Terbinafine-associated hepatic injury.

abstract：:Hepatitis C virus genotype and the amounts of circulating HCV RNA are the most important factors in determining the efficacy of interferon therapy for chronic hepatitis C. To clarify the correlation of these two factors to the progression of liver disease, we classified 148 Japanese patients with type C chronic liver ...

journal_title：Journal of hepatology

authors： Mita E,Hayashi N,Kanazawa Y,Hagiwara H,Ueda K,Kasahara A,Fusamoto H,Kamada T

更新日期：1994-09-01 00:00:00

abstract：BACKGROUND/AIMS:Nephropathy associated with alpha1-antitrypsin deficiency is assumed to be an unusual entity. We describe the case of a 23-year-old woman with severe alpha1-antitrypsin (PiZ homozygosity) deficiency who developed hepatic cirrhosis in childhood, and glomerulonephritis and nephrotic syndrome in adult life...

journal_title：Journal of hepatology

authors： Elzouki AN,Lindgren S,Nilsson S,Veress B,Eriksson S

更新日期：1997-06-01 00:00:00

abstract：:We measured the number and the morphometric characteristics of perisinusoidal cells in perfusion-fixed biopsy samples from 7 control patients with normal liver histology. On 1-micron section, the number of cells was 18 +/- 1.5/0.1 mm2; 25% of cells did not apparently contain lipids. There were no significant zonal dif...

journal_title：Journal of hepatology

authors： Sztark F,Dubroca J,Latry P,Quinton A,Balabaud C,Bioulac-Sage P

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND/AIMS:Liver allograft is known to protect simultaneously transplanted organs from acute rejection. We have reported that only 6% of combined liver-kidney recipients, versus 32.5% of kidney recipients, develop kidney graft acute rejection. Release of soluble human leukocyte antigen (HLA) molecules by the liver...

journal_title：Journal of hepatology

authors： Créput C,Durrbach A,Menier C,Guettier C,Samuel D,Dausset J,Charpentier B,Carosella ED,Rouas-Freiss N

更新日期：2003-10-01 00:00:00

abstract：BACKGROUND & AIMS:Current techniques for predicting outcome and requirement for emergency liver transplantation (ELT) in acute liver failure (ALF) are imperfect, though The Kings College Criteria (KCC) are the most commonly applied tools for this purpose. Their performance in identification of patients with non-paracet...

journal_title：Journal of hepatology

authors： McPhail MJ,Wendon JA,Bernal W

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND/AIMS:Aberrant c-Jun N-terminal kinase (JNK) activation has been linked to hepatocellular carcinoma (HCC) in mouse models. It remains unclear whether JNK activation plays an important role in human HCC and, if so, how JNK signaling contributes to the initiation or progression of HCC. METHODS:The JNK activati...

journal_title：Journal of hepatology

authors： Chang Q,Zhang Y,Beezhold KJ,Bhatia D,Zhao H,Chen J,Castranova V,Shi X,Chen F

更新日期：2009-02-01 00:00:00

abstract：:The present study investigated the hemodynamic effects of nicardipine, a new calcium channel blocker, and placebo in 14 patients with cirrhosis. Sixty minutes after nicardipine administration (20 mg orally; n = 8), there was a significant increase in hepatic blood flow (25 +/- 21%; p < 0.05) and azygos blood flow (33 ...

journal_title：Journal of hepatology

authors： García-Pagán JC,Feu F,Luca A,Fernández M,Pizcueta P,Bosch J,Rodés J

更新日期：1994-06-01 00:00:00

abstract：BACKGROUND/AIMS:Alcoholic cirrhosis is a common indication for liver transplantation. The present study was aimed to assess the influence of superimposed alcoholic hepatitis on the outcome of liver transplantation in patients with alcoholic cirrhosis. METHODS:Survival rates of 68 patients transplanted for alcoholic ci...

journal_title：Journal of hepatology

authors： Tomé S,Martinez-Rey C,González-Quintela A,Gude F,Brage A,Otero E,Abdulkader I,Forteza J,Bustamante M,Varo E

更新日期：2002-06-01 00:00:00

abstract：BACKGROUND/AIMS:[corrected] Hepatobiliary carcinoma (HBC) has been considered to be a late complication of end-stage primary sclerosing cholangitis (PSC). The incidence of HBC is approximately 20% in PSC patients evaluated for liver transplantation. The diagnosis of HBC is difficult, at least at an early stage and the ...

journal_title：Journal of hepatology

authors： Leidenius M,Höckersted K,Broomé U,Ericzon BG,Friman S,Olausson M,Schrumpf E

更新日期：2001-06-01 00:00:00

abstract：BACKGROUND & AIMS:Chronic hepatitis C virus (HCV)-infected patients with cirrhosis are a high-priority population for treatment. To help inform the benefit-risk profile of the all-oral direct-acting antiviral (DAA) combination regimen of ombitasvir, paritaprevir, and ritonavir, with or without dasabuvir (OBV/PTV/r±DSV)...

journal_title：Journal of hepatology

authors： Poordad F,Nelson DR,Feld JJ,Fried MW,Wedemeyer H,Larsen L,Cohen DE,Cohen E,Mobashery N,Tatsch F,Foster GR

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND/AIMS:We have previously shown that an abnormality in cardiac autonomic reflexes (AN) is an independent predictor of mortality in patients with chronic liver disease. Aim of this study was to determine whether there was an association between prolonged QTc interval and cardiac AN. METHODS:Cardiac AN and QTc ...

journal_title：Journal of hepatology

authors： Puthumana L,Chaudhry V,Thuluvath PJ

更新日期：2001-12-01 00:00:00

abstract：BACKGROUND & AIMS:Direct-acting antiviral (DAA) therapy is used in patients with HCV-related decompensated cirrhosis with the expectation of improving hepatic function. However, little is known about the long-term hepatic benefit of successful antiviral treatment. METHODS:Patients with advanced/decompensated cirrhosis...

journal_title：Journal of hepatology

authors： Verna EC,Morelli G,Terrault NA,Lok AS,Lim JK,Di Bisceglie AM,Zeuzem S,Landis CS,Kwo P,Hassan M,Manns MP,Vainorius M,Akushevich L,Nelson DR,Fried MW,Reddy KR

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND/AIMS:Norfloxacin is useful to prevent infections in hospitalized cirrhotic patients with low ascitic fluid protein concentrations. It is also effective in preventing the recurrence of spontaneous bacterial peritonitis. The aim of our study was to determine the efficacy of norfloxacin in the primary prophylax...

journal_title：Journal of hepatology

authors： Grangé JD,Roulot D,Pelletier G,Pariente EA,Denis J,Ink O,Blanc P,Richardet JP,Vinel JP,Delisle F,Fischer D,Flahault A,Amiot X

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND & AIMS:Statins are widely used to treat hypercholesterolemia. Statins may prevent hepatocellular carcinoma (HCC), but have not yet been fully studied, particularly in patients at high risk. Therefore, we investigated the risk of HCC after statin use in the whole general population and evaluated the effects o...

journal_title：Journal of hepatology

authors： Kim G,Jang SY,Nam CM,Kang ES

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND & AIMS:In patients with primary biliary cholangitis (PBC), the efficacy of budesonide, a synthetic corticosteroid displaying high first-pass metabolism, is unresolved. In a placebo-controlled, double-blind trial, we evaluated the added-value of budesonide in those with PBC and ongoing risk of progressive dis...

journal_title：Journal of hepatology

authors： Hirschfield GM,Beuers U,Kupcinskas L,Ott P,Bergquist A,Färkkilä M,Manns MP,Parés A,Spengler U,Stiess M,Greinwald R,Pröls M,Wendum D,Drebber U,Poupon R

更新日期：2021-02-01 00:00:00

abstract：BACKGROUND/AIM:Steatosis is commonly present in chronic hepatitis C. Our aim was to evaluate host- and disease-specific factors associated with its occurrence. METHODS:Histologic findings in 60 patients were correlated with body mass index, human leukocyte antigens, and other conventional parameters. Comparisons were ...

journal_title：Journal of hepatology

authors： Czaja AJ,Carpenter HA,Santrach PJ,Moore SB

更新日期：1998-08-01 00:00:00

abstract：BACKGROUND/AIMS:The relationship between HCV RNA levels and the severity of HCV-related liver disease has been addressed in a few studies, which has led to conflicting results. To clarify this point, we studied serum HCV RNA levels in patients with HCV liver disease at various stages, using a second-generation branched...

journal_title：Journal of hepatology

authors： Duvoux C,Pawlotsky JM,Bastie A,Cherqui D,Soussy CJ,Dhumeaux D

更新日期：1999-10-01 00:00:00

abstract：BACKGROUND/AIMS:The x gene of hepatitis B virus encodes a transactivating factor of 154 amino acids, termed HBx, which stimulates transcription of multiple viral and cellular genes. The transactivating function is probably associated with a tumorigenic potential of HBx, since x gene sequences, encoding functional HBx, ...

journal_title：Journal of hepatology

authors： Renner M,Haniel A,Bürgelt E,Hofschneider PH,Koch W

更新日期：1995-07-01 00:00:00

abstract：BACKGROUND & AIMS:Cerebral oxidative stress plays an important role in the pathogenesis of hepatic encephalopathy (HE), but the underlying mechanisms are incompletely understood. Herein, we analyzed a role of heme oxygenase (HO)1, iron and NADPH oxidase 4 (Nox4) for the induction of oxidative stress and senescence in H...

journal_title：Journal of hepatology

authors： Görg B,Karababa A,Schütz E,Paluschinski M,Schrimpf A,Shafigullina A,Castoldi M,Bidmon HJ,Häussinger D

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND/AIMS:The use of cell lines in bioartificial liver support systems (BALSS) to treat fulminant hepatic failure (FHF) is hindered by their reduced metabolic functions, which could be further decreased by the patient's serum/plasma. Hence, the aim of this study was to (i) test the effect of the FHF serum on C3A ...

journal_title：Journal of hepatology

authors： Filippi C,Keatch SA,Rangar D,Nelson LJ,Hayes PC,Plevris JN

更新日期：2004-10-01 00:00:00

abstract：:Portal hypertension is the main cause of complications in patients with chronic liver disease. Over the past 25 years, progress in the understanding of the pathophysiology of portal hypertension was followed by the introduction of an effective pharmacological therapy, consisting mainly of treatments aimed at correctin...

journal_title：Journal of hepatology

authors： Bosch J,Abraldes JG,Fernández M,García-Pagán JC

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND/AIMS:Combinations of beta-blockers and vasodilators have been assessed for their ability to lower portal pressure and so prevent variceal haemorrhage. However, reservations have been raised particularly with respect to renal function and perfusion after the use of these medicines in patients with chronic liv...

journal_title：Journal of hepatology

authors： Forrest EH,Bouchier IA,Hayes PC

更新日期：1996-12-01 00:00:00

abstract：BACKGROUND/AIMS:Chronic hepatitis B virus (HBV) disease is caused by both necroinflammation and active viral replication. The role of ALT levels as a predictor of liver injury has recently been questioned. The aim of the study was to determine whether normal ALT is associated with liver injury in a cohort of HBV patien...

journal_title：Journal of hepatology

authors： Lai M,Hyatt BJ,Nasser I,Curry M,Afdhal NH

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND & AIMS:Surgery in cirrhosis is associated with a high morbidity and mortality. Retrospectively reported prognostic factors include emergency procedures, liver function (MELD/Child-Pugh scores) and portal hypertension (assessed by indirect markers). This study assessed the prognostic role of hepatic venous pr...

journal_title：Journal of hepatology

authors： Reverter E,Cirera I,Albillos A,Debernardi-Venon W,Abraldes JG,Llop E,Flores A,Martínez-Palli G,Blasi A,Martínez J,Turon F,García-Valdecasas JC,Berzigotti A,de Lacy AM,Fuster J,Hernández-Gea V,Bosch J,García-Pagán JC

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND & AIMS:Non-selective beta blockers (NSBBs) have been shown to have deleterious outcomes in patients with refractory ascites, alcoholic hepatitis and spontaneous bacterial peritonitis leading many physicians to stop the drug in these cases. Acute-on-chronic liver failure (ACLF) is characterized by systemic in...

journal_title：Journal of hepatology

authors： Mookerjee RP,Pavesi M,Thomsen KL,Mehta G,Macnaughtan J,Bendtsen F,Coenraad M,Sperl J,Gines P,Moreau R,Arroyo V,Jalan R,CANONIC Study Investigators of the EASL-CLIF Consortium.

更新日期：2016-03-01 00:00:00

abstract：:The influence of hepatitis C virus and its subtypes on the clinical course of liver disease in alcoholics was assessed. Hepatitis C virus infection was confirmed by a reverse transcription and polymerase chain reaction method for the hepatitis C virus NS-5 region in the sera of alcoholics with various stages of histol...

journal_title：Journal of hepatology

authors： Yokoyama H,Ishii H,Moriya S,Nagata S,Watanabe T,Kamegaya K,Takahashi H,Maruyama K,Haber P,Tsuchiya M

更新日期：1995-02-01 00:00:00

abstract：Background & Aims:Liver enzyme abnormalities are common in patients with coronavirus disease 2019 (COVID-19). Whether or not severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can lead to liver damage per se remains unknown. Herein, we reported the clinical characteristics and liver pathological man...

journal_title：Journal of hepatology

authors： Wang Y,Liu S,Liu H,Li W,Lin F,Jiang L,Li X,Xu P,Zhang L,Zhao L,Cao Y,Kang J,Yang J,Li L,Liu X,Li Y,Nie R,Mu J,Lu F,Zhao S,Lu J,Zhao J

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND/AIMS:Extrahepatic biliary atresia (EHBA) and chronic progressive intra-hepatic cholestasis (Byler's disease) are two distinct disorders of unknown etiology in the neonate, characterized by profound cholestasis. The aim of the present study was to investigate the inflammatory reaction in liver tissue from pat...

journal_title：Journal of hepatology

authors： Broomé U,Nemeth A,Hultcrantz R,Scheynius A

更新日期：1997-04-01 00:00:00

abstract：BACKGROUND/AIMS:Patients undergoing transjugular intrahepatic portosystemic shunt (TIPS) are at risk of early death due to end-stage liver failure. The aim of this study was to compare model of end-stage liver disease (MELD) and Child-Pugh scores as predictors of survival after TIPS. METHODS:We studied 140 cirrhotic p...

journal_title：Journal of hepatology

authors： Salerno F,Merli M,Cazzaniga M,Valeriano V,Rossi P,Lovaria A,Meregaglia D,Nicolini A,Lubatti L,Riggio O

更新日期：2002-04-01 00:00:00

abstract：BACKGROUND/AIMS:Primary sclerosing cholangitis (PSC) is a cholestatic liver disease of unknown etiology. Although the primary defect affects cholangiocytes, cholestatic injury of hepatocytes may promote further liver damage. Since down-regulation of hepatocellular organic anion transporters is implicated in the molecul...

journal_title：Journal of hepatology

authors： Geier A,Dietrich CG,Lammert F,Orth T,Mayet WJ,Matern S,Gartung C

更新日期：2002-06-01 00:00:00