HCV-core protein accelerates recovery from the insensitivity of liver cells to Fas-mediated apoptosis induced by an injection of anti-Fas antibody in mice.

abstract：:The etiologic agent responsible for epidemics of enterically-transmitted non-A, non-B hepatitis has been molecularly characterized as the hepatitis E virus (HEV). The cloning of a portion of the Burma strain of HEV (HEV(B); 'Old World' strain) has been described together with the isolation of a contiguous overlapping ...

journal_title：Journal of hepatology

authors： Reyes GR,Huang CC,Yarbough PO,Tam AW

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND/AIMS:Inflammation in the liver is a complex interaction between parenchymal and non-parenchymal cells, and therefore can not be studied in vitro in pure cultures of these cells. METHODS:We investigated whether Kupffer cells in the liver slice are still responsive to an inflammatory stimulus of lipopolysacch...

journal_title：Journal of hepatology

authors： Olinga P,Merema MT,de Jager MH,Derks F,Melgert BN,Moshage H,Slooff MJ,Meijer DK,Poelstra K,Groothuis GM

更新日期：2001-08-01 00:00:00

abstract：BACKGROUND & AIMS:Autophagy plays a crucial role in hepatic homeostasis and its deregulation has been associated with chronic liver disease. However, the effect of autophagy on the release of fibrogenic extracellular vesicles (EVs) by platelet-derived growth factor (PDGF)-stimulated hepatic stellate cells (HSCs) remain...

journal_title：Journal of hepatology

authors： Gao J,Wei B,de Assuncao TM,Liu Z,Hu X,Ibrahim S,Cooper SA,Cao S,Shah VH,Kostallari E

更新日期：2020-11-01 00:00:00

abstract：:Dermatological adverse events (AEs) are an existing concern during hepatitis C virus (HCV) infection and peginterferon/ribavirin treatment. HCV infection leads to dermatological and muco-cutaneous manifestations including small-vessel vasculitis as part of the mixed cryoglobulinemic syndrome. Peginterferon/ribavirin t...

journal_title：Journal of hepatology

authors： Cacoub P,Bourlière M,Lübbe J,Dupin N,Buggisch P,Dusheiko G,Hézode C,Picard O,Pujol R,Segaert S,Thio B,Roujeau JC

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND/AIMS:The glycosphingolipid alpha-galactosylceramide has been shown to activate invariant natural killer T cells when presented in the context of CD1d and induces powerful antiviral immune responses via the production of inflammatory cytokines. The aim of this study was to investigate the safety and the antiv...

journal_title：Journal of hepatology

authors： Veldt BJ,van der Vliet HJ,von Blomberg BM,van Vlierberghe H,Gerken G,Nishi N,Hayashi K,Scheper RJ,de Knegt RJ,van den Eertwegh AJ,Janssen HL,van Nieuwkerk CM

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND/AIMS:Patients with cholestatic liver disease have 'low-turnover' osteoporosis. Since we reported that bile-duct ligated (BDL) rats develop bone disease with low bone formation and mass, we examined whether their reduced bone mass results in skeletal fragility, and whether the reduction in osteoprogenitor cel...

journal_title：Journal of hepatology

authors： Weinreb M,Pollak RD,Ackerman Z

更新日期：2004-03-01 00:00:00

abstract：BACKGROUND/AIMS:The objective of this study was to validate, with an independent prospective cohort of patients, our previous data indicating that the proliferating cell nuclear antigen-labeling index (PCNA-LI) reflects the liver functional reserve in human cirrhosis and might have prognostic significance for patient s...

journal_title：Journal of hepatology

authors： Delhaye M,Louis H,Degraef C,Le Moine O,Devière J,Peny MO,Adler M,Galand P

更新日期：1999-03-01 00:00:00

abstract：:The heart and liver are organs that are closely related in both health and disease. Patients who undergo liver transplantation may suffer from heart disease that is: (a) related to the original cause of the liver disease such as hemochromatosis, (b) related to the liver disease itself, or (c) related to other associat...

journal_title：Journal of hepatology

authors： Ripoll C,Yotti R,Bermejo J,Bañares R

更新日期：2011-04-01 00:00:00

abstract：:The interaction between fat-storing cells (FSCs) and Kupffer cells (KCs) in vitro has been studied in an attempt to clarify certain aspects of the pathogenesis of fibrotic process in the liver. FSCs and KCs were isolated from the livers of rats either treated with CCl4 for 6 weeks, or with vitamin A for 6 weeks or fro...

journal_title：Journal of hepatology

authors： Shiratori Y,Geerts A,Ichida T,Kawase T,Wisse E

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND/AIMS:The primary cause of Familial Amyloidotic Polyneuropathy is a variant transthyretin gene on chromosome 18. Progressive polyneuropathy followed by fatal cardiac and renal failure commonly manifest during middle age. Within 10 years after onset of clinical symptoms, affected individuals usually die due to...

journal_title：Journal of hepatology

authors： Schmidt HH,Nashan B,Pröpsting MJ,Nakazato M,Flemming P,Kubicka S,Böker K,Pichlmayr R,Manns MP

更新日期：1999-02-01 00:00:00

abstract：BACKGROUND/AIM:The aim of this study was to assess the pathology and pathogenic mechanisms involved in the occlusion of transjugular intrahepatic portosystemic stent-shunts. METHODS:Thirty-four patients with transjugular intrahepatic portosystemic stent-shunt who had at least two portographic assessments of shunt func...

journal_title：Journal of hepatology

authors： Jalan R,Harrison DJ,Redhead DN,Hayes PC

更新日期：1996-02-01 00:00:00

abstract：BACKGROUND & AIMS:Biliary tree, liver, and pancreas share a common embryological origin. We previously demonstrated the presence of stem/progenitor cells of endodermal origin in the adult human extrahepatic biliary tree. This study evaluated the human foetal biliary trees as sources of stem/progenitor cells of multiple...

journal_title：Journal of hepatology

authors： Semeraro R,Carpino G,Cardinale V,Onori P,Gentile R,Cantafora A,Franchitto A,Napoli C,Anceschi M,Brunelli R,Bosco D,Torrice A,Reid L,Gaudio E,Alvaro D

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND & AIMS:High oxidative stress plays a major role in increasing hepatic vascular resistance in cirrhosis, by facilitating liver fibrosis and by increasing hepatic vascular tone. This study is aimed at investigating whether the use of the novel isoform of recombinant human manganese superoxide dismutase (rMnSOD...

journal_title：Journal of hepatology

authors： Guillaume M,Rodriguez-Vilarrupla A,Gracia-Sancho J,Rosado E,Mancini A,Bosch J,Garcia-Pagán JC

更新日期：2013-02-01 00:00:00

abstract：:To define the epidemiologic and clinical significance of delta infection in the Naples area, we sought anti-delta antibodies in all cases of HBV-associated liver diseases, hospitalized in our department during 1983 (234 acute hepatitis, 9 of which fulminant; 51 chronic hepatitis; 32 cirrhosis; 19 hepatocarcinomas) and...

journal_title：Journal of hepatology

authors： Amoroso P,Giorgio A,Fico P,Lettieri G,de Stefano G,Scala V,Pesce G,Pierri P,Pempinello R,Finelli L

更新日期：1986-01-01 00:00:00

abstract：:Lactitol is a disaccharide analogue of lactulose which is available as a pure crystalline powder. The efficacy of lactitol in the treatment of chronic hepatic encephalopathy was assessed in 9 cirrhotic patients in a randomised, double-blind, cross-over comparison with lactulose. The sugars were dispensed in solutions,...

journal_title：Journal of hepatology

authors： Morgan MY,Hawley KE,Stambuk D

更新日期：1987-04-01 00:00:00

abstract：:The aim of the present study was to determine the prevalence of hepatocellular carcinoma in adults with heterozygous alpha 1-antitrypsin deficiency and to assess the presence of possible co-risk factors for the development of hepatocellular carcinoma. Two hundred and forty patients with cirrhosis of different aetiolog...

journal_title：Journal of hepatology

authors： Propst T,Propst A,Dietze O,Judmaier G,Braunsteiner H,Vogel W

更新日期：1994-12-01 00:00:00

abstract：BACKGROUND/AIMS:Phase I/II studies of 4 weeks duration have confirmed the ALT lowering effect of glycyrrhizin in Western chronic hepatitis C patients. Our aim was to determine the dose frequency of glycyrrhizin required to maintain the ALT response beyond 4 weeks and evaluate its effect on liver histology and quality o...

journal_title：Journal of hepatology

authors： Orlent H,Hansen BE,Willems M,Brouwer JT,Huber R,Kullak-Ublick GA,Gerken G,Zeuzem S,Nevens F,Tielemans WC,Zondervan PE,Lagging M,Westin J,Schalm SW

更新日期：2006-10-01 00:00:00

abstract：BACKGROUND/AIMS:In chronic hepatitis C, disease progression and clinical manifestations are heterogenous. To clarify the role and interactions of viral and host factors in inducing liver cell injury, we examined the associations of several virological and metabolic variables with serum alanine aminotransferase levels. ...

journal_title：Journal of hepatology

authors： Prati D,Shiffman ML,Diago M,Gane E,Rajender Reddy K,Pockros P,Farci P,O'Brien CB,Lardelli P,Blotner S,Zeuzem S

更新日期：2006-04-01 00:00:00

abstract：:Secondary biliary cirrhosis in the rat is an attractive model since unlike other models it does not rely on exogenous toxic compounds to induce cirrhosis. However, because little is known about the microcirculatory abnormalities of this model, this study investigated hemodynamics in rats with predefined functional imp...

journal_title：Journal of hepatology

authors： Ohara N,Schaffner T,Reichen J

更新日期：1993-02-01 00:00:00

abstract：BACKGROUND & AIMS:Disturbance in lipid metabolism is one of the features of chronic hepatitis C, being a crucial determinant of the progression of liver fibrosis. Experimental studies have revealed that the core protein of hepatitis C virus (HCV) induces steatosis. METHODS:The activities of fatty acid metabolizing enz...

journal_title：Journal of hepatology

authors： Miyoshi H,Moriya K,Tsutsumi T,Shinzawa S,Fujie H,Shintani Y,Fujinaga H,Goto K,Todoroki T,Suzuki T,Miyamura T,Matsuura Y,Yotsuyanagi H,Koike K

更新日期：2011-03-01 00:00:00

abstract：:Three patients with Budd-Chiari syndrome in association with the 'lupus' anticoagulant are described. This anticoagulant was looked for in our patients with an otherwise idiopathic hepatic venous thrombosis because of the presence of a pronounced thrombocytopenia, a prolonged activated partial thromboplastin time or a...

journal_title：Journal of hepatology

authors： Van Steenbergen W,Beyls J,Vermylen J,Fevery J,Marchal G,Desmet V,De Groote J

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND & AIMS:Inflammatory gene expression plays a pathological role in acute and chronic hepatic inflammation, yet, inflammation also promotes liver repair by inducing protective mechanisms to limit collateral tissue damage by priming hepatocytes for proliferation. Early growth response (Egr)-1, a transcription fa...

journal_title：Journal of hepatology

authors： Pritchard MT,Cohen JI,Roychowdhury S,Pratt BT,Nagy LE

更新日期：2010-10-01 00:00:00

abstract：:Twenty patients with paracetamol(acetaminophen)-induced acute liver damage of varying severity were studied longitudinally with assessment of clinical state, standard liver function tests and radiometric hyaluronate (HYA) assay (Pharmacia). In patients (n = 6) who developed coma, HYA rose rapidly with clinical deterio...

journal_title：Journal of hepatology

authors： Bramley PN,Rathbone BJ,Forbes MA,Cooper EH,Losowsky MS

更新日期：1991-07-01 00:00:00

abstract：:Intraperitoneal inoculation into sensitive BALB/c mice of D85, a thermosensitive (ts) mutant, provokes acute hepatitis followed by recovery of the mice. The ts mutant was able to replicate in the liver. However, the maximal viral titre was obtained 2 days later than was the case with the wild-type (wt) MHV 3 infection...

journal_title：Journal of hepatology

authors： Martin JP,Bingen A,Koehren F,Gut JP,Kirn A

更新日期：1991-07-01 00:00:00

abstract：BACKGROUND/AIMS:Partial hepatectomy results in activation of genes in the residual liver tissue which serve to restore glucose homeostasis and regenerate liver mass. Expression of insulin-like growth factor binding protein-1 (IGFBP-1) is up-regulated following partial hepatectomy and IGFBP-1 can modulate both the metab...

journal_title：Journal of hepatology

authors： Liu YY,Rajkumar K,Murphy LJ

更新日期：1999-04-01 00:00:00

abstract：:It has been postulated that one of the mechanisms of hypotension associated with cirrhosis is an attenuated responsiveness to catecholamines despite the increased activity of the sympathetic nervous system and the elevated plasma concentrations of the sympathetic neurotransmitter, norepinephrine. This abnormality was ...

journal_title：Journal of hepatology

authors： Bomzon A,Binah O,Blendis LM

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND/AIMS:Hepatic stellate cells (HSCs) are known to play a role in hepatic regeneration. We investigated hepatocyte/HSC interaction and HSC activation at various times after 70% partial hepatectomy (PHx) in the rat. METHODS:The hepatic microcirculation was studied using intravital fluorescence microscopy (IVFM)...

journal_title：Journal of hepatology

authors： Mabuchi A,Mullaney I,Sheard PW,Hessian PA,Mallard BL,Tawadrous MN,Zimmermann A,Senoo H,Wheatley AM

更新日期：2004-06-01 00:00:00

abstract：BACKGROUND & AIMS:Although antiviral treatment for hepatitis C (HCV) is highly effective, side effects often occur, including weight loss, digestive symptoms, and impaired quality of life. We aimed at exploring the beneficial effects of preventive nutritional support. METHODS:In a randomized controlled trial, 53 HCV p...

journal_title：Journal of hepatology

authors： Huisman EJ,van Hoek B,van Soest H,van Nieuwkerk KM,Arends JE,Siersema PD,van Erpecum KJ

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND & AIMS:Diabetes occurring as a direct consequence of loss of liver function is usually characterized by non-diabetic fasting plasma glucose (FPG) and haemoglobin A1c (HbA1c) levels and should regress after orthotopic liver transplantation (OLT). This observational, longitudinal study investigated the relatio...

journal_title：Journal of hepatology

authors： Grancini V,Trombetta M,Lunati ME,Boselli ML,Gatti S,Donato MF,Palmieri E,Resi V,Pugliese G,Bonadonna RC,Orsi E

更新日期：2019-05-01 00:00:00

abstract：:Recently antibodies to hepatitis C virus were detected in sera of chronic active hepatitis patients, with anti-smooth muscle autoantibodies or with anti-liver/kidney microsomal type 1 autoantibodies. As the latter were used to differentiate autoimmune chronic active hepatitis from chronic non-A, non-B virus hepatitis,...

journal_title：Journal of hepatology

authors： Abuaf N,Lunel F,Giral P,Borotto E,Laperche S,Poupon R,Opolon P,Huraux JM,Homberg JC

更新日期：1993-07-01 00:00:00