当前位置： SCI文献检索 > JOURNAL OF HEPATOLOGY期刊下所有文献 > Regulation of organic anion transporters in a new rat model of acute and chronic cholangitis resembling human primary sclerosing cholangitis.

Regulation of organic anion transporters in a new rat model of acute and chronic cholangitis resembling human primary sclerosing cholangitis.

Abstract：

BACKGROUND/AIMS:Primary sclerosing cholangitis (PSC) is a cholestatic liver disease of unknown etiology. Although the primary defect affects cholangiocytes, cholestatic injury of hepatocytes may promote further liver damage. Since down-regulation of hepatocellular organic anion transporters is implicated in the molecular pathogenesis of cholestasis, expression of these transporters was determined in a novel rat model, which closely resembles human PSC. METHODS:Hepatic protein and mRNA expression of basolateral (Ntcp, Oatp1, 2 and 4) and canalicular (Mrp2, Bsep) organic anion transporters were analyzed 1, 4 and 12 weeks after induction of experimental PSC by 2,4,6-trinitrobenzenesulfonic acid (TNBS). RESULTS:Specific down-regulation of basolateral and canalicular transport systems except Oatp4 and Bsep proteins occurred during the acute phase of inflammation. In chronic cholangitis 12 weeks after TNBS Mrp2 protein and mRNA remained down-regulated by 40-50% of controls (P<0.05). In addition Oatp1 protein was also reduced by 40+/-13% (P<0.05), whereas all other transporters returned to control values. CONCLUSIONS:In chronic cholangitis only canalicular Mrp2 expression remained down-regulated. This might represent the first injury to hepatocytes in chronic cholangitis as an extension of liver injury from the level of cholangiocytes to hepatocytes in PSC.

journal_name

J Hepatol

journal_title

Journal of hepatology

authors

Geier A,Dietrich CG,Lammert F,Orth T,Mayet WJ,Matern S,Gartung C

doi

10.1016/s0168-8278(02)00052-1

subject

Has Abstract

pub_date

2002-06-01 00:00:00

pages

718-24

issue

6

eissn

0168-8278

issn

1600-0641

pii

S0168827802000521

journal_volume

36

pub_type

杂志文章

相关文献

JOURNAL OF HEPATOLOGY文献大全
  • Pathogenesis of lipid metabolism disorder in hepatitis C: polyunsaturated fatty acids counteract lipid alterations induced by the core protein.

    abstract：BACKGROUND & AIMS:Disturbance in lipid metabolism is one of the features of chronic hepatitis C, being a crucial determinant of the progression of liver fibrosis. Experimental studies have revealed that the core protein of hepatitis C virus (HCV) induces steatosis. METHODS:The activities of fatty acid metabolizing enz...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2010.07.039

    authors： Miyoshi H,Moriya K,Tsutsumi T,Shinzawa S,Fujie H,Shintani Y,Fujinaga H,Goto K,Todoroki T,Suzuki T,Miyamura T,Matsuura Y,Yotsuyanagi H,Koike K

    更新日期：2011-03-01 00:00:00

  • Macrophages from rat livers with micronodular and macronodular cirrhosis differ with respect to mediator release and DNA-synthesis.

    abstract：BACKGROUND/AIMS:Liver macrophages play an essential role in necro-inflammatory liver damage which leads to fibrosis and cirrhosis. The aim of the present study was to compare the mediator release and the DNA synthesis of macrophages at an early and at a later stage of liver cirrhosis induced by thioacetamide. METHODS:...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(97)80118-3

    authors： Vogl S,Junker U,Vogelsang H,Dargel R

    更新日期：1997-05-01 00:00:00

  • Hepatocellular proliferation in patients with chronic hepatitis C and persistently normal or abnormal aminotransferase levels.

    abstract：BACKGROUND/AIMS:Some patients chronically infected with the hepatitis C virus (HCV) have persistently normal alanine aminotransferase (ALT) levels while progressive liver damage is observed histologically. In the present study, we compared the rate of proliferation, apoptosis, and necrosis in liver biopsy specimens of ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1034/j.1600-0641.2000.033004640.x

    authors： Kronenberger B,Rüster B,Lee JH,Sarrazin C,Roth WK,Herrmann G,Zeuzem S

    更新日期：2000-10-01 00:00:00

  • Protective effects of FUT-175 on acute massive hepatic necrosis induced in mice following endotoxin injection and immunization with liver proteins.

    abstract：:Experimental autoimmune hepatitis was induced in C57BL/6 mice by immunization with syngeneic liver protein and adjuvant. Hepatitis was characterized by marked cellular infiltrates, but hepatic necrosis was mild to moderate. A small dose of endotoxin (25 micrograms/mouse) produced lethal hepatitis with elevation of ser...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(05)80548-3

    authors： Ogawa M,Mori Y,Ueda S,Mori T,Makino Y,Hori J,Ohto M,Wakashin M

    更新日期：1993-11-01 00:00:00

  • Differential effect of ARA-AMP on serum DNA polymerase activity and serum HBV-DNA in chronic hepatitis B virus infection. A possible reason for lack of efficacy.

    abstract：:An uncontrolled pilot study of adenine arabinoside monophosphate intramuscularly (ARA-AMP) for 5 days at 10 mg/kg/day and 23 days at 5 mg/kg/day in divided doses, was conducted in 15 consecutive patients known to be HBeAg-positive for a minimum of 12 months. Two patients were lost to follow-up (1 having developed an h...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(86)80104-0

    authors： Alexander GJ,Fagan EA,Rolando N,Guarner P,Callender ME,Eddleston AL,Williams R

    更新日期：1986-01-01 00:00:00

  • Fatty acid composition of adipose tissue in patients with chronic liver disease.

    abstract：:In this study plasma free fatty acids and adipose tissue fatty acid composition in 10 cirrhotic patients, 5 patients with non-cirrhotic chronic liver disease and in 5 controls have been investigated. Fatty acid composition of adipose tissue in cirrhotic patients demonstrated a significant increase of 16:1 and a decrea...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(86)80153-2

    authors： Merli M,Iapichino S,Bolognese A,Bruni A,Cantafora A,Riggio O,Capocaccia L

    更新日期：1986-01-01 00:00:00

  • Short-term effect of recombinant human growth hormone in patients with alcoholic cirrhosis.

    abstract：:As growth hormone possesses anabolic properties that are active on protein metabolism, and thus of potential benefit to patients with chronic liver disease, we determined the metabolic effects of recombinant human growth hormone on insulin-like growth factor-I (IGF-I) its specific binding proteins, and liver function....

    journal_title：Journal of hepatology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0168-8278(94)80228-9

    authors： Møller S,Becker U,Grønbaek M,Juul A,Winkler K,Skakkebaek NE

    更新日期：1994-11-01 00:00:00

  • Endoscopic ultrasonography classification of gastric varices in patients with cirrhosis. Comparison with endoscopic findings.

    abstract：:Endoscopic ultrasonography was performed in 80 cirrhotic patients and 50 control subjects. The aim of the study was to describe and classify the vascular abnormalities of the gastric wall as observed on echoendoscopy in cirrhotic patients and to compare the data with endoscopy. The size of gastric varices was classifi...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(05)80581-1

    authors： Boustière C,Dumas O,Jouffre C,Letard JC,Patouillard B,Etaix JP,Barthélémy C,Audigier JC

    更新日期：1993-09-01 00:00:00

  • Usefulness of biochemical remission and transient elastography in monitoring disease course in autoimmune hepatitis.

    abstract：BACKGROUND & AIMS:Liver fibrosis regression but also progression may occur in patients with autoimmune hepatitis (AIH) under treatment. There is a need for non-invasive surrogate markers for fibrosis development in AIH to better guide immunosuppressive treatment. The aims of the study were to assess the impact of compl...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2017.11.020

    authors： Hartl J,Ehlken H,Sebode M,Peiseler M,Krech T,Zenouzi R,von Felden J,Weiler-Normann C,Schramm C,Lohse AW

    更新日期：2018-04-01 00:00:00

  • Longitudinal study on osteodystrophy in primary biliary cirrhosis (PBC) and a pilot study on calcitonin treatment.

    abstract：:The aims of this study were to evaluate bone metabolism in primary biliary cirrhosis (PBC) and the effect of ADFR (activate, depress, free, repeat) therapy with vitamin D, calcium and calcitonin in preventing bone resorption. Sixty-nine female subjects entered the study: 38 PBC (AMA + ve) patients, 11 AMA-negative chr...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/0168-8278(91)90941-4

    authors： Floreani A,Chiaramonte M,Giannini S,Malvasi L,Lodetti MG,Castrignano R,Giacomini A,D'Angelo A,Naccarato R

    更新日期：1991-03-01 00:00:00

  • Phenprocoumon-induced liver disease ranges from mild acute hepatitis to (sub-) acute liver failure.

    abstract：BACKGROUND/AIMS:Except for bleeding complications, other serious adverse reactions of coumarin anticoagulants such as hepatotoxicity or skin necrosis are comparatively rare. Nonetheless, a small number of coumarin-induced (sub-) acute liver failures has been published. METHODS:A retrospective analysis was performed of...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2004.03.010

    authors： Schimanski CC,Burg J,Möhler M,Höhler T,Kanzler S,Otto G,Galle PR,Lohse AW

    更新日期：2004-07-01 00:00:00

  • Liver stiffness measurement selects patients with cirrhosis at risk of bearing large oesophageal varices.

    abstract：BACKGROUND/AIMS:Periodic endoscopic screening for oesophageal varices is recommended in patients with cirrhosis, but might be limited to a subgroup of patients if a simple non-invasive test was available to select those at risk of bleeding. METHODS:We studied in 165 patients with cirrhosis the relation between the pre...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2006.04.006

    authors： Kazemi F,Kettaneh A,N'kontchou G,Pinto E,Ganne-Carrie N,Trinchet JC,Beaugrand M

    更新日期：2006-08-01 00:00:00

  • Procoagulant imbalance in patients with non-alcoholic fatty liver disease.

    abstract：BACKGROUND & AIMS:Non-alcoholic fatty liver disease (NAFLD) is characterized by increased risk of cardiovascular events and liver-fibrosis. Both could be explained by a procoagulant-imbalance that was surmised but never directly demonstrated. We investigated 113 patients with varying histological liver damage [steatosi...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2014.03.013

    authors： Tripodi A,Fracanzani AL,Primignani M,Chantarangkul V,Clerici M,Mannucci PM,Peyvandi F,Bertelli C,Valenti L,Fargion S

    更新日期：2014-07-01 00:00:00

  • New virological tools for screening, diagnosis and monitoring of hepatitis B and C in resource-limited settings.

    abstract：:Worldwide, the increasingly dominant model of laboratory testing is the centralised laboratory, in which automation of analytical processes increases, enabling the analysis of large numbers of samples at a relatively low cost. However, this trend does not fulfil the requirements for care of patients with chronic hepat...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jhep.2018.05.017

    authors： Chevaliez S,Pawlotsky JM

    更新日期：2018-10-01 00:00:00

  • Analysis of the cost of population screening for haemochromatosis using biochemical and genetic markers.

    abstract：AIMS:To estimate the cost of population screening for haemochromatosis in Australia and to compare the cost of alternative screening strategies. METHODS:The costs of screening for haemochromatosis were analysed in a hypothetical study using transferrin saturation as the primary screening test, with confirmation of the...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(97)80357-1

    authors： Bassett ML,Leggett BA,Halliday JW,Webb S,Powell LW

    更新日期：1997-09-01 00:00:00

  • Treatment of recurrent hepatitis C in liver transplants: efficacy of a six versus a twelve month course of interferon alfa 2b with ribavirin.

    abstract：BACKGROUND/AIMS:Interferon (IFN) with ribavirin combination therapy (CT) was proposed for the treatment of hepatitis C recurring in liver transplants. We assessed the efficacy of two protocols of CT in transplanted patients with recurrent severe hepatitis C virus (HCV) hepatitis. METHODS:Fifty-seven patients (68% geno...

    journal_title：Journal of hepatology

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0168-8278(02)00109-5

    authors： Lavezzo B,Franchello A,Smedile A,David E,Barbui A,Torrani M,Ottobrelli A,Zamboni F,Fadda M,Bobbio A,Salizzoni M,Rizzetto M

    更新日期：2002-08-01 00:00:00

  • Hepatitis E virus. Comparison of 'New and Old World' isolates.

    abstract：:The etiologic agent responsible for epidemics of enterically-transmitted non-A, non-B hepatitis has been molecularly characterized as the hepatitis E virus (HEV). The cloning of a portion of the Burma strain of HEV (HEV(B); 'Old World' strain) has been described together with the isolation of a contiguous overlapping ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/0168-8278(91)90050-l

    authors： Reyes GR,Huang CC,Yarbough PO,Tam AW

    更新日期：1991-01-01 00:00:00

  • SARS-CoV-2 infection of the liver directly contributes to hepatic impairment in patients with COVID-19.

    abstract：Background & Aims:Liver enzyme abnormalities are common in patients with coronavirus disease 2019 (COVID-19). Whether or not severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can lead to liver damage per se remains unknown. Herein, we reported the clinical characteristics and liver pathological man...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2020.05.002

    authors： Wang Y,Liu S,Liu H,Li W,Lin F,Jiang L,Li X,Xu P,Zhang L,Zhao L,Cao Y,Kang J,Yang J,Li L,Liu X,Li Y,Nie R,Mu J,Lu F,Zhao S,Lu J,Zhao J

    更新日期：2020-10-01 00:00:00

  • The clinical significance of persistently normal ALT in chronic hepatitis B infection.

    abstract：BACKGROUND/AIMS:Chronic hepatitis B virus (HBV) disease is caused by both necroinflammation and active viral replication. The role of ALT levels as a predictor of liver injury has recently been questioned. The aim of the study was to determine whether normal ALT is associated with liver injury in a cohort of HBV patien...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2007.07.022

    authors： Lai M,Hyatt BJ,Nasser I,Curry M,Afdhal NH

    更新日期：2007-12-01 00:00:00

  • Complete removal of the tumor-bearing portal territory decreases local tumor recurrence and improves disease-specific survival of patients with hepatocellular carcinoma.

    abstract：BACKGROUND & AIMS:Anatomic resection (AR) of the tumor-bearing portal territory has been reported to be associated with a decreased recurrence of hepatocellular carcinoma (HCC). However, because of the heterogeneity of the study populations, its oncologic advantage remains controversial. The objective of the present st...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2015.10.015

    authors： Shindoh J,Makuuchi M,Matsuyama Y,Mise Y,Arita J,Sakamoto Y,Hasegawa K,Kokudo N

    更新日期：2016-03-01 00:00:00

  • Sustained virological response to antiviral therapy reduces mortality in HCV reinfection after liver transplantation.

    abstract：BACKGROUND/AIMS:HCV infection recurs almost in all HCV-positive patients receiving liver transplantation and carries a poor prognosis. Aim of this study was to analyze efficacy and effect on survival of antiviral therapy in this clinical setting. METHODS:Pegylated-interferon alpha-2b and ribavirin were administered at...

    journal_title：Journal of hepatology

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.jhep.2006.10.017

    authors： Picciotto FP,Tritto G,Lanza AG,Addario L,De Luca M,Di Costanzo GG,Lampasi F,Tartaglione MT,Marsilia GM,Calise F,Cuomo O,Ascione A

    更新日期：2007-03-01 00:00:00

  • Transactivating function and expression of the x gene of hepatitis B virus.

    abstract：BACKGROUND/AIMS:The x gene of hepatitis B virus encodes a transactivating factor of 154 amino acids, termed HBx, which stimulates transcription of multiple viral and cellular genes. The transactivating function is probably associated with a tumorigenic potential of HBx, since x gene sequences, encoding functional HBx, ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/0168-8278(95)80311-4

    authors： Renner M,Haniel A,Bürgelt E,Hofschneider PH,Koch W

    更新日期：1995-07-01 00:00:00

  • Lactitol versus lactulose in the treatment of chronic hepatic encephalopathy. A double-blind, randomised, cross-over study.

    abstract：:Lactitol is a disaccharide analogue of lactulose which is available as a pure crystalline powder. The efficacy of lactitol in the treatment of chronic hepatic encephalopathy was assessed in 9 cirrhotic patients in a randomised, double-blind, cross-over comparison with lactulose. The sugars were dispensed in solutions,...

    journal_title：Journal of hepatology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0168-8278(87)80086-7

    authors： Morgan MY,Hawley KE,Stambuk D

    更新日期：1987-04-01 00:00:00

  • Hepatitis C virus and blood transfusion: past and present risks.

    abstract：:The risk of HCV transmission by blood and blood products has been greatly reduced since the early 1980's. Selection of non-remunerated donors, donor selection to prevent HIV transmission, initial surrogate testing in some regions, and introduction of anti-HCV testing have all contributed to this. ALT surrogate testing...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,评审

    doi：10.1016/s0168-8278(99)80384-5

    authors： van der Poel CL

    更新日期：1999-01-01 00:00:00

  • Second-hand smoke stimulates lipid accumulation in the liver by modulating AMPK and SREBP-1.

    abstract：BACKGROUND/AIMS:The underlying mechanisms of steatosis, the first stage of non-alcoholic fatty liver disease (NAFLD) that is characterized by the accumulation of lipids in hepatocytes, remain unclear. Our study aimed to investigate the hypothesis that cigarette smoke is known to change circulating lipid profiles and th...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2009.03.026

    authors： Yuan H,Shyy JY,Martins-Green M

    更新日期：2009-09-01 00:00:00

  • Analysis of T-cell receptor Vbeta repertoire in liver-infiltrating lymphocytes in chronic hepatitis C.

    abstract：BACKGROUND/AIMS:To examine the T-cell repertoire which is involved in the immunopathogenesis of chronic hepatitis, we analyzed the T-cell receptor Vbeta gene usage in liver-infiltrating lymphocytes by reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemical technique. METHODS:Complementary DNA ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(97)80408-4

    authors： Kashii Y,Shimizu Y,Nambu S,Minemura M,Okada K,Higuchi K,Watanabe A

    更新日期：1997-03-01 00:00:00

  • The hepatitis B virus and the host response.

    abstract：:The clearance of hepatitis B virus infected cells from the liver is probably dependent on an interplay between the interferon system and the cellular limb of the host immune response. Although the importance of the nucleocapsid proteins as targets for sensitized cytotoxic T cells is established in chronic hepatitis B ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,评审

    doi：10.1016/0168-8278(90)90170-v

    authors： Thomas HC

    更新日期：1990-01-01 00:00:00

  • Effect of HBV polymerase inhibitors on renal function in patients with chronic hepatitis B.

    abstract：BACKGROUND & AIMS:Therapy of chronic hepatitis B with HBV-polymerase inhibitors, in particular tenofovir or adefovir, may affect renal function. To assess renal function more accurately in the normal range, we used the recently validated, Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula to calculate ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2011.03.030

    authors： Mauss S,Berger F,Filmann N,Hueppe D,Henke J,Hegener P,Athmann C,Schmutz G,Herrmann E

    更新日期：2011-12-01 00:00:00

  • Detection of hepatitis C virus antigen by immuno-histochemical staining: a histological marker of hepatitis C virus infection.

    abstract：:Hepatitis C virus has been recognized as a major cause of non-A, non-B viral hepatitis. Although serologic tests have been commercialized, no specific histological or immuno-histochemical markers for hepatitis C virus infection are available for routine use. In an effort to detect hepatitis C virus antigen in liver ti...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(05)80069-8

    authors： Yap SH,Willems M,Van den Oord J,Habets W,Middeldorp JM,Hellings JA,Nevens F,Moshage H,Desmet V,Fevery J

    更新日期：1994-02-01 00:00:00

  • Deterioration of health-related quality of life and fatigue in patients with chronic hepatitis C: Association with demographic factors, inflammatory activity, and degree of fibrosis.

    abstract：BACKGROUND/AIMS:Health-related quality of life (HRQoL) is impaired in patients with chronic hepatitis C. We investigated HRQoL and fatigue in patients with chronic hepatitis C virus (HCV) infection in relation to the degree of fibrosis and inflammation, and controlled for the influence of relevant demographic and medic...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jhep.2008.07.025

    authors： Teuber G,Schäfer A,Rimpel J,Paul K,Keicher C,Scheurlen M,Zeuzem S,Kraus MR

    更新日期：2008-12-01 00:00:00