Targeted vaccination programme successful in reducing acute hepatitis B in men having sex with men in Amsterdam, the Netherlands.

abstract：:Non-alcoholic fatty liver disease (NAFLD) has become one of the most common forms of chronic liver disease worldwide and its prevalence is expected to continue rising. NAFLD has traditionally been considered a consequence of metabolic syndrome (MetS). However, the link between NAFLD and MetS components, especially typ...

journal_title：Journal of hepatology

authors： Lonardo A,Nascimbeni F,Mantovani A,Targher G

更新日期：2018-02-01 00:00:00

abstract：:Familial hypobetalipoproteinemia (FHBL) is an monogenic co-dominant disorder characterized by reduced plasma levels of cholesterol, low density lipoproteins (LDL) and apolipoprotein B (apoB) often associated with non-alcoholic fatty liver disease (NAFLD). It has been suggested that FHBL might predispose to gallstone d...

journal_title：Journal of hepatology

authors： Lancellotti S,Zaffanello M,Di Leo E,Costa L,Lonardo A,Tarugi P

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND/AIMS:As conditional knockout mice for stat3 are impaired in liver regeneration after partial hepatectomy while those for gp130 have defects in early STAT3 phosphorylation but have normal DNA synthesis, late STAT3 phosphorylation induced independently of gp130 seems to be essential for liver regeneration. Sin...

journal_title：Journal of hepatology

authors： Seki E,Kondo Y,Iimuro Y,Naka T,Son G,Kishimoto T,Fujimoto J,Tsutsui H,Nakanishi K

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND/AIMS:In these studies, we tested the hypothesis that increased lipid intake would exacerbate the severity of nutritional steatohepatitis. METHODS:C57Bl/6J mice were fed methionine-and-choline deficient (MCD) diets containing 20% (high) or 5% (low) fat by weight for 3 weeks and compared to lipid-matched cont...

journal_title：Journal of hepatology

authors： Larter CZ,Yeh MM,Williams J,Bell-Anderson KS,Farrell GC

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND & AIMS:Living donor liver transplantation (LDLT) provides a timely alternative to deceased donor liver transplantation (DDLT) for patients with hepatitis C virus-related (HCV-related) diseases in the circumstances of severe organ dearth. However, the patient and graft outcomes, and recurrence of HCV after LD...

journal_title：Journal of hepatology

authors： Hu A,Liang W,Zheng Z,Guo Z,He X

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND & AIMS:Common IL28B locus polymorphisms (SNPs rs8099917 and rs12979860) have been reported to affect peg-interferon plus ribavirin combination therapy (PEG-RBV) for hepatitis C virus (HCV) genotype 1b, but few reports have examined their effect on other two common genotypes, 2a and 2b. METHODS:We analyzed p...

journal_title：Journal of hepatology

authors： Kawaoka T,Hayes CN,Ohishi W,Ochi H,Maekawa T,Abe H,Tsuge M,Mitsui F,Hiraga N,Imamura M,Takahashi S,Kubo M,Tsunoda T,Nakamura Y,Kumada H,Chayama K

更新日期：2011-03-01 00:00:00

abstract：:Recently, GBV-C and HGV-two isolates of the same new flavivirus-were identified in serum samples of patients with indeterminate hepatitis and posttransfusion hepatitis, respectively. The pathogenic relevance of these viruses is still uncertain. As viral infections are presumed to trigger autoimmune processes, we inves...

journal_title：Journal of hepatology

authors： Heringlake S,Tillmann HL,Cordes-Temme P,Trautwein C,Hunsmann G,Manns MP

更新日期：1996-12-01 00:00:00

abstract：AIMS/METHODS:During cholestasis, components normally excreted into bile, e.g. bilirubin, accumulate in liver cells and biliary passages. In order to assess the conjugation of bilirubin retained in the hepatocyte during cholestasis, we analyzed the pattern of bilirubin pigments in rat serum and bile, using reversed phas...

journal_title：Journal of hepatology

authors： Mesa VA,De Vos R,Fevery J

更新日期：1997-11-01 00:00:00

abstract：BACKGROUND & AIMS:Virus-specific T cells capable of controlling HBV and eliminating hepatocellular carcinoma (HCC) expressing HBV antigens are deleted or dysfunctional in patients with chronic HBV or HBV-related HCC. The goal of this study was to determine if T cell receptor (TCR) gene transfer can reconstitute HBV-spe...

journal_title：Journal of hepatology

authors： Gehring AJ,Xue SA,Ho ZZ,Teoh D,Ruedl C,Chia A,Koh S,Lim SG,Maini MK,Stauss H,Bertoletti A

更新日期：2011-07-01 00:00:00

abstract：:Liver fibrosis is one of the most important factors of disturbed liver function, but could not be measured by simple blood tests until recently. Among several parameters used for this purpose, the aminoterminal procollagen type III peptide (PIIIP) appears to be the most widely accepted. Studies conducted in several cl...

journal_title：Journal of hepatology

authors： Hahn EG

更新日期：1985-01-01 00:00:00

abstract：:Hepatitis C virus (HCV) cDNA sequence in the nonstructural region NS3 was amplified from the serum of 66% French non-A, non-B hepatitis patients by the nested polymerase chain reaction. A 407 base-pair sequence was determined from four such cases, which revealed the presence of two different virus genotypes F1 (three ...

journal_title：Journal of hepatology

authors： Li JS,Tong SP,Vitvitski L,Lepot D,Trépo C

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND/AIMS:Lamivudine is an antiviral drug that is used to treat hepatitis B virus (HBV) infection. Long-term therapy does not completely suppress viral replication, and resistant mutants emerge. Resistance is mediated by changes in the tyrosine-methionine-apartate-aspartate (YMDD) motif in the catalytic site of t...

journal_title：Journal of hepatology

authors： Punia P,Cane P,Teo CG,Saunders N

更新日期：2004-06-01 00:00:00

abstract：:Liver disease is common in patients with cystic fibrosis, but the pathogenesis is poorly understood. The chronic colonization of bacteria in the lower airways leads to repeated treatments with antibiotics, especially aminoglycosides in high dosages. To investigate the possible role of aminoglycoside treatment in the n...

journal_title：Journal of hepatology

authors： Lindblad A,Hultcrantz R,Strandvik B

更新日期：1994-02-01 00:00:00

abstract：BACKGROUND/AIMS:The aim was to study the reproducibility of magnetic resonance velocity mapping, when measuring portal vein and superior mesenteric artery blood flow, under fasting and post-prandial conditions. Magnetic resonance flow measurements for the portal vein were compared with echo-Doppler measurements in the ...

journal_title：Journal of hepatology

authors： Lycklama à Nijeholt GJ,Burggraaf K,Wasser MN,Schultze Kool LJ,Schoemaker RC,Cohen AF,de Roos A

更新日期：1997-02-01 00:00:00

abstract：:The oesophageal pH was recorded for 3 h after a test-meal in 27 healthy control subjects (group I), 40 patients with alcoholic cirrhosis (group II), and 22 patients with a normal liver and symptoms of gastro-oesophageal reflux (control refluxers). Gastro-oesophageal reflux was observed in 10 of the cirrhotic patients....

journal_title：Journal of hepatology

authors： Arsene D,Bruley des Varannes S,Galmiche JP,Denis P,Chayvialle JA,Hellot MF,Ducrotte P,Colin R

更新日期：1987-04-01 00:00:00

abstract：:Intracellular ion homeostasis in liver cell is accomplished through the concerted action of ion pumps, carriers and channels. Description of these elements includes the Na+/K+-ATPase, Na+/H+- and Cl-/ HCO3(-)-exchange and Na+-HCO-3(-)- and Na(+)-K(+)-2 Cl(-)-cotransport as well as K+-, Cl(-)-, Na+ and nonselective cat...

journal_title：Journal of hepatology

authors： Graf J,Häussinger D

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND/AIMS:Excessive formation of nitric oxide may mediate the generalized vasorelaxation and hyporesponsiveness to vasoconstrictors observed in portal hypertensive states. Endotoxin, released from the bowel and detoxified by the liver, could stimulate inducible nitric oxide synthase directly or indirectly via the...

journal_title：Journal of hepatology

authors： Chu CJ,Lee FY,Wang SS,Chang FY,Lin HC,Lu RH,Wu SL,Chan CC,Tai CC,Lai IN,Lee SD

更新日期：1999-06-01 00:00:00

abstract：BACKGROUND & AIMS:HCV related liver disease is one of the most important complications in persons with HIV, with accelerated fibrosis progression in coinfected persons compared to those with HCV alone. We hypothesized that HCV-HIV coinfection increases HCV related hepatocyte apoptosis and that HCV and HIV influence TRA...

journal_title：Journal of hepatology

authors： Jang JY,Shao RX,Lin W,Weinberg E,Chung WJ,Tsai WL,Zhao H,Goto K,Zhang L,Mendez-Navarro J,Jilg N,Peng LF,Brockman MA,Chung RT

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND/AIMS:Vaccination strategies able to induce strong T-cell responses might contribute to eradicate hepatitis C virus (HCV) infection. We previously demonstrated that fusion of an antigen to the extra domain A from fibronectin (EDA) targets the antigen to TLR4-expressing dendritic cells (DC) and improves its im...

journal_title：Journal of hepatology

authors： Mansilla C,Gorraiz M,Martinez M,Casares N,Arribillaga L,Rudilla F,Echeverria I,Riezu-Boj JI,Sarobe P,Borrás-Cuesta F,Prieto J,Lasarte JJ

更新日期：2009-09-01 00:00:00

abstract：:Linoleic and alpha-linolenic acids are the fatty acids designated as "essential" since they are not synthesized by mammalian cells and must be provided in the diet. The recent dietary shift towards the consumption of n-6 (omega-6) at the expense of n-3 (omega-3) polyunsaturated fatty acids (PUFAs) is thought to be a p...

journal_title：Journal of hepatology

authors： El-Badry AM,Graf R,Clavien PA

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND/AIMS:Cirrhotic livers exhibit endothelial dysfunction that contributes to the increased hepatic vascular resistance. The present study evaluates the role of cyclooxygenase (COX)-derived prostanoids, implicated in the pathogenesis of endothelial dysfunction in other settings, in the pathogenesis of endothelia...

journal_title：Journal of hepatology

authors： Graupera M,García-Pagán JC,Parés M,Abraldes JG,Roselló J,Bosch J,Rodés J

更新日期：2003-10-01 00:00:00

abstract：BACKGROUND/AIMS:Health-related quality of life (HRQoL) is impaired in patients with chronic hepatitis C. We investigated HRQoL and fatigue in patients with chronic hepatitis C virus (HCV) infection in relation to the degree of fibrosis and inflammation, and controlled for the influence of relevant demographic and medic...

journal_title：Journal of hepatology

authors： Teuber G,Schäfer A,Rimpel J,Paul K,Keicher C,Scheurlen M,Zeuzem S,Kraus MR

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND & AIMS:Hallmarks of non-alcoholic fatty liver disease (NAFLD) are increased triglyceride accumulation within hepatocytes. The prevalence of NAFLD increases steadily with increasing thyrotropin (TSH) levels. However, the underlying mechanisms are largely unknown. Here, we focused on exploring the effect and m...

journal_title：Journal of hepatology

authors： Yan F,Wang Q,Lu M,Chen W,Song Y,Jing F,Guan Y,Wang L,Lin Y,Bo T,Zhang J,Wang T,Xin W,Yu C,Guan Q,Zhou X,Gao L,Xu C,Zhao J

更新日期：2014-12-01 00:00:00

abstract：:Endoscopic ultrasonography was performed in 80 cirrhotic patients and 50 control subjects. The aim of the study was to describe and classify the vascular abnormalities of the gastric wall as observed on echoendoscopy in cirrhotic patients and to compare the data with endoscopy. The size of gastric varices was classifi...

journal_title：Journal of hepatology

authors： Boustière C,Dumas O,Jouffre C,Letard JC,Patouillard B,Etaix JP,Barthélémy C,Audigier JC

更新日期：1993-09-01 00:00:00

abstract：BACKGROUND & AIMS:Autophagy plays a crucial role in hepatic homeostasis and its deregulation has been associated with chronic liver disease. However, the effect of autophagy on the release of fibrogenic extracellular vesicles (EVs) by platelet-derived growth factor (PDGF)-stimulated hepatic stellate cells (HSCs) remain...

journal_title：Journal of hepatology

authors： Gao J,Wei B,de Assuncao TM,Liu Z,Hu X,Ibrahim S,Cooper SA,Cao S,Shah VH,Kostallari E

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND & AIMS:Absence or low anti-HBV surface antibody (anti-HBs) is associated with an increased risk of HBV reactivation in patients with lymphoma and resolved HBV infection receiving rituximab-containing chemotherapy. Quantification of anti-HBV core antibody (anti-HBc) is a new marker associated with the natural...

journal_title：Journal of hepatology

authors： Yang HC,Tsou HH,Pei SN,Chang CS,Chen JH,Yao M,Lin SJ,Lin J,Yuan Q,Xia N,Liu TW,Chen PJ,Cheng AL,Hsu C,Taiwan Cooperative Oncology Group.

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND/AIMS:The factors which predict the long-term outcome in patients with hepatocellular carcinoma who are treated with percutaneous laser ablation (PLA) are not well established. METHODS:We prospectively analyzed treatment and survival parameters of 148 cirrhotic patients with nonsurgical hepatocellular carcin...

journal_title：Journal of hepatology

authors： Pacella CM,Bizzarri G,Francica G,Forlini G,Petrolati A,Valle D,Anelli V,Bianchini A,Nuntis SD,Pacella S,Rossi Z,Osborn J,Stasi R

更新日期：2006-05-01 00:00:00

abstract：:Porphyria cutanea tarda (PCT) is a metabolic disorder characterized by a reduced hepatic activity of uroporphynogen decarboxylase (URO-D), an enzyme of the heme synthesis. The clinical features of PCT may be brought into light by hepatic injury induced by hepatitis C virus (HCV). A significant association between HCV ...

journal_title：Journal of hepatology

authors： Thevenot T,Bachmeyer C,Hammi R,Dumouchel P,Ducamp-Posak I,Cadranel JF

更新日期：2005-04-01 00:00:00

abstract：BACKGROUND & AIMS:Serological markers of hepatocellular carcinoma (HCC) indicate its invasiveness. We aimed to investigate whether the prognostic impact of surgical resection (SR) and radiofrequency thermal ablation (RFA) on patients with single nodular HCC ⩽5cm were different regarding positive conditions of the follo...

journal_title：Journal of hepatology

authors： Ueno M,Hayami S,Shigekawa Y,Kawai M,Hirono S,Okada K,Tamai H,Shingaki N,Mori Y,Ichinose M,Yamaue H

更新日期：2015-12-01 00:00:00

abstract：:This article has been withdrawn at the request of the authors and with approval of the editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

journal_title：Journal of hepatology

authors： Xi B,Zeng T

更新日期：2011-02-22 00:00:00