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Histologically advanced chronic hepatitis C treated with recombinant alpha-interferon: a randomized placebo-controlled double-blind cross-over study.

Abstract：

:Chronic hepatitis C is common in Saudi Arabia and most often presents in an advanced stage. To assess the response of patients to interferon, a randomized placebo-controlled double-blind study was undertaken. All but 1 patient had cirrhosis or fibrosis before interferon. After a 24-week observation period patients received alpha 2a interferon, 3 mega units sc tiw or placebo for 24 weeks, then the opposite treatment for another 24 weeks followed by 24 weeks of observation. Liver biopsies were performed before and after each of the treatment phases. Twenty-two out of 24 patients completed the study. The mean alanine aminotransferase (ALT) levels fell from 150.7 +/- 118.7 units/l to 91.0 +/- 42.6 units/l after 6 months interferon treatment (P = 0.03) but only 3 patients (14%) had complete normalization of mean ALT levels and 4 (18%) had > 50% reduction. The mean hepatitis activity index fell from 12.2 +/- 2.6 immediately before to 11.6 +/- 2.5 just after interferon (P = 0.4). After interferon there was an insignificant raise in 6-month mean ALT. Hepatitis C virus-RNA was positive in all 17 patients tested and remained so after treatment. Side-effects were mild and well tolerated. Alpha interferon 3 mega units tiw for 24 weeks is not an effective treatment of histologically advanced chronic hepatitis C.

journal_name

J Hepatol

journal_title

Journal of hepatology

authors

Sieck JO,Ellis ME,Alfurayh O,Ali MA,Ali HA,Ayub A,al-Fadda M,Zafar M,Halim M,Bernvil SS

doi

10.1016/s0168-8278(05)80552-5

subject

Has Abstract,Author List Incomplete

pub_date

1993-11-01 00:00:00

pages

418-23

issue

3

eissn

0168-8278

issn

1600-0641

pii

S0168-8278(05)80552-5

journal_volume

19

pub_type

临床试验,杂志文章,随机对照试验

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