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EWI-2wint--a host cell factor inhibiting hepatitis C virus entry.

Abstract：

:Two to three percent of the world's population is chronically infected with hepatitis C virus (HCV) and thus at risk of developing liver cancer. Although precise mechanisms regulating HCV entry into hepatic cells are still unknown, several cell surface proteins have been identified as entry factors for this virus. Among these molecules, the tetraspanin CD81 is essential for HCV entry. Here, we have identified a partner of CD81, EWI-2wint, which is expressed in several cell lines but not in hepatocytes. Ectopic expression of EWI-2wint in a hepatoma cell line susceptible to HCV infection blocked viral entry by inhibiting the interaction between the HCV envelope glycoproteins and CD81. This finding suggests that, in addition to the presence of specific entry factors in the hepatocytes, the lack of a specific inhibitor can contribute to the hepatotropism of HCV. This is the first example of a pathogen gaining entry into host cells that lack a specific inhibitory factor.

journal_name

J Hepatol

journal_title

Journal of hepatology

authors

Schuster C,Baumert TF

doi

10.1016/j.jhep.2008.10.009

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

222-4

issue

1

eissn

0168-8278

issn

1600-0641

pii

S0168-8278(08)00689-2

journal_volume

50

pub_type

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