当前位置： SCI文献检索 > JOURNAL OF HEPATOLOGY期刊下所有文献 > Let-7g targets collagen type I alpha2 and inhibits cell migration in hepatocellular carcinoma.

Let-7g targets collagen type I alpha2 and inhibits cell migration in hepatocellular carcinoma.

Abstract：

BACKGROUND & AIMS:Hepatocellular carcinoma (HCC) is an aggressive cancer with a poor prognosis mainly due to metastasis. MicroRNAs are endogenous small noncoding RNAs that regulate cellular gene expression and are functionally linked to tumourigenesis. Using microarray analysis, we recently identified 20 miRNAs associated with HCC metastasis. Here, we carried out further analyses on one of these microRNAs, let-7g, to determine whether it is functionally linked to HCC metastasis. METHODS:Quantitative real-time polymerase chain reaction was used to determine the level of mature let-7g transcript in HCC clinical specimens and its correlation with patient survival. Ectopic expression of let-7g was carried out in HCC cell lines to assess its influence on cell growth, migration, and invasion. RESULTS:We confirmed that the level of let-7g was significantly lower in metastatic HCCs compared to metastasis-free HCCs. Moreover, low let-7g expression in a tumour was predictive of poor survival in HCC patients. Functional studies indicated that ectopic expression of let-7g significantly inhibits HCC cell migration and cell growth. In-silico analysis revealed members of soluble collagens as potential targets of let-7g. Consistently, the levels of type I collagen alpha2 (COL1A2) and let-7g were inversely correlated in HCC clinical specimens. COL1A2 was experimentally validated as a direct target of let-7g. Moreover, addition of COL1A2 counteracted the inhibitory effect of let-7g on cell migration. CONCLUSIONS:These results suggest that let-7g may suppress HCC metastasis partially through targeting COL1A2.

journal_name

J Hepatol

journal_title

Journal of hepatology

authors

Ji J,Zhao L,Budhu A,Forgues M,Jia HL,Qin LX,Ye QH,Yu J,Shi X,Tang ZY,Wang XW

doi

10.1016/j.jhep.2009.12.025

subject

Has Abstract

pub_date

2010-05-01 00:00:00

pages

690-7

issue

5

eissn

0168-8278

issn

1600-0641

pii

S0168-8278(10)00084-X

journal_volume

52

pub_type

杂志文章

相关文献

JOURNAL OF HEPATOLOGY文献大全
  • Hepatocellular ballooning in NASH.

    abstract：BACKGROUND & AIMS:Hepatocellular ballooning is a key finding in nonalcoholic steatohepatitis (NASH). It is conventionally defined by hemotoxylin and eosin (H&E) staining showing enlarged cells with rarefied cytoplasm and recently by changes in the cytoskeleton. Fat droplets are emerging as important organelles in cell ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2010.04.031

    authors： Caldwell S,Ikura Y,Dias D,Isomoto K,Yabu A,Moskaluk C,Pramoonjago P,Simmons W,Scruggs H,Rosenbaum N,Wilkinson T,Toms P,Argo CK,Al-Osaimi AM,Redick JA

    更新日期：2010-10-01 00:00:00

  • Roles of alcohol consumption in fatty liver: a longitudinal study.

    abstract：BACKGROUND & AIMS:Roles of alcohol consumption in non-alcoholic fatty liver disease are still controversial, although several cross-sectional studies have suggested the beneficial effect of light to moderate drinking on fatty liver. We analyzed the longitudinal relationship between drinking pattern and fatty liver. ME...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2014.11.025

    authors： Moriya A,Iwasaki Y,Ohguchi S,Kayashima E,Mitsumune T,Taniguchi H,Ando M,Yamamoto K

    更新日期：2015-04-01 00:00:00

  • WITHDRAWN: Null genotypes of GSTM1 and GSTT1 both associated with increased hepatocellular carcinoma risk in Asians: new evidence.

    abstract：:This article has been withdrawn at the request of the authors and with approval of the editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2010.12.044

    authors： Xi B,Zeng T

    更新日期：2011-02-22 00:00:00

  • Purinergic P2Y2 receptors promote hepatocyte resistance to hypoxia.

    abstract：BACKGROUND/AIMS:ATP stimulation of purinergic P2 receptors (P2YR and P2XR) regulates several hepatic functions. Here we report the involvement of ATP-mediated signals in enhancing hepatocyte tolerance to lethal stress. METHODS:The protection given by purinergic agonists was investigated in rat hepatocytes exposed to h...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2006.02.017

    authors： Carini R,Alchera E,De Cesaris MG,Splendore R,Piranda D,Baldanzi G,Albano E

    更新日期：2006-08-01 00:00:00

  • Normothermic regional perfusion vs. super-rapid recovery in controlled donation after circulatory death liver transplantation.

    abstract：BACKGROUND & AIMS:Although there is increasing interest in its use, definitive evidence demonstrating a benefit for postmortem normothermic regional perfusion (NRP) in controlled donation after circulatory death (cDCD) liver transplantation is lacking. The aim of this study was to compare results of cDCD liver transpla...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2018.12.013

    authors： Hessheimer AJ,Coll E,Torres F,Ruíz P,Gastaca M,Rivas JI,Gómez M,Sánchez B,Santoyo J,Ramírez P,Parrilla P,Marín LM,Gómez-Bravo MÁ,García-Valdecasas JC,López-Monclús J,Boscá A,López-Andújar R,Fundora-Suárez J,Villar J,

    更新日期：2019-04-01 00:00:00

  • Macrophages from rat livers with micronodular and macronodular cirrhosis differ with respect to mediator release and DNA-synthesis.

    abstract：BACKGROUND/AIMS:Liver macrophages play an essential role in necro-inflammatory liver damage which leads to fibrosis and cirrhosis. The aim of the present study was to compare the mediator release and the DNA synthesis of macrophages at an early and at a later stage of liver cirrhosis induced by thioacetamide. METHODS:...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(97)80118-3

    authors： Vogl S,Junker U,Vogelsang H,Dargel R

    更新日期：1997-05-01 00:00:00

  • Fatty acid composition of adipose tissue in patients with chronic liver disease.

    abstract：:In this study plasma free fatty acids and adipose tissue fatty acid composition in 10 cirrhotic patients, 5 patients with non-cirrhotic chronic liver disease and in 5 controls have been investigated. Fatty acid composition of adipose tissue in cirrhotic patients demonstrated a significant increase of 16:1 and a decrea...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(86)80153-2

    authors： Merli M,Iapichino S,Bolognese A,Bruni A,Cantafora A,Riggio O,Capocaccia L

    更新日期：1986-01-01 00:00:00

  • Role of aquaporin-4 in the development of brain oedema in liver failure.

    abstract：BACKGROUND & AIMS:Liver failure is associated with progressive cytotoxic brain oedema (astrocyte swelling), which underlies hepatic encephalopathy (HE). Ammonia and superimposed inflammation are key synergistic factors in HE, but the mechanism(s) involved remain unknown. We aimed to determine whether aquaporin-4 (AQP4)...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2010.02.020

    authors： Wright G,Soper R,Brooks HF,Stadlbauer V,Vairappan B,Davies NA,Andreola F,Hodges S,Moss RF,Davies DC,Jalan R

    更新日期：2010-07-01 00:00:00

  • The delay of rearterialization after initial portal reperfusion in living donor liver transplantation significantly determines the development of microvascular graft dysfunction.

    abstract：BACKGROUND/AIMS:Graft reperfusion in liver transplantation is usually performed by initial portal reperfusion (IPR) and delayed rearterialization. Its influence on graft microcirculation is unknown. This study aimed to assess sinusoidal perfusion in dependence to this reperfusion technique during human living-donor liv...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2004.04.017

    authors： Puhl G,Schaser KD,Pust D,Köhler K,Vollmar B,Menger MD,Neuhaus P,Settmacher U

    更新日期：2004-08-01 00:00:00

  • Heterogeneous immunogenomic features and distinct escape mechanisms in multifocal hepatocellular carcinoma.

    abstract：BACKGROUND & AIMS:The presence of multifocal tumors, developed either from intrahepatic metastasis (IM) or multicentric occurrence (MO), is a distinct feature of hepatocellular carcinoma (HCC). Immunogenomic characterization of multifocal HCC is important for understanding immune escape in different lesions and develop...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2019.12.014

    authors： Dong LQ,Peng LH,Ma LJ,Liu DB,Zhang S,Luo SZ,Rao JH,Zhu HW,Yang SX,Xi SJ,Chen M,Xie FF,Li FQ,Li WH,Ye C,Lin LY,Wang YJ,Wang XY,Gao DM,Zhou H,Yang HM,Wang J,Zhu SD,Wang XD,Cao Y,Zhou J,Fan J,Wu K,Gao

    更新日期：2020-05-01 00:00:00

  • Epidemiology and natural history of hepatitis C infections in liver transplant recipients.

    abstract：:Hepatitis C infection is common in patients undergoing liver transplantation. Few studies have focused on the prevalence and epidemiology of hepatitis C infection among liver transplant recipients since the implementation of donor screening for antibodies against the hepatitis C virus (anti-HCV). Using reverse transcr...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：

    authors： Weinstein JS,Poterucha JJ,Zein N,Wiesner RH,Persing DH,Rakela J

    更新日期：1995-01-01 00:00:00

  • The submicrosomal localization of uridine 5'-diphosphate-glucose dolichyl-phosphate glucosyltransferase and bile acid glucosyltransferase in the human liver.

    abstract：:Uridine 5'-diphosphate-glucose dolichyl-phosphate glucosyltransferase and bile acid glucosyltransferase were quantitatively determined in subcellular fractions obtained by differential centrifugation of human liver homogenate. Both enzymes were exclusively enriched in the microsomal fraction with a recovery of total e...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(05)80464-7

    authors： Gartung C,Matern S,Matern H

    更新日期：1994-01-01 00:00:00

  • Long-term outcome of asymptomatic liver hydatidosis.

    abstract：BACKGROUND/AIMS:The aim of this study was to determine the outcome of asymptomatic liver hydatid cysts in a cohort of 33 out of 59 carriers by evaluating clinical and ultrasonographic (US) changes 10-12 years after initial diagnosis. METHODS:We compared US features and cyst size with the original descriptions from 198...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(99)80066-x

    authors： Frider B,Larrieu E,Odriozola M

    更新日期：1999-02-01 00:00:00

  • IL-6 pathway in the liver: From physiopathology to therapy.

    abstract：:Interleukin 6 (IL-6) is a pleiotropic four-helix-bundle cytokine that exerts multiple functions in the body. In the liver, IL-6 is an important inducer of the acute phase response and infection defense. IL-6 is furthermore crucial for hepatocyte homeostasis and is a potent hepatocyte mitogen. It is not only implicated...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jhep.2016.02.004

    authors： Schmidt-Arras D,Rose-John S

    更新日期：2016-06-01 00:00:00

  • Alterations of leptin during IFN-alpha therapy in patients with chronic viral hepatitis.

    abstract：BACKGROUND/AIMS:Leptin has a particular profibrogenic role in the liver. We investigated whether IFN-alpha influences leptin production in patients with chronic hepatitis B (CHB) and C (CHC). Leptin was determined in serial samples from 63 CHB and 42 CHC IFN-alpha treated patients. Furthermore, we evaluated whether lep...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2006.01.025

    authors： Zografos TA,Rigopoulou EI,Liaskos C,Togousidis E,Zachou K,Gatselis N,Germenis A,Dalekos GN

    更新日期：2006-05-01 00:00:00

  • Evidence for Galalpha(1-3)Gal expression on primary porcine hepatocytes: implications for bioartificial liver systems.

    abstract：BACKGROUND/AIMS:To bridge acute liver failure (ALF) patients to orthotopic liver transplantation, several bioartificial liver (BAL) systems have been developed. The bio-component of most BAL systems consists mainly of porcine hepatocytes. Plasma or blood of ALF patients is perfused through the BAL thereby contacting po...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2004.11.041

    authors： van de Kerkhove MP,Germans MR,Deurholt T,Hoekstra R,Joziasse DH,van Wijk AC,van Gulik TM,Chamuleau RA,Roos A

    更新日期：2005-04-01 00:00:00

  • In situ hybridization studies of hepatitis A viral RNA in patients with acute hepatitis A.

    abstract：:In situ hybridization with oligonucleotide probes has been used to localise hepatitis A virus RNA genomic sequences in formalin-fixed and routinely processed human liver biopsies from three patients. Using radiolabelled Sulphur-35 antisense probes, viral genomic sequences were found in all three cases, but signal inte...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(94)80012-x

    authors： Taylor M,Goldin RD,Ladva S,Scheuer PJ,Thomas HC

    更新日期：1994-03-01 00:00:00

  • Primary hepatocellular neoplasms in a MODY3 family with a novel HNF1A germline mutation.

    abstract：:Maturity onset diabetes of the young type 3 (MODY3) and hepatocellular adenomas (HCAs) are associated with mutations in the HNF1A gene. HNF1A codes for the transcription factor HNF1α, which interacts with DNA as a homodimer or a heterodimer with HNF1β, to regulate multiple cellular functions including glucidic metabol...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2013.05.024

    authors： Willson JS,Godwin TD,Wiggins GA,Guilford PJ,McCall JL

    更新日期：2013-10-01 00:00:00

  • Resveratrol improves intrahepatic endothelial dysfunction and reduces hepatic fibrosis and portal pressure in cirrhotic rats.

    abstract：BACKGROUND & AIMS:Resveratrol, a polyphenol found in a variety of fruits, exerts a wide range of beneficial effects on the endothelium, regulates multiple vasoactive substances and decreases oxidative stress, factors involved in the pathophysiology of portal hypertension. Our study aimed at evaluating the effects of re...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2012.12.012

    authors： Di Pascoli M,Diví M,Rodríguez-Vilarrupla A,Rosado E,Gracia-Sancho J,Vilaseca M,Bosch J,García-Pagán JC

    更新日期：2013-05-01 00:00:00

  • Influence of 48 hours of cold storage in University of Wisconsin organ preservation solution on metabolic capacity of rat hepatocytes.

    abstract：BACKGROUND/AIMS:Suspensions of isolated hepatocytes are a valuable tool to study liver functions. For optimal use of the isolated hepatocytes, methods are needed to preserve the hepatocytes while maintaining their viability, metabolic and transport functions. Until now, little has been known about the maintenance of th...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(97)80091-8

    authors： Olinga P,Merema M,Slooff MJ,Meijer DK,Groothuis GM

    更新日期：1997-10-01 00:00:00

  • Impact of immunoprophylaxis and patient selection on outcome of transplantation for HBsAg-positive liver recipients.

    abstract：:We have studied the roles of immunoprophylaxis, patient selection policy and coexistent hepatitis D virus infection in the outcome of 56 HBsAg-positive elective liver transplant recipients. Twenty-nine unselected patients not treated with immunoprophylaxis formed group 1 and were compared to a recent consecutive serie...

    journal_title：Journal of hepatology

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0168-8278(05)80396-4

    authors： Devlin J,Smith HM,O'Grady JG,Portmann B,Tan KC,Williams R

    更新日期：1994-08-01 00:00:00

  • Sustained JNK1 activation is associated with altered histone H3 methylations in human liver cancer.

    abstract：BACKGROUND/AIMS:Aberrant c-Jun N-terminal kinase (JNK) activation has been linked to hepatocellular carcinoma (HCC) in mouse models. It remains unclear whether JNK activation plays an important role in human HCC and, if so, how JNK signaling contributes to the initiation or progression of HCC. METHODS:The JNK activati...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2008.07.037

    authors： Chang Q,Zhang Y,Beezhold KJ,Bhatia D,Zhao H,Chen J,Castranova V,Shi X,Chen F

    更新日期：2009-02-01 00:00:00

  • CTLA-4 gene polymorphism confers susceptibility to primary biliary cirrhosis.

    abstract：BACKGROUND/AIM:Primary biliary cirrhosis (PBC) is an autoimmune cholestatic liver disease thought to develop through a complex interaction of genetic and environmental factors. It is characterised by T-cell-mediated non-suppurative destructive cholangitis. We have studied the polymorphic cytotoxic T lymphocyte-associat...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(00)80213-5

    authors： Agarwal K,Jones DE,Daly AK,James OF,Vaidya B,Pearce S,Bassendine MF

    更新日期：2000-04-01 00:00:00

  • Hepatocellular proliferation in patients with chronic hepatitis C and persistently normal or abnormal aminotransferase levels.

    abstract：BACKGROUND/AIMS:Some patients chronically infected with the hepatitis C virus (HCV) have persistently normal alanine aminotransferase (ALT) levels while progressive liver damage is observed histologically. In the present study, we compared the rate of proliferation, apoptosis, and necrosis in liver biopsy specimens of ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1034/j.1600-0641.2000.033004640.x

    authors： Kronenberger B,Rüster B,Lee JH,Sarrazin C,Roth WK,Herrmann G,Zeuzem S

    更新日期：2000-10-01 00:00:00

  • Evidence for selection of hepatitis B mutants after liver transplantation through peripheral blood mononuclear cell infection.

    abstract：BACKGROUND/AIMS:Despite anti-HBs immunoglobulin therapy, hepatitis B virus (HBV) infection recurs in a high proportion of patients transplanted for HBsAg positive and serum HBV DNA negative chronic liver disease. The contribution of HBV genetic variability to disease recurrence has not been yet thoroughly addressed. We...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(97)80035-9

    authors： Brind A,Jiang J,Samuel D,Gigou M,Feray C,Bréchot C,Kremsdorf D

    更新日期：1997-02-01 00:00:00

  • MCD-induced steatohepatitis is associated with hepatic adiponectin resistance and adipogenic transformation of hepatocytes.

    abstract：BACKGROUND/AIMS:In these studies, we tested the hypothesis that increased lipid intake would exacerbate the severity of nutritional steatohepatitis. METHODS:C57Bl/6J mice were fed methionine-and-choline deficient (MCD) diets containing 20% (high) or 5% (low) fat by weight for 3 weeks and compared to lipid-matched cont...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2008.03.026

    authors： Larter CZ,Yeh MM,Williams J,Bell-Anderson KS,Farrell GC

    更新日期：2008-09-01 00:00:00

  • Hepatic and extrahepatic malignancies in autoimmune hepatitis. A long-term follow-up in 473 Swedish patients.

    abstract：BACKGROUND/AIMS:Autoimmune Hepatitis (AIH) is a liver disease which may lead to liver cirrhosis. Cirrhosis is a well-known risk factor for hepatocellular cancer. Lymphoma is a disease, where immune modulating drugs as well as the autoimmune disease itself may contribute to the elevated risk. The aim was to investigate ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2008.08.022

    authors： Werner M,Almer S,Prytz H,Lindgren S,Wallerstedt S,Björnsson E,Bergquist A,Sandberg-Gertzén H,Hultcrantz R,Sangfelt P,Weiland O,Danielsson A

    更新日期：2009-02-01 00:00:00

  • DR human leukocyte antigens and disease severity in chronic hepatitis C.

    abstract：BACKGROUND/AIMS:Immune mechanisms may modulate disease severity in chronic hepatitis C and the DR human leukocyte antigens may affect these mechanisms. Our aims were to evaluate the association between the DR antigens and disease severity at presentation and to seek correlation between these antigens, disease severity ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(96)80261-3

    authors： Czaja AJ,Carpenter H,Santrach PJ,Moore SB

    更新日期：1996-06-01 00:00:00

  • EWI-2wint--a host cell factor inhibiting hepatitis C virus entry.

    abstract：:Two to three percent of the world's population is chronically infected with hepatitis C virus (HCV) and thus at risk of developing liver cancer. Although precise mechanisms regulating HCV entry into hepatic cells are still unknown, several cell surface proteins have been identified as entry factors for this virus. Amo...

    journal_title：Journal of hepatology

    pub_type： 评论,杂志文章

    doi：10.1016/j.jhep.2008.10.009

    authors： Schuster C,Baumert TF

    更新日期：2009-01-01 00:00:00

  • Cytomegalovirus infection of bile duct epithelial cells, hepatic artery and portal venous endothelium in relation to chronic rejection of liver grafts.

    abstract：BACKGROUND/AIM:Chronic rejection is an important cause of graft loss following liver transplantation. A number of risk factors for chronic rejection have been identified previously, albeit inconsistently. These include cytomegalovirus infection detected by a number of different techniques, including immunohistochemical...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(99)80294-3

    authors： Evans PC,Coleman N,Wreghitt TG,Wight DG,Alexander GJ

    更新日期：1999-11-01 00:00:00