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Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.

Abstract：

:Hepatocellular carcinoma (HCC) is among the most prevalent human malignancies worldwide with rising incidence in industrialised countries, few therapeutic options and poor prognosis. To expand and improve therapeutic strategies, identification of drug targets involved in several liver cancer-related pathways is crucial. Virtually all signal transduction cascades cross the nuclear envelope and therefore require components of the nuclear transport system (NTS), including nuclear transport receptors (e.g. importins and exportins) and the nuclear pore complex. Accordingly, members of the NTS represent promising targets for therapeutic intervention. Selective inhibitors of nuclear export have already entered clinical trials for various malignancies. Herein, we review the current knowledge regarding alterations of the NTS and their potential for targeted therapy in HCC.

journal_name

J Hepatol

journal_title

Journal of hepatology

authors

Beck M,Schirmacher P,Singer S

doi

10.1016/j.jhep.2017.06.021

subject

Has Abstract

pub_date

2017-11-01 00:00:00

pages

1051-1061

issue

5

eissn

0168-8278

issn

1600-0641

pii

S0168-8278(17)32122-0

journal_volume

67

pub_type

杂志文章,评审

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