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Natural history and outcome in 32 Swedish patients with small duct primary sclerosing cholangitis (PSC).

Abstract：

BACKGROUND/AIMS:This study aims at describing the natural history and outcome of small duct primary sclerosing cholangitis (PSC). METHODS:Thirty-two patients with small duct PSC were studied. The average time taken for diagnosis was 69 (1-168) months. The median follow-up time was 63 (1-194) months. RESULTS:All patients including one who underwent liver transplantation because of end-stage liver disease and hepatocellular carcinoma were alive at follow-up. None developed cholangiocarcinoma. In 27 patients repeated cholangiographic examinations were done after a median time of 72 (12-192) months from first ERCP. Four developed features of large duct PSC. CONCLUSIONS:Small duct PSC rarely progresses to large bile duct PSC and it seems to have a benign course in most patients and no development of cholangiocarcinoma was found.

journal_name

J Hepatol

journal_title

Journal of hepatology

authors

Broomé U,Glaumann H,Lindstöm E,Lööf L,Almer S,Prytz H,Sandberg-Gertzén H,Lindgren S,Fork FT,Järnerot G,Olsson R

doi

10.1016/s0168-8278(02)00036-3

subject

Has Abstract

pub_date

2002-05-01 00:00:00

pages

586-9

issue

5

eissn

0168-8278

issn

1600-0641

pii

S0168827802000363

journal_volume

36

pub_type

杂志文章

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