The bidirectional impacts of alcohol consumption and the metabolic syndrome: Cofactors for progressive fatty liver disease.

Abstract:

:Current medical practice artificially dichotomises a diagnosis of fatty liver disease into one of two common forms: alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD). Together, these account for the majority of chronic liver diseases worldwide. In recent years, there has been a dramatic increase in the prevalence of obesity and metabolic syndrome within the general population. These factors now coexist with alcohol consumption in a substantial proportion of the population. Each exposure sensitises the liver to the injurious effects of the other; an interaction that drives and potentially accelerates the genesis of liver disease. We review the epidemiological evidence and scientific literature that considers how alcohol consumption interacts with components of the metabolic syndrome to exert synergistic or supra-additive effects on the development and progression of liver disease, before discussing how these interactions may be addressed in clinical practice.

journal_name

J Hepatol

journal_title

Journal of hepatology

authors

Boyle M,Masson S,Anstee QM

doi

10.1016/j.jhep.2017.11.006

subject

Has Abstract

pub_date

2018-02-01 00:00:00

pages

251-267

issue

2

eissn

0168-8278

issn

1600-0641

pii

S0168-8278(17)32426-1

journal_volume

68

pub_type

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