Ultrasonographic Multimodality Diagnostic Model of Thyroid Nodules.


:The aim of this study was to identify independent risk factors for thyroid cancer, establish an ultrasonographic multimodality diagnostic model for thyroid nodules, and explore the diagnostic value of the model. From November 2011 to February 2015, 307 patients with a total of 367 thyroid nodules underwent conventional ultrasound, contrast-enhanced ultrasound (CEUS), and ultrasound elastography examinations before surgery. A binary logistic regression analysis was performed to identify independent risk factors for thyroid cancer and to establish a multimodality diagnostic model for thyroid nodules. The diagnostic performance of conventional ultrasound, CEUS, ultrasound elastography, and the multimodality diagnostic model was assessed and compared. The following seven independent risk factors were included in the logistic regression models: age, irregular shape, hypoechoic pattern, marked hypoechoic pattern, irregular blood flow distribution, heterogeneous enhancement, and an elastic score of 3/4. The multimodality diagnostic model had a diagnostic accuracy of 86.9%, with a sensitivity of 93.5% and a specificity of 77.3%. The multimodality diagnostic model improved the diagnostic accuracy compared with that of conventional ultrasound, CEUS, and ultrasound elastography. Independent risk factors for thyroid cancer included age, irregular shape, hypoechoic pattern, marked hypoechoic pattern, irregular blood flow distribution, heterogeneous enhancement, and an elastic score of 3/4. The multimodality diagnostic model was demonstrated to be effective in the diagnosis of thyroid nodules.


Ultrason Imaging


Ultrasonic imaging


Zhao RN,Zhang B,Jiang YX,Yang X,Lai XJ,Zhu SL,Zhang XY




Has Abstract


2019-03-01 00:00:00












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    abstract::To perform computer-aided diagnosis of the thyroid nodules on ultrasound images, the location and boundary of nodules should be clearly defined. However, the identification of thyroid nodule boundary is a difficult issue due to the biological characteristics of the nodules, the physics and quality of ultrasound imagin...

    journal_title:Ultrasonic imaging

    pub_type: 杂志文章


    authors: Chiu LY,Chen A

    更新日期:2019-07-01 00:00:00

  • Ultrasound attenuation measurements of the liver in vivo using a commercial sector scanner.

    abstract::Attenuation measurements of various tissue mimicking phantoms and three different groups of patients were obtained using a modified commercial sector scanner. Estimates of attenuation were made using the spectral shift method with mean frequencies at different depths of a region of interest being obtained by both zero...

    journal_title:Ultrasonic imaging

    pub_type: 杂志文章


    authors: Garra BS,Shawker TH,Nassi M,Russell MA

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  • On the feasibility of imaging peripheral nerves using acoustic radiation force impulse imaging.

    abstract::Regional anesthesia is preferred over general anesthesia for many surgical procedures; however, challenges associated with poor image guidance limit its widespread acceptance as a viable alternative. In B-mode ultrasound images, the current standard for guidance, nerves can be difficult to visualize due to their simil...

    journal_title:Ultrasonic imaging

    pub_type: 杂志文章


    authors: Palmeri ML,Dahl JJ,MacLeod DB,Grant SA,Nightingale KR

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    abstract::An algorithm for deconvolution of medical ultrasound images is presented. The procedure involves estimation of the basic one-dimensional ultrasound pulse, determining the ratio of the covariance of the noise to the covariance of the reflection signal, and finally deconvolution of the rf signal from the transducer. Usi...

    journal_title:Ultrasonic imaging

    pub_type: 杂志文章


    authors: Jensen JA,Mathorne J,Gravesen T,Stage B

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  • A Review of Ultrasound Tissue Characterization with Mean Scatterer Spacing.

    abstract::Tissues exhibiting quasi-periodic structures can be modeled as a collection of diffuse scatterers and coherent scatterers. The mean scatterer spacing (MSS) of coherent and quasi-periodic components is directly related to tissue microstructure and has become an important quantitative ultrasound (QUS) parameter in the c...

    journal_title:Ultrasonic imaging

    pub_type: 杂志文章,评审


    authors: Zhou Z,Wu W,Wu S,Jia K,Tsui PH

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  • Feasibility exploration of blood flow estimation by contrast-assisted Nakagami imaging.

    abstract::The microbubble contrast agent destruction/replenishment technique has been widely applied to ultrasound-based blood flow estimation. The rate of increase of the time-intensity curve (TIC) due to microbubbles flowing into the region of interest as measured from B-mode images closely reflects the flow velocity. In this...

    journal_title:Ultrasonic imaging

    pub_type: 杂志文章


    authors: Tsui PH,Yeh CK,Chang CC

    更新日期:2008-07-01 00:00:00

  • Optimal transmit phasing for harmonic-background suppression with bipolar square-wave pulser.

    abstract::Optimal transmit phasing has been proposed to increase contrast-to-tissue ratio (CTR) by relatively phasing the tissue and leakage harmonic components to cancel each other out for tissue-background suppression in harmonic imaging. Since most clinical systems are only equipped with a bipolar square-wave pulser, effecti...

    journal_title:Ultrasonic imaging

    pub_type: 杂志文章


    authors: Shen CC,Yang YC,Chen WS

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  • Phase-derivative imaging. II: Effects of beam diffraction and scatterer density.

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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    journal_title:Ultrasonic imaging

    pub_type: 杂志文章


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  • Neural-network-based Motion Tracking for Breast Ultrasound Strain Elastography: An Initial Assessment of Performance and Feasibility.

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    journal_title:Ultrasonic imaging

    pub_type: 杂志文章


    authors: Peng B,Xian Y,Zhang Q,Jiang J

    更新日期:2020-03-01 00:00:00

  • Acoustic Structure Quantification Analysis of the Thyroid in Patients with Diffuse Autoimmune Thyroid Disease.

    abstract::The aim of this study was to assess whether acoustic structure quantification (ASQ) can differentiate normal from pathological thyroid parenchyma in patients with diffuse autoimmune thyroid disease (AITD). We evaluated 83 subjects (72 [87%] women and 11 [13%] men) aged 19 to 94 years with a mean age of 53 years. We pe...

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    pub_type: 杂志文章


    authors: Zandieh S,Bernt R,Zwerina J,Haller J,Knoll P,Seyeddain O,Mirzaei S

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  • Attenuation estimation with the zero-crossing technique: phantom studies.

    abstract::Global and local attenuation coefficient estimations were performed in a phantom using a pulse echo method based on the rate of decay of zero crossing density. Focussed and unfocussed 3.5 MHz transducers were used. It was found that good global estimates could be made with either transducer over a 2:1 range of attenua...

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    pub_type: 杂志文章


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  • A quantitative approach to speckle reduction via frequency compounding.

    abstract::Coherent speckle is a source of image noise in ultrasonic B-mode imaging. The use of multiple imaging frequencies has been suggested as a technique for speckle contrast reduction. This technique involves the averaging of images whose speckle patterns have been modified by a change in the spectrum of the transmitted or...

    journal_title:Ultrasonic imaging

    pub_type: 杂志文章


    authors: Trahey GE,Allison JW,Smith SW,von Ramm OT

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  • Linear arrays for vibro-acoustography: a numerical simulation study.

    abstract::In this work, we study linear array beamforming for vibro-acoustography systems. The goal of this research is to assess the feasibility of vibro-acoustography imaging systems based on linear arrays for clinical applications. The vibro-acoustography transducer is designed with two arrays driven by two continuous-wave o...

    journal_title:Ultrasonic imaging

    pub_type: 杂志文章


    authors: Silva GT,Greenleaf JF,Fatemi M

    更新日期:2004-01-01 00:00:00

  • In vivo study of online liver tissue classification based on envelope power spectrum analysis.

    abstract::An ultrasonic imaging and signal analysis system, combining a 3.5 MHz linear array B-scanner and an array processor, has been realized for a clinical liver tissue classification study. Based on the complete unprocessed rf data set of a real time B-image, local envelope power spectra averaged over interactively defined...

    journal_title:Ultrasonic imaging

    pub_type: 杂志文章


    authors: Lang M,Ermert H,Heuser L

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  • A comparison method for mean frequency estimators for Doppler ultrasound.

    abstract::Mean frequency estimators as used in pulsed Doppler ultrasound equipment should provide an accurate (quality) and consistent (robustness) estimate over a wide range of signal conditions. In a simplified signal model, the main parameters to consider are the noise level, mean frequency, bandwidth and power of both the D...

    journal_title:Ultrasonic imaging

    pub_type: 杂志文章


    authors: Brands PJ,Hoeks AP

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  • Investigation of optimal method for inducing harmonic motion in tissue using a linear ultrasound phased array--a simulation study.

    abstract::Many noninvasive ultrasound techniques have been developed to explore mechanical properties of soft tissues. One of these methods, Localized Harmonic Motion Imaging (LHMI), has been proposed to be used for ultrasound surgery monitoring. In LHMI, dynamic ultrasound radiation-force stimulation induces displacements in a...

    journal_title:Ultrasonic imaging

    pub_type: 杂志文章


    authors: Heikkilä J,Hynynen K

    更新日期:2006-04-01 00:00:00

  • A method for in vitro mapping of ultrasonic speed and density in breast tissue.

    abstract::A method has been developed for mapping density and ultrasonic speed in 1 mm thick slices of soft tissue with a resolution of about 1 mm. Tests using phantom sections have verified the accuracy and resolution of the ultrasonic speed maps. The method has been applied to breast tissues of three patients including tumors...

    journal_title:Ultrasonic imaging

    pub_type: 杂志文章


    authors: Yang JN,Murphy AD,Madsen EL,Zagzebski JA,Gilchrist KW,Frank GR,Macdonald MC,Millard CA,Faraggi A,Jaramillo CA

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    journal_title:Ultrasonic imaging

    pub_type: 杂志文章


    authors: Pua EC,Idriss SF,Wolf PD,Smith SW

    更新日期:2004-10-01 00:00:00

  • Reconstructive ultrasound elasticity imaging for renal transplant diagnosis: kidney ex vivo results.

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    journal_title:Ultrasonic imaging

    pub_type: 杂志文章


    authors: Emelianov SY,Lubinski MA,Skovoroda AR,Erkamp RQ,Leavey SF,Wiggins RC,O'Donnell M

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    abstract::An adaptive scan sequence is proposed for real-time ultrasound three-dimensional (3-D) imaging. Generally, the refresh rate of 3-D imaging is limited by the view window, resolution and sound speed in the human body. If the object is transformed or moved during the data set acquisition, the 3-D image will be distorted....

    journal_title:Ultrasonic imaging

    pub_type: 杂志文章


    authors: Hashimoto H,Takeuchi Y

    更新日期:2003-10-01 00:00:00

  • Experimental Validation of ARFI Surveillance of Subcutaneous Hemorrhage (ASSH) Using Calibrated Infusions in a Tissue-Mimicking Model and Dogs.

    abstract::Acoustic radiation force impulse (ARFI) Surveillance of Subcutaneous Hemorrhage (ASSH) has been previously demonstrated to differentiate bleeding phenotype and responses to therapy in dogs and humans, but to date, the method has lacked experimental validation. This work explores experimental validation of ASSH in a po...

    journal_title:Ultrasonic imaging

    pub_type: 杂志文章


    authors: Geist RE,DuBois CH,Nichols TC,Caughey MC,Merricks EP,Raymer R,Gallippi CM

    更新日期:2016-09-01 00:00:00

  • Quantitative assessment of in vivo backscatter enhancement from gelatin microspheres.

    abstract::Experimental work using a quantitative C-scan technique to measure in situ enhancement of hepatic backscatter resulting from the administration of gelatin microspheres to dogs is reported. We have found that reproducible enhancement of hepatic backscatter on the order of 2 dB followed the peripheral administration of ...

    journal_title:Ultrasonic imaging

    pub_type: 杂志文章


    authors: Ophir J,Gobuty A,Maklad N,Tyler T,Jaeger P,McWhirt R

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  • Reduction of the clutter component in Doppler ultrasound signals based on singular value decomposition: a simulation study.

    abstract::In pulsed Doppler ultrasound systems, the ultrasound radiofrequency (RF) signals received can be employed to estimate noninvasively the time-dependent blood velocity distribution within and artery. The RF signals are composed of signals originating from clutter (e.g., vessel walls) and scatterers (e.g., red blood cell...

    journal_title:Ultrasonic imaging

    pub_type: 杂志文章


    authors: Ledoux LA,Brands PJ,Hoeks AP

    更新日期:1997-01-01 00:00:00

  • GPU-accelerated Kernel Regression Reconstruction for Freehand 3D Ultrasound Imaging.

    abstract::Volume reconstruction method plays an important role in improving reconstructed volumetric image quality for freehand three-dimensional (3D) ultrasound imaging. By utilizing the capability of programmable graphics processing unit (GPU), we can achieve a real-time incremental volume reconstruction at a speed of 25-50 f...

    journal_title:Ultrasonic imaging

    pub_type: 杂志文章


    authors: Wen T,Li L,Zhu Q,Qin W,Gu J,Yang F,Xie Y

    更新日期:2017-07-01 00:00:00

  • Diffraction tomography using arbitrary transmitter and receiver surfaces.

    abstract::The theory of diffraction tomography for two-dimensional objects within the Born approximation is presented for cases where the scattered field is measured over arbitrarily shaped boundaries surrounding the object. Reconstruction algorithms are presented for both plane wave (parallel beam) and cylindrical wave (fan be...

    journal_title:Ultrasonic imaging

    pub_type: 杂志文章


    authors: Devaney AJ,Beylkin G

    更新日期:1984-04-01 00:00:00

  • Time reversal focusing applied to lithotripsy.

    abstract::Time reversal of ultrasonic field allows a very efficient approach to focusing pulsed ultrasonic waves through lossless inhomogeneous media. Time reversal mirrors (TRM) are made of large transducer arrays, allowing the incident acoustic field to be sampled, time reversed and re-emitted. Time reversal processing permit...

    journal_title:Ultrasonic imaging

    pub_type: 杂志文章,评审


    authors: Thomas JL,Wu F,Fink M

    更新日期:1996-04-01 00:00:00

  • Adaptive texture feature extraction with application to ultrasonic image analysis.

    abstract::Computer texture analysis methods use texture features that are traditionally chosen from a large set of fixed features known in literature. These fixed features are often not specifically designed to the problem at hand, and as a result they may have low discriminative power, and/or may be correlated. Increasing the ...

    journal_title:Ultrasonic imaging

    pub_type: 杂志文章,评审


    authors: Huisman HJ,Thijssen JM

    更新日期:1998-04-01 00:00:00

  • The Maltese cross processor: speckle reduction for circular transducers.

    abstract::A new online signal processing technique is described to reduce speckle noise in ultrasound images. In the imaging system, a focused piston transducer is divided into thirty-two sectors. In the receive mode, parallel signal processing arranges the sectors into eight maltese crosses. The rf signals of the perpendicular...

    journal_title:Ultrasonic imaging

    pub_type: 杂志文章


    authors: Smith SW,von Ramm OT

    更新日期:1988-07-01 00:00:00