Abstract:
BACKGROUND & AIMS:Nutrients influence non-alcoholic fatty liver disease. Essential fatty acids deficiency promotes various syndromes, including hepatic steatosis, through increased de novo lipogenesis. The mechanisms underlying such increased lipogenic response remain unidentified. METHODS:We used wild type mice and mice lacking Liver X Receptors to perform a nutrigenomic study that aimed at examining the role of these transcription factors. RESULTS:We showed that, in the absence of Liver X Receptors, essential fatty acids deficiency does not promote steatosis. Consistent with this, Liver X Receptors are required for the elevated expression of genes involved in lipogenesis in response to essential fatty acids deficiency. CONCLUSIONS:This work identifies, for the first time, the central role of Liver X Receptors in steatosis induced by essential fatty acids deficiency.
journal_name
J Hepatoljournal_title
Journal of hepatologyauthors
Ducheix S,Montagner A,Polizzi A,Lasserre F,Marmugi A,Bertrand-Michel J,Podechard N,Al Saati T,Chétiveaux M,Baron S,Boué J,Dietrich G,Mselli-Lakhal L,Costet P,Lobaccaro JM,Pineau T,Theodorou V,Postic C,Martin PG,Guildoi
10.1016/j.jhep.2013.01.006subject
Has Abstractpub_date
2013-05-01 00:00:00pages
984-92issue
5eissn
0168-8278issn
1600-0641pii
S0168-8278(13)00020-2journal_volume
58pub_type
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