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Mechanism of hepatic fatty acid uptake.

Abstract：

:In recent years a new concept of the mechanism of hepatic fatty acid uptake has been described. It was shown that this major class of energy yielding substrates enters hepatocytes by a carrier-mediated uptake system. After the dissociation of the fatty acid-albumin complex at the sinusoidal liver cell plasma membrane, fatty acid binds with high affinity to a specific, newly identified, 40 kDa membrane fatty acid binding protein (MFABP). This protein functions as transmembrane transporter for long chain fatty acids. Hepatocellular uptake of fatty acids was shown to be sodium-dependent and electrogenic, compatible with a Na+-fatty acid cotransport system.

journal_name

J Hepatol

journal_title

Journal of hepatology

authors

Stremmel W

doi

10.1016/0168-8278(89)90148-7

subject

Has Abstract

pub_date

1989-11-01 00:00:00

pages

374-82

issue

3

eissn

0168-8278

issn

1600-0641

pii

0168-8278(89)90148-7

journal_volume

9

pub_type

杂志文章,评审

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