Treatment options in patients with decompensated cirrhosis, pre- and post-transplantation.

abstract：:Hepatitis C infection is common in patients undergoing liver transplantation. Few studies have focused on the prevalence and epidemiology of hepatitis C infection among liver transplant recipients since the implementation of donor screening for antibodies against the hepatitis C virus (anti-HCV). Using reverse transcr...

journal_title：Journal of hepatology

authors： Weinstein JS,Poterucha JJ,Zein N,Wiesner RH,Persing DH,Rakela J

更新日期：1995-01-01 00:00:00

abstract：:The addition of protease inhibitors, boceprevir or telaprevir, to peginterferon+ribavirin (PegIFN/RBV) increases the frequency as well as the severity, and hence, clinical relevance of anemia, which has now become one of the major complications associated with triple therapy. Most significant factors associated with a...

journal_title：Journal of hepatology

authors： Romero-Gómez M,Berenguer M,Molina E,Calleja JL

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Retrorsine, a naturally occurring pyrrolizidine alkaloid, impairs liver regeneration after partial hepatectomy by mechanisms that are still unclear. AIM:The aim of the study was to clarify the influence of retrorsine on cell cycle progression in the regenerating liver lobes of rats after portal branch ligat...

journal_title：Journal of hepatology

authors： Picard C,Lambotte L,Starkel P,Sempoux C,Saliez A,Van Den Berge V,de Saeger C,Horsmans Y

更新日期：2003-07-01 00:00:00

abstract：BACKGROUND/AIMS:Alamifovir is a purine nucleotide analogue prodrug that shows potent activity against wild type and lamivudine resistant hepatitis B virus in preclinical studies. The aim of this study was to assess the safety and potential antiviral effects of alamifovir in humans. METHODS:A randomised, placebo contro...

journal_title：Journal of hepatology

authors： Soon DK,Lowe SL,Teng CH,Yeo KP,McGill J,Wise SD

更新日期：2004-11-01 00:00:00

abstract：:We investigated whether regulation of interferon-alpha gene expression could be involved in liver tumor biology and the role, if any, of hepatitis B virus in the regulation of tumor cytokine gene expression. Gene expression was investigated at the transcriptional level using 'in situ' hybridization of cytokine message...

journal_title：Journal of hepatology

authors： d'Arville CN,Nouri-Aria KT,Johnson P,Williams R

更新日期：1993-03-01 00:00:00

abstract：:Alcoholics admitted for detoxification were entered into a double blind placebo controlled trial of oral supplementation with an antioxidant cocktail (vitamin E, beta carotene, vitamin C and selenium) in order to determine the effect of this supplementation on the rate of resolution of a serum marker of free radical a...

journal_title：Journal of hepatology

authors： Butcher GP,Rhodes JM,Walker R,Krasner N,Jackson MJ

更新日期：1993-08-01 00:00:00

abstract：AIMS:To assess the presence of autonomic neuropathy in patients with non-alcoholic chronic liver disease and its relationships with the severity of liver damage. METHODS:Thirty non-alcoholic patients with chronic liver disease and 26 healthy control subjects were studied. The silicone imprint technique was used to qua...

journal_title：Journal of hepatology

authors： Oliver MI,Miralles R,Rubíes-Prat J,Navarro X,Espadaler JM,Solá R,Andreu M

更新日期：1997-06-01 00:00:00

abstract：:Infection with the hepatitis C virus (HCV) is the major cause of nonA-nonB hepatitis worldwide. Although this virus cannot be cultivated in vitro, several of its key features have been elucidated in the past few years. The viral genome is a positive-sense, single-stranded, 9.6 kb long RNA molecule. The viral genome is...

journal_title：Journal of hepatology

authors： De Francesco R

更新日期：1999-01-01 00:00:00

abstract：:Liver diseases affect millions of people worldwide. In most developed countries, the incidence of viral hepatitis is waning as a result of modern advances in disease prevention, diagnosis, and therapies. Expanded programmes for systematic immunisation against hepatitis B virus have also significantly brought down the ...

journal_title：Journal of hepatology

authors： Xiao J,Wang F,Wong NK,He J,Zhang R,Sun R,Xu Y,Liu Y,Li W,Koike K,He W,You H,Miao Y,Liu X,Meng M,Gao B,Wang H,Li C

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND/AIMS:Periodic endoscopic screening for oesophageal varices is recommended in patients with cirrhosis, but might be limited to a subgroup of patients if a simple non-invasive test was available to select those at risk of bleeding. METHODS:We studied in 165 patients with cirrhosis the relation between the pre...

journal_title：Journal of hepatology

authors： Kazemi F,Kettaneh A,N'kontchou G,Pinto E,Ganne-Carrie N,Trinchet JC,Beaugrand M

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND & AIMS:Roles of alcohol consumption in non-alcoholic fatty liver disease are still controversial, although several cross-sectional studies have suggested the beneficial effect of light to moderate drinking on fatty liver. We analyzed the longitudinal relationship between drinking pattern and fatty liver. ME...

journal_title：Journal of hepatology

authors： Moriya A,Iwasaki Y,Ohguchi S,Kayashima E,Mitsumune T,Taniguchi H,Ando M,Yamamoto K

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND/AIMS:Patients infected with hepatitis C virus (HCV) genotype 2 or 3 usually respond better to interferon (IFN) treatment than those infected with genotype 1. In this study, we investigated whether the non-structural 5A protein (NS5A) of HCV genotypes 1 and 2 (1b-NS5A and 2a-NS5A, respectively) exerted differ...

journal_title：Journal of hepatology

authors： Tsai YH,Kuang WF,Lu TY,Kao JH,Lai MY,Liu CJ,Chen PJ,Hwang LH

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND & AIMS:To evaluate the efficacy and safety of telaprevir in combination with peginterferon-α2b (PEG-IFN) and ribavirin (RBV) in patients with chronic hepatitis C. METHODS:In a multi-center randomized clinical trial in Japan, on patients infected with HCV of genotype 1, 126 patients were assigned to telaprev...

journal_title：Journal of hepatology

authors： Kumada H,Toyota J,Okanoue T,Chayama K,Tsubouchi H,Hayashi N

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND/AIMS:Inflammation in the liver is a complex interaction between parenchymal and non-parenchymal cells, and therefore can not be studied in vitro in pure cultures of these cells. METHODS:We investigated whether Kupffer cells in the liver slice are still responsive to an inflammatory stimulus of lipopolysacch...

journal_title：Journal of hepatology

authors： Olinga P,Merema MT,de Jager MH,Derks F,Melgert BN,Moshage H,Slooff MJ,Meijer DK,Poelstra K,Groothuis GM

更新日期：2001-08-01 00:00:00

abstract：BACKGROUND & AIMS:Cholangiocarcinoma (CCA) carries a very poor prognosis due to a typically late clinical presentation and a poor response to current therapeutics. While these tumors commonly express PD-1 and PD-L1, the response to immune checkpoint inhibitors (ICI) is poor. Stimulating antigen-presenting cells includi...

journal_title：Journal of hepatology

authors： Diggs LP,Ruf B,Ma C,Heinrich B,Cui L,Zhang Q,McVey JC,Wabitsch S,Heinrich S,Rosato U,Lai W,Subramanyam V,Longerich T,Loosen SH,Luedde T,Neumann UP,Desar S,Kleiner D,Gores G,Wang XW,Greten TF

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND & AIMS:Mannose-binding lectin (MBL) is a serum lectin synthesized by the liver and involved in innate host defense. MBL deficiency increases the risk of various infectious diseases mostly in immune-deficient conditions. Bacterial infections are a significant cause of morbidity and mortality in liver cirrhosi...

journal_title：Journal of hepatology

authors： Altorjay I,Vitalis Z,Tornai I,Palatka K,Kacska S,Farkas G,Udvardy M,Harsfalvi J,Dinya T,Orosz P,Lombay B Jr,Par G,Par A,Csak T,Osztovits J,Szalay F,Csepregi A,Lakatos PL,Papp M

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND/AIMS:In order to prevent the occurrence of drug-resistant mutants associated with treatment for chronic hepatitis B virus (HBV) infection, combination therapy is being developed. To determine the efficacy of adefovir dipivoxil (ADV) plus emtricitabine (FTC) combination therapy in chronic HBV infection. METH...

journal_title：Journal of hepatology

authors： Hui CK,Zhang HY,Bowden S,Locarnini S,Luk JM,Leung KW,Yueng YH,Wong A,Rousseau F,Yuen KY,Naoumov NN,Lau GK

更新日期：2008-05-01 00:00:00

abstract：:Twelve cirrhotic patients and six controls were fed an eucaloric high carbohydrate (CHO) diet for 3 days. Fasting serum triglyceride (TG), non-esterified fatty acids (NEFA), glucose, insulin and glycerol were estimated daily. On the 3rd day of the study we measured NEFA, glucose, insulin, and fructose every 45 min fro...

journal_title：Journal of hepatology

authors： Avgerinos A,Harry D,Bousboulas S,Theodossiadou E,Komesidou V,Pallikari A,Raptis S,McIntyre N

更新日期：1992-01-01 00:00:00

abstract：:Since the early 1990's, hepatitis B immune globulin (HBIG) has been central to the prevention of hepatitis B virus (HBV) recurrence after liver transplantation. When used in combination with oral nucleos(t)ide analogues, HBIG prevents reinfection with HBV in ⩾90% of transplant recipients. While HBIG is highly efficaci...

journal_title：Journal of hepatology

authors： Fox AN,Terrault NA

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND & AIMS:Severe cholestasis may cause cholemic nephropathy that can be modeled in common bile duct ligated (CBDL) mice. We aimed to explore the therapeutic efficacy and mechanisms of norursodeoxycholic acid (norUDCA) in cholemic nephropathy. METHODS:In 8-week CBDL mice fed with norUDCA (prior or post CBDL) or...

journal_title：Journal of hepatology

authors： Krones E,Eller K,Pollheimer MJ,Racedo S,Kirsch AH,Frauscher B,Wahlström A,Ståhlman M,Trauner M,Grahammer F,Huber TB,Wagner K,Rosenkranz AR,Marschall HU,Fickert P

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND/AIMS:[corrected] Hepatobiliary carcinoma (HBC) has been considered to be a late complication of end-stage primary sclerosing cholangitis (PSC). The incidence of HBC is approximately 20% in PSC patients evaluated for liver transplantation. The diagnosis of HBC is difficult, at least at an early stage and the ...

journal_title：Journal of hepatology

authors： Leidenius M,Höckersted K,Broomé U,Ericzon BG,Friman S,Olausson M,Schrumpf E

更新日期：2001-06-01 00:00:00

abstract：:The relationship of the endoscopic aspect of esophageal varices, portal quantitative Doppler ultrasound parameters and clinical and biochemical findings was assessed in 149 patients with cirrhosis stratified according to the presence of esophageal varices (n = 115) and the absence of previous bleeding (n = 96). In thi...

journal_title：Journal of hepatology

authors： Siringo S,Bolondi L,Gaiani S,Sofia S,Di Febo G,Zironi G,Rigamonti A,Miglioli M,Cavalli G,Barbara L

更新日期：1994-01-01 00:00:00

abstract：:Liver transplantation is performed successfully across major HLA differences between donor and recipient. This may be influenced by the organ specific expression of major histocompatibility complex (MHC) molecules which determine the local immune reactivity and rejection response. The tissue expression of MHC molecule...

journal_title：Journal of hepatology

authors： Steinhoff G

更新日期：1990-07-01 00:00:00

abstract：BACKGROUND & AIMS:Non-alcoholic fatty liver disease (NAFLD) affects up to 30% of the population and signifies increased risk of liver fibrosis and cirrhosis, type 2 diabetes, and cardiovascular disease. Therapies are limited. Weight loss is of benefit but is difficult to maintain. We aimed at examining the effect of th...

journal_title：Journal of hepatology

authors： Ryan MC,Itsiopoulos C,Thodis T,Ward G,Trost N,Hofferberth S,O'Dea K,Desmond PV,Johnson NA,Wilson AM

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND/AIMS:Natural killer T (NKT) cells are present in the liver of mice. We examined whether NKT cells and other leukocytes were associated with hepatic inflammation after partial hepatectomy. METHODS:Approximately 70% of the liver was removed from mice using the method described by Higgins and Anderson. RESULT...

journal_title：Journal of hepatology

authors： Kato T,Sato Y,Takahashi S,Kawamura H,Hatakeyama K,Abo T

更新日期：2004-02-01 00:00:00

abstract：:The peripheral arterial vasodilation hypothesis has been most influential in the field of cirrhosis and its complications. It has given rise to hundreds of pathophysiological studies in experimental and human cirrhosis and is the theoretical basis of life-saving treatments. It is undisputed that splanchnic arterial va...

journal_title：Journal of hepatology

authors： Bernardi M,Moreau R,Angeli P,Schnabl B,Arroyo V

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND & AIMS:To compare the management and the virological and serological efficacy of treatments for chronic hepatitis B (CHB) in HIV positive and negative patients. METHODS:Two hundred and forty-six HIV positive and 205 HIV negative consecutive patients with past or present CHB, seen in October 2008 in particip...

journal_title：Journal of hepatology

authors： Piroth L,Pol S,Lacombe K,Miailhes P,Rami A,Rey D,Loustau-Ratti V,Morlat P,Goderel I,Sene D,Rosenthal E,Carrat F,Cacoub P,GERMIVIC Study Group.

更新日期：2010-12-01 00:00:00

abstract：:The epidemiology of HDV infection in Italy was assessed in a retrospective study involving 1556 HBsAg chronic carriers on their first presentation at one of the 35 Liver Units in 1987. Total anti-HD was detected in 23.4% of HBsAg carriers and was significantly more frequent in southern than in northern Italy (26.6% vs...

journal_title：Journal of hepatology

authors： Sagnelli E,Stroffolini T,Ascione A,Bonino F,Chiaramonte M,Colombo M,Craxi A,Giusti G,Manghisi OG,Pastore G

更新日期：1992-05-01 00:00:00

abstract：BACKGROUND & AIMS:Lysosomal acid lipase deficiency is an autosomal recessive enzyme deficiency resulting in lysosomal accumulation of cholesteryl esters and triglycerides. LAL-CL04, an ongoing extension study, investigates the long-term effects of sebelipase alfa, a recombinant human lysosomal acid lipase. METHODS:Seb...

journal_title：Journal of hepatology

authors： Valayannopoulos V,Malinova V,Honzík T,Balwani M,Breen C,Deegan PB,Enns GM,Jones SA,Kane JP,Stock EO,Tripuraneni R,Eckert S,Schneider E,Hamilton G,Middleton MS,Sirlin C,Kessler B,Bourdon C,Boyadjiev SA,Sharma R,Twe

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND/AIMS:Hepatobiliary malignancies are frequently seen in primary sclerosing cholangitis (PSC) and they complicate the evaluation of patients and timing of liver transplantation. METHODS:Data from all Nordic PSC patients listed for liver transplantation during 1990-2001 were recorded prospectively. Predictors ...

journal_title：Journal of hepatology

authors： Brandsaeter B,Isoniemi H,Broomé U,Olausson M,Bäckman L,Hansen B,Schrumpf E,Oksanen A,Ericzon BG,Höckerstedt K,Mäkisalo H,Kirkegaard P,Friman S,Bjøro K

更新日期：2004-05-01 00:00:00