Control of cyclins, cyclin-dependent kinase inhibitors, p21 and p27, and cell cycle progression in rat hepatocytes by extracellular matrix.

abstract：BACKGROUND & AIMS:It was recently shown that semi-annual surveillance for hepatocellular carcinoma (HCC) in cirrhotic patients provides a prognostic advantage over the annual program; however, its cost-effectiveness (CE) in the general cirrhotic population still needs to be defined. METHODS:A Markov model was built to...

journal_title：Journal of hepatology

authors： Cucchetti A,Trevisani F,Cescon M,Ercolani G,Farinati F,Poggio PD,Rapaccini G,Nolfo MAD,Benvegnù L,Zoli M,Borzio F,Giannini EG,Caturelli E,Chiaramonte M,Pinna AD,Italian Liver Cancer (ITA.LI.CA) Group.

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND & AIMS:Chronic hepatitis C virus (HCV)-infected patients with cirrhosis are a high-priority population for treatment. To help inform the benefit-risk profile of the all-oral direct-acting antiviral (DAA) combination regimen of ombitasvir, paritaprevir, and ritonavir, with or without dasabuvir (OBV/PTV/r±DSV)...

journal_title：Journal of hepatology

authors： Poordad F,Nelson DR,Feld JJ,Fried MW,Wedemeyer H,Larsen L,Cohen DE,Cohen E,Mobashery N,Tatsch F,Foster GR

更新日期：2017-10-01 00:00:00

abstract：:Mutant HBV genomes unable to produce preS2 protein were identified in the serum of a highly viremic chronic carrier. By direct sequencing of the amplified preS region and by sequencing of 50 cloned amplified preS DNA fragments all molecules were found to have deleted the preS2 translation initiation codon and three am...

journal_title：Journal of hepatology

authors： Fernholz D,Stemler M,Brunetto M,Bonino F,Will H

更新日期：1991-01-01 00:00:00

abstract：:Thirty-five consecutive patients with primary biliary cirrhosis were examined using liver biopsy, laboratory tests and ultrasonography of the hepato-duodenal ligament to investigate the possible correlation between enlarged lymph nodes in the hepato-duodenal ligament and biochemical activity, histologic activity or st...

journal_title：Journal of hepatology

authors： Lyttkens K,Prytz H,Forsberg L,Hederström E,Hägerstrand I

更新日期：1992-05-01 00:00:00

abstract：BACKGROUND/AIMS:Lipid peroxidation has been found to be associated with Ito cell activation. Ito cells are the principal collagen-producing cells and the main storage sites of retinoids. However, the relationship between retinoids and hepatic fibrosis is complex. The aim of this study was to elucidate the role of retin...

journal_title：Journal of hepatology

authors： Mizobuchi Y,Shimizu I,Yasuda M,Hori H,Shono M,Ito S

更新日期：1998-12-01 00:00:00

abstract：:The mechanism responsible for liver cell necrosis in patients with hepatitis A is not known. Since the type of hepatic lesions and the clinical presentation of acute hepatitis B are similar and are probably related to the cell-mediated immune response to a viral antigen located in the liver cell, it is possible that a...

journal_title：Journal of hepatology

authors： Fasel-Folley J,Overby LR,Frei PC

更新日期：1986-01-01 00:00:00

abstract：Background & Aims:Liver enzyme abnormalities are common in patients with coronavirus disease 2019 (COVID-19). Whether or not severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can lead to liver damage per se remains unknown. Herein, we reported the clinical characteristics and liver pathological man...

journal_title：Journal of hepatology

authors： Wang Y,Liu S,Liu H,Li W,Lin F,Jiang L,Li X,Xu P,Zhang L,Zhao L,Cao Y,Kang J,Yang J,Li L,Liu X,Li Y,Nie R,Mu J,Lu F,Zhao S,Lu J,Zhao J

更新日期：2020-10-01 00:00:00

abstract：:Hepatitis viruses are major threats to human health. During the last decade, highly diverse viruses related to human hepatitis viruses were found in animals other than primates. Herein, we describe both surprising conservation and striking differences of the unique biological properties and infection patterns of human...

journal_title：Journal of hepatology

authors： Rasche A,Sander AL,Corman VM,Drexler JF

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND/AIMS:The number of perisinusoidal myofibroblasts has been shown to be increased in hepatocellular carcinoma, as compared to cirrhosis. This increase might suggest a cooperative relationship between tumour cells and myofibroblasts. To assess this relationship, we undertook: (a) an immunohistochemical study to...

journal_title：Journal of hepatology

authors： Nhieu JT,Brochériou I,Préaux AM,Mallat A,Cherqui D,Zafrani ES,Mavier P

更新日期：1998-07-01 00:00:00

abstract：BACKGROUND/AIMS:Progressive familial intrahepatic cholestasis type 2 (PFIC-2) patients have a defect in the hepatocanalicular bile salt secretion. The disease is caused by mutations in the bile salt export pump (BSEP). Ten different missense mutations have been described. In this study, we analysed the effect of the D4...

journal_title：Journal of hepatology

authors： Plass JR,Mol O,Heegsma J,Geuken M,de Bruin J,Elling G,Müller M,Faber KN,Jansen PL

更新日期：2004-01-01 00:00:00

abstract：:Ten patients with non-alcoholic cirrhosis and ten control subjects were studied in basal conditions and after ingestion of a standard mixed test meal. Plasma somatostatin, blood glucose, plasma insulin, C-peptide and glucagon were determined before and 15, 30, 45, 60, 90, 120 and 180 min after the start of the meal. B...

journal_title：Journal of hepatology

authors： Barreca T,Franceschini R,Cataldi A,Rolandi E

更新日期：1991-01-01 00:00:00

abstract：:The establishment of robust HCV cell culture systems and characterization of the viral life cycle provided the molecular basis for highly innovative, successful years in HCV drug development. With the identification of direct-acting antiviral agents (DAAs), such as NS3/4A protease inhibitors, NS5A replication complex ...

journal_title：Journal of hepatology

authors： Welzel TM,Dultz G,Zeuzem S

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND/AIMS:The endogenous low molecular weight iron chelator, citrate, is considered to be an important contributor to iron transport and the liver the main site of uptake of iron citrate in subjects suffering from diseases of iron overload. Moreover, the citrate-metabolising enzyme, aconitase, is implicated in th...

journal_title：Journal of hepatology

authors： Graham RM,Morgan EH,Baker E

更新日期：1998-10-01 00:00:00

abstract：:A total of 37 patients with histologically confirmed chronic viral hepatitis B and presence of HBV-DNA and HBsAg in the serum were treated in a randomized, prospectively controlled multicenter trial either with recombinant IFN alpha-2b alone or a combination of IFN alpha-2b and recombinant IL-2. Twenty-two patients fr...

journal_title：Journal of hepatology

authors： Bruch HR,Korn A,Klein H,Markus R,Malmus K,Baumgarten R,Müller R

更新日期：1993-01-01 00:00:00

abstract：:This study set out to examine the relative effectiveness and tolerability of 12- versus 24-week courses of thrice weekly intramuscular lymphoblastoid interferon in the treatment of hepatitis B 'e' antigen (HBeAg)-positive chronic hepatitis B virus (HBV) infection, and to identify pretreatment factors predicting the ou...

journal_title：Journal of hepatology

authors： Scully LJ,Shein R,Karayiannis P,McDonald JA,Thomas HC

更新日期：1987-08-01 00:00:00

abstract：:The First European Consensus Conference on the Treatment of Chronic Hepatitis B and C in HIV Co-infected Patients aimed to produce recommendations that could be applied across Europe. However, some important differences exist around Europe, in terms of access to treatment and tests for monitoring. This short survey of...

journal_title：Journal of hepatology

authors： Salmon D,Robain M,Rockstroh JK,Benhamou Y

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND & AIMS:Evidence on the efficacy of antiviral treatment in chronic hepatitis C (CHC) patients with hepatocellular carcinoma (HCC) after curative treatment is scarce. We aimed to evaluate the efficacy and safety of pegylated interferon-alpha plus ribavirin (pegIFN/RBV) combination therapy in these patients, co...

journal_title：Journal of hepatology

authors： Huang JF,Yu ML,Huang CF,Chiu CF,Dai CY,Huang CI,Yeh ML,Yang JF,Hsieh MY,Hou NJ,Lin ZY,Chen SC,Wang LY,Chuang WL

更新日期：2011-02-01 00:00:00

abstract：:This review will highlight some of the important recent trends in liver transplantation. When possible, we will compare and contrast these trends across various regions of the world, in an effort to improve global consensus and better recognition of emerging data. ...

journal_title：Journal of hepatology

authors： Burra P,Freeman R

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND/AIMS:Gene therapy for inherited liver diseases requires permanent expression of the therapeutic gene. However, in vivo liver transduction with retroviral vectors triggers an immune elimination of transduced hepatocytes. Here we investigated whether immune response could be prevented by treatment with compoun...

journal_title：Journal of hepatology

authors： Puppi J,Guillonneau C,Pichard V,Bellodi-Privato M,Cuturi MC,Anegon I,Ferry N

更新日期：2004-08-01 00:00:00

abstract：BACKGROUND & AIMS:This study aimed to identify preoperative magnetic resonance (MR) imaging biomarkers for predicting microvascular invasion (MVI), to determine their diagnostic performance and to evaluate whether they are associated with early recurrence after surgery for single hepatocellular carcinoma (HCC). METHOD...

journal_title：Journal of hepatology

authors： Lee S,Kim SH,Lee JE,Sinn DH,Park CK

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND/AIMS:While combination of peginterferon-alpha (PEG-IFN) and ribavirin (RBV) therapy is the current standard of care for chronic hepatitis C (CHC), only 44-51% of genotype-1 patients achieve a sustained virological response (SVR), and both agents produce treatment-limiting toxicities. In the hepatitis C virus...

journal_title：Journal of hepatology

authors： Marcellin P,Horsmans Y,Nevens F,Grange JD,Bronowicki JP,Vetter D,Purdy S,Garg V,Bengtsson L,McNair L,Alam J

更新日期：2007-10-01 00:00:00

abstract：:The aim of the present study was to determine the prevalence of hepatocellular carcinoma in adults with heterozygous alpha 1-antitrypsin deficiency and to assess the presence of possible co-risk factors for the development of hepatocellular carcinoma. Two hundred and forty patients with cirrhosis of different aetiolog...

journal_title：Journal of hepatology

authors： Propst T,Propst A,Dietze O,Judmaier G,Braunsteiner H,Vogel W

更新日期：1994-12-01 00:00:00

abstract：BACKGROUND & AIMS:Liver sinusoidal endothelial cells (LSECs) are prominent liver-resident antigen (cross-)presenting cells. LSEC cross-priming of naïve CD8 T cells does not require CD4 T cell help in contrast to priming by dendritic cells (DC) but leads to the formation of memory T cells that is preceded by transient G...

journal_title：Journal of hepatology

authors： Wittlich M,Dudek M,Böttcher JP,Schanz O,Hegenbarth S,Bopp T,Schmitt E,Kurts C,Garbers C,Rose John S,Knolle PA,Wohlleber D

更新日期：2017-05-01 00:00:00

abstract：:The high incidence of non-anastomotic biliary strictures (NAS) after transplantation of livers from extended criteria donors is currently a major barrier to widespread use of these organs. This review provides an update on the most recent advances in the understanding of the etiology of NAS. These new insights give re...

journal_title：Journal of hepatology

authors： Weeder PD,van Rijn R,Porte RJ

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND/AIMS:The major regulatory events leading to cell proliferation occur in the G1 phase of cell cycle, and the deranged expression of G1 cyclins is related to oncogenesis. In this study, we analyzed the aberrant expressions of cyclins D1 and E, and their role in hepatocellular carcinoma. METHODS:We examined pa...

journal_title：Journal of hepatology

authors： Peng SY,Chou SP,Hsu HC

更新日期：1998-08-01 00:00:00

abstract：BACKGROUND & AIMS:Biliary atresia represents obstructive cholangiopathy in infants progressing rapidly to cirrhosis and end-stage liver disease. Activated NK cells expressing Nkg2d have been linked to bile duct injury and obstruction by establishing contact with cholangiocytes. To define the mechanisms used by cytotoxi...

journal_title：Journal of hepatology

authors： Shivakumar P,Mourya R,Bezerra JA

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND/AIMS:Cholangiocarcinoma comprises 5-20% of all primary malignant tumors of the liver. However, the lack of information about the genetic basis of cholangiocarcinoma has impeded characterization and understanding of its biological behavior. METHODS:In this study, genome-wide aberrations in 13 cases of cholan...

journal_title：Journal of hepatology

authors： Wong N,Li L,Tsang K,Lai PB,To KF,Johnson PJ

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND/AIMS:Modifications of the Child-Pugh classification of liver cirrhosis by incorporation of hyaluronan were tested to improve the prognostic power for long term evaluation of liver cirrhosis in 126 patients observed over a period of 10 years. METHODS:Serum concentrations of HA were determined at study entry....

journal_title：Journal of hepatology

authors： Körner T,Kropf J,Kosche B,Kristahl H,Jaspersen D,Gressner AM

更新日期：2003-12-01 00:00:00

abstract：BACKGROUND & AIMS:Thrombopoietin receptor agonists are a new class of compounds licenced for the treatment of immune thrombocytopenic purpura. They are currently being studied for patients with thrombopenia in advanced liver disease or under therapy for hepatitis C. There are indications that the risk for development o...

journal_title：Journal of hepatology

authors： Dultz G,Kronenberger B,Azizi A,Mihm U,Vogl TJ,Sarrazin U,Sarrazin C,Zeuzem S,Hofmann WP

更新日期：2011-07-01 00:00:00

abstract：:Recent progress in basic research has enhanced our understanding of the molecular mechanisms of normal bile secretion and their alterations in cholestasis. Genetic transporter variants contribute to an entire spectrum of cholestatic liver diseases and can cause hereditary cholestatic syndromes or determine susceptibil...

journal_title：Journal of hepatology

authors： Wagner M,Zollner G,Trauner M

更新日期：2009-09-01 00:00:00