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Acute-on chronic liver failure.

Abstract：

:Acute-on-chronic liver failure (ACLF) is an increasingly recognised entity encompassing an acute deterioration of liver function in patients with cirrhosis, which is usually associated with a precipitating event and results in the failure of one or more organs and high short term mortality. Prospective data to define this is lacking but there is a large body of circumstantial evidence suggesting that this condition is a distinct clinical entity. From the pathophysiologic perspective, altered host response to injury and infection play important roles in its development. This review focuses upon the current understanding of this syndrome from the clinical, prognostic and pathophysiologic perspectives and indicates potential biomarkers and therapeutic targets for intervention.

journal_name

J Hepatol

journal_title

Journal of hepatology

authors

Jalan R,Gines P,Olson JC,Mookerjee RP,Moreau R,Garcia-Tsao G,Arroyo V,Kamath PS

doi

10.1016/j.jhep.2012.06.026

subject

Has Abstract

pub_date

2012-12-01 00:00:00

pages

1336-48

issue

6

eissn

0168-8278

issn

1600-0641

pii

S0168-8278(12)00519-3

journal_volume

57

pub_type

杂志文章,评审

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