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Inherited non-alcoholic fatty liver disease and dyslipidemia due to monoallelic ABHD5 mutations.

Abstract：

BACKGROUND & AIMS:Non-alcoholic fatty liver disease (NAFLD) is a multifactorial condition and the most common liver disease worldwide, affecting more than one-third of the population. So far there have been no reports on mendelian inheritance in families with NAFLD. METHODS:We performed whole-exome or targeted next-generation sequencing on patients with autosomal dominant NAFLD. RESULTS:We report a heritable form of NAFLD and/or dyslipidemia due to monoallelic ABHD5 mutations, with complete clinical expression after the fourth decade of life, in 7 unrelated multiplex families encompassing 39 affected individuals. The prevalence of ABHD5-associated NAFLD was estimated to be 1 in 1,137 individuals in a normal population. CONCLUSION:We associate a Mendelian form of NAFLD and/or dyslipidemia with monoallelic ABHD5 mutations. LAY SUMMARY:Non-alcoholic fatty liver disease (NAFLD) is a common multifactorial disorder with a strong genetic component. Inherited forms of NAFLD have been suspected but, their molecular pathogenesis has not been disclosed. Here we report a heritable form of NAFLD with clinical expression after 40 years of age, associated with monoallelic ABHD5 mutations.

journal_name

J Hepatol

journal_title

Journal of hepatology

authors

Youssefian L,Vahidnezhad H,Saeidian AH,Pajouhanfar S,Sotoudeh S,Mansouri P,Amirkashani D,Zeinali S,Levine MA,Peris K,Colombo R,Uitto J

doi

10.1016/j.jhep.2019.03.026

subject

Has Abstract

pub_date

2019-08-01 00:00:00

pages

366-370

issue

2

eissn

0168-8278

issn

1600-0641

pii

S0168-8278(19)30220-X

journal_volume

71

pub_type

杂志文章

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