Essential fatty acids deficiency promotes lipogenic gene expression and hepatic steatosis through the liver X receptor.

Abstract:

BACKGROUND & AIMS:Nutrients influence non-alcoholic fatty liver disease. Essential fatty acids deficiency promotes various syndromes, including hepatic steatosis, through increased de novo lipogenesis. The mechanisms underlying such increased lipogenic response remain unidentified. METHODS:We used wild type mice and mice lacking Liver X Receptors to perform a nutrigenomic study that aimed at examining the role of these transcription factors. RESULTS:We showed that, in the absence of Liver X Receptors, essential fatty acids deficiency does not promote steatosis. Consistent with this, Liver X Receptors are required for the elevated expression of genes involved in lipogenesis in response to essential fatty acids deficiency. CONCLUSIONS:This work identifies, for the first time, the central role of Liver X Receptors in steatosis induced by essential fatty acids deficiency.

journal_name

J Hepatol

journal_title

Journal of hepatology

authors

Ducheix S,Montagner A,Polizzi A,Lasserre F,Marmugi A,Bertrand-Michel J,Podechard N,Al Saati T,Chétiveaux M,Baron S,Boué J,Dietrich G,Mselli-Lakhal L,Costet P,Lobaccaro JM,Pineau T,Theodorou V,Postic C,Martin PG,Guil

doi

10.1016/j.jhep.2013.01.006

subject

Has Abstract

pub_date

2013-05-01 00:00:00

pages

984-92

issue

5

eissn

0168-8278

issn

1600-0641

pii

S0168-8278(13)00020-2

journal_volume

58

pub_type

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