当前位置： SCI文献检索 > JOURNAL OF HEPATOLOGY期刊下所有文献 > A genome-wide association study of HCV-induced liver cirrhosis in the Japanese population identifies novel susceptibility loci at the MHC region.

A genome-wide association study of HCV-induced liver cirrhosis in the Japanese population identifies novel susceptibility loci at the MHC region.

Abstract：

BACKGROUND & AIMS:We performed a genome-wide association study (GWAS) of hepatitis C virus (HCV)-induced liver cirrhosis (LC) to identify predictive biomarkers for the risk of LC in patients with chronic hepatitis C (CHC). METHODS:A total of 682 HCV-induced LC cases and 1045 CHC patients of Japanese origin were genotyped by Illumina Human Hap 610-Quad bead Chip. RESULTS:Eight SNPs which showed possible associations (p<1.0 × 10(-5)) at the GWAS stage were further genotyped using 936 LC cases and 3809 CHC patients. We found that two SNPs within the major histocompatibility complex (MHC) region on chromosome 6p21, rs910049 and rs3135363, were significantly associated with the progression from CHC to LC (pcombined=9.15 × 10(-11) and 1.45 × 10(-10), odds ratio (OR)=1.46 and 1.37, respectively). We also found that HLA-DQA1(*)0601 and HLA-DRB1(*)0405 were associated with the progression from CHC to LC (p=4.53 × 10(-4) and 1.54 × 10(-4) with OR=2.80 and 1.45, respectively). Multiple logistic regression analysis revealed that rs3135363, rs910049, and HLA-DQA1(*)0601 were independently associated with the risk of HCV-induced LC. In addition, individuals with four or more risk alleles for these three loci have a 2.83-fold higher risk for LC than those with no risk allele, indicating the cumulative effects of these variations. CONCLUSIONS:Our findings elucidated the crucial roles of multiple genetic variations within the MHC region as prognostic/predictive biomarkers for CHC patients.

journal_name

J Hepatol

journal_title

Journal of hepatology

authors

Urabe Y,Ochi H,Kato N,Kumar V,Takahashi A,Muroyama R,Hosono N,Otsuka M,Tateishi R,Lo PH,Tanikawa C,Omata M,Koike K,Miki D,Abe H,Kamatani N,Toyota J,Kumada H,Kubo M,Chayama K,Nakamura Y,Matsuda K

doi

10.1016/j.jhep.2012.12.024

subject

Has Abstract

pub_date

2013-05-01 00:00:00

pages

875-82

issue

5

eissn

0168-8278

issn

1600-0641

pii

S0168-8278(13)00011-1

journal_volume

58

pub_type

杂志文章

相关文献

JOURNAL OF HEPATOLOGY文献大全
  • Hepatic and skeletal muscle glycogen metabolism in rats with short-term cholestasis.

    abstract：BACKGROUND/AIMS:To study the effect of short-term cholestasis on glycogen metabolism. METHODS:Rats were bile duct ligated (BDL) for 4 or 8 days and compared to sham-operated control rats pair-fed to BDL (pair-fed CON) or fed ad libitum (ad libitum-fed CON). RESULTS:Four days after surgery, the hepatic glycogen conten...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(01)00287-2

    authors： Lang C,Schäfer M,Varga L,Zimmermann A,Krähenbühl S,Krähenbühl L

    更新日期：2002-01-01 00:00:00

  • Gene expression of interstitial collagenase in both progressive and recovery phase of rat liver fibrosis induced by carbon tetrachloride.

    abstract：BACKGROUND/AIMS:Liver fibrosis is a dynamic state between matrix production and degradation. Since our report in 1974, many studies have examined collagenase and liver fibrosis, but not the identification of cells responsible for collagenase production in vivo. The aim of this study was to investigate the gene expressi...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(00)80363-3

    authors： Watanabe T,Niioka M,Hozawa S,Kameyama K,Hayashi T,Arai M,Ishikawa A,Maruyama K,Okazaki I

    更新日期：2000-08-01 00:00:00

  • Non-radioactive hybridization with hepatitis C virus-specific probes created during polymerase chain reaction: a fast and simple procedure to verify hepatitis C virus infection.

    abstract：:All routinely available assays to detect hepatitis C virus (HCV) infection are based on the specific reaction of serum antibodies to corresponding viral antigens. The only method to detect viral nucleic acids in serum or liver is the enzymatic amplification of reversely transcribed HCV-RNA by polymerase chain reaction...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/0168-8278(92)90074-y

    authors： Geiger CP,Caselmann WH

    更新日期：1992-07-01 00:00:00

  • Functional activity of isolated pig hepatocytes attached to different extracellular matrix substrates. Implication for application of pig hepatocytes in a bioartificial liver.

    abstract：:For the manufacture of a bioartificial liver for human application, large amounts of viable and active hepatocytes are needed. Pig hepatocytes are considered to be the best alternative to scarce human hepatocytes. In vitro hepatocyte functions have so far been tested under different circumstances, mainly with rat hepa...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/0168-8278(95)80333-5

    authors： te Velde AA,Ladiges NC,Flendrig LM,Chamuleau RA

    更新日期：1995-08-01 00:00:00

  • Pan-mTOR inhibitor MLN0128 is effective against intrahepatic cholangiocarcinoma in mice.

    abstract：BACKGROUND & AIMS:Intrahepatic cholangiocarcinoma (ICC) is a lethal malignancy without effective treatment options. MLN0128, a second generation pan-mTOR inhibitor, shows efficacy for multiple tumor types. We evaluated the therapeutic potential of MLN0128 vs. gemcitabine/oxaliplatin in a novel ICC mouse model. METHODS...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2017.07.006

    authors： Zhang S,Song X,Cao D,Xu Z,Fan B,Che L,Hu J,Chen B,Dong M,Pilo MG,Cigliano A,Evert K,Ribback S,Dombrowski F,Pascale RM,Cossu A,Vidili G,Porcu A,Simile MM,Pes GM,Giannelli G,Gordan J,Wei L,Evert M,Cong W,C

    更新日期：2017-12-01 00:00:00

  • Risk of chronic kidney disease in patients with non-alcoholic fatty liver disease: is there a link?

    abstract：:Non-alcoholic fatty liver disease (NAFLD) has emerged as a growing public health problem worldwide. Increasing recognition of the importance of NAFLD and its association with the features of the metabolic syndrome has stimulated an interest in its putative role in the development and progression of chronic kidney dise...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jhep.2010.11.007

    authors： Targher G,Chonchol M,Zoppini G,Abaterusso C,Bonora E

    更新日期：2011-05-01 00:00:00

  • Delta infection in the Naples area. Epidemiologic and clinical significance.

    abstract：:To define the epidemiologic and clinical significance of delta infection in the Naples area, we sought anti-delta antibodies in all cases of HBV-associated liver diseases, hospitalized in our department during 1983 (234 acute hepatitis, 9 of which fulminant; 51 chronic hepatitis; 32 cirrhosis; 19 hepatocarcinomas) and...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(86)80003-4

    authors： Amoroso P,Giorgio A,Fico P,Lettieri G,de Stefano G,Scala V,Pesce G,Pierri P,Pempinello R,Finelli L

    更新日期：1986-01-01 00:00:00

  • miR-122 regulates collagen production via targeting hepatic stellate cells and suppressing P4HA1 expression.

    abstract：BACKGROUND & AIMS:MicroRNAs (miRNAs) have been shown to be involved in many biological processes by affecting their target gene expression. miR-122 has been extensively studied in hepatocarcinogenesis. However, the role of miR-122 in liver fibrosis remains unknown. METHODS:The mRNA expression levels of miR-122, prolyl...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2012.11.011

    authors： Li J,Ghazwani M,Zhang Y,Lu J,Li J,Fan J,Gandhi CR,Li S

    更新日期：2013-03-01 00:00:00

  • Participation of different cell types in the restitutive response of the rat liver to periportal injury induced by allyl alcohol.

    abstract：BACKGROUND/AIM:Restitution of periportal liver necrosis induced by allyl alcohol involves proliferation and differentiation of putative liver stem cells. The participation of different non-epithelial cell types required to restore the liver cord structure in this process has not been well documented. The aim of the stu...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(99)80043-9

    authors： Yin L,Lynch D,Sell S

    更新日期：1999-09-01 00:00:00

  • The finest branches of the biliary tree might induce biliary vascularization necessary for biliary regeneration.

    abstract：BACKGROUND/AIMS:The finer branches of the biliary tree play an important role in biliary regeneration. They are consistently escorted by microvessels. Defects in the vascularization of these structures could impair bile duct regeneration. Therefore, we investigated the pattern of the escorting microvessels during the d...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2005.08.011

    authors： van den Heuvel MC,Gouw AS,Boot M,Slooff MJ,Poppema S,de Jong KP

    更新日期：2006-05-01 00:00:00

  • Increased IgM B cell differentiation lymphokine production by T lymphocytes from patients with primary biliary cirrhosis.

    abstract：:Hypergammaglobulinemia, mainly due to increased serum immunoglobulin M concentrations, is a common and distinctive feature of primary biliary cirrhosis. T-B cell cooperation plays a pivotal role in the regulation of immunoglobulin secretion. In this paper, the production of regulatory B lymphokines by T cells, as well...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(05)80488-x

    authors： Menéndez-Caro JL,Alvarez-Mon M,Girón JA,Manzano L,Garrido A,Abreu L,Albillos A,Durántez A

    更新日期：1994-04-01 00:00:00

  • Unsaturated fatty acids promote hepatoma proliferation and progression through downregulation of the tumor suppressor PTEN.

    abstract：BACKGROUND/AIMS:The impact of dietary fatty acids on the development of cancers is highly controversial. We recently demonstrated that unsaturated fatty acids trigger the downregulation of the tumor suppressor PTEN through an mTOR/NF-kappaB-dependent mechanism in hepatocytes. In this study, we investigated whether unsa...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2009.01.027

    authors： Vinciguerra M,Carrozzino F,Peyrou M,Carlone S,Montesano R,Benelli R,Foti M

    更新日期：2009-06-01 00:00:00

  • Phenocopies of poor metabolizers of omeprazole caused by liver disease and drug treatment.

    abstract：BACKGROUND/AIMS:The kinetics of omeprazole and its primary metabolites 5'-hydroxyomeprazole and omeprazole sulfone were studied in healthy volunteers to evaluate omeprazole as a probe drug for the S-mephenytoin hydroxylase (CYP2C19) polymorphism. The plasma metabolic ratio obtained from the concentrations of omeprazole...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：

    authors： Rost KL,Brockmöller J,Esdorn F,Roots I

    更新日期：1995-09-01 00:00:00

  • Matrix metalloproteinase-9 contributes to brain extravasation and edema in fulminant hepatic failure mice.

    abstract：BACKGROUND/AIMS:Fulminant hepatic failure (FHF) can be dreadful. When coma sets in, brain edema develops taking FHF into a lethal course. Mechanisms of brain extravasation leading to brain edema remain incompletely understood. Matrix metalloproteinase (MMP)-9 is implicated in various brain injuries. We hypothesized tha...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2005.09.019

    authors： Nguyen JH,Yamamoto S,Steers J,Sevlever D,Lin W,Shimojima N,Castanedes-Casey M,Genco P,Golde T,Richelson E,Dickson D,McKinney M,Eckman CB

    更新日期：2006-06-01 00:00:00

  • Advances in functional and molecular MRI technologies in chronic liver diseases.

    abstract：:MRI has emerged as the most comprehensive non-invasive diagnostic tool for liver diseases. In recent years, the value of MRI in hepatology has been significantly enhanced by a wide range of contrast agents, both clinically available and under development, that add functional information to anatomically detailed morpho...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jhep.2020.06.020

    authors： Zhou IY,Catalano OA,Caravan P

    更新日期：2020-11-01 00:00:00

  • Caspase 8 differentially controls hepatocytes and non-parenchymal liver cells during chronic cholestatic liver injury in mice.

    abstract：BACKGROUND & AIMS:Receptor mediated cell death through the activation of caspases has been identified as an important mechanism to control life and death in various tissues and is thus crucial for the maintenance of liver tissue homeostasis. Here we investigated how caspase 8 (Casp8) differentially regulates immune-med...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2013.07.026

    authors： Chaudhary K,Liedtke C,Wertenbruch S,Trautwein C,Streetz KL

    更新日期：2013-12-01 00:00:00

  • Doxorubicin coupled to lactosaminated albumin inhibits the growth of hepatocellular carcinomas induced in rats by diethylnitrosamine.

    abstract：BACKGROUND/AIMS:The hepatocyte receptor for asialoglycoproteins internalizes galactosyl terminating macromolecules which can be used as hepatotropic drug carriers. Since this receptor is also expressed on the cells of well differentiated human hepatocellular carcinomas (HCCs), we studied whether conjugation of doxorubi...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2005.02.045

    authors： Fiume L,Bolondi L,Busi C,Chieco P,Kratz F,Lanza M,Mattioli A,Di Stefano G

    更新日期：2005-10-01 00:00:00

  • Management of adverse events with tailored sorafenib dosing prolongs survival of hepatocellular carcinoma patients.

    abstract：BACKGROUND & AIMS:Sorafenib is associated with multiple adverse events (AEs), potentially causing its permanent interruption. It is unknown how physicians' experience has impacted on the management of these AEs and consequently on clinical outcomes. We aimed to assess whether AE management changed over time and if thes...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2019.08.015

    authors： Tovoli F,Ielasi L,Casadei-Gardini A,Granito A,Foschi FG,Rovesti G,Negrini G,Orsi G,Renzulli M,Piscaglia F

    更新日期：2019-12-01 00:00:00

  • Problems in the management of chronic hepatitis B with interferon: experience in a randomized, multicentre study.

    abstract：:In a multicentre trial, 82 patients known to be hepatitis B e antigen and hepatitis B virus DNA positive for at least 1 year, with elevated serum alanine aminotransferase levels and chronic liver lesions on biopsy, were randomized to receive either recombinant interferon alfa-2a at a dose of 4.5 million units thrice w...

    journal_title：Journal of hepatology

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1016/0168-8278(90)90179-u

    authors： Realdi G,Fattovich G,Pastore G,Caredda F,Noventa F,Santantonio T,Moroni M,Criscuolo D,Maladorno D,Rugge M

    更新日期：1990-01-01 00:00:00

  • Randomized placebo controlled phase I/II trial of alpha-galactosylceramide for the treatment of chronic hepatitis C.

    abstract：BACKGROUND/AIMS:The glycosphingolipid alpha-galactosylceramide has been shown to activate invariant natural killer T cells when presented in the context of CD1d and induces powerful antiviral immune responses via the production of inflammatory cytokines. The aim of this study was to investigate the safety and the antiv...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.jhep.2007.04.018

    authors： Veldt BJ,van der Vliet HJ,von Blomberg BM,van Vlierberghe H,Gerken G,Nishi N,Hayashi K,Scheper RJ,de Knegt RJ,van den Eertwegh AJ,Janssen HL,van Nieuwkerk CM

    更新日期：2007-09-01 00:00:00

  • The epidemiology of hepatitis delta infection in Italy. Promoting Group.

    abstract：:The epidemiology of HDV infection in Italy was assessed in a retrospective study involving 1556 HBsAg chronic carriers on their first presentation at one of the 35 Liver Units in 1987. Total anti-HD was detected in 23.4% of HBsAg carriers and was significantly more frequent in southern than in northern Italy (26.6% vs...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/0168-8278(92)90038-q

    authors： Sagnelli E,Stroffolini T,Ascione A,Bonino F,Chiaramonte M,Colombo M,Craxi A,Giusti G,Manghisi OG,Pastore G

    更新日期：1992-05-01 00:00:00

  • Hepatic lipid profiling in chronic hepatitis C: an in vitro and in vivo proton magnetic resonance spectroscopy study.

    abstract：BACKGROUND & AIMS:Hepatic steatosis is an important factor in pathogenesis, progression and response to treatment in hepatitis C. We aimed to investigate differences in hepatic lipid composition in liver biopsies from patients with chronic hepatitis C using proton magnetic resonance spectroscopy ((1)H MRS) and to trans...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2009.10.006

    authors： Cobbold JF,Patel JH,Goldin RD,North BV,Crossey MM,Fitzpatrick J,Wylezinska M,Thomas HC,Cox IJ,Taylor-Robinson SD

    更新日期：2010-01-01 00:00:00

  • Hypertension, diabetes, atherosclerosis and NASH: Cause or consequence?

    abstract：:Non-alcoholic fatty liver disease (NAFLD) has become one of the most common forms of chronic liver disease worldwide and its prevalence is expected to continue rising. NAFLD has traditionally been considered a consequence of metabolic syndrome (MetS). However, the link between NAFLD and MetS components, especially typ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jhep.2017.09.021

    authors： Lonardo A,Nascimbeni F,Mantovani A,Targher G

    更新日期：2018-02-01 00:00:00

  • Interleukin-15 increases hepatic regenerative activity.

    abstract：BACKGROUND/AIMS:Interleukin-15 (IL-15) is expressed in many organs. It generally inhibits apoptosis and increases cellular proliferation and differentiation. However, IL-15's roles in liver are unknown. We aimed to determine if IL-15 influences hepatic integrity and regenerative activity. METHODS:Expression of IL-15 a...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2006.04.008

    authors： Suzuki A,McCall S,Choi SS,Sicklick JK,Huang J,Qi Y,Zdanowicz M,Camp T,Li YX,Diehl AM

    更新日期：2006-09-01 00:00:00

  • Comparison of test performance profile for blood tests of liver fibrosis in chronic hepatitis C.

    abstract：BACKGROUND/AIMS:We evaluated the test performance profile (TPP) of blood tests of liver fibrosis. METHODS:Three hundred and fifty-six patients with C chronic hepatitis were included in two centers. Metavir staging of liver specimens by two independent pathologists and the following tests were evaluated: Fibrotest (FT)...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2006.09.020

    authors： Halfon P,Bacq Y,De Muret A,Penaranda G,Bourliere M,Ouzan D,Tran A,Botta D,Renou C,Bréchot MC,Degott C,Paradis V

    更新日期：2007-03-01 00:00:00

  • Involvement of natural killer T cells and granulocytes in the inflammation induced by partial hepatectomy.

    abstract：BACKGROUND/AIMS:Natural killer T (NKT) cells are present in the liver of mice. We examined whether NKT cells and other leukocytes were associated with hepatic inflammation after partial hepatectomy. METHODS:Approximately 70% of the liver was removed from mice using the method described by Higgins and Anderson. RESULT...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2003.10.017

    authors： Kato T,Sato Y,Takahashi S,Kawamura H,Hatakeyama K,Abo T

    更新日期：2004-02-01 00:00:00

  • Effect of vascular endothelial growth factor on hepatic regenerative activity following partial hepatectomy in rats.

    abstract：BACKGROUND/AIMS:Vascular endothelial growth factor (VEGF) is an angiogenic factor with a growth-promoting effect that is thought to be restricted to vascular endothelial cells. Its essential role during liver regeneration has yet to be determined. The aim of this study was to document the effect of exogenous VEGF admin...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(99)80147-0

    authors： Assy N,Spira G,Paizi M,Shenkar L,Kraizer Y,Cohen T,Neufeld G,Dabbah B,Enat R,Baruch Y

    更新日期：1999-05-01 00:00:00

  • Nod2 deficiency protects mice from cholestatic liver disease by increasing renal excretion of bile acids.

    abstract：BACKGROUND & AIMS:Chronic liver disease is characterized by fibrosis that may progress to cirrhosis. Nucleotide oligomerization domain 2 (Nod2), a member of the Nod-like receptor (NLR) family of intracellular immune receptors, plays an important role in the defense against bacterial infection through binding to the lig...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2014.02.012

    authors： Wang L,Hartmann P,Haimerl M,Bathena SP,Sjöwall C,Almer S,Alnouti Y,Hofmann AF,Schnabl B

    更新日期：2014-06-01 00:00:00

  • Ethanol binging exacerbates sinusoidal endothelial and parenchymal injury elicited by acetaminophen.

    abstract：BACKGROUND/AIMS:The pathophysiology of binge drinking of ethanol and its potentiation of acetaminophen (APAP) toxicity has received very little attention. To evaluate if ethanol binging sensitizes hepatic sinusoidal endothelial cells (SEC) and liver to APAP toxicity. METHODS:The histopathological responses to APAP wer...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2004.11.033

    authors： McCuskey RS,Bethea NW,Wong J,McCuskey MK,Abril ER,Wang X,Ito Y,DeLeve LD

    更新日期：2005-03-01 00:00:00

  • Impaired liver regeneration in Ldlr-/- mice is associated with an altered hepatic profile of cytokines, growth factors, and lipids.

    abstract：BACKGROUND & AIMS:It is widely recognized that in the early stages of liver regeneration after partial hepatectomy, the hepatocytes accumulate a significant amount of lipids. The functional meaning of this transient steatosis and its effect on hepatocellular proliferation are not well defined. In addition, the basic me...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2013.05.026

    authors： Pauta M,Rotllan N,Vales F,Fernandez-Hernando A,Allen RM,Ford DA,Marí M,Jiménez W,Baldán A,Morales-Ruiz M,Fernández-Hernando C

    更新日期：2013-10-01 00:00:00