Abstract:
:Current medical practice artificially dichotomises a diagnosis of fatty liver disease into one of two common forms: alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD). Together, these account for the majority of chronic liver diseases worldwide. In recent years, there has been a dramatic increase in the prevalence of obesity and metabolic syndrome within the general population. These factors now coexist with alcohol consumption in a substantial proportion of the population. Each exposure sensitises the liver to the injurious effects of the other; an interaction that drives and potentially accelerates the genesis of liver disease. We review the epidemiological evidence and scientific literature that considers how alcohol consumption interacts with components of the metabolic syndrome to exert synergistic or supra-additive effects on the development and progression of liver disease, before discussing how these interactions may be addressed in clinical practice.
journal_name
J Hepatoljournal_title
Journal of hepatologyauthors
Boyle M,Masson S,Anstee QMdoi
10.1016/j.jhep.2017.11.006subject
Has Abstractpub_date
2018-02-01 00:00:00pages
251-267issue
2eissn
0168-8278issn
1600-0641pii
S0168-8278(17)32426-1journal_volume
68pub_type
杂志文章,评审abstract:BACKGROUND/AIMS:The ability to transfer foreign genes into the biliary tract would be useful for the treatment of biliary tract diseases, including cancer, cystic fibrosis and other genetic diseases. To introduce a foreign gene precisely into the rat biliary epithelial cells, we developed a new technique, inserting a p...
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journal_title:Journal of hepatology
pub_type: 杂志文章,评审
doi:10.1016/j.jhep.2007.08.005
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abstract:BACKGROUND/AIMS:IgM antibodies to hepatitis C virus have been found in a variable proportion of patients with chronic hepatitis C. We have evaluated whether IgM anti-core antibodies correlate with viraemia or hepatic injury in chronic hepatitis C. METHODS:Serum from 106 patients with chronic hepatitis C with varying s...
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更新日期:1996-01-01 00:00:00
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journal_title:Journal of hepatology
pub_type: 杂志文章
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abstract::The mechanism responsible for liver cell necrosis in patients with hepatitis A is not known. Since the type of hepatic lesions and the clinical presentation of acute hepatitis B are similar and are probably related to the cell-mediated immune response to a viral antigen located in the liver cell, it is possible that a...
journal_title:Journal of hepatology
pub_type: 杂志文章
doi:10.1016/s0168-8278(86)80082-4
更新日期:1986-01-01 00:00:00
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journal_title:Journal of hepatology
pub_type: 杂志文章
doi:10.1016/j.jhep.2012.01.007
更新日期:2012-06-01 00:00:00
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journal_title:Journal of hepatology
pub_type: 杂志文章
doi:10.1016/j.jhep.2010.01.039
更新日期:2010-07-01 00:00:00
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journal_title:Journal of hepatology
pub_type: 杂志文章
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更新日期:2006-12-01 00:00:00
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journal_title:Journal of hepatology
pub_type: 杂志文章
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更新日期:2017-04-01 00:00:00
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journal_title:Journal of hepatology
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
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journal_title:Journal of hepatology
pub_type: 杂志文章
doi:10.1016/s0168-8278(99)80043-9
更新日期:1999-09-01 00:00:00
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journal_title:Journal of hepatology
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2016-05-01 00:00:00
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journal_title:Journal of hepatology
pub_type: 杂志文章
doi:10.1016/s0168-8278(97)80108-0
更新日期:1997-05-01 00:00:00
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journal_title:Journal of hepatology
pub_type: 杂志文章
doi:10.1016/s0168-8278(05)80330-7
更新日期:1994-09-01 00:00:00
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journal_title:Journal of hepatology
pub_type: 杂志文章,多中心研究
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更新日期:2011-02-01 00:00:00
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pub_type: 杂志文章,多中心研究
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journal_title:Journal of hepatology
pub_type: 杂志文章
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journal_title:Journal of hepatology
pub_type: 杂志文章
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journal_title:Journal of hepatology
pub_type: 杂志文章
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journal_title:Journal of hepatology
pub_type: 杂志文章
doi:10.1016/0168-8278(92)90174-n
更新日期:1992-03-01 00:00:00
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journal_title:Journal of hepatology
pub_type: 杂志文章
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更新日期:2002-10-01 00:00:00
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pub_type: 杂志文章
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journal_title:Journal of hepatology
pub_type: 杂志文章
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journal_title:Journal of hepatology
pub_type: 杂志文章,评审
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abstract:BACKGROUND & AIMS:Living donor liver transplantation (LDLT) provides a timely alternative to deceased donor liver transplantation (DDLT) for patients with hepatitis C virus-related (HCV-related) diseases in the circumstances of severe organ dearth. However, the patient and graft outcomes, and recurrence of HCV after LD...
journal_title:Journal of hepatology
pub_type: 杂志文章,meta分析,评审
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更新日期:2012-12-01 00:00:00