Abstract:
BACKGROUND/AIMS:The electroencephalogram (EEG) is frequently altered in cirrhotic patients. We, therefore, performed a study to ascertain the features and the prognosis of cirrhotic patients without current overt hepatic encephalopathy (OHE) who have EEG alterations. METHODS:A series of 296 consecutive cirrhotic patients who had undergone quantified-EEG was studied. The median follow-up was 442 days, 128 patients had bouts of OHE and 78 patients died from liver-related causes. Another group of 124 cirrhotic patients with a median follow-up of 223 days was examined to validate the prognostic model. RESULTS:EEG alterations were detected in 38% of the patients. The prevalence of EEG alterations was associated with the severity of cirrhosis (class B: odds ratio (OR) = 2.3, 95% confidence interval (CI) = 1.2-4.7; class C: OR = 3.5, 95% CI = 1.6-7.7), but not with the aetiology (alcoholic vs. non-alcoholic: OR = 0.9; 95% CI = 0.5-1.5). The EEG predicted the occurrence of OHE (chi2 = 26; P < 0.001) and mortality (chi2 = 34; P < 0.001), also adjusting for Child-Pugh class by a multivariate analysis. In the patients with a Child-Pugh score of > or = 8, the EEG discriminated between those patients with a higher 1-year risk of OHE (hazard ratio (HR) = 3.3, 95% CI = 1.8-6.1) and death (HR = 3.1, 95% CI = 1.7-5.6). CONCLUSIONS:In conclusion, quantified-EEG had a prognostic value for the occurrence of bouts of OHE and mortality in cirrhotic patients.
journal_name
J Hepatoljournal_title
Journal of hepatologyauthors
Amodio P,Del Piccolo F,Pettenò E,Mapelli D,Angeli P,Iemmolo R,Muraca M,Musto C,Gerunda G,Rizzo C,Merkel C,Gatta Adoi
10.1016/s0168-8278(01)00129-5subject
Has Abstractpub_date
2001-07-01 00:00:00pages
37-45issue
1eissn
0168-8278issn
1600-0641pii
S0168827801001295journal_volume
35pub_type
杂志文章abstract:BACKGROUND/AIMS:While combination of peginterferon-alpha (PEG-IFN) and ribavirin (RBV) therapy is the current standard of care for chronic hepatitis C (CHC), only 44-51% of genotype-1 patients achieve a sustained virological response (SVR), and both agents produce treatment-limiting toxicities. In the hepatitis C virus...
journal_title:Journal of hepatology
pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Journal of hepatology
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pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章
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更新日期:2012-10-01 00:00:00
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journal_title:Journal of hepatology
pub_type: 杂志文章
doi:10.1016/s0168-8278(96)80326-6
更新日期:1996-07-01 00:00:00
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journal_title:Journal of hepatology
pub_type: 杂志文章
doi:10.1016/j.jhep.2003.10.008
更新日期:2004-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.jhep.2004.04.015
更新日期:2004-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.jhep.2005.05.033
更新日期:2005-11-01 00:00:00
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journal_title:Journal of hepatology
pub_type: 杂志文章
doi:10.1016/j.jhep.2005.03.028
更新日期:2005-11-01 00:00:00
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journal_title:Journal of hepatology
pub_type: 杂志文章,评审
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更新日期:2012-11-01 00:00:00
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doi:10.1016/0168-8278(95)80201-0
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pub_type: 杂志文章
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更新日期:2002-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2002-03-01 00:00:00
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journal_title:Journal of hepatology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期:1993-01-01 00:00:00
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journal_title:Journal of hepatology
pub_type: 杂志文章
doi:10.1016/j.jhep.2003.10.017
更新日期:2004-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:1989-07-01 00:00:00
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journal_title:Journal of hepatology
pub_type: 杂志文章,评审
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更新日期:2012-05-01 00:00:00
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journal_title:Journal of hepatology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1986-01-01 00:00:00
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journal_title:Journal of hepatology
pub_type: 杂志文章
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更新日期:1996-08-01 00:00:00
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journal_title:Journal of hepatology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期:1998-09-01 00:00:00
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journal_title:Journal of hepatology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.jhep.2011.12.033
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND & AIMS:In this study, adenoviral vectors encoding an antisense RNA complementary to the 5' non-coding region (5'NCR) of the HCV-genome were generated to inhibit HCV-RNA gene expression in cell culture and in vivo. METHODS:First and second-generation (with E4-deletion) adenoviruses encoding the HCV5'NCR in a...
journal_title:Journal of hepatology
pub_type: 杂志文章
doi:10.1016/j.jhep.2010.11.010
更新日期:2011-07-01 00:00:00
abstract::In situ hybridization with oligonucleotide probes has been used to localise hepatitis A virus RNA genomic sequences in formalin-fixed and routinely processed human liver biopsies from three patients. Using radiolabelled Sulphur-35 antisense probes, viral genomic sequences were found in all three cases, but signal inte...
journal_title:Journal of hepatology
pub_type: 杂志文章
doi:10.1016/s0168-8278(94)80012-x
更新日期:1994-03-01 00:00:00