Long-term outcome of interferon-alpha therapy for chronic hepatitis B.

abstract：BACKGROUND & AIMS:The incidence of cirrhosis and subsequent development of organ dysfunction (OD) requiring intensive care unit (ICU) support is rising. Historically, critically ill cirrhotics are perceived as having poor prognosis and substantial cost of care. METHODS:The aim was to prospectively analyse resource uti...

journal_title：Journal of hepatology

authors： Shawcross DL,Austin MJ,Abeles RD,McPhail MJW,Yeoman AD,Taylor NJ,Portal AJ,Jamil K,Auzinger G,Sizer E,Bernal W,Wendon JA

更新日期：2012-05-01 00:00:00

abstract：AIM:In order to study the short-term effect of moderate and severe reduction of liver function by acetaminophen poisoning of different severity on gene expression for liver-specific functions, rats were given 3.75 and 7.5 g per kg body weight acetaminophen intragastrically. The lower dose is associated with low mortali...

journal_title：Journal of hepatology

authors： Tygstrup N,Jensen SA,Krog B,Dalhoff K

更新日期：1996-08-01 00:00:00

abstract：:It was discovered that eight patients with complications of non-cirrhotic portal hypertension had received an arsenical preparation for psoriasis as Fowler's solution some years age. Seven of them were admitted for bleeding oesophageal varices. Upon admission, splenomegaly and hypersplenism were present. Liver tests w...

journal_title：Journal of hepatology

authors： Nevens F,Fevery J,Van Steenbergen W,Sciot R,Desmet V,De Groote J

更新日期：1990-07-01 00:00:00

abstract：:Chronic hepatitis C is common in Saudi Arabia and most often presents in an advanced stage. To assess the response of patients to interferon, a randomized placebo-controlled double-blind study was undertaken. All but 1 patient had cirrhosis or fibrosis before interferon. After a 24-week observation period patients rec...

journal_title：Journal of hepatology

authors： Sieck JO,Ellis ME,Alfurayh O,Ali MA,Ali HA,Ayub A,al-Fadda M,Zafar M,Halim M,Bernvil SS

更新日期：1993-11-01 00:00:00

abstract：:In this report we describe the case of a 7-year-old boy, suffering from autoimmune-type chronic active hepatitis (AI-CAH) associated with vitiligo, nail dystrophy, alopecia areata and a variant of liver kidney microsomal (LKM) autoantibodies. This patient's antibodies are different from LKM-1 which are directed agains...

journal_title：Journal of hepatology

authors： Sacher M,Blümel P,Thaler H,Manns M

更新日期：1990-05-01 00:00:00

abstract：BACKGROUND/AIMS:Phase I/II studies of 4 weeks duration have confirmed the ALT lowering effect of glycyrrhizin in Western chronic hepatitis C patients. Our aim was to determine the dose frequency of glycyrrhizin required to maintain the ALT response beyond 4 weeks and evaluate its effect on liver histology and quality o...

journal_title：Journal of hepatology

authors： Orlent H,Hansen BE,Willems M,Brouwer JT,Huber R,Kullak-Ublick GA,Gerken G,Zeuzem S,Nevens F,Tielemans WC,Zondervan PE,Lagging M,Westin J,Schalm SW

更新日期：2006-10-01 00:00:00

abstract：BACKGROUND & AIMS:Data on the natural history of chronic hepatitis C virus (HCV) genotype 6 is lacking. METHODS:We compared the natural history of 138 HCV genotype 1 patients (median age: 50) with 78 HCV genotype 6 patients (median age: 46.5). Baseline demographic data including gender, route of transmission, liver bi...

journal_title：Journal of hepatology

authors： Seto WK,Lai CL,Fung J,Hung I,Yuen J,Young J,Wong DK,Yuen MF

更新日期：2010-09-01 00:00:00

abstract：:We report a case of chronic active hepatitis caused by benzarone, a benzofuran derivative used in Europe for the treatment of peripheral venous disorders. Jaundice and serum alanine aminotransferase activity increased while drug administration was continued, but promptly decreased when it was eventually interrupted. L...

journal_title：Journal of hepatology

authors： Babany G,Larrey D,Pessayre D,Degott C,Rueff B,Benhamou JP

更新日期：1987-12-01 00:00:00

abstract：BACKGROUND/AIMS:The use of cell lines in bioartificial liver support systems (BALSS) to treat fulminant hepatic failure (FHF) is hindered by their reduced metabolic functions, which could be further decreased by the patient's serum/plasma. Hence, the aim of this study was to (i) test the effect of the FHF serum on C3A ...

journal_title：Journal of hepatology

authors： Filippi C,Keatch SA,Rangar D,Nelson LJ,Hayes PC,Plevris JN

更新日期：2004-10-01 00:00:00

abstract：BACKGROUND & AIMS:A causal relationship between infection, systemic inflammation, and hepatic encephalopathy (HE) has been suggested in cirrhosis. No study, however, has specifically examined, in cirrhotic patients with infection, the complete pattern of clinical and subclinical cognitive alterations and its reversibil...

journal_title：Journal of hepatology

authors： Merli M,Lucidi C,Pentassuglio I,Giannelli V,Giusto M,Di Gregorio V,Pasquale C,Nardelli S,Lattanzi B,Venditti M,Riggio O

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND/AIMS:Primary sclerosing cholangitis (PSC) is associated with a high risk of cholangiocarcinoma. Our aim was to evaluate the diagnostic value of trypsinogen-1, trypsinogen-2, tumour-associated trypsin inhibitor, human chorionic gonadotropin beta and trypsin-2-alpha(1)-antitrypsin for cholangiocarcinoma and to...

journal_title：Journal of hepatology

authors： Lempinen M,Isoniemi H,Mäkisalo H,Nordin A,Halme L,Arola J,Höckerstedt K,Stenman UH

更新日期：2007-11-01 00:00:00

abstract：:The clinical course of cirrhosis is mostly determined by the progressive increase of portal hypertension, hyperdynamic circulation, bacterial translocation and activation of systemic inflammation. Different disease states, encompassing compensated and decompensated cirrhosis and a late decompensated state, are related...

journal_title：Journal of hepatology

authors： D'Amico G,Morabito A,D'Amico M,Pasta L,Malizia G,Rebora P,Valsecchi MG

更新日期：2018-03-01 00:00:00

abstract：:Liver diseases affect millions of people worldwide. In most developed countries, the incidence of viral hepatitis is waning as a result of modern advances in disease prevention, diagnosis, and therapies. Expanded programmes for systematic immunisation against hepatitis B virus have also significantly brought down the ...

journal_title：Journal of hepatology

authors： Xiao J,Wang F,Wong NK,He J,Zhang R,Sun R,Xu Y,Liu Y,Li W,Koike K,He W,You H,Miao Y,Liu X,Meng M,Gao B,Wang H,Li C

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND & AIMS:Several studies have shown that chronic hepatitis C (CHC) infection has a negative impact on kidney function, as well as survival, in patients with chronic kidney disease (CKD) or on hemodialysis. The aim of this nationwide registry study was to describe renal disease in Swedish patients with CHC. ME...

journal_title：Journal of hepatology

authors： Söderholm J,Millbourn C,Büsch K,Kövamees J,Schvarcz R,Lindahl K,Bruchfeld A

更新日期：2018-05-01 00:00:00

abstract：:The aim of the present study was to determine the prevalence of hepatocellular carcinoma in adults with heterozygous alpha 1-antitrypsin deficiency and to assess the presence of possible co-risk factors for the development of hepatocellular carcinoma. Two hundred and forty patients with cirrhosis of different aetiolog...

journal_title：Journal of hepatology

authors： Propst T,Propst A,Dietze O,Judmaier G,Braunsteiner H,Vogel W

更新日期：1994-12-01 00:00:00

abstract：BACKGROUND/AIMS:Not all alcoholic patients develop severe liver disease with fibrosis progressing to cirrhosis. It is of practical importance to determine whether some markers can predict progression of liver fibrosis. METHODS:We used a baboon model that mimics human alcoholic liver disease. Cytokeratin 7 and 19 expre...

journal_title：Journal of hepatology

authors： Ren C,Paronetto F,Mak KM,Leo MA,Lieber CS

更新日期：2003-06-01 00:00:00

abstract：BACKGROUND & AIMS:CD4(+) CD25(+) Foxp3(+) regulatory T cells (Tregs) have a profound ability to control immune responses. We have previously shown that the liver is a major source of peripherally induced Tregs. Here, we investigate the liver cell types and molecular mechanisms responsible for hepatic Treg induction. M...

journal_title：Journal of hepatology

authors： Carambia A,Freund B,Schwinge D,Heine M,Laschtowitz A,Huber S,Wraith DC,Korn T,Schramm C,Lohse AW,Heeren J,Herkel J

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND/AIMS:Liver negative-strand hepatitis C virus (HCV) RNA is the most direct indicator of active viral replication but has only been examined in a few semiquantitative studies. METHODS:Positive- and negative-strand HCV RNA in the right (R) and left (L) liver lobes was quantified by rTth-based strand-specific r...

journal_title：Journal of hepatology

authors： Yuki N,Matsumoto S,Tadokoro K,Mochizuki K,Kato M,Yamaguchi T

更新日期：2006-02-01 00:00:00

abstract：:A substantial production of prostaglandin E2 (PGE2) was induced in primary cultures of rat Kupffer cells by zymosan, calcium ionophore A23187, phorbol ester and arachidonic acid, whereas contact with latex particles, glucan or immunocomplexes led to a minor PGE2 release only. Superoxide generation, on the other hand, ...

journal_title：Journal of hepatology

authors： Dieter P,Schulze-Specking A,Decker K

更新日期：1988-04-01 00:00:00

abstract：:To summarize, nowadays it seems clear that in patients with cirrhosis: (a) the pulmonary circulation is usually markedly dilated. (b) This vasodilation is due to a loss of vascular tone and it is characterized by a poor (or even absent) vascular reactivity in front of the hypoxic stimulus. (c) This abnormal behaviour ...

journal_title：Journal of hepatology

authors： Agustí AG,Roca J,Bosch J,Rodriguez-Roisin R

更新日期：1990-03-01 00:00:00

abstract：BACKGROUND/AIMS:Adrenomedullin recently discovered in human pheochromocytoma is a potent vasodilatory peptide mainly derived from vascular endothelial and smooth muscle cells. Hyperdynamic circulation, ultimately leading to ascites formation, has been attributed to peripheral vasodilatation in liver cirrhosis. However,...

journal_title：Journal of hepatology

authors： Kojima H,Tsujimoto T,Uemura M,Takaya A,Okamoto S,Ueda S,Nishio K,Miyamoto S,Kubo A,Minamino N,Kangawa K,Matsuo H,Fukui H

更新日期：1998-05-01 00:00:00

abstract：BACKGROUND & AIMS:Primary non-function and ischaemic cholangiopathy are the most feared complications following donation-after-circulatory-death (DCD) liver transplantation. The aim of this study was to design a new score on risk assessment in liver-transplantation DCD based on donor-and-recipient parameters. METHODS:...

journal_title：Journal of hepatology

authors： Schlegel A,Kalisvaart M,Scalera I,Laing RW,Mergental H,Mirza DF,Perera T,Isaac J,Dutkowski P,Muiesan P

更新日期：2018-03-01 00:00:00

abstract：:The burden of hepatocellular carcinoma (HCC) is highest in East Asia and Africa, although its incidence and mortality are rapidly rising in the United States and Europe. With the implementation of hepatitis B vaccination and hepatitis C treatment programmes worldwide, the epidemiology of HCC is shifting away from a di...

journal_title：Journal of hepatology

authors： Singal AG,Lampertico P,Nahon P

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND & AIMS:Hepatocellular carcinoma (HCC) risk stratification in individuals with dysmetabolism is a major unmet need. Genetic predisposition contributes to non-alcoholic fatty liver disease (NAFLD). We aimed to exploit robust polygenic risk scores (PRS) that can be evaluated in the clinic to gain insight into t...

journal_title：Journal of hepatology

authors： Bianco C,Jamialahmadi O,Pelusi S,Baselli G,Dongiovanni P,Zanoni I,Santoro L,Maier S,Liguori A,Meroni M,Borroni V,D'Ambrosio R,Spagnuolo R,Alisi A,Federico A,Bugianesi E,Petta S,Miele L,Vespasiani-Gentilucci U,Anstee

更新日期：2020-11-25 00:00:00

abstract：BACKGROUND/AIMS:Primary sclerosing cholangitis (PSC) is a cholestatic liver disease of unknown etiology. Although the primary defect affects cholangiocytes, cholestatic injury of hepatocytes may promote further liver damage. Since down-regulation of hepatocellular organic anion transporters is implicated in the molecul...

journal_title：Journal of hepatology

authors： Geier A,Dietrich CG,Lammert F,Orth T,Mayet WJ,Matern S,Gartung C

更新日期：2002-06-01 00:00:00

abstract：BACKGROUND/AIMS:The efficacy and safety of rifaximin in comparison with lactitol in the treatment of acute hepatic encephalopathy was assessed in a prospective randomized, double-blind, double-dummy, controlled trial. METHODS:A total of 103 patients with grade I-III acute hepatic encephalopathy were randomized to rece...

journal_title：Journal of hepatology

authors： Mas A,Rodés J,Sunyer L,Rodrigo L,Planas R,Vargas V,Castells L,Rodríguez-Martínez D,Fernández-Rodríguez C,Coll I,Pardo A,Spanish Association for the Study of the Liver Hepatic Encephalopathy Cooperative Group.

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND/AIMS:Primary and secondary liver tumours are a common clinical problem, with a poor prognosis in most cases. Surgical resection offers the best outcome, but is only appropriate for the minority. Thermal ablation techniques have been described, but the lack of an optimal means of monitoring has limited their ...

journal_title：Journal of hepatology

authors： de Jode MG,Lamb GM,Thomas HC,Taylor-Robinson SD,Gedroyc WM

更新日期：1999-08-01 00:00:00

abstract：BACKGROUND & AIMS:High-carbohydrate diets contribute to the development of liver stress and fatty liver disease. While saturated fatty acids are known to induce liver stress, the role of monounsaturated fatty acids (MUFA), synthesized by the stearoyl-CoA desaturase (SCD) family of enzymes, in regulation of liver functi...

journal_title：Journal of hepatology

authors： Liu X,Burhans MS,Flowers MT,Ntambi JM

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND/AIMS:Previously, trichostatin A (TSA), a histone deacetylase inhibitor, has been shown to exhibit strong antifibrotic characteristics in hepatic stellate cells (HSC), which are known to play a central role in chronic liver diseases. TSA retained a more quiescent phenotype in spite of culture conditions that ...

journal_title：Journal of hepatology

authors： Rombouts K,Knittel T,Machesky L,Braet F,Wielant A,Hellemans K,De Bleser P,Gelman I,Ramadori G,Geerts A

更新日期：2002-12-01 00:00:00

abstract：BACKGROUND/AIMS:Vaccination strategies able to induce strong T-cell responses might contribute to eradicate hepatitis C virus (HCV) infection. We previously demonstrated that fusion of an antigen to the extra domain A from fibronectin (EDA) targets the antigen to TLR4-expressing dendritic cells (DC) and improves its im...

journal_title：Journal of hepatology

authors： Mansilla C,Gorraiz M,Martinez M,Casares N,Arribillaga L,Rudilla F,Echeverria I,Riezu-Boj JI,Sarobe P,Borrás-Cuesta F,Prieto J,Lasarte JJ

更新日期：2009-09-01 00:00:00