Abstract:
:Peripheral artery disease is often asymptomatic, and various imaging and nonimaging techniques have been used for assessment and monitoring treatments. This study is designed to demonstrate the ability of photoacoustic imaging to noninvasively determine changes in tissue oxygenation that occur in mice's hind limb skeletal muscle as they age. Mice from two age cohorts were scanned bilaterally with a pulsed laser. The photoacoustic signal was unmixed to generate a parametric map of estimated oxygen saturation and then overlaid on grayscale ultrasound images. Tissue oxygenation measured in young and old mice was compared. Photoacoustic imaging visually and quantitatively showed the decrease in skeletal muscle oxygenation that occurs with age. Percent tissue oxygenation decreased from 30.2% to 3.5% (p < 0.05). This reduction corresponded to reduced fractional area of oxygenation, which decreased from 60.6% to 6.0% (p < 0.05). The change in oxygenation capacity of the still active vascular regions was insignificant (p > 0.05). Intrasubject, intra-, and interobserver comparisons showed low variability in measurements, exhibited by high regression and intraclass correlations exceeding 0.81 for all ages. The decrease in oxygenation detected by photoacoustic imaging paralleled the known oxygenation decrease observed in aging tissues, demonstrating that photoacoustic imaging can assess age-related changes in a mouse calf muscle. These intramuscular changes could potentially act as a strong diagnostic marker for peripheral artery disease. This study thus opens the doors for a novel, affordable, noninvasive method of evaluation free of radiation or exogenous material.
journal_name
Ultrason Imagingjournal_title
Ultrasonic imagingauthors
Kirkham BM,Schultz SM,Ashi K,Sehgal CMdoi
10.1177/0161734619862287subject
Has Abstractpub_date
2019-09-01 00:00:00pages
290-300issue
5eissn
0161-7346issn
1096-0910journal_volume
41pub_type
杂志文章abstract::Breast ultrasound (BUS) imaging has become a crucial modality, especially for providing a complementary view when other modalities (i.e., mammography) are not conclusive in the task of assessing lesions. The specificity in cancer detection using BUS imaging is low. These false-positive findings often lead to an increa...
journal_title:Ultrasonic imaging
pub_type: 杂志文章
doi:10.1177/0161734615589287
更新日期:2016-05-01 00:00:00
abstract::Tracking large deformations in tissue using ultrasound can enable the reconstruction of nonlinear elastic parameters, but poses a challenge to displacement estimation algorithms. Such large deformations have to be broken up into steps, each of which contributes an estimation error to the final accumulated displacement...
journal_title:Ultrasonic imaging
pub_type: 杂志文章
doi:10.1177/0161734613479246
更新日期:2013-04-01 00:00:00
abstract::This ex vivo study explores the relationship of ultrasonic attenuation and backscatter to dermal microarchitecture by comparing ultrasonic measurements of these parameters (11-27 MHz) to a microscopic analysis of three parameters describing the collagen distribution (mean thickness and spacing of collagen bundles alon...
journal_title:Ultrasonic imaging
pub_type: 杂志文章
doi:10.1177/016173460602800103
更新日期:2006-01-01 00:00:00
abstract::Acoustic radiation force (ARF) has become a common excitation mechanism in elasticity imaging. The high acoustic intensities and subsequent generation of harmonics, however, hamper the effectiveness of using conventional radiofrequency (rf) tracking to investigate the dynamics of tissues and catheter-based transducers...
journal_title:Ultrasonic imaging
pub_type: 杂志文章
doi:
更新日期:2009-01-01 00:00:00
abstract::A scalable architecture for forming real-time synthetic focus images is described and the design of a 256-channel system using currently-available technology is presented as an example implementation of the architecture. The parallelism of the system scales directly with the number of array elements and the image comp...
journal_title:Ultrasonic imaging
pub_type: 杂志文章
doi:10.1177/016173460302500303
更新日期:2003-07-01 00:00:00
abstract::Our group has proposed the concept of subharmonic aided pressure estimation (SHAPE) utilizing microbubble-based ultrasound contrast agent signals for the noninvasive estimation of hydrostatic blood pressures. An experimental system for in vitro SHAPE was constructed based on two single-element transducers assembled co...
journal_title:Ultrasonic imaging
pub_type: 杂志文章
doi:10.1177/016173461103300301
更新日期:2011-07-01 00:00:00
abstract::In this paper, quantitative tomographic reconstructions of biological tissue are presented. First, the experimental setup and a hybrid filtered backpropagation (FBP) technique are briefly described. Using this technique, which includes exact backpropagation of data prior to reconstruction by means of the classical FBP...
journal_title:Ultrasonic imaging
pub_type: 杂志文章
doi:10.1177/016173469401600102
更新日期:1994-01-01 00:00:00
abstract::An adaptive scan sequence is proposed for real-time ultrasound three-dimensional (3-D) imaging. Generally, the refresh rate of 3-D imaging is limited by the view window, resolution and sound speed in the human body. If the object is transformed or moved during the data set acquisition, the 3-D image will be distorted....
journal_title:Ultrasonic imaging
pub_type: 杂志文章
doi:10.1177/016173460302500401
更新日期:2003-10-01 00:00:00
abstract::Modern ultrasound Doppler systems are facing the problem of processing increasingly shorter data sets. Spectral analysis of the strongly nonstationary Doppler signal needs to shorten the analysis window while maintaining a low variance and high resolution spectrum. Color flow imaging requires estimation of the Doppler...
journal_title:Ultrasonic imaging
pub_type: 杂志文章
doi:10.1177/016173469501700101
更新日期:1995-01-01 00:00:00
abstract::Attenuation measurements of various tissue mimicking phantoms and three different groups of patients were obtained using a modified commercial sector scanner. Estimates of attenuation were made using the spectral shift method with mean frequencies at different depths of a region of interest being obtained by both zero...
journal_title:Ultrasonic imaging
pub_type: 杂志文章
doi:10.1177/016173468400600402
更新日期:1984-10-01 00:00:00
abstract::Acoustic Radiation Force Impulse (ARFI) imaging is a method for characterizing local variations in tissue mechanical properties. In this method, a single ultrasonic transducer array is used to both apply temporally short localized radiation forces within tissue and to track the resulting displacements through time. In...
journal_title:Ultrasonic imaging
pub_type: 杂志文章
doi:10.1177/016173460202400301
更新日期:2002-07-01 00:00:00
abstract::To perform computer-aided diagnosis of the thyroid nodules on ultrasound images, the location and boundary of nodules should be clearly defined. However, the identification of thyroid nodule boundary is a difficult issue due to the biological characteristics of the nodules, the physics and quality of ultrasound imagin...
journal_title:Ultrasonic imaging
pub_type: 杂志文章
doi:10.1177/0161734619839648
更新日期:2019-07-01 00:00:00
abstract::Computer texture analysis methods use texture features that are traditionally chosen from a large set of fixed features known in literature. These fixed features are often not specifically designed to the problem at hand, and as a result they may have low discriminative power, and/or may be correlated. Increasing the ...
journal_title:Ultrasonic imaging
pub_type: 杂志文章,评审
doi:10.1177/016173469802000204
更新日期:1998-04-01 00:00:00
abstract::Statistical pattern recognition procedures allow a quantitative description of ultrasound-B-scan image texture. According to well-established animal models, different types of fatty liver disease were induced in female Wistar rats. For the correlation of the computerized ultrasound image with its underlying histology ...
journal_title:Ultrasonic imaging
pub_type: 杂志文章
doi:10.1177/016173469001200302
更新日期:1990-07-01 00:00:00
abstract::Previously reported data on the temperature dependence of propagation speed in tissues generally span only temperature ranges up to 60 degrees C. However, with the emerging use of thermal ablative therapies, information on variation in this parameter over higher temperature ranges is needed. Measurements of the ultras...
journal_title:Ultrasonic imaging
pub_type: 杂志文章
doi:10.1177/016173460202400404
更新日期:2002-10-01 00:00:00
abstract::Global and local attenuation coefficient estimations were performed in a phantom using a pulse echo method based on the rate of decay of zero crossing density. Focussed and unfocussed 3.5 MHz transducers were used. It was found that good global estimates could be made with either transducer over a 2:1 range of attenua...
journal_title:Ultrasonic imaging
pub_type: 杂志文章
doi:10.1177/016173468500700202
更新日期:1985-04-01 00:00:00
abstract::The liver has been hypothesized to have a unique arrangement of microvasculature that presents as an arrangement of quasiperiodic scatterers to an interrogating ultrasound pulse. The mean scatterer spacing (MSS) of these quasiperiodic scatterers has been proposed as a useful quantitative ultrasound biomarker for chara...
journal_title:Ultrasonic imaging
pub_type: 杂志文章
doi:10.1177/0161734613511232
更新日期:2014-04-01 00:00:00
abstract::Portable ultrasound is recently emerging as a new medical imaging modality featuring high portability, easy connectivity, and real-time on-site diagnostic ability. However, it does not yet provide ultrasound elastography function that enables the diagnosis of malignant lesions using elastic properties. This is mainly ...
journal_title:Ultrasonic imaging
pub_type: 杂志文章
doi:10.1177/0161734617716938
更新日期:2017-11-01 00:00:00
abstract::Conventional ultrasonic B-mode images qualitatively describe tissue structures but are unsuitable for quantitative analyses of scatterer properties. We have recently developed an ultrasonic parametric imaging technique based on the Nakagami statistical distribution that is able to quantify scatterer concentrations. Th...
journal_title:Ultrasonic imaging
pub_type: 杂志文章
doi:10.1177/016173460803000202
更新日期:2008-04-01 00:00:00
abstract::In this work, we study linear array beamforming for vibro-acoustography systems. The goal of this research is to assess the feasibility of vibro-acoustography imaging systems based on linear arrays for clinical applications. The vibro-acoustography transducer is designed with two arrays driven by two continuous-wave o...
journal_title:Ultrasonic imaging
pub_type: 杂志文章
doi:10.1177/016173460402600101
更新日期:2004-01-01 00:00:00
abstract::In medical ultrasound imaging, two-dimensional (2-D) array transducers are desirable to implement dynamic focusing and phase aberration correction in two dimensions as well as volumetric imaging. Unfortunately, the small size of a 2-D array element results in a small clamped capacitance and a large electrical impedanc...
journal_title:Ultrasonic imaging
pub_type: 杂志文章
doi:10.1177/016173469501700202
更新日期:1995-04-01 00:00:00
abstract::Mathematical techniques are described for analyzing tongue shapes obtained with ultrasound images. The surface of the mid-sagittal section of the tongue was approximated by discrete points. In turn, these points were used to approximate position, slope and curvature of the tongue surface at a fixed time during speech....
journal_title:Ultrasonic imaging
pub_type: 杂志文章
doi:10.1177/016173468400600104
更新日期:1984-01-01 00:00:00
abstract::The propagation of pressure pulses of arbitrary time form in inhomogeneous attenuating media with characteristics similar to real biological tissues is considered. A mathematical model using the quasi-optical approximation is developed to solve the wave equation. Such a model proves to be convenient for computer reali...
journal_title:Ultrasonic imaging
pub_type: 杂志文章
doi:10.1177/016173469301500106
更新日期:1993-01-01 00:00:00
abstract::Transesophageal echocardiography (TEE) is an essential diagnostic tool in patients with poor transthoracic echocardiographic windows or when detailed imaging of structures distant from the chest wall is necessary. A real-time 3D TEE probe has been fabricated in our laboratory in order to increase the amount of informa...
journal_title:Ultrasonic imaging
pub_type: 杂志文章
doi:10.1177/016173460402600402
更新日期:2004-10-01 00:00:00
abstract::It is well-documented in literature that benign breast lesions, such as fibroadenomas, are loosely bonded to their surrounding tissue and tend to slip under a small quasi-static compression, whereas malignant lesions being firmly bonded to their surrounding tissue do not slip. Recent developments in quasi-static ultra...
journal_title:Ultrasonic imaging
pub_type: 杂志文章
doi:10.1177/0161734616686746
更新日期:2017-05-01 00:00:00
abstract::Regional anesthesia is preferred over general anesthesia for many surgical procedures; however, challenges associated with poor image guidance limit its widespread acceptance as a viable alternative. In B-mode ultrasound images, the current standard for guidance, nerves can be difficult to visualize due to their simil...
journal_title:Ultrasonic imaging
pub_type: 杂志文章
doi:10.1177/016173460903100303
更新日期:2009-07-01 00:00:00
abstract::The potential of using the phase derivative (PD) for echographic imaging was investigated. The PD data were calculated by four methods: zero crossing (ZCS) with squelch addition, analytic signal either with squelch addition (ASS) or with employment of a Wiener kernel (ASW), and unwrapped phase (UWP). The large peaks w...
journal_title:Ultrasonic imaging
pub_type: 杂志文章
doi:10.1177/016173468700900301
更新日期:1987-07-01 00:00:00
abstract::Experimental work using a quantitative C-scan technique to measure in situ enhancement of hepatic backscatter resulting from the administration of gelatin microspheres to dogs is reported. We have found that reproducible enhancement of hepatic backscatter on the order of 2 dB followed the peripheral administration of ...
journal_title:Ultrasonic imaging
pub_type: 杂志文章
doi:10.1177/016173468500700402
更新日期:1985-10-01 00:00:00
abstract::Generation of the second harmonic signal was studied for finite amplitude distortion based harmonic imaging. Acoustic field amplitudes along the range axis of a fixed focus transducer were measured using a PVDF needle hydrophone. Results indicated that on-axis amplitudes strongly depended on the f-number at both the f...
journal_title:Ultrasonic imaging
pub_type: 杂志文章
doi:10.1177/016173469902100401
更新日期:1999-10-01 00:00:00
abstract::An autoregressive (AR) spectral estimation method was considered for the purpose of estimating scatterer size images. The variance and bias of the resulting estimates were compared with those using classical FFT periodograms for a range of input signal-to-noise ratios and echo-signal durations corresponding to various...
journal_title:Ultrasonic imaging
pub_type: 杂志文章
doi:10.1177/016173469601800102
更新日期:1996-01-01 00:00:00