Enhanced detection of cholangiocarcinoma with serum trypsinogen-2 in patients with severe bile duct strictures.

abstract：BACKGROUND/AIMS:5-Aminolevulinic acid (ALA), a precursor of porphyrins is used for photodynamic diagnosis and therapy within topical or systemic applications. A potential toxic effect on the human liver is of major interest and therefore we investigated the impact of a repeated application of ALA without illumination o...

journal_title：Journal of hepatology

authors： Weiss TS,Pahernik S,Scheruebl I,Jauch KW,Thasler WE

更新日期：2003-04-01 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) has emerged as a growing public health problem worldwide. Increasing recognition of the importance of NAFLD and its association with the features of the metabolic syndrome has stimulated an interest in its putative role in the development and progression of chronic kidney dise...

journal_title：Journal of hepatology

authors： Targher G,Chonchol M,Zoppini G,Abaterusso C,Bonora E

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND & AIMS:Reactive cholangiocytes acquire a neuroendocrine-like phenotype, with synthesis and local release of neuropeptides and hormones. The mechanism that drives such phenotypical changes is still undefined. Pancreatic Duodenal Homeobox-1 (PDX-1) is a transcription factor required for pancreatic development,...

journal_title：Journal of hepatology

authors： Marzioni M,Saccomanno S,Candelaresi C,Rychlicki C,Agostinelli L,Shanmukhappa K,Trozzi L,Pierantonelli I,De Minicis S,Benedetti A

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND & AIMS:The pathogenesis and progression of non-alcoholic fatty liver disease (NAFLD) is still incompletely understood. Several nuclear receptors play a role in liver lipid metabolism and can promote hepatosteatosis, but the possible role of vitamin D receptor (VDR) in NAFLD has not been investigated. METHOD...

journal_title：Journal of hepatology

authors： Bozic M,Guzmán C,Benet M,Sánchez-Campos S,García-Monzón C,Gari E,Gatius S,Valdivielso JM,Jover R

更新日期：2016-10-01 00:00:00

abstract：:We report a novel method to assess bile secretory pressure using a Statham pressure transducer. The studies were performed in vivo in male Sprague-Dawley rats under pentobarbital anesthesia. Maximal secretory pressure averaged 21.8 +/- 1.1 (S.D.) cmH2O. The bile accumulated after 10 min of obstruction was 7.7 +/- 2.8 ...

journal_title：Journal of hepatology

authors： Cotting J,Reichen J

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND/AIMS:The relationship between HCV RNA levels and the severity of HCV-related liver disease has been addressed in a few studies, which has led to conflicting results. To clarify this point, we studied serum HCV RNA levels in patients with HCV liver disease at various stages, using a second-generation branched...

journal_title：Journal of hepatology

authors： Duvoux C,Pawlotsky JM,Bastie A,Cherqui D,Soussy CJ,Dhumeaux D

更新日期：1999-10-01 00:00:00

abstract：BACKGROUND & AIM:Hydrogen peroxide-inducible clone-5 (Hic-5), also named as transforming growth factor beta-1-induced transcript 1 protein (Tgfb1i1), was found to be induced by TGF-β. Previous studies have shown that TGF-β is a principal mediator of hepatic stellate cell (HSC) activation in liver fibrosis. However, thi...

journal_title：Journal of hepatology

authors： Lei XF,Fu W,Kim-Kaneyama JR,Omoto T,Miyazaki T,Li B,Miyazaki A

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND/AIMS:Terlipressin is a long-acting vasopressin analogue that has been proved useful in the treatment of variceal haemorrhage. This study investigates the time profile of the haemodynamic effects of terlipressin on portal hypertension as well as the efficacy in decreasing portal-pressure and collateral blood ...

journal_title：Journal of hepatology

authors： Escorsell A,Bandi JC,Moitinho E,Feu F,García-Pagan JC,Bosch J,Rodés J

更新日期：1997-03-01 00:00:00

abstract：AIM/METHODS:To elucidate the metabolic effect of interferon alpha, the following tests were performed on 14 patients with chronic active hepatitis C before and after interferon therapy (6 million units/day for 2 weeks): (1) oral glucose tolerance tests to measure insulin secretion; (2) euglycemic hyperinsulinemic clamp...

journal_title：Journal of hepatology

authors： Imano E,Kanda T,Ishigami Y,Kubota M,Ikeda M,Matsuhisa M,Kawamori R,Yamasaki Y

更新日期：1998-02-01 00:00:00

abstract：BACKGROUND & AIMS:Common genetic variation within the IL28 locus has been found to influence the effect of peg-interferon and ribavirin combination therapy against chronic hepatitis C virus (HCV) infection. Expression of IL28 in peripheral blood cells has been reported to be higher in patients with IL28 SNP genotypes a...

journal_title：Journal of hepatology

authors： Abe H,Hayes CN,Ochi H,Maekawa T,Tsuge M,Miki D,Mitsui F,Hiraga N,Imamura M,Takahashi S,Kubo M,Nakamura Y,Chayama K

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND & AIMS:Data from clinical trials suggest a potential role for on-treatment monitoring of serum HBsAg titres during interferon-alpha (pegIFN) therapy in predicting virological responses. However, baseline HBsAg titres during the natural history of chronic hepatitis B (CHB) have not been well-characterized. We...

journal_title：Journal of hepatology

authors： Nguyen T,Thompson AJ,Bowden S,Croagh C,Bell S,Desmond PV,Levy M,Locarnini SA

更新日期：2010-04-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is an accepted indication for liver transplantation (LT). Pre-LT adjuvant ablation treatments to prevent tumour progression and drop out from the waiting list have been increasingly adopted at most transplant centers. Trans-catheter arterial chemo-embolization (TACE) is frequently used, ...

journal_title：Journal of hepatology

authors： Addario L,Di Costanzo GG,Tritto G,Cavaglià E,Angrisani B,Ascione A

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND/AIMS:The impact of dietary fatty acids on the development of cancers is highly controversial. We recently demonstrated that unsaturated fatty acids trigger the downregulation of the tumor suppressor PTEN through an mTOR/NF-kappaB-dependent mechanism in hepatocytes. In this study, we investigated whether unsa...

journal_title：Journal of hepatology

authors： Vinciguerra M,Carrozzino F,Peyrou M,Carlone S,Montesano R,Benelli R,Foti M

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND & AIMS:The pathogenesis of autoimmune hepatitis (AIH) is not understood, but it was suggested that AIH may be related to a numerical or functional impairment of CD4+CD25+FOXP3+ regulatory T cells (Treg), which are important mediators of immune tolerance to self-antigens. However, the role of Treg in AIH is n...

journal_title：Journal of hepatology

authors： Peiseler M,Sebode M,Franke B,Wortmann F,Schwinge D,Quaas A,Baron U,Olek S,Wiegard C,Lohse AW,Weiler-Normann C,Schramm C,Herkel J

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND/AIMS:Previously, trichostatin A (TSA), a histone deacetylase inhibitor, has been shown to exhibit strong antifibrotic characteristics in hepatic stellate cells (HSC), which are known to play a central role in chronic liver diseases. TSA retained a more quiescent phenotype in spite of culture conditions that ...

journal_title：Journal of hepatology

authors： Rombouts K,Knittel T,Machesky L,Braet F,Wielant A,Hellemans K,De Bleser P,Gelman I,Ramadori G,Geerts A

更新日期：2002-12-01 00:00:00

abstract：BACKGROUND/AIMS:Catabolism is associated with decreased serum concentrations of insulin-like growth factor (IGF)-I and insulin-like growth factor binding protein (IGFBP)-3 associated with elevated IGFBP-3 protease activity and increased concentrations of IGFBP-1 and -4. The effects of the acute phase mediators interleu...

journal_title：Journal of hepatology

authors： Lelbach A,Scharf JG,Ramadori G

更新日期：2001-11-01 00:00:00

abstract：:Medical treatment of cirrhotic ascites is essentially supportive, dictated by the patient's discomfort, impaired cardiovascular or respiratory function and potential for infection. Treatment of 'simple' ascites (moderate fluid accumulation, serum albumin > 3.5 g/dl, serum creatinine < 1.5 mg/dl, no electrolyte disturb...

journal_title：Journal of hepatology

authors： Gerbes AL

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND/AIMS:The ability to transfer foreign genes into the biliary tract would be useful for the treatment of biliary tract diseases, including cancer, cystic fibrosis and other genetic diseases. To introduce a foreign gene precisely into the rat biliary epithelial cells, we developed a new technique, inserting a p...

journal_title：Journal of hepatology

authors： Uehara T,Honda K,Hatano E,Terao R,Iimuro Y,Yamamoto N,Yamamoto M,Kaneda Y,Yamaoka Y

更新日期：1999-05-01 00:00:00

abstract：:Intravascular coagulation is involved in the development of certain types of liver injury, including that induced by dimethylnitrosamine. Nitric oxide inhibits platelet aggregation and adhesion; however, its role in protecting against intravascular coagulation has not been clarified. We therefore investigated the effe...

journal_title：Journal of hepatology

authors： Nagase S,Isobe H,Ayukawa K,Sakai H,Nawata H

更新日期：1995-11-01 00:00:00

abstract：BACKGROUND/AIMS:To examine the T-cell repertoire which is involved in the immunopathogenesis of chronic hepatitis, we analyzed the T-cell receptor Vbeta gene usage in liver-infiltrating lymphocytes by reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemical technique. METHODS:Complementary DNA ...

journal_title：Journal of hepatology

authors： Kashii Y,Shimizu Y,Nambu S,Minemura M,Okada K,Higuchi K,Watanabe A

更新日期：1997-03-01 00:00:00

abstract：BACKGROUND & AIMS:Hepatocytes differentiated from human embryonic stem cells (hESCs) have the potential to overcome the shortage of primary hepatocytes for clinical use and drug development. Many strategies for this process have been reported, but the functionality of the resulting cells is incomplete. We hypothesize t...

journal_title：Journal of hepatology

authors： Touboul T,Chen S,To CC,Mora-Castilla S,Sabatini K,Tukey RH,Laurent LC

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND/AIMS:We have previously shown that an abnormality in cardiac autonomic reflexes (AN) is an independent predictor of mortality in patients with chronic liver disease. Aim of this study was to determine whether there was an association between prolonged QTc interval and cardiac AN. METHODS:Cardiac AN and QTc ...

journal_title：Journal of hepatology

authors： Puthumana L,Chaudhry V,Thuluvath PJ

更新日期：2001-12-01 00:00:00

abstract：BACKGROUND & AIMS:Therapeutic options for patients failing hepatitis C retreatment are limited. EPIC(3) included a prospective trial assessing long-term peginterferon alfa-2b (PegIFNα-2b) maintenance therapy in patients with METAVIR fibrosis scores (MFS) of F2 or F3 who previously failed hepatitis C retreatment. METHO...

journal_title：Journal of hepatology

authors： Poynard T,Bruix J,Schiff ER,Diago M,Berg T,Moreno-Otero R,Lyra AC,Carrilho F,Griffel LH,Boparai N,Jiang R,Burroughs M,Brass CA,Albrecht JK

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND/AIM:A low-titered hepatitis B virus infection without immunological markers was identified in a prospective study in the serum of a kidney transplant recipient by PCR. The aim of this study was to analyze HBV genomes and their biological significance. METHODS:The genome was amplified in two overlapping frag...

journal_title：Journal of hepatology

authors： Schories M,Peters T,Rasenack J

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND & AIMS:Recent studies have suggested that insulin resistance exerts a strong influence on chronic hepatitis C virus (HCV) infection. We analyzed pretreatment factors useful for predicting sustained virological response (SVR), especially interleukin (IL) 28B polymorphism and Homeostasis Model Assessment of In...

journal_title：Journal of hepatology

authors： Ogawa E,Furusyo N,Murata M,Ikezaki H,Ihara T,Hayashi T,Toyoda K,Taniai H,Okada K,Kainuma M,Hayashi J

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND/AIMS:Liver fibrosis is a dynamic state between matrix production and degradation. Since our report in 1974, many studies have examined collagenase and liver fibrosis, but not the identification of cells responsible for collagenase production in vivo. The aim of this study was to investigate the gene expressi...

journal_title：Journal of hepatology

authors： Watanabe T,Niioka M,Hozawa S,Kameyama K,Hayashi T,Arai M,Ishikawa A,Maruyama K,Okazaki I

更新日期：2000-08-01 00:00:00

abstract：:We have studied the roles of immunoprophylaxis, patient selection policy and coexistent hepatitis D virus infection in the outcome of 56 HBsAg-positive elective liver transplant recipients. Twenty-nine unselected patients not treated with immunoprophylaxis formed group 1 and were compared to a recent consecutive serie...

journal_title：Journal of hepatology

authors： Devlin J,Smith HM,O'Grady JG,Portmann B,Tan KC,Williams R

更新日期：1994-08-01 00:00:00

abstract：BACKGROUND & AIMS:γδ T cells comprise a substantial proportion of tissue-associated lymphocytes. However, our current understanding of human γδ T cells is primarily based on peripheral blood subsets, while the immunobiology of tissue-associated subsets remains largely unclear. Therefore, we aimed to elucidate the T cel...

journal_title：Journal of hepatology

authors： Hunter S,Willcox CR,Davey MS,Kasatskaya SA,Jeffery HC,Chudakov DM,Oo YH,Willcox BE

更新日期：2018-09-01 00:00:00

abstract：:The circuitous cell signalling pathways of hepatocytes comprise several factors that operate to downgrade or even interrupt the transmission of a given signal. These down-regulating influences are essential to keep cell proliferation and cell survival in check and if impaired, can alter a delicate balance in favour of...

journal_title：Journal of hepatology

authors： Dufour JF,Huber O,Kozma SC,Lu X,Toftgård R

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND/AIMS:In families of patients with clinically detected hereditary hemochromatosis (HH) early screening has been suggested to prevent morbidity and mortality. Here, we aim to identify determinants for iron overload in first-degree family members of C282Y homozygous probands with clinically detected HH. METHOD...

journal_title：Journal of hepatology

authors： Jacobs EM,Hendriks JC,van Deursen CT,Kreeftenberg HG,de Vries RA,Marx JJ,Stalenhoef AF,Verbeek AL,Swinkels DW

更新日期：2009-01-01 00:00:00