当前位置： SCI文献检索 > JOURNAL OF HEPATOLOGY期刊下所有文献 > Hepatitis C virus Core Antigen as a predictor of non-response in genotype 1 chronic hepatitis C patients treated with peginterferon alpha-2b plus ribavirin.

Hepatitis C virus Core Antigen as a predictor of non-response in genotype 1 chronic hepatitis C patients treated with peginterferon alpha-2b plus ribavirin.

Abstract：

BACKGROUND/AIMS:Chronic hepatitis C patients infected by genotype 1 are the least responsive to combination therapy and therefore monitoring response is important in identifying non-responders quickly, permitting therapy discontinuation and avoiding side effects and costs. We examined the usefulness of measuring total HCV Core Ag in early treatment with peginterferon alpha-2b and ribavirin in genotype 1 patients in the prediction of response and compared the results with those from HCV RNA quantification. METHODS:Two hundred and sixty-eight serum samples from 46 genotype 1 patients receiving combination therapy were examined for HCV Core Ag and quantitative HCV RNA. RESULTS:At baseline, mean HCV RNA and HCV Core Ag concentrations were significantly lower in sustained virologic responders than in non-responders. The negative predictive value of HCV Core Ag testing in predicting non-response at week 12 is 100%, and for a 2 log drop in HCV RNA, using two quantitative tests, it is 88%. CONCLUSIONS:HCV Core Ag determination allows the identification of non-responders with only one test at week 12 and permits stopping therapy in these patients. HCV Core Antigen testing is cheaper and easier to perform than HCV RNA quantification.

journal_name

J Hepatol

journal_title

Journal of hepatology

authors

Buti M,Mendez C,Schaper M,Sauleda S,Valdes A,Rodriguez-Frias F,Jardi R,Esteban R

doi

10.1016/j.jhep.2003.11.026

subject

Has Abstract

pub_date

2004-03-01 00:00:00

pages

527-32

issue

3

eissn

0168-8278

issn

1600-0641

pii

S016882780300624X

journal_volume

40

pub_type

杂志文章

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