Cytotoxic T-cell responses to the nucleocapsid proteins of HBV in chronic hepatitis. Evidence that antibody modulation may cause protracted infection.

abstract：BACKGROUND & AIMS:The advent of new chronic hepatitis C virus (HCV) therapies requires characterization of patients in order to predict adequate treatment. A good candidate marker is Programmed Cell Death-1 (PD-1) which is involved in progression of HCV infection. The aim of this study was to analyse the effect of seve...

journal_title：Journal of hepatology

authors： Vidal-Castiñeira JR,López-Vázquez A,Alonso-Arias R,Moro-García MA,Martinez-Camblor P,Melón S,Prieto J,López-Rodriguez R,Sanz-Cameno P,Rodrigo L,Pérez-López R,Pérez-Álvarez R,López-Larrea C

更新日期：2012-06-01 00:00:00

abstract：:Interleukin-6 has a variety of biological effects, mainly on the immune system. The regulation of this signal at both the site of production and the site of action is necessary to maintain the organism's homeostasis. In the microenvironment of the hepatic sinusoids, Kupffer cells as resident macrophages are the most p...

journal_title：Journal of hepatology

authors： Hoffmann R,Henninger HP,Schulze-Specking A,Decker K

更新日期：1994-10-01 00:00:00

abstract：BACKGROUND/AIMS:The aims were to study: 1) the prevalence of diabetes mellitus in patients with end-stage liver cirrhosis due to hepatitis C, alcohol, or cholestatic liver disease, 2) viral and host immunogenetic factors that may predispose to diabetes, and 3) liver transplantation outcome in patients with or without d...

journal_title：Journal of hepatology

authors： Zein NN,Abdulkarim AS,Wiesner RH,Egan KS,Persing DH

更新日期：2000-02-01 00:00:00

abstract：:A quantitative immunohistochemical study of Kupffer cells in liver biopsies from alcoholics was carried out. Two markers were compared, lysozyme and an antimacrophage monoclonal antibody EMB/11. The results showed that there is no significant reduction in Kupffer cell numbers in acute and chronic alcoholic liver disea...

journal_title：Journal of hepatology

authors： Kelly PM,Heryet AR,McGee JO

更新日期：1989-03-01 00:00:00

abstract：BACKGROUND/AIMS:Septins are ubiquitous and multifunctional scaffold proteins involved in cytoskeletal organization, exocytosis and other cellular processes. We disclose the quiescent hepatic stellate cells (HSCs)-specific expression of a septin subunit Sept4 in the liver, and explore the significance of the septin syst...

journal_title：Journal of hepatology

authors： Iwaisako K,Hatano E,Taura K,Nakajima A,Tada M,Seo S,Tamaki N,Sato F,Ikai I,Uemoto S,Kinoshita M

更新日期：2008-11-01 00:00:00

abstract：:Abnormalities of carbohydrate metabolism, including hyperinsulinaemia and insulin resistance, are well recognised complications of cirrhosis. While diabetes mellitus can be explained in many instances on the basis of coincident pancreatic disease, in most the characteristic glucose intolerance of cirrhosis is not read...

journal_title：Journal of hepatology

authors： Allison ME,Wreghitt T,Palmer CR,Alexander GJ

更新日期：1994-12-01 00:00:00

abstract：BACKGROUND & AIMS:The prognosis of patients with chronic liver disease is to a great extent determined by the presence and degree of portal hypertension (PHT). Hepatic venous pressure gradient (HVPG) has been shown to be an accurate prognostic index in patients with cirrhosis. Transient elastography is a non-invasive p...

journal_title：Journal of hepatology

authors： Robic MA,Procopet B,Métivier S,Péron JM,Selves J,Vinel JP,Bureau C

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND & AIM:Natural killer T (NKT) cells are CD1d-restricted innate-like T cells that modulate innate and adaptive immune responses. Unlike the well-characterized invariant/type I NKT cells, type II NKT cells with a diverse T cell receptor repertoire are poorly understood. This study defines the pathogenic role of...

journal_title：Journal of hepatology

authors： Weng X,He Y,Visvabharathy L,Liao CM,Tan X,Balakumar A,Wang CR

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND/AIMS:Type 2 autoimmune hepatitis (AIH) is characterized by the presence of anti-liver kidney microsome (anti-LKM-1) and/or anti-liver cytosol type 1 (anti-LC1) autoantibodies. However, the correlation between these autoantibodies and the genetic background has not been studied. METHODS:Frequencies of HLA cl...

journal_title：Journal of hepatology

authors： Djilali-Saiah I,Fakhfakh A,Louafi H,Caillat-Zucman S,Debray D,Alvarez F

更新日期：2006-12-01 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) has become one of the most common forms of chronic liver disease worldwide and its prevalence is expected to continue rising. NAFLD has traditionally been considered a consequence of metabolic syndrome (MetS). However, the link between NAFLD and MetS components, especially typ...

journal_title：Journal of hepatology

authors： Lonardo A,Nascimbeni F,Mantovani A,Targher G

更新日期：2018-02-01 00:00:00

abstract：:An uncontrolled pilot study of adenine arabinoside monophosphate intramuscularly (ARA-AMP) for 5 days at 10 mg/kg/day and 23 days at 5 mg/kg/day in divided doses, was conducted in 15 consecutive patients known to be HBeAg-positive for a minimum of 12 months. Two patients were lost to follow-up (1 having developed an h...

journal_title：Journal of hepatology

authors： Alexander GJ,Fagan EA,Rolando N,Guarner P,Callender ME,Eddleston AL,Williams R

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND & AIMS:Repair from biliary damages requires the biliary specification of hepatic progenitor cells and the remodeling of ductular reactive structures into branching biliary tubules. We hypothesized that the morphogenetic role of Notch signaling is maintained during the repair process and have addressed this h...

journal_title：Journal of hepatology

authors： Fiorotto R,Raizner A,Morell CM,Torsello B,Scirpo R,Fabris L,Spirli C,Strazzabosco M

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND/AIMS:The purpose of this study was to compare the epidemiological, biochemical, virological and histological characteristics of patients with chronic hepatitis B and C with those of patients suffering from chronic hepatitis C alone. METHODS:Twenty-three patients with chronic hepatitis C, who were anti-HCV p...

journal_title：Journal of hepatology

authors： Zarski JP,Bohn B,Bastie A,Pawlotsky JM,Baud M,Bost-Bezeaux F,Tran van Nhieu J,Seigneurin JM,Buffet C,Dhumeaux D

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND/AIMS:The benefit of amantadine combination therapy, either with interferon (IFN) alone (double therapy) or with ribavirin and IFN (triple therapy) is unknown. METHODS:We analyzed the effect of amantadine on the end-of-treatment virological response and the sustained response using meta-analysis of 31 random...

journal_title：Journal of hepatology

authors： Deltenre P,Henrion J,Canva V,Dharancy S,Texier F,Louvet A,De Maeght S,Paris JC,Mathurin P

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND/AIMS:Vascular endothelial growth factor (VEGF) is an angiogenic factor with a growth-promoting effect that is thought to be restricted to vascular endothelial cells. Its essential role during liver regeneration has yet to be determined. The aim of this study was to document the effect of exogenous VEGF admin...

journal_title：Journal of hepatology

authors： Assy N,Spira G,Paizi M,Shenkar L,Kraizer Y,Cohen T,Neufeld G,Dabbah B,Enat R,Baruch Y

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND/AIMS:The pathogenesis of the inflammatory lesion in primary sclerosing cholangitis is unknown. The clinical picture is characterized by i.a. episodes of fever, the cause of which also remains speculative. Previous studies of bacterial isolates in the liver or bile ducts in primary sclerosing cholangitis have...

journal_title：Journal of hepatology

authors： Olsson R,Björnsson E,Bäckman L,Friman S,Höckerstedt K,Kaijser B,Olausson M

更新日期：1998-03-01 00:00:00

abstract：BACKGROUND/AIMS:Evidence that the geno/subtype of hepatitis C virus (HCV) is predictive of the response to interferon-alpha therapy suggests that typing methods are clinically useful. In the present study, HCV isolates obtained from 74 patients with chronic hepatitis C were used to evaluate three genotyping and two ser...

journal_title：Journal of hepatology

authors： Lee JH,Roth WK,Zeuzem S

更新日期：1997-05-01 00:00:00

abstract：BACKGROUND & AIMS:Autoimmune hepatitis (AIH) is a chronic autoimmune liver disease usually requiring life-long immunosuppression. The mechanisms for disease initiation and chronicity are largely unknown. A contribution of deficient regulatory T cells (Tregs) in the blood was controversially discussed recently. So far i...

journal_title：Journal of hepatology

authors： Taubert R,Hardtke-Wolenski M,Noyan F,Wilms A,Baumann AK,Schlue J,Olek S,Falk CS,Manns MP,Jaeckel E

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND/AIMS:Interleukin-15 (IL-15) is expressed in many organs. It generally inhibits apoptosis and increases cellular proliferation and differentiation. However, IL-15's roles in liver are unknown. We aimed to determine if IL-15 influences hepatic integrity and regenerative activity. METHODS:Expression of IL-15 a...

journal_title：Journal of hepatology

authors： Suzuki A,McCall S,Choi SS,Sicklick JK,Huang J,Qi Y,Zdanowicz M,Camp T,Li YX,Diehl AM

更新日期：2006-09-01 00:00:00

abstract：:Worldwide, the increasingly dominant model of laboratory testing is the centralised laboratory, in which automation of analytical processes increases, enabling the analysis of large numbers of samples at a relatively low cost. However, this trend does not fulfil the requirements for care of patients with chronic hepat...

journal_title：Journal of hepatology

authors： Chevaliez S,Pawlotsky JM

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND/AIMS:Liver allograft is known to protect simultaneously transplanted organs from acute rejection. We have reported that only 6% of combined liver-kidney recipients, versus 32.5% of kidney recipients, develop kidney graft acute rejection. Release of soluble human leukocyte antigen (HLA) molecules by the liver...

journal_title：Journal of hepatology

authors： Créput C,Durrbach A,Menier C,Guettier C,Samuel D,Dausset J,Charpentier B,Carosella ED,Rouas-Freiss N

更新日期：2003-10-01 00:00:00

abstract：BACKGROUND:The expression and the distribution of fibrillin-1 and elastin were studied in normal and pathological human liver samples. METHODS:As controls, histologically normal/subnormal liver samples (n = 24) were used. Pathological samples corresponded to seven cirrhosis and eight hepatocellular carcinomas (HCC) de...

journal_title：Journal of hepatology

authors： Dubuisson L,Lepreux S,Bioulac-Sage P,Balabaud C,Costa AM,Rosenbaum J,Desmoulière A

更新日期：2001-04-01 00:00:00

abstract：BACKGROUND & AIMS:Transcatheter arterial chemoembolization with lipiodol (TACE) is widely performed in patients with hepatocellular carcinoma (HCC) unsuitable for curative treatment. It has recently been recommended for patients with 2 or 3 tumors >3 cm or ≥4 tumors in a treatment algorithm proposed by Japanese guideli...

journal_title：Journal of hepatology

authors： Takayasu K,Arii S,Kudo M,Ichida T,Matsui O,Izumi N,Matsuyama Y,Sakamoto M,Nakashima O,Ku Y,Kokudo N,Makuuchi M

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND & AIMS:Tumor shrinkage has been considered a fundamental surrogate efficacy measure for new cancer treatments. However, in patients treated with sorafenib for advanced hepatocellular carcinoma (HCC), tumor shrinkage rarely accompanies increased survival, thereby questioning the prognostic value of imaging-ba...

journal_title：Journal of hepatology

authors： Personeni N,Bozzarelli S,Pressiani T,Rimassa L,Tronconi MC,Sclafani F,Carnaghi C,Pedicini V,Giordano L,Santoro A

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND & AIMS:Simeprevir is an oral hepatitis C virus (HCV) NS3/4A protease inhibitor approved for treatment of chronic HCV infection. Baseline NS3 polymorphisms in all patients and emerging mutations in patients who failed to achieve sustained virologic response (SVR) with simeprevir plus peginterferon/ribavirin (...

journal_title：Journal of hepatology

authors： Lenz O,Verbinnen T,Fevery B,Tambuyzer L,Vijgen L,Peeters M,Buelens A,Ceulemans H,Beumont M,Picchio G,De Meyer S

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:Chronic liver disease and liver transplantation (LT) can delay both timing and ability of women to conceive. With increased awareness and availability of in vitro fertilisation (IVF), the need for accurate counselling is paramount. To date, minimal data exists to inform outcomes of IVF in patients with chron...

journal_title：Journal of hepatology

authors： Rahim MN,Theocharidou E,Yen Lau KG,Ahmed R,Marattukalam F,Long L,Cannon MD,Heneghan MA

更新日期：2021-01-15 00:00:00

abstract：BACKGROUND & AIMS:Recent research has suggested that dietary fructose intake may increase serum uric acid (UA) concentrations. Both UA concentration and fructose consumption maybe also increase in NAFLD. It is not known whether dietary fructose consumption and UA concentration are independently associated with non-alco...

journal_title：Journal of hepatology

authors： Mosca A,Nobili V,De Vito R,Crudele A,Scorletti E,Villani A,Alisi A,Byrne CD

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND & AIMS:Hallmarks of non-alcoholic fatty liver disease (NAFLD) are increased triglyceride accumulation within hepatocytes. The prevalence of NAFLD increases steadily with increasing thyrotropin (TSH) levels. However, the underlying mechanisms are largely unknown. Here, we focused on exploring the effect and m...

journal_title：Journal of hepatology

authors： Yan F,Wang Q,Lu M,Chen W,Song Y,Jing F,Guan Y,Wang L,Lin Y,Bo T,Zhang J,Wang T,Xin W,Yu C,Guan Q,Zhou X,Gao L,Xu C,Zhao J

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND AND AIMS:Primary sclerosing cholangitis (PSC) is an idiopathic, chronic cholestatic liver disorder characterized by biliary inflammation and fibrosis. Increased numbers of intrahepatic interferon-γ- (IFNγ) producing lymphocytes have been documented in patients with PSC, yet their functional role remains to b...

journal_title：Journal of hepatology

authors： Ravichandran G,Neumann K,Berkhout LK,Weidemann S,Langeneckert AE,Schwinge D,Poch T,Huber S,Schiller B,Hess LU,Ziegler AE,Oldhafer KJ,Barikbin R,Schramm C,Altfeld M,Tiegs G

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND/AIMS:Circulatory abnormalities with activation of vasoconstrictor systems after large-volume paracentesis are generally considered secondary to an increased extravasation of fluid from the intravascular compartment to the extravascular space with subsequent reduction in plasma volume. To test this hypothesis...

journal_title：Journal of hepatology

authors： Saló J,Ginès A,Ginès P,Piera C,Jiménez W,Guevara M,Fernández-Esparrach G,Sort P,Bataller R,Arroyo V,Rodés J

更新日期：1997-10-01 00:00:00