Quantification of HBV core antibodies may help predict HBV reactivation in patients with lymphoma and resolved HBV infection.

abstract：BACKGROUND & AIMS:The MELD score predicts short-term mortality in patients with cirrhosis; however, some patients with low scores develop complications and die unexpectedly. Consequently, we evaluated the diagnostic accuracy of the methacetin breath test (MBT), an assay of liver metabolic function, and the MELD score, ...

journal_title：Journal of hepatology

authors： Stravitz RT,Reuben A,Mizrahi M,Lalazar G,Brown K,Gordon SC,Ilan Y,Sanyal A

更新日期：2015-12-01 00:00:00

abstract：:Hepatitis C infection is common in patients undergoing liver transplantation. Few studies have focused on the prevalence and epidemiology of hepatitis C infection among liver transplant recipients since the implementation of donor screening for antibodies against the hepatitis C virus (anti-HCV). Using reverse transcr...

journal_title：Journal of hepatology

authors： Weinstein JS,Poterucha JJ,Zein N,Wiesner RH,Persing DH,Rakela J

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND/AIMS:Multidrug resistance-associated protein 3 (MRP3) is a carrier-type transport protein belonging to the ABC transporters. It is expressed in normal tissues, and enhanced expression in many cancers has been reported. In this study, we investigated the usefulness of MRP3 as a target antigen in immunotherapy...

journal_title：Journal of hepatology

authors： Mizukoshi E,Honda M,Arai K,Yamashita T,Nakamoto Y,Kaneko S

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND/AIMS:Recent reports have shown a high frequency of anti-hepatitis C virus antibodies in patients with cryoglobulinemia. The factors involved in the production of cryoglobulins in hepatitis C virus-infected patients are unknown. To assess the role of hepatitis C virus genotypes in the pathogenesis of mixed cr...

journal_title：Journal of hepatology

authors： Frangeul L,Musset L,Cresta P,Cacoub P,Huraux JM,Lunel F

更新日期：1996-10-01 00:00:00

abstract：:Secondary biliary cirrhosis in the rat is an attractive model since unlike other models it does not rely on exogenous toxic compounds to induce cirrhosis. However, because little is known about the microcirculatory abnormalities of this model, this study investigated hemodynamics in rats with predefined functional imp...

journal_title：Journal of hepatology

authors： Ohara N,Schaffner T,Reichen J

更新日期：1993-02-01 00:00:00

abstract：:In recent years a new concept of the mechanism of hepatic fatty acid uptake has been described. It was shown that this major class of energy yielding substrates enters hepatocytes by a carrier-mediated uptake system. After the dissociation of the fatty acid-albumin complex at the sinusoidal liver cell plasma membrane,...

journal_title：Journal of hepatology

authors： Stremmel W

更新日期：1989-11-01 00:00:00

abstract：BACKGROUND/AIMS:A distinct subgroup of angiotensin II type 1 receptor (AT1R) blockers (ARBs) have been reported to suppress the development of hepatic steatosis. These effects were generally explained by selective peroxisome proliferator-activated receptor (PPAR) gamma modulating properties of ARBs, independent of thei...

journal_title：Journal of hepatology

authors： Nabeshima Y,Tazuma S,Kanno K,Hyogo H,Chayama K

更新日期：2009-06-01 00:00:00

abstract：:Current medical practice artificially dichotomises a diagnosis of fatty liver disease into one of two common forms: alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD). Together, these account for the majority of chronic liver diseases worldwide. In recent years, there has been a dramatic incre...

journal_title：Journal of hepatology

authors： Boyle M,Masson S,Anstee QM

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND & AIMS:Recent studies have suggested that insulin resistance exerts a strong influence on chronic hepatitis C virus (HCV) infection. We analyzed pretreatment factors useful for predicting sustained virological response (SVR), especially interleukin (IL) 28B polymorphism and Homeostasis Model Assessment of In...

journal_title：Journal of hepatology

authors： Ogawa E,Furusyo N,Murata M,Ikezaki H,Ihara T,Hayashi T,Toyoda K,Taniai H,Okada K,Kainuma M,Hayashi J

更新日期：2012-09-01 00:00:00

abstract：:Two patients presented with neonatal cholestasis and acholic stools as first manifestations of McCune-Albright syndrome. Both went through an extensive evaluation including an exploratory laparotomy with peroperative cholangiography which ruled out biliary atresia. One patient presented from the fourth month of life w...

journal_title：Journal of hepatology

authors： Silva ES,Lumbroso S,Medina M,Gillerot Y,Sultan C,Sokal EM

更新日期：2000-01-01 00:00:00

abstract：:The burden of hepatocellular carcinoma (HCC) is highest in East Asia and Africa, although its incidence and mortality are rapidly rising in the United States and Europe. With the implementation of hepatitis B vaccination and hepatitis C treatment programmes worldwide, the epidemiology of HCC is shifting away from a di...

journal_title：Journal of hepatology

authors： Singal AG,Lampertico P,Nahon P

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND/AIMS:To study the effect of short-term cholestasis on glycogen metabolism. METHODS:Rats were bile duct ligated (BDL) for 4 or 8 days and compared to sham-operated control rats pair-fed to BDL (pair-fed CON) or fed ad libitum (ad libitum-fed CON). RESULTS:Four days after surgery, the hepatic glycogen conten...

journal_title：Journal of hepatology

authors： Lang C,Schäfer M,Varga L,Zimmermann A,Krähenbühl S,Krähenbühl L

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND/AIMS:Catabolism is associated with decreased serum concentrations of insulin-like growth factor (IGF)-I and insulin-like growth factor binding protein (IGFBP)-3 associated with elevated IGFBP-3 protease activity and increased concentrations of IGFBP-1 and -4. The effects of the acute phase mediators interleu...

journal_title：Journal of hepatology

authors： Lelbach A,Scharf JG,Ramadori G

更新日期：2001-11-01 00:00:00

abstract：BACKGROUND/AIMS:To examine the T-cell repertoire which is involved in the immunopathogenesis of chronic hepatitis, we analyzed the T-cell receptor Vbeta gene usage in liver-infiltrating lymphocytes by reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemical technique. METHODS:Complementary DNA ...

journal_title：Journal of hepatology

authors： Kashii Y,Shimizu Y,Nambu S,Minemura M,Okada K,Higuchi K,Watanabe A

更新日期：1997-03-01 00:00:00

abstract：BACKGROUND & AIMS:Receptor mediated cell death through the activation of caspases has been identified as an important mechanism to control life and death in various tissues and is thus crucial for the maintenance of liver tissue homeostasis. Here we investigated how caspase 8 (Casp8) differentially regulates immune-med...

journal_title：Journal of hepatology

authors： Chaudhary K,Liedtke C,Wertenbruch S,Trautwein C,Streetz KL

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND/AIMS:A sequence of 40 amino acids within the nonstructural protein 5A of hepatitis C virus (HCV) has been suggested to be an interferon sensitivity determining region (ISDR). The variations in the ISDR after 12-14 years of chronic infection and the correlation between ISDR and interferon response were studie...

journal_title：Journal of hepatology

authors： Rispeter K,Lu M,Zibert A,Wiese M,de Oliveira JM,Roggendorf M

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND/AIMS:Chronic hepatitis C can lead to cirrhosis and hepatocellular carcinoma. Interferon-alfa therapy may prevent the progression of the disease. The expressions of decorin and alfa-smooth muscle cell actin of the extracellular matrix play a central role in liver fibrosis. We set out to assess the expressions...

journal_title：Journal of hepatology

authors： Jármay K,Gallai M,Karácsony G,Ozsvár Z,Schaff Z,Lonovics J,Kovalszky I

更新日期：2000-06-01 00:00:00

abstract：BACKGROUND/AIMS:The impact of dietary fatty acids on the development of cancers is highly controversial. We recently demonstrated that unsaturated fatty acids trigger the downregulation of the tumor suppressor PTEN through an mTOR/NF-kappaB-dependent mechanism in hepatocytes. In this study, we investigated whether unsa...

journal_title：Journal of hepatology

authors： Vinciguerra M,Carrozzino F,Peyrou M,Carlone S,Montesano R,Benelli R,Foti M

更新日期：2009-06-01 00:00:00

abstract：:We previously reported that high-dose ursodeoxycholate (UDC) infusion in rats resulted in extensive glucuronidation of UDC, and speculated that the glucuronidation causes bicarbonate-rich hypercholeresis induced by UDC (Takikawa, H., Sano, N., Narita, T. and Yamanaka, M. Hepatology 1990; 11: 743-749). To test this hyp...

journal_title：Journal of hepatology

authors： Takikawa H,Sano N,Minagawa K,Yamanaka M

更新日期：1992-05-01 00:00:00

abstract：:Management of decompensated cirrhosis is currently geared towards the treatment of complications once they occur. To date there is no established disease-modifying therapy aimed at halting progression of the disease and preventing the development of complications in patients with decompensated cirrhosis. The design of...

journal_title：Journal of hepatology

authors： Solà E,Pose E,Campion D,Piano S,Roux O,Simon-Talero M,Uschner F,de Wit K,Zaccherini G,Alessandria C,Beuers U,Caraceni P,Francoz C,Mookerjee RP,Trebicka J,Vargas V,Serra M,Torres F,Montagnese S,Krag A,Hernaez R,K

更新日期：2021-01-01 00:00:00

abstract：:The activation of protein kinase C (PKC) has been implicated in the pathogenesis of gram-negative sepsis. The effects of PKC modulation on hepatic flow and metabolism were studied using isolated liver perfusion. The liver was isolated from well-fed or overnight-fasted, male Sprague-Dawley rats weighing 250-310 g, and ...

journal_title：Journal of hepatology

authors： Inaba H,Araki M,Numai T

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND/AIMS:This study aims at describing the natural history and outcome of small duct primary sclerosing cholangitis (PSC). METHODS:Thirty-two patients with small duct PSC were studied. The average time taken for diagnosis was 69 (1-168) months. The median follow-up time was 63 (1-194) months. RESULTS:All patie...

journal_title：Journal of hepatology

authors： Broomé U,Glaumann H,Lindstöm E,Lööf L,Almer S,Prytz H,Sandberg-Gertzén H,Lindgren S,Fork FT,Järnerot G,Olsson R

更新日期：2002-05-01 00:00:00

abstract：:The First European Consensus Conference on the Treatment of Chronic Hepatitis B and C in HIV Co-infected Patients aimed to produce recommendations that could be applied across Europe. However, some important differences exist around Europe, in terms of access to treatment and tests for monitoring. This short survey of...

journal_title：Journal of hepatology

authors： Salmon D,Robain M,Rockstroh JK,Benhamou Y

更新日期：2006-01-01 00:00:00

abstract：:Three patients with Budd-Chiari syndrome in association with the 'lupus' anticoagulant are described. This anticoagulant was looked for in our patients with an otherwise idiopathic hepatic venous thrombosis because of the presence of a pronounced thrombocytopenia, a prolonged activated partial thromboplastin time or a...

journal_title：Journal of hepatology

authors： Van Steenbergen W,Beyls J,Vermylen J,Fevery J,Marchal G,Desmet V,De Groote J

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND:Chronic liver disease and liver transplantation (LT) can delay both timing and ability of women to conceive. With increased awareness and availability of in vitro fertilisation (IVF), the need for accurate counselling is paramount. To date, minimal data exists to inform outcomes of IVF in patients with chron...

journal_title：Journal of hepatology

authors： Rahim MN,Theocharidou E,Yen Lau KG,Ahmed R,Marattukalam F,Long L,Cannon MD,Heneghan MA

更新日期：2021-01-15 00:00:00

abstract：BACKGROUND & AIMS:Alcohol is the main contributing factor of alcoholic cirrhosis, but less is known about the significance of drinking pattern. METHODS:We investigated the risk of alcoholic cirrhosis among 55,917 participants (aged 50-64 years) in the Danish Cancer, Diet, and Health study (1993-2011). Baseline informa...

journal_title：Journal of hepatology

authors： Askgaard G,Grønbæk M,Kjær MS,Tjønneland A,Tolstrup JS

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND/AIMS:Previous studies have shown that hepatic natural killer (NK) cells, also called pit cells, have a higher cytotoxicity against certain tumor cells and have a higher expression of the cell adhesion molecule CD11a as compared with blood NK cells. We further investigated the involvement of the adhesion mole...

journal_title：Journal of hepatology

authors： Luo D,Vermijlen D,Vanderkerken K,Kuppen PJ,Seynaeve C,Eddouks M,Baekeland M,Wisse E

更新日期：1999-07-01 00:00:00

abstract：:Thirty-two patients with chronic hepatitis B were randomly assigned to two groups. Sixteen patients received 10 million units of alpha-interferon per square meter of body surface (MU/m2), three times weekly for 4 months. Sixteen patients were treated simultaneously with gamma-interferon at a dose of 2 MU/m2, and 10 MU...

journal_title：Journal of hepatology

authors： Carreño V,Moreno A,Galiana F,Bartolomé FJ

更新日期：1993-03-01 00:00:00

abstract：BACKGROUND & AIMS:We previously showed that Reptin is overexpressed in hepatocellular carcinoma (HCC), and that in vitro depletion of Reptin with siRNAs led to HCC cell growth arrest and apoptosis. Here, we asked whether in vivo targeting of Reptin in established tumours had a therapeutic effect. METHODS:We used lenti...

journal_title：Journal of hepatology

authors： Ménard L,Taras D,Grigoletto A,Haurie V,Nicou A,Dugot-Senant N,Costet P,Rousseau B,Rosenbaum J

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND/AIMS:Intrahepatic cholestasis of pregnancy is characterized by pruritus and increased levels of serum bile acids, and is often associated with premature delivery, fetal distress, and perinatal mortality. The aims of the present study were: (i) to better define the serum bile acid profile in intrahepatic chol...

journal_title：Journal of hepatology

authors： Brites D,Rodrigues CM,Oliveira N,Cardoso M,Graça LM

更新日期：1998-01-01 00:00:00