The correlation of the patient's genotypes with the clinical course supports the existence of a phenotypic continuum between BRIC2 and PFIC2. ...

journal_title：Journal of hepatology

authors： Lam CW,Cheung KM,Tsui MS,Yan MS,Lee CY,Tong SF

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND/AIMS:The electroencephalogram (EEG) is frequently altered in cirrhotic patients. We, therefore, performed a study to ascertain the features and the prognosis of cirrhotic patients without current overt hepatic encephalopathy (OHE) who have EEG alterations. METHODS:A series of 296 consecutive cirrhotic patie...

journal_title：Journal of hepatology

authors： Amodio P,Del Piccolo F,Pettenò E,Mapelli D,Angeli P,Iemmolo R,Muraca M,Musto C,Gerunda G,Rizzo C,Merkel C,Gatta A

更新日期：2001-07-01 00:00:00

abstract：BACKGROUND & AIMS:Regulatory CD4(+) T cells (Tregs) are considered to affect outcomes of HCV infection, because they increase in number during chronic hepatitis C and can suppress T-cell functions. METHODS:Using microarray analysis, in situ immunofluorescence, ELISA, and flowcytometry, we characterised functional diff...

journal_title：Journal of hepatology

authors： Langhans B,Krämer B,Louis M,Nischalke HD,Hüneburg R,Staratschek-Jox A,Odenthal M,Manekeller S,Schepke M,Kalff J,Fischer HP,Schultze JL,Spengler U

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND & AIMS:Therapeutic options for patients failing hepatitis C retreatment are limited. EPIC(3) included a prospective trial assessing long-term peginterferon alfa-2b (PegIFNα-2b) maintenance therapy in patients with METAVIR fibrosis scores (MFS) of F2 or F3 who previously failed hepatitis C retreatment. METHO...

journal_title：Journal of hepatology

authors： Poynard T,Bruix J,Schiff ER,Diago M,Berg T,Moreno-Otero R,Lyra AC,Carrilho F,Griffel LH,Boparai N,Jiang R,Burroughs M,Brass CA,Albrecht JK

更新日期：2013-03-01 00:00:00

abstract：:We report a case of chronic active hepatitis caused by benzarone, a benzofuran derivative used in Europe for the treatment of peripheral venous disorders. Jaundice and serum alanine aminotransferase activity increased while drug administration was continued, but promptly decreased when it was eventually interrupted. L...

journal_title：Journal of hepatology

authors： Babany G,Larrey D,Pessayre D,Degott C,Rueff B,Benhamou JP

更新日期：1987-12-01 00:00:00

abstract：:The epidemiology of HDV infection in Italy was assessed in a retrospective study involving 1556 HBsAg chronic carriers on their first presentation at one of the 35 Liver Units in 1987. Total anti-HD was detected in 23.4% of HBsAg carriers and was significantly more frequent in southern than in northern Italy (26.6% vs...

journal_title：Journal of hepatology

authors： Sagnelli E,Stroffolini T,Ascione A,Bonino F,Chiaramonte M,Colombo M,Craxi A,Giusti G,Manghisi OG,Pastore G

更新日期：1992-05-01 00:00:00

abstract：:Management of decompensated cirrhosis is currently geared towards the treatment of complications once they occur. To date there is no established disease-modifying therapy aimed at halting progression of the disease and preventing the development of complications in patients with decompensated cirrhosis. The design of...

journal_title：Journal of hepatology

authors： Solà E,Pose E,Campion D,Piano S,Roux O,Simon-Talero M,Uschner F,de Wit K,Zaccherini G,Alessandria C,Beuers U,Caraceni P,Francoz C,Mookerjee RP,Trebicka J,Vargas V,Serra M,Torres F,Montagnese S,Krag A,Hernaez R,K

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND & AIMS:To evaluate the hypothesis that increasing T cell frequency and activity may provide durable control of hepatitis B virus (HBV), we administered nivolumab, a programmed death receptor 1 (PD-1) inhibitor, with or without GS-4774, an HBV therapeutic vaccine, in virally suppressed patients with HBV e ant...

journal_title：Journal of hepatology

authors： Gane E,Verdon DJ,Brooks AE,Gaggar A,Nguyen AH,Subramanian GM,Schwabe C,Dunbar PR

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND & AIMS:Absence or low anti-HBV surface antibody (anti-HBs) is associated with an increased risk of HBV reactivation in patients with lymphoma and resolved HBV infection receiving rituximab-containing chemotherapy. Quantification of anti-HBV core antibody (anti-HBc) is a new marker associated with the natural...

journal_title：Journal of hepatology

authors： Yang HC,Tsou HH,Pei SN,Chang CS,Chen JH,Yao M,Lin SJ,Lin J,Yuan Q,Xia N,Liu TW,Chen PJ,Cheng AL,Hsu C,Taiwan Cooperative Oncology Group.

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND & AIMS:The pathogenesis of autoimmune hepatitis (AIH) is not understood, but it was suggested that AIH may be related to a numerical or functional impairment of CD4+CD25+FOXP3+ regulatory T cells (Treg), which are important mediators of immune tolerance to self-antigens. However, the role of Treg in AIH is n...

journal_title：Journal of hepatology

authors： Peiseler M,Sebode M,Franke B,Wortmann F,Schwinge D,Quaas A,Baron U,Olek S,Wiegard C,Lohse AW,Weiler-Normann C,Schramm C,Herkel J

更新日期：2012-07-01 00:00:00

abstract：:A young female, who had been in excellent health and had used third-generation oral contraceptives, was admitted to hospital because of abdominal pain and ascites. Budd-Chiari syndrome (BCS) was diagnosed by radiographic and histological examination. Tests for myeloproliferative disease, deficiency of coagulation inhi...

journal_title：Journal of hepatology

authors： Minnema MC,Janssen HL,Niermeijer P,de Man RA

更新日期：2000-09-01 00:00:00

abstract：:This review summarizes recent progress in the knowledge of catecholamines in cirrhosis. Compensated patients have normal plasma concentration of noradrenaline. Highly elevated plasma noradrenaline concentration in decompensated patients indicates that the sympathetic nervous system is enhanced in this condition. This ...

journal_title：Journal of hepatology

authors： Henriksen JH,Ring-Larsen H,Christensen NJ

更新日期：1985-01-01 00:00:00

abstract：:Hepatitis C virus (HCV) infection is associated with tremendous morbidity and mortality due to liver complications. HCV infection is also associated with many extrahepatic manifestations including cardiovascular diseases, glucose metabolism impairment, cryoglobulinemia vasculitis, B cell non-Hodgkin lymphoma and chron...

journal_title：Journal of hepatology

authors： Cacoub P,Desbois AC,Isnard-Bagnis C,Rocatello D,Ferri C

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND/AIMS:This study assesses the safety, pharmacokinetics and efficacy of transarterial chemoembolization using drug eluting beads (DEB), an embolizing device that slowly releases chemotherapy to decrease systemic toxicity. METHODS:Twenty-seven Child-Pugh A cirrhotics (76% male, 59% HCV) with untreated large/mu...

journal_title：Journal of hepatology

authors： Varela M,Real MI,Burrel M,Forner A,Sala M,Brunet M,Ayuso C,Castells L,Montañá X,Llovet JM,Bruix J

更新日期：2007-03-01 00:00:00

abstract：:A total of 37 patients with histologically confirmed chronic viral hepatitis B and presence of HBV-DNA and HBsAg in the serum were treated in a randomized, prospectively controlled multicenter trial either with recombinant IFN alpha-2b alone or a combination of IFN alpha-2b and recombinant IL-2. Twenty-two patients fr...

journal_title：Journal of hepatology

authors： Bruch HR,Korn A,Klein H,Markus R,Malmus K,Baumgarten R,Müller R

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND & AIMS:To compare the management and the virological and serological efficacy of treatments for chronic hepatitis B (CHB) in HIV positive and negative patients. METHODS:Two hundred and forty-six HIV positive and 205 HIV negative consecutive patients with past or present CHB, seen in October 2008 in particip...

journal_title：Journal of hepatology

authors： Piroth L,Pol S,Lacombe K,Miailhes P,Rami A,Rey D,Loustau-Ratti V,Morlat P,Goderel I,Sene D,Rosenthal E,Carrat F,Cacoub P,GERMIVIC Study Group.

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:The association between polyarteritis nodosa and viral hepatitis B infection is well established and still remains a therapeutic challenge. Famciclovir--a new nucleoside analog--has a broad spectrum of antiviral activity against herpes viruses and the human hepatitis B virus. CASE REPORT:A 56-year-old man w...

journal_title：Journal of hepatology

authors： Kruger M,Böker KH,Zeidler H,Manns MP

更新日期：1997-04-01 00:00:00