Caspase 8 differentially controls hepatocytes and non-parenchymal liver cells during chronic cholestatic liver injury in mice.

abstract：BACKGROUND/AIMS:Albumin administration prevents renal failure and improves survival in spontaneous bacterial peritonitis. This study characterizes the mechanisms of action of albumin in this condition. METHODS:Systemic and splanchnic hemodynamics, plasma renin activity and plasma concentration of interleukin-6, serum ...

journal_title：Journal of hepatology

authors： Fernández J,Navasa M,Garcia-Pagan JC,G-Abraldes J,Jiménez W,Bosch J,Arroyo V

更新日期：2004-09-01 00:00:00

abstract：:Hypergammaglobulinemia, mainly due to increased serum immunoglobulin M concentrations, is a common and distinctive feature of primary biliary cirrhosis. T-B cell cooperation plays a pivotal role in the regulation of immunoglobulin secretion. In this paper, the production of regulatory B lymphokines by T cells, as well...

journal_title：Journal of hepatology

authors： Menéndez-Caro JL,Alvarez-Mon M,Girón JA,Manzano L,Garrido A,Abreu L,Albillos A,Durántez A

更新日期：1994-04-01 00:00:00

abstract：BACKGROUND/AIMS:Liver growth factor (LGF) is a hepatic mitogen, however, the hepatic stimulation pathway remains to be characterized. The aim of this study was to determine whether tumor necrosis factor alpha (TNF-alpha) stimulation constitutes a step in the mitogenic pathway of LGF. METHODS:Rats were injected with 4....

journal_title：Journal of hepatology

authors： Díaz-Gil JJ,Majano PL,López-Cabrera M,Sánchez-López V,Rúa C,Machín C,Trilla C,García-Cañero R,Moreno-Otero R

更新日期：2003-05-01 00:00:00

abstract：:Medical treatment of cirrhotic ascites is essentially supportive, dictated by the patient's discomfort, impaired cardiovascular or respiratory function and potential for infection. Treatment of 'simple' ascites (moderate fluid accumulation, serum albumin > 3.5 g/dl, serum creatinine < 1.5 mg/dl, no electrolyte disturb...

journal_title：Journal of hepatology

authors： Gerbes AL

更新日期：1993-01-01 00:00:00

abstract：:Mutant HBV genomes unable to produce preS2 protein were identified in the serum of a highly viremic chronic carrier. By direct sequencing of the amplified preS region and by sequencing of 50 cloned amplified preS DNA fragments all molecules were found to have deleted the preS2 translation initiation codon and three am...

journal_title：Journal of hepatology

authors： Fernholz D,Stemler M,Brunetto M,Bonino F,Will H

更新日期：1991-01-01 00:00:00

abstract：:A substantial production of prostaglandin E2 (PGE2) was induced in primary cultures of rat Kupffer cells by zymosan, calcium ionophore A23187, phorbol ester and arachidonic acid, whereas contact with latex particles, glucan or immunocomplexes led to a minor PGE2 release only. Superoxide generation, on the other hand, ...

journal_title：Journal of hepatology

authors： Dieter P,Schulze-Specking A,Decker K

更新日期：1988-04-01 00:00:00

abstract：BACKGROUND & AIMS:To determine whether amino acid mutations in the core region of hepatitis C virus (HCV) genotype 1 are associated with response to interferon (IFN) therapy and development of hepatocellular carcinoma (HCC). METHODS:We followed up 361 patients (median duration, 121 months), and IFN monotherapy was adm...

journal_title：Journal of hepatology

authors： Nakamoto S,Imazeki F,Fukai K,Fujiwara K,Arai M,Kanda T,Yonemitsu Y,Yokosuka O

更新日期：2010-01-01 00:00:00

abstract：AIMS:To estimate the cost of population screening for haemochromatosis in Australia and to compare the cost of alternative screening strategies. METHODS:The costs of screening for haemochromatosis were analysed in a hypothetical study using transferrin saturation as the primary screening test, with confirmation of the...

journal_title：Journal of hepatology

authors： Bassett ML,Leggett BA,Halliday JW,Webb S,Powell LW

更新日期：1997-09-01 00:00:00

abstract：:The clinical course of cirrhosis is mostly determined by the progressive increase of portal hypertension, hyperdynamic circulation, bacterial translocation and activation of systemic inflammation. Different disease states, encompassing compensated and decompensated cirrhosis and a late decompensated state, are related...

journal_title：Journal of hepatology

authors： D'Amico G,Morabito A,D'Amico M,Pasta L,Malizia G,Rebora P,Valsecchi MG

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND/AIMS:Autoimmune Hepatitis (AIH) is a liver disease which may lead to liver cirrhosis. Cirrhosis is a well-known risk factor for hepatocellular cancer. Lymphoma is a disease, where immune modulating drugs as well as the autoimmune disease itself may contribute to the elevated risk. The aim was to investigate ...

journal_title：Journal of hepatology

authors： Werner M,Almer S,Prytz H,Lindgren S,Wallerstedt S,Björnsson E,Bergquist A,Sandberg-Gertzén H,Hultcrantz R,Sangfelt P,Weiland O,Danielsson A

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND & AIMS:We previously showed that Reptin is overexpressed in hepatocellular carcinoma (HCC), and that in vitro depletion of Reptin with siRNAs led to HCC cell growth arrest and apoptosis. Here, we asked whether in vivo targeting of Reptin in established tumours had a therapeutic effect. METHODS:We used lenti...

journal_title：Journal of hepatology

authors： Ménard L,Taras D,Grigoletto A,Haurie V,Nicou A,Dugot-Senant N,Costet P,Rousseau B,Rosenbaum J

更新日期：2010-05-01 00:00:00

abstract：:The etiologic agent responsible for epidemics of enterically-transmitted non-A, non-B hepatitis has been molecularly characterized as the hepatitis E virus (HEV). The cloning of a portion of the Burma strain of HEV (HEV(B); 'Old World' strain) has been described together with the isolation of a contiguous overlapping ...

journal_title：Journal of hepatology

authors： Reyes GR,Huang CC,Yarbough PO,Tam AW

更新日期：1991-01-01 00:00:00

abstract：:Our understanding of the process whereby replicating Hepatitis B virus is eradicated has been substantially modified by the development of highly sensitive assays of viral replication, such as the detection of HBV-DNA in serum. The implications of these developments on our therapeutic approach in terms of both timing ...

journal_title：Journal of hepatology

authors： Williams R,Alexander GJ

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND/AIMS:Extrahepatic biliary atresia (EHBA) and chronic progressive intra-hepatic cholestasis (Byler's disease) are two distinct disorders of unknown etiology in the neonate, characterized by profound cholestasis. The aim of the present study was to investigate the inflammatory reaction in liver tissue from pat...

journal_title：Journal of hepatology

authors： Broomé U,Nemeth A,Hultcrantz R,Scheynius A

更新日期：1997-04-01 00:00:00

abstract：:The natural history of HBV is known to be complicated by HIV-co-infection. In contrast, the effect of HBV on the outcome of patients infected with HIV-1 is controversial. Some cohort studies from the pre-HAART era described a more rapid progression to AIDS in patients carrying antibodies to the core-antigen or having ...

journal_title：Journal of hepatology

authors： Rockstroh JK

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND & AIMS:Biliary atresia (BA) is a pediatric inflammatory disease of the biliary system which leads to cirrhosis and the need for liver transplantation. One theory regarding etiology is that bile duct injury is due to virus-induced autoreactive T cell-mediated inflammation. Regulatory T cell (Treg) abnormaliti...

journal_title：Journal of hepatology

authors： Tucker RM,Feldman AG,Fenner EK,Mack CL

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND/AIMS:In order to explore the role of cytokines in the pathogenesis of liver cirrhosis, we analyzed their gene expression in hepatic biopsies from patients with alcoholic liver cirrhosis, post-hepatitis C liver cirrhosis, and with idiopathic portal hypertension without cirrhosis. METHODS:We assessed the gene...

journal_title：Journal of hepatology

authors： Llorent L,Richaud-Patin Y,Alcocer-Castillejos N,Ruiz-Soto R,Mercado MA,Orozco H,Gamboa-Domínguez A,Alcocer-Varela J

更新日期：1996-05-01 00:00:00

abstract：BACKGROUND/AIMS:To elucidate the mechanisms of action of interferon (IFN) against hepatitis C virus (HCV), we studied the serum HCV dynamics of free-virions (FV) and immune-complexes (IC) in patients treated with IFN. METHODS:FV and IC were separated by immunoprecipitation using anti-human immunoglobulin and quantifie...

journal_title：Journal of hepatology

authors： Fujita N,Kaito M,Takeo M,Horiike S,Tanaka H,Ikoma J,Watanabe S,Adachi Y

更新日期：2003-12-01 00:00:00

abstract：BACKGROUND/AIMS:The aim of this study was to investigate whether both matrix metalloproteinase-2 (MMP-2) and membrane type 1 MMP (MT1-MMP) participate in the spontaneous resolution of liver fibrosis. METHODS:Transcription of both genes was examined by reverse transcription-polymerase chain reaction (RT-PCR) and in sit...

journal_title：Journal of hepatology

authors： Watanabe T,Niioka M,Ishikawa A,Hozawa S,Arai M,Maruyama K,Okada A,Okazaki I

更新日期：2001-10-01 00:00:00

abstract：BACKGROUND/AIMS:Primary sclerosing cholangitis (PSC) is a cholestatic liver disease of unknown etiology. Although the primary defect affects cholangiocytes, cholestatic injury of hepatocytes may promote further liver damage. Since down-regulation of hepatocellular organic anion transporters is implicated in the molecul...

journal_title：Journal of hepatology

authors： Geier A,Dietrich CG,Lammert F,Orth T,Mayet WJ,Matern S,Gartung C

更新日期：2002-06-01 00:00:00

abstract：BACKGROUND/AIMS:Vascular endothelial growth factor (VEGF) is an angiogenic factor with a growth-promoting effect that is thought to be restricted to vascular endothelial cells. Its essential role during liver regeneration has yet to be determined. The aim of this study was to document the effect of exogenous VEGF admin...

journal_title：Journal of hepatology

authors： Assy N,Spira G,Paizi M,Shenkar L,Kraizer Y,Cohen T,Neufeld G,Dabbah B,Enat R,Baruch Y

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND AIMS:In hepatitis C there is controversy over the linearity of the rate of progression and the significance of gender, mode of infection and viral factors. METHODS:2313 untreated patients with a reliable estimated duration of infection and liver fibrosis were included. Fibrosis progression was calculated us...

journal_title：Journal of hepatology

authors： Poynard T,Ratziu V,Charlotte F,Goodman Z,McHutchison J,Albrecht J

更新日期：2001-05-01 00:00:00

abstract：:Infections with the hepatotropic viruses non-A, non-B (NANB), hepatitis B (HBV) and delta agent (HDV) are described in two patients with haemophilia. The first patient illustrates the phenomenon of interference following a simultaneous exposure to NANB and HBV. The second patient, a carrier of hepatitis B surface anti...

journal_title：Journal of hepatology

authors： Lee CA,Kernoff PB,Karayiannis P,Farci P,Thomas HC

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND & AIMS:Intrahepatic cholangiocarcinoma (ICC) is a lethal malignancy without effective treatment options. MLN0128, a second generation pan-mTOR inhibitor, shows efficacy for multiple tumor types. We evaluated the therapeutic potential of MLN0128 vs. gemcitabine/oxaliplatin in a novel ICC mouse model. METHODS...

journal_title：Journal of hepatology

authors： Zhang S,Song X,Cao D,Xu Z,Fan B,Che L,Hu J,Chen B,Dong M,Pilo MG,Cigliano A,Evert K,Ribback S,Dombrowski F,Pascale RM,Cossu A,Vidili G,Porcu A,Simile MM,Pes GM,Giannelli G,Gordan J,Wei L,Evert M,Cong W,C

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND/AIMS:Haematopoietic stem cells (HSC) have previously been shown in some studies to migrate to damaged and diseased liver where a small proportion will engraft. Such cells can promote liver repair in rodent models of liver injury and lead to improved liver function in uncontrolled clinical studies. In order t...

journal_title：Journal of hepatology

authors： Crosby HA,Lalor PF,Ross E,Newsome PN,Adams DH

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND/AIMS:The tropical parasite Schistosoma mansoni causes granulomatous inflammation following lodging of eggs in portal capillaries. In vitro studies indicated that the host reaction should involve reactive oxygen intermediates; however, it is not known what occurs in vivo at the site of the disease. Moreover, ...

journal_title：Journal of hepatology

authors： Gharib B,Abdallahi OM,Dessein H,De Reggi M

更新日期：1999-04-01 00:00:00

abstract：BACKGROUND:NGM282, an engineered analogue of the gut hormone FGF19, improves hepatic steatosis and fibrosis biomarkers in patients with non-alcoholic steatohepatitis (NASH). However, NGM282 increases serum cholesterol levels by inhibiting CYP7A1, which encodes the rate-limiting enzyme in the conversion of cholesterol t...

journal_title：Journal of hepatology

authors： Rinella ME,Trotter JF,Abdelmalek MF,Paredes AH,Connelly MA,Jaros MJ,Ling L,Rossi SJ,DePaoli AM,Harrison SA

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND/AIMS:Hepatic stellate cells (HSCs) are known to play a role in hepatic regeneration. We investigated hepatocyte/HSC interaction and HSC activation at various times after 70% partial hepatectomy (PHx) in the rat. METHODS:The hepatic microcirculation was studied using intravital fluorescence microscopy (IVFM)...

journal_title：Journal of hepatology

authors： Mabuchi A,Mullaney I,Sheard PW,Hessian PA,Mallard BL,Tawadrous MN,Zimmermann A,Senoo H,Wheatley AM

更新日期：2004-06-01 00:00:00

abstract：BACKGROUND/AIMS:Bio-artificial liver support systems for treatment of hepatic failure require maintained expression of hepatocyte function in vitro. We studied cultures of human hepatocyte cell-lines proliferating within alginate beads, investigating the hypothesis that 3-dimensional cohesive colonies of hepatocyte cel...

journal_title：Journal of hepatology

authors： Khalil M,Shariat-Panahi A,Tootle R,Ryder T,McCloskey P,Roberts E,Hodgson H,Selden C

更新日期：2001-01-01 00:00:00

abstract：:The burden of hepatocellular carcinoma (HCC) is highest in East Asia and Africa, although its incidence and mortality are rapidly rising in the United States and Europe. With the implementation of hepatitis B vaccination and hepatitis C treatment programmes worldwide, the epidemiology of HCC is shifting away from a di...

journal_title：Journal of hepatology

authors： Singal AG,Lampertico P,Nahon P

更新日期：2020-02-01 00:00:00