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Activation of dendritic cells by local ablation of hepatocellular carcinoma.

Abstract：

BACKGROUND/AIMS:Local ablation methods are an effective treatment for hepatocellular carcinoma (HCC). The rate of recurrence or development of intra-hepatic metastases may be lowered by antitumoral immune responses. Since HCCs are in general only weakly immunogenic, cell injury induced by local tumor ablation (PEI/RFTA) may increase HCC immunogenicity and may release endogenous adjuvants that activate dendritic cells (DC). The aim of the study, therefore, was the analysis whether PEI or RFTA induced injury results in an adjuvant effect for immune responses to HCCs. METHODS:Eight HCC patients were treated with PEI or RFTA and serially analyzed for 4 weeks. Plasmocytoid (PDC) and myeloid dendritic cells (MDC) were analyzed directly ex vivo and in vitro using FACS and proliferation assays. RESULTS:HCC ablation induced a functional transient activation of MDC but not of PDC associated with increased serum levels of TNF-alpha and IL-1beta. CONCLUSIONS:These findings suggest that the combination of PEI or RFTA and active antigen specific immunotherapeutic approaches using DCs is a promising approach for the induction of sustained antitumoral immune responses aiming at the reduction of tumor recurrence and metastases in HCC patients.

journal_name

J Hepatol

journal_title

Journal of hepatology

authors

Ali MY,Grimm CF,Ritter M,Mohr L,Allgaier HP,Weth R,Bocher WO,Endrulat K,Blum HE,Geissler M

doi

10.1016/j.jhep.2005.04.016

subject

Has Abstract

pub_date

2005-11-01 00:00:00

pages

817-22

issue

5

eissn

0168-8278

issn

1600-0641

pii

S0168-8278(05)00371-5

journal_volume

43

pub_type

杂志文章

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