当前位置： SCI文献检索 > JOURNAL OF HEPATOLOGY期刊下所有文献 > A performance evaluation of the expert system 'Jaundice' in comparison with that of three hepatologists.

A performance evaluation of the expert system 'Jaundice' in comparison with that of three hepatologists.

Abstract：

:The diagnostic performance of an Expert System (Jaundice) designed to discriminate between different causes of jaundice was evaluated in a test sample of 200 consecutive in-patients with serum bilirubin greater than or equal to 51 mumol/l. The average probability assigned to true diagnosis, the non-error rate and the overall accuracy were, respectively, 55%, 77% and 70%. The Expert System's discriminatory ability in probabilistic prediction, assessed by a method based on continuous functions of the diagnostic probabilities (Brier score) was good. We also compared the ability of our Expert System to that of three experienced hepatologists, who were required to give a diagnosis in 20 cases following the same protocol used by computer (i.e., by asking only clinical and laboratory items). Both the hepatologists and Jaundice achieved a correct diagnosis in 70% of 20 cases, but the Expert System asked a significantly higher average number of questions during each consultation. Analysis of the reasoning pathway made by an external referee showed a high agreement between the diagnostic strategies of the Expert System and the physicians. We conclude that Jaundice can be a useful tool to support a physician with insufficient clinical experience in this field to generate correct diagnostic hypotheses.

journal_name

J Hepatol

journal_title

Journal of hepatology

authors

Cammà C,Garofalo G,Almasio P,Tinè F,Craxì A,Palazzo U,Pinzello G,Fiorello F,Angelo PM,Pagliaro L

doi

10.1016/0168-8278(91)90069-n

subject

Has Abstract

pub_date

1991-11-01 00:00:00

pages

279-85

issue

3

eissn

0168-8278

issn

1600-0641

pii

0168-8278(91)90069-N

journal_volume

13

pub_type

杂志文章

相关文献

JOURNAL OF HEPATOLOGY文献大全
  • Lactitol versus lactulose in the treatment of chronic hepatic encephalopathy. A double-blind, randomised, cross-over study.

    abstract：:Lactitol is a disaccharide analogue of lactulose which is available as a pure crystalline powder. The efficacy of lactitol in the treatment of chronic hepatic encephalopathy was assessed in 9 cirrhotic patients in a randomised, double-blind, cross-over comparison with lactulose. The sugars were dispensed in solutions,...

    journal_title：Journal of hepatology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0168-8278(87)80086-7

    authors： Morgan MY,Hawley KE,Stambuk D

    更新日期：1987-04-01 00:00:00

  • Actin is a target antigen of anti-neutrophil cytoplasmic antibodies (ANCA) in autoimmune hepatitis type-1.

    abstract：BACKGROUND/AIM:Anti-neutrophil cytoplasmic antibodies (ANCA) are a group of autoantibodies first associated with Wegener's granulomatosis and microscopic polyangiitis. The significance of ANCA in autoimmune hepatitis remains uncertain; the nature of the antigen or antigens has not been defined yet. The purpose of this ...

    journal_title：Journal of hepatology

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0168-8278(97)80007-4

    authors： Orth T,Gerken G,Kellner R,Meyer zum Büschenfelde KH,Mayet WJ

    更新日期：1997-01-01 00:00:00

  • Targeted vaccination programme successful in reducing acute hepatitis B in men having sex with men in Amsterdam, the Netherlands.

    abstract：BACKGROUND & AIMS:In the Netherlands, transmission of hepatitis B virus occurs mainly within behavioural high-risk groups, such as in men who have sex with men. Therefore, a vaccination programme has targeted these high-risk groups. This study evaluates the impact of the vaccination programme targeting Amsterdam's larg...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2013.08.002

    authors： van Rijckevorsel G,Whelan J,Kretzschmar M,Siedenburg E,Sonder G,Geskus R,Coutinho R,van den Hoek A

    更新日期：2013-12-01 00:00:00

  • The "interferon sensitivity determining region" of hepatitis C virus is a stable sequence element.

    abstract：BACKGROUND/AIMS:A sequence of 40 amino acids within the nonstructural protein 5A of hepatitis C virus (HCV) has been suggested to be an interferon sensitivity determining region (ISDR). The variations in the ISDR after 12-14 years of chronic infection and the correlation between ISDR and interferon response were studie...

    journal_title：Journal of hepatology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0168-8278(98)80051-2

    authors： Rispeter K,Lu M,Zibert A,Wiese M,de Oliveira JM,Roggendorf M

    更新日期：1998-09-01 00:00:00

  • Serum laminin and type IV collagen are accurate markers of histologically severe alcoholic hepatitis in patients with cirrhosis.

    abstract：BACKGROUND/AIMS:Severe alcoholic hepatitis occurs mainly in patients with cirrhosis, and has a high death rate. Corticosteroid therapy has been particularly advocated as reducing mortality in patients with severe histologic lesions. However, identification of these patients is difficult, requiring transvenous liver bio...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(00)80391-8

    authors： Castera L,Hartmann DJ,Chapel F,Guettier C,Mall F,Lons T,Richardet JP,Grimbert S,Morassi O,Beaugrand M,Trinchet JC

    更新日期：2000-03-01 00:00:00

  • Treatment options in patients with decompensated cirrhosis, pre- and post-transplantation.

    abstract：:Interferon-based treatments have a poor safety profile and limited efficacy in patients with advanced liver disease and in patients with hepatitis C (HCV) recurrence after liver transplantation (LT). Despite the recent approval of the first interferon-free regimen, which will be followed by several other interferon-fr...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jhep.2014.07.020

    authors： Gambato M,Lens S,Navasa M,Forns X

    更新日期：2014-11-01 00:00:00

  • Hepatitis B virus-induced modulation of liver macrophage function promotes hepatocyte infection.

    abstract：BACKGROUND & AIMS:Liver macrophages can be involved in both pathogen clearance and/or pathogenesis. To get further insight on their role during chronic hepatitis B virus (HBV) infections, our aim was to phenotypically and functionally characterize in vivo and ex vivo the interplay between HBV, primary human liver macro...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2019.06.032

    authors： Faure-Dupuy S,Delphin M,Aillot L,Dimier L,Lebossé F,Fresquet J,Parent R,Matter MS,Rivoire M,Bendriss-Vermare N,Salvetti A,Heide D,Flores L,Klumpp K,Lam A,Zoulim F,Heikenwälder M,Durantel D,Lucifora J

    更新日期：2019-12-01 00:00:00

  • 'Lupus' anticoagulant and thrombosis of the hepatic veins (Budd-Chiari syndrome). Report of three patients and review of the literature.

    abstract：:Three patients with Budd-Chiari syndrome in association with the 'lupus' anticoagulant are described. This anticoagulant was looked for in our patients with an otherwise idiopathic hepatic venous thrombosis because of the presence of a pronounced thrombocytopenia, a prolonged activated partial thromboplastin time or a...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(86)80151-9

    authors： Van Steenbergen W,Beyls J,Vermylen J,Fevery J,Marchal G,Desmet V,De Groote J

    更新日期：1986-01-01 00:00:00

  • Hepatitis B core-specific memory B cell responses associate with clinical parameters in patients with chronic HBV.

    abstract：BACKGROUND & AIMS:Little is known about the frequency, phenotype and function of HBV-specific B cells during chronic infection. Here we study HBcAg and HBsAg-specific B cells in different clinical phases of a chronic HBV infection. METHODS:We included 118 treatment naïve and 34 nucleos(t)ide analogue-treated patients ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2020.01.024

    authors： Vanwolleghem T,Groothuismink ZMA,Kreefft K,Hung M,Novikov N,Boonstra A

    更新日期：2020-07-01 00:00:00

  • Hepatitis B virus and human immunodeficiency virus drugs in pregnancy: findings from the Antiretroviral Pregnancy Registry.

    abstract：BACKGROUND & AIMS:Fetal safety of antiviral therapies is important given the long-term treatment of women with chronic hepatitis B (CHB) infection who may become pregnant. We analyzed neonatal safety data from the Antiretroviral Pregnancy Registry (APR), the largest safety database in pregnancy for antivirals used for ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2012.06.031

    authors： Brown RS Jr,Verna EC,Pereira MR,Tilson HH,Aguilar C,Leu CS,Buti M,Fagan EA

    更新日期：2012-11-01 00:00:00

  • Glucagon increases hepatic efficacy for urea synthesis.

    abstract：:The effect of glucagon on the relation between urea synthesis and blood amino acid concentration was studied in seven healthy volunteers. Alanine was given as prime-continuous infusions and, after 1 hr for equilibration, the urea nitrogen synthesis rate was measured in two periods of about 2 hrs as urinary excretion c...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/0168-8278(90)90072-y

    authors： Vilstrup H,Hansen BA,Almdal TP

    更新日期：1990-01-01 00:00:00

  • Mutations in DCDC2 (doublecortin domain containing protein 2) in neonatal sclerosing cholangitis.

    abstract：BACKGROUND & AIMS:Neonatal sclerosing cholangitis (NSC) is a severe neonatal-onset cholangiopathy commonly leading to liver transplantation (LT) for end-stage liver disease in childhood. Liver biopsy findings histopathologically resemble those in biliary atresia (BA); however, in NSC extrahepatic bile ducts are patent,...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2016.07.017

    authors： Grammatikopoulos T,Sambrotta M,Strautnieks S,Foskett P,Knisely AS,Wagner B,Deheragoda M,Starling C,Mieli-Vergani G,Smith J,University of Washington Center for Mendelian Genomics.,Bull L,Thompson RJ

    更新日期：2016-12-01 00:00:00

  • Hepatocyte-derived extracellular vesicles promote endothelial inflammation and atherogenesis via microRNA-1.

    abstract：BACKGROUND & AIMS:Clinical evidence has indicated a close link between non-alcoholic fatty liver disease (NAFLD) and cardiovascular disease (CVD). However, the underlying mechanism remains to be elucidated. This study aimed to explore a potential role of hepatocyte-derived extracellular vesicles (EVs) in endothelial in...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2019.09.014

    authors： Jiang F,Chen Q,Wang W,Ling Y,Yan Y,Xia P

    更新日期：2020-01-01 00:00:00

  • Glucagon-like peptide-1 reduces hepatic lipogenesis via activation of AMP-activated protein kinase.

    abstract：BACKGROUND & AIMS:Glucagon-like peptide-1 (GLP-1), a gut-derived peptide degraded by dipeptidyl peptidase-4 (DPP4), stimulates insulin secretion in response to nutrients, yet its direct effect on the liver is controversial. We investigated the effects of GLP-1 on hepatic fat and glucose metabolism and elucidated its me...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2010.09.032

    authors： Ben-Shlomo S,Zvibel I,Shnell M,Shlomai A,Chepurko E,Halpern Z,Barzilai N,Oren R,Fishman S

    更新日期：2011-06-01 00:00:00

  • Budd-Chiari syndrome: combination of genetic defects and the use of oral contraceptives leading to hypercoagulability.

    abstract：:A young female, who had been in excellent health and had used third-generation oral contraceptives, was admitted to hospital because of abdominal pain and ascites. Budd-Chiari syndrome (BCS) was diagnosed by radiographic and histological examination. Tests for myeloproliferative disease, deficiency of coagulation inhi...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(00)80290-1

    authors： Minnema MC,Janssen HL,Niermeijer P,de Man RA

    更新日期：2000-09-01 00:00:00

  • Inhibition of inducible nitric oxide synthase protects against liver injury induced by mycobacterial infection and endotoxins.

    abstract：BACKGROUND/AIMS:Bacillus Calmette Guerin (BCG) infection causes hepatic injury following granuloma formation and secretion of cytokines which render mice highly sensitive to endotoxin-mediated hepatotoxicity. This work investigates the role of inducible nitric oxide synthase (iNOS) in liver damage induced by BCG and en...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2004.07.031

    authors： Guler R,Olleros ML,Vesin D,Parapanov R,Vesin C,Kantengwa S,Rubbia-Brandt L,Mensi N,Angelillo-Scherrer A,Martinez-Soria E,Tacchini-Cottier F,Garcia I

    更新日期：2004-11-01 00:00:00

  • High doses of aminoglycosides did not produce liver toxicity in patients with cystic fibrosis.

    abstract：:Liver disease is common in patients with cystic fibrosis, but the pathogenesis is poorly understood. The chronic colonization of bacteria in the lower airways leads to repeated treatments with antibiotics, especially aminoglycosides in high dosages. To investigate the possible role of aminoglycoside treatment in the n...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(05)80058-3

    authors： Lindblad A,Hultcrantz R,Strandvik B

    更新日期：1994-02-01 00:00:00

  • Type I interferon receptor signaling delays Kupffer cell replenishment during acute fulminant viral hepatitis.

    abstract：BACKGROUND & AIM:Virus-induced fulminant hepatitis is a major cause of acute liver failure. During acute viral hepatitis the impact of type I interferon (IFN-I) on myeloid cells, including liver-resident Kupffer cells (KC), is only partially understood. Herein, we dissected the impact of locally induced IFN-I responses...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2017.11.029

    authors： Borst K,Frenz T,Spanier J,Tegtmeyer PK,Chhatbar C,Skerra J,Ghita L,Namineni S,Lienenklaus S,Köster M,Heikenwaelder M,Sutter G,Kalinke U

    更新日期：2018-04-01 00:00:00

  • Deletion of angiotensin II type I receptor reduces hepatic steatosis.

    abstract：BACKGROUND/AIMS:A distinct subgroup of angiotensin II type 1 receptor (AT1R) blockers (ARBs) have been reported to suppress the development of hepatic steatosis. These effects were generally explained by selective peroxisome proliferator-activated receptor (PPAR) gamma modulating properties of ARBs, independent of thei...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2009.01.018

    authors： Nabeshima Y,Tazuma S,Kanno K,Hyogo H,Chayama K

    更新日期：2009-06-01 00:00:00

  • Multiple hepatic mitochondrial DNA deletions suggest premature oxidative aging in alcoholic patients.

    abstract：BACKGROUND/AIMS:A 4977-base pair deletion has been detected in the hepatic mitochondrial DNA of alcoholic patients with microvesicular steatosis, a lesion ascribed to impaired mitochondrial beta-oxidation. However, only a single deletion had been looked for in this previous study, and it could not be determined whether...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(97)80286-3

    authors： Mansouri A,Fromenty B,Berson A,Robin MA,Grimbert S,Beaugrand M,Erlinger S,Pessayre D

    更新日期：1997-07-01 00:00:00

  • Genetic factors of susceptibility and of severity in primary biliary cirrhosis.

    abstract：BACKGROUND/AIMS:In primary biliary cirrhosis (PBC), pathogenesis is influenced by genetic factors that remain poorly elucidated up to now. We investigated the impact of sequence diversity in candidate genes involved in immunity (CTLA-4 and TNFalpha), in bile formation (10 hepatobiliary transporter genes) and in the ada...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2008.07.027

    authors： Poupon R,Ping C,Chrétien Y,Corpechot C,Chazouillères O,Simon T,Heath SC,Matsuda F,Poupon RE,Housset C,Barbu V

    更新日期：2008-12-01 00:00:00

  • Severity of iron overload of proband determines serum ferritin levels in families with HFE-related hemochromatosis: the HEmochromatosis FAmily Study.

    abstract：BACKGROUND/AIMS:In families of patients with clinically detected hereditary hemochromatosis (HH) early screening has been suggested to prevent morbidity and mortality. Here, we aim to identify determinants for iron overload in first-degree family members of C282Y homozygous probands with clinically detected HH. METHOD...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2008.08.014

    authors： Jacobs EM,Hendriks JC,van Deursen CT,Kreeftenberg HG,de Vries RA,Marx JJ,Stalenhoef AF,Verbeek AL,Swinkels DW

    更新日期：2009-01-01 00:00:00

  • Differences and similarities in early atherosclerosis between patients with non-alcoholic steatohepatitis and chronic hepatitis B and C.

    abstract：BACKGROUND/AIMS:To compare carotid intima-media thickness (IMT) - an index of early atherosclerosis - among patients with non-alcoholic steatohepatitis (NASH), patients with chronic hepatitis B (HBV) or C (HCV) and control subjects. METHODS:We studied 60 consecutive patients with biopsy-proven NASH, 60 patients with H...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2007.01.021

    authors： Targher G,Bertolini L,Padovani R,Rodella S,Arcaro G,Day C

    更新日期：2007-06-01 00:00:00

  • p53 haploinsufficiency and increased mTOR signalling define a subset of aggressive hepatocellular carcinoma.

    abstract：BACKGROUND & AIMS:p53 mutations occur frequently in human HCC. Activation of the mammalian target of rapamycin (mTOR) pathway is also associated with HCC. However, it is still unknown whether these changes together initiate HCC and can be targeted as a potential therapeutic strategy. METHODS:We generated mouse models ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2020.07.036

    authors： Luo YD,Fang L,Yu HQ,Zhang J,Lin XT,Liu XY,Wu D,Li GX,Huang D,Zhang YJ,Chen S,Jiang Y,Shuai L,He Y,Zhang LD,Bie P,Xie CM

    更新日期：2021-01-01 00:00:00

  • Non-invasive response prediction in prophylactic carvedilol therapy for cirrhotic patients with esophageal varices.

    abstract：BACKGROUND & AIMS:Non-selective beta-blockers (NSBBs) are the mainstay of primary prophylaxis of esophageal variceal bleeding in patients with liver cirrhosis. We investigated whether non-invasive markers of portal hypertension correlate with hemodynamic responses to NSBBs in cirrhotic patients with esophageal varices....

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2018.10.018

    authors： Kim HY,So YH,Kim W,Ahn DW,Jung YJ,Woo H,Kim D,Kim MY,Baik SK

    更新日期：2019-03-01 00:00:00

  • Different hepatitis C virus dynamics of free-virions and immune-complexes after initiation of interferon-alpha in patients with chronic hepatitis C.

    abstract：BACKGROUND/AIMS:To elucidate the mechanisms of action of interferon (IFN) against hepatitis C virus (HCV), we studied the serum HCV dynamics of free-virions (FV) and immune-complexes (IC) in patients treated with IFN. METHODS:FV and IC were separated by immunoprecipitation using anti-human immunoglobulin and quantifie...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(03)00472-0

    authors： Fujita N,Kaito M,Takeo M,Horiike S,Tanaka H,Ikoma J,Watanabe S,Adachi Y

    更新日期：2003-12-01 00:00:00

  • Ketoconazole exacerbates mitophagy to induce apoptosis by downregulating cyclooxygenase-2 in hepatocellular carcinoma.

    abstract：BACKGROUND & AIMS:Hepatocellular carcinoma (HCC) is a common cancer worldwide and remains a major clinical challenge. Ketoconazole, a traditional antifungal agent, has attracted considerable attention as a therapeutic option for cancer treatment. However, its mechanism of action is still not clearly defined. We aimed t...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2018.09.022

    authors： Chen Y,Chen HN,Wang K,Zhang L,Huang Z,Liu J,Zhang Z,Luo M,Lei Y,Peng Y,Zhou ZG,Wei Y,Huang C

    更新日期：2019-01-01 00:00:00

  • Hepatocyte growth factor inhibits insulin-stimulated glycogen synthesis in primary cultured hepatocytes.

    abstract：BACKGROUND/AIMS:Hepatocyte growth factor (HGF) plays an important role as a mitogen in liver regeneration. However, little is known about the metabolic effects of HGF in the liver. Studies were performed to examine whether HGF influences carbohydrate metabolism, which is drastically changed in the early course of the r...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(02)00455-5

    authors： Kaibori M,Kwon AH,Teshima S,Nakanishi H,Kitano T,Kamiyama Y,Okumura T

    更新日期：2003-04-01 00:00:00

  • Alcohol in combination with malnutrition causes increased liver fibrosis in rats.

    abstract：:Rats were malnourished for 12 months with a highly inadequate fat-rich, calorie-sufficient but otherwise poly-deficient liquid diet composed of mashed potatoes with mayonnaise, comparable with the nutritional intake of many chronic alcoholics. When alcohol was incorporated into this diet, administered as whisky in dri...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(05)80319-8

    authors： Bosma A,Seifert WF,van Thiel-de Ruiter GC,van Leeuwen RE,Blauw B,Roholl P,Knook DL,Brouwer A

    更新日期：1994-09-01 00:00:00

  • Magnetic resonance imaging and spectroscopy accurately estimate the severity of steatosis provided the stage of fibrosis is considered.

    abstract：BACKGROUND/AIMS:Currently the diagnosis and severity of hepatic steatosis can be established accurately only by liver biopsy. Previous small studies found that steatosis measured by magnetic resonance spectroscopy (MRS) and imaging (MRI) correlated with histological assessment of liver triglyceride content. However, th...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2009.04.012

    authors： McPherson S,Jonsson JR,Cowin GJ,O'Rourke P,Clouston AD,Volp A,Horsfall L,Jothimani D,Fawcett J,Galloway GJ,Benson M,Powell EE

    更新日期：2009-08-01 00:00:00