Abstract:
:Acoustic radiation force impulse (ARFI) Surveillance of Subcutaneous Hemorrhage (ASSH) has been previously demonstrated to differentiate bleeding phenotype and responses to therapy in dogs and humans, but to date, the method has lacked experimental validation. This work explores experimental validation of ASSH in a poroelastic tissue-mimic and in vivo in dogs. The experimental design exploits calibrated flow rates and infusion durations of evaporated milk in tofu or heparinized autologous blood in dogs. The validation approach enables controlled comparisons of ASSH-derived bleeding rate (BR) and time to hemostasis (TTH) metrics. In tissue-mimicking experiments, halving the calibrated flow rate yielded ASSH-derived BRs that decreased by 44% to 48%. Furthermore, for calibrated flow durations of 5.0 minutes and 7.0 minutes, average ASSH-derived TTH was 5.2 minutes and 7.0 minutes, respectively, with ASSH predicting the correct TTH in 78% of trials. In dogs undergoing calibrated autologous blood infusion, ASSH measured a 3-minute increase in TTH, corresponding to the same increase in the calibrated flow duration. For a measured 5% decrease in autologous infusion flow rate, ASSH detected a 7% decrease in BR. These tissue-mimicking and in vivo preclinical experimental validation studies suggest the ASSH BR and TTH measures reflect bleeding dynamics.
journal_name
Ultrason Imagingjournal_title
Ultrasonic imagingauthors
Geist RE,DuBois CH,Nichols TC,Caughey MC,Merricks EP,Raymer R,Gallippi CMdoi
10.1177/0161734615617940subject
Has Abstractpub_date
2016-09-01 00:00:00pages
346-58issue
5eissn
0161-7346issn
1096-0910pii
0161734615617940journal_volume
38pub_type
杂志文章abstract::The aim of this study was to assess whether acoustic structure quantification (ASQ) can differentiate normal from pathological thyroid parenchyma in patients with diffuse autoimmune thyroid disease (AITD). We evaluated 83 subjects (72 [87%] women and 11 [13%] men) aged 19 to 94 years with a mean age of 53 years. We pe...
journal_title:Ultrasonic imaging
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abstract::An algorithm for deconvolution of medical ultrasound images is presented. The procedure involves estimation of the basic one-dimensional ultrasound pulse, determining the ratio of the covariance of the noise to the covariance of the reflection signal, and finally deconvolution of the rf signal from the transducer. Usi...
journal_title:Ultrasonic imaging
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abstract::For a class of scattering objects the mean separation between the scatterers is determined. Over a range of frequencies, ultrasonic back-scattered pressure signals are recorded. It is suggested to derive the mean spacing of an unknown scattering object by employing Fourier analysis and comparing the signal with signal...
journal_title:Ultrasonic imaging
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journal_title:Ultrasonic imaging
pub_type: 杂志文章,评审
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journal_title:Ultrasonic imaging
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journal_title:Ultrasonic imaging
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journal_title:Ultrasonic imaging
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journal_title:Ultrasonic imaging
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journal_title:Ultrasonic imaging
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abstract::In pulsed Doppler ultrasound systems, the ultrasound radiofrequency (RF) signals received can be employed to estimate noninvasively the time-dependent blood velocity distribution within and artery. The RF signals are composed of signals originating from clutter (e.g., vessel walls) and scatterers (e.g., red blood cell...
journal_title:Ultrasonic imaging
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journal_title:Ultrasonic imaging
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journal_title:Ultrasonic imaging
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journal_title:Ultrasonic imaging
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