HBe antibody unrelated to 'e minus' hepatitis B virus variant infection in patients with chronic type D hepatitis.


:The presence of HBV-DNA sequences was evaluated in DNA extracted from serum samples, peripheral blood lymphocytes and liver biopsy specimens of five HBsAg/anti-HBe-positive carriers with chronic HDV infection. DNAs were tested by polymerase chain reaction (PCR) amplification technique using two pairs of oligonucleotide primers specific for the preC/C and S regions of the HBV; viral sequences were found exclusively in liver extracts and only in three out of the five cases. The direct sequencing of the amplified preC/C regions showed wild-type sequences in two cases, while in the third case a combination of 'wild' and 'e minus variant' viral populations was observed. Moreover, liver DNA of one positive case was electrophoresed through a low melting agarose gel and the following amplification, performed on DNA re-extracted from three different fragments of the gel, showed the presence of free HBV genomes but the absence of replicative intermediate forms. These results show that anti-HBe positivity is not constantly related to precore mutant HBV infection and suggest that HDV inhibits HBeAg production. Moreover, as it was observed in 'e minus' HBV variants, also during a chronic HBV wild-type infection, the viral replication might be suppressed to undetectable levels.


J Hepatol


Journal of hepatology


Raimondo G,Rodinò G,Brancatelli S,Sardo MA,Campo S,Smedile V,Villari D,Pernice M,Longo G,Squadrito G




Has Abstract


1991-01-01 00:00:00








13 Suppl 4


  • Bile duct bacterial isolates in primary sclerosing cholangitis: a study of explanted livers.

    abstract:BACKGROUND/AIMS:The pathogenesis of the inflammatory lesion in primary sclerosing cholangitis is unknown. The clinical picture is characterized by i.a. episodes of fever, the cause of which also remains speculative. Previous studies of bacterial isolates in the liver or bile ducts in primary sclerosing cholangitis have...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Olsson R,Björnsson E,Bäckman L,Friman S,Höckerstedt K,Kaijser B,Olausson M

    更新日期:1998-03-01 00:00:00

  • Different expression of HLA-DR and ICAM-1 in livers from patients with biliary atresia and Byler's disease.

    abstract:BACKGROUND/AIMS:Extrahepatic biliary atresia (EHBA) and chronic progressive intra-hepatic cholestasis (Byler's disease) are two distinct disorders of unknown etiology in the neonate, characterized by profound cholestasis. The aim of the present study was to investigate the inflammatory reaction in liver tissue from pat...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Broomé U,Nemeth A,Hultcrantz R,Scheynius A

    更新日期:1997-04-01 00:00:00

  • Quality of life and cognitive function in hepatitis C at different stages of liver disease.

    abstract:BACKGROUND/AIMS:Hepatitis C has been associated with a decrease in quality of life and with neurological abnormalities. The aim of our study was to investigate the relationship between quality of life and cognitive function. METHODS:Quality of life, clinical variables and neuropsychological function were evaluated in ...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Córdoba J,Flavià M,Jacas C,Sauleda S,Esteban JI,Vargas V,Esteban R,Guardia J

    更新日期:2003-08-01 00:00:00

  • Antitumor effect of the nucleoside analogs 2-chlorodeoxyadenosine and 2',2'-difluorodeoxycytidine on human hepatoma HepG2 cells.

    abstract:BACKGROUND/AIMS:Hepatocellular carcinoma is one of the most malignant tumors in the world. Although a wide range of therapeutic options is available, the efficacy of these methods and the prognosis of hepatocellular carcinoma are still very poor. The nucleoside analogs 2-chlorodeoxyadenosine (Cladribine, 2-CdA) and 2',...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Graziadei I,Kelly T,Schirmer M,Geisen FH,Vogel W,Konwalinka G

    更新日期:1998-03-01 00:00:00

  • Prevalence of elevated ALT values, HBsAg, and anti-HCV in the primary care setting and evaluation of guideline defined hepatitis risk scenarios.

    abstract:BACKGROUND & AIMS:Prevalence data for hepatitis B and C and an evaluation of a guideline based screening in the primary care setting are not yet available. We therefore implemented a hepatitis B surface antigen (HBsAg) and anti-hepatitis C virus (HCV) screening and developed guideline based screening strategies. METHO...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Wolffram I,Petroff D,Bätz O,Jedrysiak K,Kramer J,Tenckhoff H,Berg T,Wiegand J,German Check-Up 35+ Study Group.

    更新日期:2015-06-01 00:00:00

  • FOXP3+ regulatory T cells in autoimmune hepatitis are fully functional and not reduced in frequency.

    abstract:BACKGROUND & AIMS:The pathogenesis of autoimmune hepatitis (AIH) is not understood, but it was suggested that AIH may be related to a numerical or functional impairment of CD4+CD25+FOXP3+ regulatory T cells (Treg), which are important mediators of immune tolerance to self-antigens. However, the role of Treg in AIH is n...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Peiseler M,Sebode M,Franke B,Wortmann F,Schwinge D,Quaas A,Baron U,Olek S,Wiegard C,Lohse AW,Weiler-Normann C,Schramm C,Herkel J

    更新日期:2012-07-01 00:00:00

  • Normothermic regional perfusion vs. super-rapid recovery in controlled donation after circulatory death liver transplantation.

    abstract:BACKGROUND & AIMS:Although there is increasing interest in its use, definitive evidence demonstrating a benefit for postmortem normothermic regional perfusion (NRP) in controlled donation after circulatory death (cDCD) liver transplantation is lacking. The aim of this study was to compare results of cDCD liver transpla...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Hessheimer AJ,Coll E,Torres F,Ruíz P,Gastaca M,Rivas JI,Gómez M,Sánchez B,Santoyo J,Ramírez P,Parrilla P,Marín LM,Gómez-Bravo MÁ,García-Valdecasas JC,López-Monclús J,Boscá A,López-Andújar R,Fundora-Suárez J,Villar J,

    更新日期:2019-04-01 00:00:00

  • The heart in liver transplantation.

    abstract::The heart and liver are organs that are closely related in both health and disease. Patients who undergo liver transplantation may suffer from heart disease that is: (a) related to the original cause of the liver disease such as hemochromatosis, (b) related to the liver disease itself, or (c) related to other associat...

    journal_title:Journal of hepatology

    pub_type: 杂志文章,评审


    authors: Ripoll C,Yotti R,Bermejo J,Bañares R

    更新日期:2011-04-01 00:00:00

  • Genomics and HCV infection: progression of fibrosis and treatment response.

    abstract::HCV infection is a global health problem that affects 170 million people worldwide. The severity of the disease varies from asymptomatic chronic infection to cirrhosis and hepatocellular carcinoma (HCC). Recently, the standard of care for genotype 1 patients has greatly improved with the addition of protease inhibitor...

    journal_title:Journal of hepatology

    pub_type: 杂志文章,评审


    authors: Estrabaud E,Vidaud M,Marcellin P,Asselah T

    更新日期:2012-11-01 00:00:00

  • Alteration of protein glycosylation in liver diseases.

    abstract::Chronic liver diseases are a serious health problem worldwide. The current gold standard to assess structural liver damage is through a liver biopsy which has several disadvantages. A non-invasive, simple and non-expensive test to diagnose liver pathology would be highly desirable. Protein glycosylation has drawn the ...

    journal_title:Journal of hepatology

    pub_type: 杂志文章,评审


    authors: Blomme B,Van Steenkiste C,Callewaert N,Van Vlierberghe H

    更新日期:2009-03-01 00:00:00

  • Pattern of HCV antibodies with special reference to NS5A reactivity in HCV-infected patients: relation to viral genotype, cryoglobulinemia and response to interferon.

    abstract:BACKGROUND/AIMS:We aimed to compare the anti-hepatitis C virus reactivity in confirmatory assays (RIBA 3.0 Ortho Diagnostic and INNO-LIA HCV Ab III Innogenetics) among patients infected with different hepatitis C virus genotypes, with or without cryoglobulinemia, and in patients treated with interferon. METHODS:One hu...

    journal_title:Journal of hepatology

    pub_type: 临床试验,杂志文章


    authors: Frangeul L,Cresta P,Perrin M,Duverlie G,Khorsi H,Musset L,Opolon P,Huraux JM,Lunel F

    更新日期:1998-04-01 00:00:00

  • The role of serial measurement of serum HBV DNA levels in patients with chronic HBeAg(-) hepatitis B infection: association with liver disease progression. A prospective cohort study.

    abstract:BACKGROUND/AIMS:To evaluate the fluctuating course of serum HBV-DNA levels during the natural history of chronic HBV infection in the general population of North-Eastern Greece, in association with liver disease progression. METHODS:Two hundred and sixty-three adults with chronic HBV, median 34 years of age, were rand...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Zacharakis G,Koskinas J,Kotsiou S,Tzara F,Vafeiadis N,Papoutselis M,Maltezos E,Sivridis E,Papoutselis K

    更新日期:2008-12-01 00:00:00

  • Long-term follow-up of chronic hepatitis C in patients diagnosed at a tertiary-care center.

    abstract:BACKGROUND/AIMS:The natural history of chronic hepatitis C (HCV) is not completely understood. This study was aimed to evaluate the long-term outcome of the disease over a prolonged period of time and to identify factors associated with progression. METHODS:One hundred and sixteen patients with non-cirrhotic chronic n...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Forns X,Ampurdanès S,Sanchez-Tapias JM,Guilera M,Sans M,Sánchez-Fueyo A,Quintó L,Joya P,Bruguera M,Rodés J

    更新日期:2001-08-01 00:00:00

  • IL28 variation affects expression of interferon stimulated genes and peg-interferon and ribavirin therapy.

    abstract:BACKGROUND & AIMS:Common genetic variation within the IL28 locus has been found to influence the effect of peg-interferon and ribavirin combination therapy against chronic hepatitis C virus (HCV) infection. Expression of IL28 in peripheral blood cells has been reported to be higher in patients with IL28 SNP genotypes a...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Abe H,Hayes CN,Ochi H,Maekawa T,Tsuge M,Miki D,Mitsui F,Hiraga N,Imamura M,Takahashi S,Kubo M,Nakamura Y,Chayama K

    更新日期:2011-06-01 00:00:00

  • Demographics and outcomes of severe herpes simplex virus hepatitis: a registry-based study.

    abstract:BACKGROUND & AIMS:Herpes simplex virus hepatitis is a rare, but severe disease, thus far only documented by case reports and short series. The present study was based on the SRTR registry, and included all listed patients for liver transplantation from 1985 to 2009 with a diagnosis of HSV hepatitis. METHODS:We assesse...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Moldovan B,Mentha G,Majno P,Berney T,Morard I,Giostra E,Wildhaber BE,Van Delden C,Morel P,Toso C

    更新日期:2011-12-01 00:00:00

  • Generation of a monoclonal human single chain antibody fragment to hepatic stellate cells--a potential mechanism for targeting liver anti-fibrotic therapeutics.

    abstract:BACKGROUND/AIMS:Hepatic stellate cells are pivotal to fibrogenesis in the liver and many potential anti-fibrotic therapeutics are required to act on targets within hepatic stellate cells. The aim of this study was to generate a human antibody fragment to hepatic stellate cells. METHODS:Phage display was used to genera...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Elrick LJ,Leel V,Blaylock MG,Duncan L,Drever MR,Strachan G,Charlton KA,Koruth M,Porter AJ,Wright MC

    更新日期:2005-06-01 00:00:00

  • Hepatic regeneration in insulin-like growth factor binding protein-1 transgenic mice.

    abstract:BACKGROUND/AIMS:Partial hepatectomy results in activation of genes in the residual liver tissue which serve to restore glucose homeostasis and regenerate liver mass. Expression of insulin-like growth factor binding protein-1 (IGFBP-1) is up-regulated following partial hepatectomy and IGFBP-1 can modulate both the metab...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Liu YY,Rajkumar K,Murphy LJ

    更新日期:1999-04-01 00:00:00

  • Assessment of hepatitis B virus DNA levels in chronic HBsAg carriers with or without hepatitis delta virus superinfection.

    abstract::In order to document the incidence of hepatitis delta virus (HDV) replication markers and their relationship to HBV replication, 91 HBsAg chronic carriers were studied. Of these, 51 were anti-HD-positive (19 HBeAg-positive and 32 anti-HBe-positive). Liver HDAg was found in 75% of anti-HD-positive patients. Of the 19 p...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Bas C,Bartolomé J,La Banda F,Porres JC,Quiroga JA,Mora I,Carreño V

    更新日期:1988-04-01 00:00:00

  • The non-structural 5A protein of hepatitis C virus exhibits genotypic differences in interferon antagonism.

    abstract:BACKGROUND/AIMS:Patients infected with hepatitis C virus (HCV) genotype 2 or 3 usually respond better to interferon (IFN) treatment than those infected with genotype 1. In this study, we investigated whether the non-structural 5A protein (NS5A) of HCV genotypes 1 and 2 (1b-NS5A and 2a-NS5A, respectively) exerted differ...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Tsai YH,Kuang WF,Lu TY,Kao JH,Lai MY,Liu CJ,Chen PJ,Hwang LH

    更新日期:2008-12-01 00:00:00

  • IL-1 receptor like 1 protects against alcoholic liver injury by limiting NF-κB activation in hepatic macrophages.

    abstract:BACKGROUND & AIM:Alcohol consumption increases intestinal permeability and causes damage to hepatocytes, leading to the release of pathogen- and damage-associated molecular pattern molecules (PAMPs and DAMPs), stimulating hepatic macrophages and activating NF-κB. The resultant inflammation exacerbates alcoholic liver d...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Wang M,Shen G,Xu L,Liu X,Brown JM,Feng D,Ross RA,Gao B,Liangpunsakul S,Ju C

    更新日期:2017-09-21 00:00:00

  • Multidrug-resistant bacterial infections in patients with decompensated cirrhosis and with acute-on-chronic liver failure in Europe.

    abstract:BACKGROUND & AIMS:Antibiotic resistance has been increasingly reported in patients with decompensated cirrhosis in single-center studies. Prospective investigations reporting broad epidemiological data are scarce. We aimed to analyze epidemiological changes in bacterial infections in patients with decompensated cirrhos...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Fernández J,Prado V,Trebicka J,Amoros A,Gustot T,Wiest R,Deulofeu C,Garcia E,Acevedo J,Fuhrmann V,Durand F,Sánchez C,Papp M,Caraceni P,Vargas V,Bañares R,Piano S,Janicko M,Albillos A,Alessandria C,Soriano G,Welz

    更新日期:2019-03-01 00:00:00

  • NorUrsodeoxycholic acid ameliorates cholemic nephropathy in bile duct ligated mice.

    abstract:BACKGROUND & AIMS:Severe cholestasis may cause cholemic nephropathy that can be modeled in common bile duct ligated (CBDL) mice. We aimed to explore the therapeutic efficacy and mechanisms of norursodeoxycholic acid (norUDCA) in cholemic nephropathy. METHODS:In 8-week CBDL mice fed with norUDCA (prior or post CBDL) or...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Krones E,Eller K,Pollheimer MJ,Racedo S,Kirsch AH,Frauscher B,Wahlström A,Ståhlman M,Trauner M,Grahammer F,Huber TB,Wagner K,Rosenkranz AR,Marschall HU,Fickert P

    更新日期:2017-07-01 00:00:00

  • Resection of hepatocellular adenoma in patients with glycogen storage disease type Ia.

    abstract:BACKGROUND/AIMS:Because dietary modifications have prolonged the life expectancy of patients with glycogen storage disease type Ia (GSD Ia), the incidence of hepatocellular adenoma (HCA) to carcinoma (HCC) transformation is increasing. The objective of this retrospective study is to assess the safety and effectiveness ...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Reddy SK,Kishnani PS,Sullivan JA,Koeberl DD,Desai DM,Skinner MA,Rice HE,Clary BM

    更新日期:2007-11-01 00:00:00

  • Association of the IL28B genotype with insulin resistance in patients with chronic hepatitis C.

    abstract:BACKGROUND & AIMS:Insulin resistance, fibrosis and steatosis are established predictors of response to peg-interferon/ribavirin therapy in chronic hepatitis C (CHC). Several host genetic polymorphisms (IL28B, PNPLA3) modify treatment-outcome, the degree of steatosis or fibrosis. The aim of our study was to evaluate the...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Stättermayer AF,Rutter K,Beinhardt S,Scherzer TM,Stadlmayr A,Hofer H,Wrba F,Steindl-Munda P,Krebs M,Datz C,Trauner M,Ferenci P

    更新日期:2012-09-01 00:00:00

  • Perforin and granzymes work in synergy to mediate cholangiocyte injury in experimental biliary atresia.

    abstract:BACKGROUND & AIMS:Biliary atresia represents obstructive cholangiopathy in infants progressing rapidly to cirrhosis and end-stage liver disease. Activated NK cells expressing Nkg2d have been linked to bile duct injury and obstruction by establishing contact with cholangiocytes. To define the mechanisms used by cytotoxi...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Shivakumar P,Mourya R,Bezerra JA

    更新日期:2014-02-01 00:00:00

  • A performance evaluation of the expert system 'Jaundice' in comparison with that of three hepatologists.

    abstract::The diagnostic performance of an Expert System (Jaundice) designed to discriminate between different causes of jaundice was evaluated in a test sample of 200 consecutive in-patients with serum bilirubin greater than or equal to 51 mumol/l. The average probability assigned to true diagnosis, the non-error rate and the ...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Cammà C,Garofalo G,Almasio P,Tinè F,Craxì A,Palazzo U,Pinzello G,Fiorello F,Angelo PM,Pagliaro L

    更新日期:1991-11-01 00:00:00

  • Enhanced detection of cholangiocarcinoma with serum trypsinogen-2 in patients with severe bile duct strictures.

    abstract:BACKGROUND/AIMS:Primary sclerosing cholangitis (PSC) is associated with a high risk of cholangiocarcinoma. Our aim was to evaluate the diagnostic value of trypsinogen-1, trypsinogen-2, tumour-associated trypsin inhibitor, human chorionic gonadotropin beta and trypsin-2-alpha(1)-antitrypsin for cholangiocarcinoma and to...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Lempinen M,Isoniemi H,Mäkisalo H,Nordin A,Halme L,Arola J,Höckerstedt K,Stenman UH

    更新日期:2007-11-01 00:00:00

  • Protein C in patients with alcoholic cirrhosis and other liver diseases.

    abstract::The coagulation inhibitor protein C was measured in 151 patients with various liver diseases. The protein C level was significantly decreased in patients with alcoholic cirrhosis (n = 73) compared to patients with steatosis (n = 24) (40 +/- 2%) vs. 88 +/- 4%, mean S.E., p less than 0.001). It was also decreased in cas...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Bell H,Odegaard OR,Andersson T,Raknerud N

    更新日期:1992-03-01 00:00:00

  • Delta infection in the Naples area. Epidemiologic and clinical significance.

    abstract::To define the epidemiologic and clinical significance of delta infection in the Naples area, we sought anti-delta antibodies in all cases of HBV-associated liver diseases, hospitalized in our department during 1983 (234 acute hepatitis, 9 of which fulminant; 51 chronic hepatitis; 32 cirrhosis; 19 hepatocarcinomas) and...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Amoroso P,Giorgio A,Fico P,Lettieri G,de Stefano G,Scala V,Pesce G,Pierri P,Pempinello R,Finelli L

    更新日期:1986-01-01 00:00:00

  • Bile acid kinetics and biliary lipid composition in cystic fibrosis.

    abstract:AIMS/METHODS:Bile acid kinetics and biliary lipid composition were studied in seven patients, aged 17-70 years with cystic fibrosis. All patients were of normal height and weight, and were in good clinical condition. Ultrasonography indicated a small gallbladder in one and non-visualized gallbladder in two patients. Se...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Strandvik B,Einarsson K,Lindblad A,Angelin B

    更新日期:1996-07-01 00:00:00