Feasibility exploration of blood flow estimation by contrast-assisted Nakagami imaging.


:The microbubble contrast agent destruction/replenishment technique has been widely applied to ultrasound-based blood flow estimation. The rate of increase of the time-intensity curve (TIC) due to microbubbles flowing into the region of interest as measured from B-mode images closely reflects the flow velocity. In this study, we monitored microbubble replenishment by a proposed new approach called the time-Nakagami-parameter curve (TNC) obtained from Nakagami-parameter images for quantifying the flow velocity. The feasibility of using the TNC to estimate the flow was evaluated in computer simulations of the TIC and TNC for flow velocities from 10 to 30 cm/s under an ultrasound frequency of 5 MHz. The clutter effects on the TIC and TNC were explored in amore realistic situation by carrying out phantom measurements of 25 MHz. The rates of increase of the TIC and TNC were expressed by the rate constants beta1 and betaN of a monoexponential model, respectively. The average beta1 increased from 38 to 110 s(-1) as the flow velocity increased from 10 to 30 cm/s (r = 0.98), and the average betaN increased from approximately 40 to 120 s(-1) for the same increase in flow velocity (r = 0.98). The p-value between the results of beta1 and betaN as a function of flow velocity was 0.77. These results represent that betaN quantifies the flow velocity similarly to the conventional beta1. In particular, both the simulation and experimental results revealed that the TNC method conditionally tolerates the presence of nonperfused areas (e.g., surrounding tissues or vessel walls) in the region of interest without requiring application of an additional wall filter to cancel the influences of clutter echoes on the flow estimation. These findings suggest that the TNC-based technique may be a potential method as a complementary tool for the conventional TIC technique to improve the estimation of blood flow.


Ultrason Imaging


Ultrasonic imaging


Tsui PH,Yeh CK,Chang CC




Has Abstract


2008-07-01 00:00:00












  • Optimization of signal-to-noise ratio for multilayer PZT transducers.

    abstract::In medical ultrasound imaging, two-dimensional (2-D) array transducers are desirable to implement dynamic focusing and phase aberration correction in two dimensions as well as volumetric imaging. Unfortunately, the small size of a 2-D array element results in a small clamped capacitance and a large electrical impedanc...

    journal_title:Ultrasonic imaging

    pub_type: 杂志文章


    authors: Goldberg RL,Smith SW

    更新日期:1995-04-01 00:00:00

  • Breast tissue classification using diagnostic ultrasound and pattern recognition techniques: II. Experimental results.

    abstract::The methods of statistical pattern recognition have been applied to the problem of in vivo ultrasonic characterization of breast disease in humans. Backscattered A-mode signals obtained from a commercial pulse imaging system were used to generate a large set of potentially useful features. Using statistical tests, a s...

    journal_title:Ultrasonic imaging

    pub_type: 杂志文章


    authors: Finette S,Bleier AR,Swindell W,Haber K

    更新日期:1983-01-01 00:00:00

  • Wavelet-based speckle noise reduction in ultrasound B-scan images.

    abstract::Speckle noise is known to be signal-dependent in ultrasound imaging. Hence, separating noise from signal becomes a difficult task. This paper describes a wavelet-based method for reducing speckle noise. We derive from the model of the displayed ultrasound image the optimal wavelet-domain filter in the least mean-squar...

    journal_title:Ultrasonic imaging

    pub_type: 杂志文章


    authors: Rakotomamonjy A,Deforge P,Marché P

    更新日期:2000-04-01 00:00:00

  • Computerized ultrasound B-scan texture analysis of experimental fatty liver disease: influence of total lipid content and fat deposit distribution.

    abstract::Statistical pattern recognition procedures allow a quantitative description of ultrasound-B-scan image texture. According to well-established animal models, different types of fatty liver disease were induced in female Wistar rats. For the correlation of the computerized ultrasound image with its underlying histology ...

    journal_title:Ultrasonic imaging

    pub_type: 杂志文章


    authors: Layer G,Zuna I,Lorenz A,Zerban H,Haberkorn U,Bannasch P,van Kaick G,Räth U

    更新日期:1990-07-01 00:00:00

  • Improved Fourier-transform-based parallel receive beam formation.

    abstract::A Fourier transform (FT)-based technique for forming parallel receive beams has been previously employed to increase the imaging frame rate in ultrasonic imaging. However, the image quality in FT-based parallel reconstruction is degraded because differences in range focusing delays are ignored and a wide transmit beam...

    journal_title:Ultrasonic imaging

    pub_type: 杂志文章


    authors: Li ML,Li PC

    更新日期:2003-04-01 00:00:00

  • Assessment of Age-related Oxygenation Changes in Calf Skeletal Muscle by Photoacoustic Imaging: A Potential Tool for Peripheral Arterial Disease.

    abstract::Peripheral artery disease is often asymptomatic, and various imaging and nonimaging techniques have been used for assessment and monitoring treatments. This study is designed to demonstrate the ability of photoacoustic imaging to noninvasively determine changes in tissue oxygenation that occur in mice's hind limb skel...

    journal_title:Ultrasonic imaging

    pub_type: 杂志文章


    authors: Kirkham BM,Schultz SM,Ashi K,Sehgal CM

    更新日期:2019-09-01 00:00:00

  • A comparison method for mean frequency estimators for Doppler ultrasound.

    abstract::Mean frequency estimators as used in pulsed Doppler ultrasound equipment should provide an accurate (quality) and consistent (robustness) estimate over a wide range of signal conditions. In a simplified signal model, the main parameters to consider are the noise level, mean frequency, bandwidth and power of both the D...

    journal_title:Ultrasonic imaging

    pub_type: 杂志文章


    authors: Brands PJ,Hoeks AP

    更新日期:1992-10-01 00:00:00

  • Mathematical simulation of pressure pulse propagation in biological tissues.

    abstract::The propagation of pressure pulses of arbitrary time form in inhomogeneous attenuating media with characteristics similar to real biological tissues is considered. A mathematical model using the quasi-optical approximation is developed to solve the wave equation. Such a model proves to be convenient for computer reali...

    journal_title:Ultrasonic imaging

    pub_type: 杂志文章


    authors: Adrov VN,Chernomordik VV

    更新日期:1993-01-01 00:00:00

  • Rotation Elastogram Estimation Using Synthetic Transmit-aperture Technique: A Feasibility Study.

    abstract::It is well-documented in literature that benign breast lesions, such as fibroadenomas, are loosely bonded to their surrounding tissue and tend to slip under a small quasi-static compression, whereas malignant lesions being firmly bonded to their surrounding tissue do not slip. Recent developments in quasi-static ultra...

    journal_title:Ultrasonic imaging

    pub_type: 杂志文章


    authors: B L,Chintada BR,Thittai AK

    更新日期:2017-05-01 00:00:00

  • Transducer characterization from pressure amplitude distribution measurements using a Kalman filter as parameter estimation algorithm.

    abstract::The amplitude and frequency contents of a received ultrasound pulse depends on the spatial pressure amplitude distribution of the sound field, as produced by the transducer in the medium, and on the position and orientation of the reflecting surface in this field. Often, the geometry of the reflecting surface and the ...

    journal_title:Ultrasonic imaging

    pub_type: 杂志文章


    authors: Linssen FM,Hoeks AP

    更新日期:1990-10-01 00:00:00

  • An adaptive approach to computing the spectrum and mean frequency of Doppler signals.

    abstract::Modern ultrasound Doppler systems are facing the problem of processing increasingly shorter data sets. Spectral analysis of the strongly nonstationary Doppler signal needs to shorten the analysis window while maintaining a low variance and high resolution spectrum. Color flow imaging requires estimation of the Doppler...

    journal_title:Ultrasonic imaging

    pub_type: 杂志文章


    authors: Herment A,Giovannelli JF

    更新日期:1995-01-01 00:00:00

  • Volumetric Hall effect tomography--a feasibility study.

    abstract::Hall effect imaging is an ultrasound-based method of mapping spatial variations in the dielectric constants of an acoustically-uniform sample. This paper presents three-dimensional Hall effect images of phantoms obtained by scanning a single transducer across a two-dimensional grid, effectively simulating two-dimensio...

    journal_title:Ultrasonic imaging

    pub_type: 杂志文章


    authors: Wen H

    更新日期:1999-07-01 00:00:00

  • Autoregressive spectral estimation in ultrasonic scatterer size imaging.

    abstract::An autoregressive (AR) spectral estimation method was considered for the purpose of estimating scatterer size images. The variance and bias of the resulting estimates were compared with those using classical FFT periodograms for a range of input signal-to-noise ratios and echo-signal durations corresponding to various...

    journal_title:Ultrasonic imaging

    pub_type: 杂志文章


    authors: Chaturvedi P,Insana MF

    更新日期:1996-01-01 00:00:00

  • Optical tracking of superficial dynamics from an acoustic radiation force-induced excitation.

    abstract::Acoustic radiation force (ARF) has become a common excitation mechanism in elasticity imaging. The high acoustic intensities and subsequent generation of harmonics, however, hamper the effectiveness of using conventional radiofrequency (rf) tracking to investigate the dynamics of tissues and catheter-based transducers...

    journal_title:Ultrasonic imaging

    pub_type: 杂志文章


    authors: Bouchard RR,Van Soest G,Trahey GE,Van Der Steen AF

    更新日期:2009-01-01 00:00:00

  • A Variance-reduction Approach to Detection of the Thyroid-nodule Boundary on Ultrasound Images.

    abstract::To perform computer-aided diagnosis of the thyroid nodules on ultrasound images, the location and boundary of nodules should be clearly defined. However, the identification of thyroid nodule boundary is a difficult issue due to the biological characteristics of the nodules, the physics and quality of ultrasound imagin...

    journal_title:Ultrasonic imaging

    pub_type: 杂志文章


    authors: Chiu LY,Chen A

    更新日期:2019-07-01 00:00:00

  • A quantitative approach to speckle reduction via frequency compounding.

    abstract::Coherent speckle is a source of image noise in ultrasonic B-mode imaging. The use of multiple imaging frequencies has been suggested as a technique for speckle contrast reduction. This technique involves the averaging of images whose speckle patterns have been modified by a change in the spectrum of the transmitted or...

    journal_title:Ultrasonic imaging

    pub_type: 杂志文章


    authors: Trahey GE,Allison JW,Smith SW,von Ramm OT

    更新日期:1986-07-01 00:00:00

  • A scalable architecture for real-time synthetic-focus imaging.

    abstract::A scalable architecture for forming real-time synthetic focus images is described and the design of a 256-channel system using currently-available technology is presented as an example implementation of the architecture. The parallelism of the system scales directly with the number of array elements and the image comp...

    journal_title:Ultrasonic imaging

    pub_type: 杂志文章


    authors: Richard WD

    更新日期:2003-07-01 00:00:00

  • Adaptive scan sequence for real-time ultrasound 3-D imaging.

    abstract::An adaptive scan sequence is proposed for real-time ultrasound three-dimensional (3-D) imaging. Generally, the refresh rate of 3-D imaging is limited by the view window, resolution and sound speed in the human body. If the object is transformed or moved during the data set acquisition, the 3-D image will be distorted....

    journal_title:Ultrasonic imaging

    pub_type: 杂志文章


    authors: Hashimoto H,Takeuchi Y

    更新日期:2003-10-01 00:00:00

  • Classification of scattering objects by regular arrays of scatterers using Fourier analysis.

    abstract::For a class of scattering objects the mean separation between the scatterers is determined. Over a range of frequencies, ultrasonic back-scattered pressure signals are recorded. It is suggested to derive the mean spacing of an unknown scattering object by employing Fourier analysis and comparing the signal with signal...

    journal_title:Ultrasonic imaging

    pub_type: 杂志文章


    authors: Koch I

    更新日期:1983-10-01 00:00:00

  • Observations of tissue response to acoustic radiation force: opportunities for imaging.

    abstract::Acoustic Radiation Force Impulse (ARFI) imaging is a method for characterizing local variations in tissue mechanical properties. In this method, a single ultrasonic transducer array is used to both apply temporally short localized radiation forces within tissue and to track the resulting displacements through time. In...

    journal_title:Ultrasonic imaging

    pub_type: 杂志文章


    authors: Nightingale K,Bentley R,Trahey G

    更新日期:2002-07-01 00:00:00

  • Breast-lesion Segmentation Combining B-Mode and Elastography Ultrasound.

    abstract::Breast ultrasound (BUS) imaging has become a crucial modality, especially for providing a complementary view when other modalities (i.e., mammography) are not conclusive in the task of assessing lesions. The specificity in cancer detection using BUS imaging is low. These false-positive findings often lead to an increa...

    journal_title:Ultrasonic imaging

    pub_type: 杂志文章


    authors: Pons G,Martí J,Martí R,Ganau S,Noble JA

    更新日期:2016-05-01 00:00:00

  • Statistical relationship between ultrasound echo envelope and envelope peak.

    abstract::This study shows that the amplitude information of ultrasound echoes is carried mainly by the envelope peaks (EPs). It is first shown that the EPs in an A-line represent the maximum number of independent amplitude data. It is then demonstrated that the entire envelope could be approximately reconstructed from the EPs....

    journal_title:Ultrasonic imaging

    pub_type: 杂志文章


    authors: He P

    更新日期:1988-10-01 00:00:00

  • In vivo imaging using a copolymer phased array.

    abstract::Phased-array images have been obtained in vivo with a steered copolymer array operating at 2.5 MHz. The array was fabricated using 28 microns copolymer film, lambda/4 resonant at 21 MHz, which was bonded to a glass ceramic backing with a thin film bond. The 32 array elements were created by laser ablation of the conti...

    journal_title:Ultrasonic imaging

    pub_type: 杂志文章


    authors: Goldberg RL,Smith SW,Brown LF

    更新日期:1992-07-01 00:00:00

  • Effects of transmit focusing on finite amplitude distortion based second harmonic generation.

    abstract::Generation of the second harmonic signal was studied for finite amplitude distortion based harmonic imaging. Acoustic field amplitudes along the range axis of a fixed focus transducer were measured using a PVDF needle hydrophone. Results indicated that on-axis amplitudes strongly depended on the f-number at both the f...

    journal_title:Ultrasonic imaging

    pub_type: 杂志文章


    authors: Li PC,Shen CC

    更新日期:1999-10-01 00:00:00

  • Real-time 3D transesophageal echocardiography.

    abstract::Transesophageal echocardiography (TEE) is an essential diagnostic tool in patients with poor transthoracic echocardiographic windows or when detailed imaging of structures distant from the chest wall is necessary. A real-time 3D TEE probe has been fabricated in our laboratory in order to increase the amount of informa...

    journal_title:Ultrasonic imaging

    pub_type: 杂志文章


    authors: Pua EC,Idriss SF,Wolf PD,Smith SW

    更新日期:2004-10-01 00:00:00

  • Reconstructive ultrasound elasticity imaging for renal transplant diagnosis: kidney ex vivo results.

    abstract::It may be possible to diagnose and monitor scarring, inflammation and edema in transplant kidney using reconstructive ultrasound elasticity imaging. Kidney elasticity is expected to change dramatically with scar, and to a lesser degree, with acute inflammation and edema. The hypothesis that changes in kidney elasticit...

    journal_title:Ultrasonic imaging

    pub_type: 杂志文章


    authors: Emelianov SY,Lubinski MA,Skovoroda AR,Erkamp RQ,Leavey SF,Wiggins RC,O'Donnell M

    更新日期:2000-07-01 00:00:00

  • Digital simulation of pulsed ultrasonic waveforms.

    abstract::When modeling or simulating an ultrasonic pulse-echo system it is necessary to know the transducer waveforms that are the input to the system. In general, accurate transducer modeling is complex and waveform calculation is computationally intensive. Because of this, investigators often assume these waveforms to be sim...

    journal_title:Ultrasonic imaging

    pub_type: 杂志文章


    authors: Barber FE,Goodsitt MM

    更新日期:1987-10-01 00:00:00

  • Neural-network-based Motion Tracking for Breast Ultrasound Strain Elastography: An Initial Assessment of Performance and Feasibility.

    abstract::Accurate tracking of tissue motion is critically important for several ultrasound elastography methods. In this study, we investigate the feasibility of using three published convolution neural network (CNN) models built for optical flow (hereafter referred to as CNN-based tracking) by the computer vision community fo...

    journal_title:Ultrasonic imaging

    pub_type: 杂志文章


    authors: Peng B,Xian Y,Zhang Q,Jiang J

    更新日期:2020-03-01 00:00:00

  • Effective scatterer diameter estimates for broad scatterer size distributions.

    abstract::Acoustic form factors have been used to model the frequency dependence of acoustic scattering in phantoms and tissues. This work demonstrates that a broad range of scatterer sizes, individually well represented by Faran theory or a Gaussian form factor, is not accurately described by a single effective scatterer from ...

    journal_title:Ultrasonic imaging

    pub_type: 杂志文章


    authors: Nordberg EP,Hall TJ

    更新日期:2015-01-01 00:00:00

  • Reduction of the clutter component in Doppler ultrasound signals based on singular value decomposition: a simulation study.

    abstract::In pulsed Doppler ultrasound systems, the ultrasound radiofrequency (RF) signals received can be employed to estimate noninvasively the time-dependent blood velocity distribution within and artery. The RF signals are composed of signals originating from clutter (e.g., vessel walls) and scatterers (e.g., red blood cell...

    journal_title:Ultrasonic imaging

    pub_type: 杂志文章


    authors: Ledoux LA,Brands PJ,Hoeks AP

    更新日期:1997-01-01 00:00:00