A multidisciplinary support programme increases the efficiency of pegylated interferon alfa-2a and ribavirin in hepatitis C.

abstract：:Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in Western countries that is predicted to become also the most frequent indication for liver transplantation by 2030. Over the last decade, it has been shown that the clinical burden of NAFLD is not only confined to liver-relat...

journal_title：Journal of hepatology

authors： Byrne CD,Targher G

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND & AIMS:Lysosomal acid lipase deficiency is an autosomal recessive enzyme deficiency resulting in lysosomal accumulation of cholesteryl esters and triglycerides. LAL-CL04, an ongoing extension study, investigates the long-term effects of sebelipase alfa, a recombinant human lysosomal acid lipase. METHODS:Seb...

journal_title：Journal of hepatology

authors： Valayannopoulos V,Malinova V,Honzík T,Balwani M,Breen C,Deegan PB,Enns GM,Jones SA,Kane JP,Stock EO,Tripuraneni R,Eckert S,Schneider E,Hamilton G,Middleton MS,Sirlin C,Kessler B,Bourdon C,Boyadjiev SA,Sharma R,Twe

更新日期：2014-11-01 00:00:00

abstract：:We measured plasma abnormal prothrombin (des-gamma-carboxy prothrombin; DCP) levels in normal subjects and in patients with hepatocellular carcinoma and other various diseases using the enzyme-linked immunosorbent assay developed by Motohara et al. (Pediatr Res 1985; 19: 354-357). Fifty-eight percent of 52 patients wi...

journal_title：Journal of hepatology

authors： Okuda H,Obata H,Nakanishi T,Furukawa R,Hashimoto E

更新日期：1987-06-01 00:00:00

abstract：BACKGROUND/AIMS:The impact of heterozygous HFE mutations on the course of chronic hepatitis C and iron indices was studied. METHODS:Ferritin, transferrin saturation (TS), serum iron, C282Y and H63D mutations were determined in 401 patients with chronic hepatitis C virus (HCV) infection and 295 healthy controls. Liver ...

journal_title：Journal of hepatology

authors： Erhardt A,Maschner-Olberg A,Mellenthin C,Kappert G,Adams O,Donner A,Willers R,Niederau C,Häussinger D

更新日期：2003-03-01 00:00:00

abstract：BACKGROUND/AIMS:The aim of this study was to determine the outcome of asymptomatic liver hydatid cysts in a cohort of 33 out of 59 carriers by evaluating clinical and ultrasonographic (US) changes 10-12 years after initial diagnosis. METHODS:We compared US features and cyst size with the original descriptions from 198...

journal_title：Journal of hepatology

authors： Frider B,Larrieu E,Odriozola M

更新日期：1999-02-01 00:00:00

abstract：BACKGROUND/AIMS:Evidence that the geno/subtype of hepatitis C virus (HCV) is predictive of the response to interferon-alpha therapy suggests that typing methods are clinically useful. In the present study, HCV isolates obtained from 74 patients with chronic hepatitis C were used to evaluate three genotyping and two ser...

journal_title：Journal of hepatology

authors： Lee JH,Roth WK,Zeuzem S

更新日期：1997-05-01 00:00:00

abstract：BACKGROUND & AIMS:Non-alcoholic fatty liver disease (NAFLD) comprises a spectrum of stages from simple steatosis to non-alcoholic steatohepatitis (NASH). However, disease pathogenesis remains largely unknown. microRNA (miRNA or miR) expression has recently been reported to be altered in human NASH, and modulated by urs...

journal_title：Journal of hepatology

authors： Castro RE,Ferreira DM,Afonso MB,Borralho PM,Machado MV,Cortez-Pinto H,Rodrigues CM

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND/AIMS:Natural killer T (NKT) cells are present in the liver of mice. We examined whether NKT cells and other leukocytes were associated with hepatic inflammation after partial hepatectomy. METHODS:Approximately 70% of the liver was removed from mice using the method described by Higgins and Anderson. RESULT...

journal_title：Journal of hepatology

authors： Kato T,Sato Y,Takahashi S,Kawamura H,Hatakeyama K,Abo T

更新日期：2004-02-01 00:00:00

abstract：INTRODUCTION:Acute decompensation (AD) of cirrhosis may present without acute-on-chronic liver failure (ACLF) (AD-No ACLF), or with ACLF phenotype (AD-ACLF) defined by organ failure(s). Precipitants may induce AD. This multicenter, prospective, observational PREDICT study (NCT03056612) analyzes and characterizes the pr...

journal_title：Journal of hepatology

authors： Trebicka J,Fernandez J,Papp M,Caraceni P,Laleman W,Gambino C,Giovo I,Uschner FE,Jansen C,Jimenez C,Mookerjee R,Gustot T,Albillos A,Bañares R,Jarcuska P,Steib C,Reiberger T,Acevedo J,Gatti P,Shawcross DL,Zeuzem S,

更新日期：2020-11-20 00:00:00

abstract：:Hepatitis B virus (HBV) variants with a stop codon, a mutated translation initiation codon or other mutations in the pre-C region which prevent e-antigen expression are highly prevalent in anti-HBe chronic carriers and can be positively selected from a mixed virus infection. Our laboratories recently described pre-C v...

journal_title：Journal of hepatology

authors： Santantonio T,Jung MC,Schneider R,Pastore G,Pape GR,Will H

更新日期：1991-11-01 00:00:00

abstract：BACKGROUND/METHODS:The cause of fulminant hepatitis is still not fully understood. We studied 23 patients with fulminant hepatitis, using polymerase chain reaction to detect hepatitis virus genomes. Tests for HBsAg and IgM anti-HAV and IgM anti-HBc were performed in all patients. Serum samples were stored at -70 degree...

journal_title：Journal of hepatology

authors： Inokuchi K,Nakata K,Hamasaki K,Daikoku M,Nakao K,Kato Y,Yatsuhashi H,Koga M,Yano M,Nagataki S

更新日期：1996-03-01 00:00:00

abstract：BACKGROUND/AIMS:Oxidative DNA damage, identifiable in the formation of 8-hydroxydeoxyguanosine (8-OHdG), is relevant in the mutagenesis/carcinogenesis process. The aim of this study was to assess 8-OHdG levels in patients with hepatitis C virus (HCV) infection in relation to extent of liver damage and HCV genotype. ME...

journal_title：Journal of hepatology

authors： Cardin R,Saccoccio G,Masutti F,Bellentani S,Farinati F,Tiribelli C

更新日期：2001-04-01 00:00:00

abstract：BACKGROUND & AIMS:Macrophages (Mϕ) represent a major component of tumor tissues and play an important role in both tumor progression and therapeutic response. Although tumor Mϕ are generally considered to be derived from circulating monocytes, emerging evidence indicates that tissue Mϕ pools can be maintained by self-r...

journal_title：Journal of hepatology

authors： Wang J,Wang Y,Chu Y,Li Z,Yu X,Huang Z,Xu J,Zheng L

更新日期：2020-10-31 00:00:00

abstract：BACKGROUND/AIMS:We evaluated the test performance profile (TPP) of blood tests of liver fibrosis. METHODS:Three hundred and fifty-six patients with C chronic hepatitis were included in two centers. Metavir staging of liver specimens by two independent pathologists and the following tests were evaluated: Fibrotest (FT)...

journal_title：Journal of hepatology

authors： Halfon P,Bacq Y,De Muret A,Penaranda G,Bourliere M,Ouzan D,Tran A,Botta D,Renou C,Bréchot MC,Degott C,Paradis V

更新日期：2007-03-01 00:00:00

abstract：:A recent study indicated that thymic hormones have antiviral effects in human hepatitis B virus infection and woodchuck hepatitis virus infection. These hormones are known to exert immunomodulatory effects on lymphocyte maturation and function; because these are abnormal in patients with chronic hepatitis B virus infe...

journal_title：Journal of hepatology

authors： Daniels HM,O'Toole A,Hussein MJ,Corridori S,Alexander GJ,Williams R

更新日期：1994-03-01 00:00:00

abstract：BACKGROUND/AIMS:Liver fibrosis is a dynamic state between matrix production and degradation. Since our report in 1974, many studies have examined collagenase and liver fibrosis, but not the identification of cells responsible for collagenase production in vivo. The aim of this study was to investigate the gene expressi...

journal_title：Journal of hepatology

authors： Watanabe T,Niioka M,Hozawa S,Kameyama K,Hayashi T,Arai M,Ishikawa A,Maruyama K,Okazaki I

更新日期：2000-08-01 00:00:00

abstract：BACKGROUND/AIMS:The objective of this study was to validate, with an independent prospective cohort of patients, our previous data indicating that the proliferating cell nuclear antigen-labeling index (PCNA-LI) reflects the liver functional reserve in human cirrhosis and might have prognostic significance for patient s...

journal_title：Journal of hepatology

authors： Delhaye M,Louis H,Degraef C,Le Moine O,Devière J,Peny MO,Adler M,Galand P

更新日期：1999-03-01 00:00:00

abstract：:Intracellular ion homeostasis in liver cell is accomplished through the concerted action of ion pumps, carriers and channels. Description of these elements includes the Na+/K+-ATPase, Na+/H+- and Cl-/ HCO3(-)-exchange and Na+-HCO-3(-)- and Na(+)-K(+)-2 Cl(-)-cotransport as well as K+-, Cl(-)-, Na+ and nonselective cat...

journal_title：Journal of hepatology

authors： Graf J,Häussinger D

更新日期：1996-01-01 00:00:00

abstract：:Hepatitis A virus (HAV) infection in adults is often symptomatic and disabling. The present article summarizes our experience with phase 2 studies of an inactivated hepatitis A virus vaccine. Pre- and post-exposure prophylaxis with immune globulin (IG) is only effective for 4-6 months. We compared the safety, tolerabi...

journal_title：Journal of hepatology

authors： Shouval D,Ashur Y,Adler R,Lewis JA,Miller W,Kuter B,Brown L,Nalin DR

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND/AIMS:Chronic hepatitis B virus (HBV) disease is caused by both necroinflammation and active viral replication. The role of ALT levels as a predictor of liver injury has recently been questioned. The aim of the study was to determine whether normal ALT is associated with liver injury in a cohort of HBV patien...

journal_title：Journal of hepatology

authors： Lai M,Hyatt BJ,Nasser I,Curry M,Afdhal NH

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND & AIMS:Hepatic stellate cells (HSCs) have a role in liver fibrosis. Guanine nucleotide-binding α-subunit 12 (Gα12) converges signals from G-protein-coupled receptors whose ligand levels are elevated in the environment during liver fibrosis; however, information is lacking on the effect of Gα12 on HSC trans-d...

journal_title：Journal of hepatology

authors： Kim KM,Han CY,Kim JY,Cho SS,Kim YS,Koo JH,Lee JM,Lim SC,Kang KW,Kim JS,Hwang SJ,Ki SH,Kim SG

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND/AIMS:IgM antibodies to hepatitis C virus have been found in a variable proportion of patients with chronic hepatitis C. We have evaluated whether IgM anti-core antibodies correlate with viraemia or hepatic injury in chronic hepatitis C. METHODS:Serum from 106 patients with chronic hepatitis C with varying s...

journal_title：Journal of hepatology

authors： Martinelli AL,Brown D,Braun HB,Michel G,Dusheiko GM

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND/AIMS:Progressive familial intrahepatic cholestasis type 2 (PFIC-2) patients have a defect in the hepatocanalicular bile salt secretion. The disease is caused by mutations in the bile salt export pump (BSEP). Ten different missense mutations have been described. In this study, we analysed the effect of the D4...

journal_title：Journal of hepatology

authors： Plass JR,Mol O,Heegsma J,Geuken M,de Bruin J,Elling G,Müller M,Faber KN,Jansen PL

更新日期：2004-01-01 00:00:00

abstract：:Interferon-alpha therapy has a beneficial effect in 30-40% of selected patients with chronic hepatitis B who respond by clearing hepatitis B e antigen (HBeAg) and hepatitis B viral (HBV) DNA from serum. This is usually associated with normalization of serum aminotransferase activities. On long-term follow-up of treate...

journal_title：Journal of hepatology

authors： Di Bisceglie AM

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND & AIMS:HCV requires host lipid metabolism for replication, and apolipoproteins have been implicated in the response to treatment. METHODS:We examined plasma apolipoprotein concentrations in three cohorts of patients: mono-infected patients with symptomatic acute hepatitis C (aHCV); those undergoing treatmen...

journal_title：Journal of hepatology

authors： Laird ME,Mohsen A,Duffy D,Mamdouh R,LeFouler L,Casrouge A,El-Daly M,Rafik M,Abdel-Hamid M,Soulier A,Pawlotsky JM,Hézode C,Rosa I,Renard P,Mohamed MK,Bonnard P,Izopet J,Mallet V,Pol S,Albert ML,Fontanet A

更新日期：2014-10-01 00:00:00

abstract：:The multidrug resistance genes encode plasma membrane glycoproteins named P-glycoproteins, that act as an ATP-dependent drug efflux pump and decrease the cytosolic concentration of chemotherapeutic agents. It has been hypothesized that in rat liver, this protein may have a physiological role as a biliary transporter o...

journal_title：Journal of hepatology

authors： Vollrath V,Wielandt AM,Acuña C,Duarte I,Andrade L,Chianale J

更新日期：1994-11-01 00:00:00

abstract：BACKGROUND/AIMS:Septins are ubiquitous and multifunctional scaffold proteins involved in cytoskeletal organization, exocytosis and other cellular processes. We disclose the quiescent hepatic stellate cells (HSCs)-specific expression of a septin subunit Sept4 in the liver, and explore the significance of the septin syst...

journal_title：Journal of hepatology

authors： Iwaisako K,Hatano E,Taura K,Nakajima A,Tada M,Seo S,Tamaki N,Sato F,Ikai I,Uemoto S,Kinoshita M

更新日期：2008-11-01 00:00:00

abstract：:Calcium concentrations in pig livers were serially estimated following ischemia-reperfusion. Ischemia was produced by clamping the hepatic artery and the portal vein for 90 min (Group 1, n = 6) or for 180 min (Group 2, n = 6) during temporary side-to-side portacaval shunt performed before the induction of ischemia. Al...

journal_title：Journal of hepatology

authors： Uchida M,Takemoto Y,Nagasue N,Kimoto T,Dhar DK,Nakamura T

更新日期：1994-06-01 00:00:00

abstract：:The oesophageal pH was recorded for 3 h after a test-meal in 27 healthy control subjects (group I), 40 patients with alcoholic cirrhosis (group II), and 22 patients with a normal liver and symptoms of gastro-oesophageal reflux (control refluxers). Gastro-oesophageal reflux was observed in 10 of the cirrhotic patients....

journal_title：Journal of hepatology

authors： Arsene D,Bruley des Varannes S,Galmiche JP,Denis P,Chayvialle JA,Hellot MF,Ducrotte P,Colin R

更新日期：1987-04-01 00:00:00

abstract：BACKGROUND/AIMS:To examine the T-cell repertoire which is involved in the immunopathogenesis of chronic hepatitis, we analyzed the T-cell receptor Vbeta gene usage in liver-infiltrating lymphocytes by reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemical technique. METHODS:Complementary DNA ...

journal_title：Journal of hepatology

authors： Kashii Y,Shimizu Y,Nambu S,Minemura M,Okada K,Higuchi K,Watanabe A

更新日期：1997-03-01 00:00:00