A randomized controlled trial of recombinant interferon alpha-2b in the treatment of Chinese patients with acute post-transfusion hepatitis C.

abstract：:Evidence is accumulating that there are changes in the expression of antigens on biliary epithelium in early primary biliary cirrhosis and graft rejection. If any of the biliary diseases including rejection are associated with specific alterations in biliary glycoprotein structure, lectin histochemistry could be usefu...

journal_title：Journal of hepatology

authors： Rhodes JM,Hubscher S,Black R,Elias E,Savage A

更新日期：1988-06-01 00:00:00

abstract：BACKGROUND & AIMS:Visceral adiposity is associated with hepatic steatosis, inflammation, and fibrosis in non-alcoholic fatty liver disease (NAFLD). The visceral adiposity index (VAI), a novel marker of visceral fat distribution and dysfunction, has been correlated with histology in hepatitis C. We assessed the ability ...

journal_title：Journal of hepatology

authors： Vongsuvanh R,George J,McLeod D,van der Poorten D

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND/AIMS:The natural history of chronic hepatitis C infection during pregnancy has not been clearly established, and thus our aim was to assess serum alanine aminotransferase levels and serum HCV RNA levels during pregnancy. METHODS:Twenty-six pregnant women with chronic hepatitis C were studied. Serum alanine ...

journal_title：Journal of hepatology

authors： Gervais A,Bacq Y,Bernuau J,Martinot M,Auperin A,Boyer N,Kilani A,Erlinger S,Valla D,Marcellin P

更新日期：2000-02-01 00:00:00

abstract：BACKGROUND & AIMS:Primary non-function and ischaemic cholangiopathy are the most feared complications following donation-after-circulatory-death (DCD) liver transplantation. The aim of this study was to design a new score on risk assessment in liver-transplantation DCD based on donor-and-recipient parameters. METHODS:...

journal_title：Journal of hepatology

authors： Schlegel A,Kalisvaart M,Scalera I,Laing RW,Mergental H,Mirza DF,Perera T,Isaac J,Dutkowski P,Muiesan P

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND/AIMS:To evaluate demographic characteristics, liver histology and virological features of hepatitis C virus (HCV) carriers with normal alanine transaminase (ALT) levels. METHODS:A nationwide prospective study was started in 1997. Four Italian centres have participated in this study. RESULTS:Eight hundred a...

journal_title：Journal of hepatology

authors： Puoti C,Castellacci R,Montagnese F,Zaltron S,Stornaiuolo G,Bergami N,Bellis L,Precone DF,Corvisieri P,Puoti M,Minola E,Gaeta GB

更新日期：2002-07-01 00:00:00

abstract：:Epstein-Barr virus infection is a benign disease, which may occasionally be fatal, particularly in children. Epstein-Barr virus infection is rare in elderly subjects and appears to have a self-limited course. An unusual case of fulminant hepatitis due to primary Epstein-Barr virus infection in a 62-year-old male 18 da...

journal_title：Journal of hepatology

authors： Papatheodoridis GV,Delladetsima JK,Kavallierou L,Kapranos N,Tassopoulos NC

更新日期：1995-09-01 00:00:00

abstract：BACKGROUND/AIMS:Primary and secondary liver tumours are a common clinical problem, with a poor prognosis in most cases. Surgical resection offers the best outcome, but is only appropriate for the minority. Thermal ablation techniques have been described, but the lack of an optimal means of monitoring has limited their ...

journal_title：Journal of hepatology

authors： de Jode MG,Lamb GM,Thomas HC,Taylor-Robinson SD,Gedroyc WM

更新日期：1999-08-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is an accepted indication for liver transplantation (LT). Pre-LT adjuvant ablation treatments to prevent tumour progression and drop out from the waiting list have been increasingly adopted at most transplant centers. Trans-catheter arterial chemo-embolization (TACE) is frequently used, ...

journal_title：Journal of hepatology

authors： Addario L,Di Costanzo GG,Tritto G,Cavaglià E,Angrisani B,Ascione A

更新日期：2008-07-01 00:00:00

abstract：:Twenty patients with paracetamol(acetaminophen)-induced acute liver damage of varying severity were studied longitudinally with assessment of clinical state, standard liver function tests and radiometric hyaluronate (HYA) assay (Pharmacia). In patients (n = 6) who developed coma, HYA rose rapidly with clinical deterio...

journal_title：Journal of hepatology

authors： Bramley PN,Rathbone BJ,Forbes MA,Cooper EH,Losowsky MS

更新日期：1991-07-01 00:00:00

abstract：BACKGROUND & AIMS:To compare the management and the virological and serological efficacy of treatments for chronic hepatitis B (CHB) in HIV positive and negative patients. METHODS:Two hundred and forty-six HIV positive and 205 HIV negative consecutive patients with past or present CHB, seen in October 2008 in particip...

journal_title：Journal of hepatology

authors： Piroth L,Pol S,Lacombe K,Miailhes P,Rami A,Rey D,Loustau-Ratti V,Morlat P,Goderel I,Sene D,Rosenthal E,Carrat F,Cacoub P,GERMIVIC Study Group.

更新日期：2010-12-01 00:00:00

abstract：:We measured plasma abnormal prothrombin (des-gamma-carboxy prothrombin; DCP) levels in normal subjects and in patients with hepatocellular carcinoma and other various diseases using the enzyme-linked immunosorbent assay developed by Motohara et al. (Pediatr Res 1985; 19: 354-357). Fifty-eight percent of 52 patients wi...

journal_title：Journal of hepatology

authors： Okuda H,Obata H,Nakanishi T,Furukawa R,Hashimoto E

更新日期：1987-06-01 00:00:00

abstract：BACKGROUND/AIMS:The endogenous low molecular weight iron chelator, citrate, is considered to be an important contributor to iron transport and the liver the main site of uptake of iron citrate in subjects suffering from diseases of iron overload. Moreover, the citrate-metabolising enzyme, aconitase, is implicated in th...

journal_title：Journal of hepatology

authors： Graham RM,Morgan EH,Baker E

更新日期：1998-10-01 00:00:00

abstract：BACKGROUND/AIMS:An interaction between human schistosomiasis and viral hepatitis B has often been suggested, but never established. The experimental investigation has been hampered by the lack of a suitable model. Only woodchucks are susceptible to both Schistosoma mansoni and a B-like hepatitis virus (WHV) infections....

journal_title：Journal of hepatology

authors： Andrade ZA,Berthillon P,Paraná R,Grimaud JA,Trépo C

更新日期：2001-01-01 00:00:00

abstract：:In 40 patients with esophageal varices, esophageal variceal pressure was assessed endoscopically using a pneumatic pressure sensor. The effects of vasopressin or nitroglycerin on variceal pressure and endoscopic findings were also assessed in two groups of seven patients. The results were as follows: (1) Variceal pres...

journal_title：Journal of hepatology

authors： Bandoh T,Mitarai Y,Kitano S,Yoshida T,Kobayashi M

更新日期：1994-09-01 00:00:00

abstract：:Liver fibrosis is one of the most important factors of disturbed liver function, but could not be measured by simple blood tests until recently. Among several parameters used for this purpose, the aminoterminal procollagen type III peptide (PIIIP) appears to be the most widely accepted. Studies conducted in several cl...

journal_title：Journal of hepatology

authors： Hahn EG

更新日期：1985-01-01 00:00:00

abstract：:All routinely available assays to detect hepatitis C virus (HCV) infection are based on the specific reaction of serum antibodies to corresponding viral antigens. The only method to detect viral nucleic acids in serum or liver is the enzymatic amplification of reversely transcribed HCV-RNA by polymerase chain reaction...

journal_title：Journal of hepatology

authors： Geiger CP,Caselmann WH

更新日期：1992-07-01 00:00:00

abstract：:It has been suggested that the cellular immune response to HBV antigens is responsible for hepatocellular injury in acute and chronic hepatitis B. However, definitive immunological studies have so far been hampered by the lack of appropriate model systems to study HBV antigen-specific T cells. The availability of high...

journal_title：Journal of hepatology

authors： Ferrari C,Penna A,DegliAntoni A,Fiaccadori F

更新日期：1988-08-01 00:00:00

abstract：BACKGROUND & AIMS:Nutrients influence non-alcoholic fatty liver disease. Essential fatty acids deficiency promotes various syndromes, including hepatic steatosis, through increased de novo lipogenesis. The mechanisms underlying such increased lipogenic response remain unidentified. METHODS:We used wild type mice and m...

journal_title：Journal of hepatology

authors： Ducheix S,Montagner A,Polizzi A,Lasserre F,Marmugi A,Bertrand-Michel J,Podechard N,Al Saati T,Chétiveaux M,Baron S,Boué J,Dietrich G,Mselli-Lakhal L,Costet P,Lobaccaro JM,Pineau T,Theodorou V,Postic C,Martin PG,Guil

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND & AIMS:Biliary atresia represents obstructive cholangiopathy in infants progressing rapidly to cirrhosis and end-stage liver disease. Activated NK cells expressing Nkg2d have been linked to bile duct injury and obstruction by establishing contact with cholangiocytes. To define the mechanisms used by cytotoxi...

journal_title：Journal of hepatology

authors： Shivakumar P,Mourya R,Bezerra JA

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND & AIMS:The pool of HCV genotype 1 patients likely to be cured by peg-interferon and ribavirin remains to be quantified. METHODS:In 1045 patients treated with peg-interferon and ribavirin, two therapeutic strategies were confronted: the first one evaluated only baseline variables associated with sustained vi...

journal_title：Journal of hepatology

authors： Andriulli A,Di Marco V,Margaglione M,Ippolito AM,Fattovich G,Smedile A,Valvano MR,Calvaruso V,Gioffreda D,Milella M,Morisco F,Felder M,Brancaccio G,Fasano M,Gatti P,Tundo P,Barone M,Cozzolongo R,Angelico M,D'Andrea

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND/AIMS:Chronic hepatitis B virus (HBV) disease is caused by both necroinflammation and active viral replication. The role of ALT levels as a predictor of liver injury has recently been questioned. The aim of the study was to determine whether normal ALT is associated with liver injury in a cohort of HBV patien...

journal_title：Journal of hepatology

authors： Lai M,Hyatt BJ,Nasser I,Curry M,Afdhal NH

更新日期：2007-12-01 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in Western countries that is predicted to become also the most frequent indication for liver transplantation by 2030. Over the last decade, it has been shown that the clinical burden of NAFLD is not only confined to liver-relat...

journal_title：Journal of hepatology

authors： Byrne CD,Targher G

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND/AIM:Smooth muscle antibodies and antinuclear antibodies characterize type 1 autoimmune hepatitis. Our aim was to correlate the appearance and disappearance of these autoantibodies with clinical and histological events. METHODS:One hundred and seven patients were evaluated successively over 128+/-9 months. A...

journal_title：Journal of hepatology

authors： Czaja AJ

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND & AIMS:Liver macrophages can be involved in both pathogen clearance and/or pathogenesis. To get further insight on their role during chronic hepatitis B virus (HBV) infections, our aim was to phenotypically and functionally characterize in vivo and ex vivo the interplay between HBV, primary human liver macro...

journal_title：Journal of hepatology

authors： Faure-Dupuy S,Delphin M,Aillot L,Dimier L,Lebossé F,Fresquet J,Parent R,Matter MS,Rivoire M,Bendriss-Vermare N,Salvetti A,Heide D,Flores L,Klumpp K,Lam A,Zoulim F,Heikenwälder M,Durantel D,Lucifora J

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND/AIMS:A distinct subgroup of angiotensin II type 1 receptor (AT1R) blockers (ARBs) have been reported to suppress the development of hepatic steatosis. These effects were generally explained by selective peroxisome proliferator-activated receptor (PPAR) gamma modulating properties of ARBs, independent of thei...

journal_title：Journal of hepatology

authors： Nabeshima Y,Tazuma S,Kanno K,Hyogo H,Chayama K

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND/AIMS:The MAGE, GAGE and BAGE genes encode tumor antigens recognized by autologous cytotoxic T lymphocytes. The aim of this study was to evaluate the possibility of using these genes as molecular markers and as the targets of specific immunotherapy for human hepatocellular carcinoma (HCC). METHODS:The expres...

journal_title：Journal of hepatology

authors： Kobayashi Y,Higashi T,Nouso K,Nakatsukasa H,Ishizaki M,Kaneyoshi T,Toshikuni N,Kariyama K,Nakayama E,Tsuji T

更新日期：2000-04-01 00:00:00

abstract：:Hydroxyethyl starch (HES) has gained wide clinical acceptance as a colloidal plasma substitute. We were able to study the liver biopsies of two patients with renal failure who developed ascites after repeated infusions of HES. All types of liver cells displayed massive accumulation of HES with the morphologic resembla...

journal_title：Journal of hepatology

authors： Dienes HP,Gerharz CD,Wagner R,Weber M,John HD

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND & AIMS:Anti-hepatitis C virus (HCV) therapy by interferon (IFN)-free regimen with oral direct-acting antiviral drugs are tolerable in aged patients, with fewer adverse effects than IFN-based therapies. We investigated the efficacy and tolerability of an IFN-free anti-HCV therapy in extremely aged patients, a...

journal_title：Journal of hepatology

authors： Toyoda H,Kumada T,Tada T,Shimada N,Takaguchi K,Senoh T,Tsuji K,Tachi Y,Hiraoka A,Ishikawa T,Shima T,Okanoue T

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND/AIMS:The aim of our study was to evaluate the proportion of patients with severe alcoholic cirrhosis who would need orthotopic liver transplantation (OLT) and to determine the optimal delay to evaluate an abstinent patient for transplantation. METHODS:Survival without OLT, improvement in liver function and ...

journal_title：Journal of hepatology

authors： Veldt BJ,Lainé F,Guillygomarc'h A,Lauvin L,Boudjema K,Messner M,Brissot P,Deugnier Y,Moirand R

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND/AIMS:A sequence of 40 amino acids within the nonstructural protein 5A of hepatitis C virus (HCV) has been suggested to be an interferon sensitivity determining region (ISDR). The variations in the ISDR after 12-14 years of chronic infection and the correlation between ISDR and interferon response were studie...

journal_title：Journal of hepatology

authors： Rispeter K,Lu M,Zibert A,Wiese M,de Oliveira JM,Roggendorf M

更新日期：1998-09-01 00:00:00