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Hepatic and extrahepatic malignancies in autoimmune hepatitis. A long-term follow-up in 473 Swedish patients.

Abstract：

BACKGROUND/AIMS:Autoimmune Hepatitis (AIH) is a liver disease which may lead to liver cirrhosis. Cirrhosis is a well-known risk factor for hepatocellular cancer. Lymphoma is a disease, where immune modulating drugs as well as the autoimmune disease itself may contribute to the elevated risk. The aim was to investigate the risks of malignancies in a large cohort of AIH patients. METHODS:Four hundred and seventy-three patients with AIH were matched to the Swedish national cancer register as well as to the death cause register. RESULTS:We found an overall higher risk of malignancies in the cohort of AIH patients from the date of diagnosis with a SIR of 1.51 (95% CI 1.10-2.03). SIR in the subpopulation of well defined catchment areas and complete case finding was 23.28 (95% CI 7.5-54.34) for HCC. Lymphomas were found a SIR of 13.09 (95% CI 4.22-30.56). CONCLUSIONS:There was an overall increased risk of malignancies in a cohort of AIH patients, which manly was caused by hepatobiliary cancers. However, the true risk of HCC in an AIH cirrhotic cohort has yet to be investigated. A significantly higher risk of lymphomas was also found, but no clear cut association to the use of immune modulators.

journal_name

J Hepatol

journal_title

Journal of hepatology

authors

Werner M,Almer S,Prytz H,Lindgren S,Wallerstedt S,Björnsson E,Bergquist A,Sandberg-Gertzén H,Hultcrantz R,Sangfelt P,Weiland O,Danielsson A

doi

10.1016/j.jhep.2008.08.022

subject

Has Abstract

pub_date

2009-02-01 00:00:00

pages

388-93

issue

2

eissn

0168-8278

issn

1600-0641

pii

S0168-8278(08)00699-5

journal_volume

50

pub_type

杂志文章

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