Abstract：
:This article summarizes the guidelines for using replacement therapy in the management of patients who have primary antibody deficiency.
journal_name
Immunol Allergy Clin North Amjournal_title
Immunology and allergy clinics of North Americaauthors
Roifman CM,Berger M,Notarangelo LDdoi
10.1016/j.iac.2008.07.003subject
Has Abstractpub_date
2008-11-01 00:00:00pages
875-6, xissue
4eissn
0889-8561issn
1557-8607pii
S0889-8561(08)00078-7journal_volume
28pub_type
杂志文章,实务指引abstract：:Urticaria and angioedema are commonly encountered complaints in children. Although the diagnosis is clear, establishing an etiology, especially with respect to chronic urticaria, can be challenging. A significant proportion of chronic urticarial cases are now considered to have an autoimmune etiology. This article rev...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2005.03.003
更新日期：2005-05-01 00:00:00
abstract：:Measurement of urinary leukotriene E(4) (uLTE(4)) is a sensitive and noninvasive method of assaying total body cysteinyl leukotriene production and changes in cysteinyl leukotriene production. Recent studies have reported on novel uLTE(4) receptor interactions, and new applications for uLTE(4), as a biomarker of envir...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2012.06.012
更新日期：2012-08-01 00:00:00
abstract：:Allergic rhinitis and asthma should be considered as organ-specific inflammatory diseases in which the genetic background has determined a local overproduction of Th2-type cytokines and an over-expansion of particular APCs and T cells. Among the latter, a potential pathogenetic role could be assumed for natural killer...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2006.11.004
更新日期：2007-02-01 00:00:00
abstract：:Eosinophilic gastrointestinal diseases (EGIDs) encompass a variety of disorders including eosinophilic esophagitis (EE), eosinophilic gastroenteritis (EG), and eosinophilic colitis. Although the pathogenesis of EGIDs is still poorly understood, dietary food antigens have been shown to cause EGIDs through several short...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2008.10.006
更新日期：2009-02-01 00:00:00
abstract：:There is some evidence to support the use of sublingual immunotherapy (SLIT) in food allergy, although its role is unclear. One randomized, double-blind, placebo-controlled trial supports the safe and efficacious use of dust mite SLIT in children with mild to moderate atopic dermatitis, but these data have not been co...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2019.09.011
更新日期：2020-02-01 00:00:00
abstract：:Based on the hygiene hypothesis association between atopy and bacillus Calmette-Guerin (BCG), purified protein derivative skin test reaction, mycobacterial disease, and environmental mycobacteria are summarized. The role of mycobacterial species in the activation of the innate immune response through Toll-like recepto...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2006.02.002
更新日期：2006-05-01 00:00:00
abstract：:Aspirin-exacerbated respiratory disease is a clinical syndrome characterized by severe, persistent asthma, hyperplastic eosinophilic sinusitis with nasal polyps, and reactions to aspirin and other nonsteroidal antiinflammatory drugs that preferentially inhibit cyclooxygenase 1. The mechanisms behind the therapeutic ef...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2012.11.003
更新日期：2013-05-01 00:00:00
abstract：:Recurrent infections in children are a cause for concern. It is essential to distinguish simple recurrent infections caused by exposures in the day care or school settings from those caused by inherent deficiencies in the immune system or other systemic diseases. Multiple diagnostic tools are available for the evaluat...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2015.07.005
更新日期：2015-11-01 00:00:00
abstract：:Asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) defines a subgroup of patients with asthma who have persistent airflow obstruction or patients with COPD who may exhibit variable airflow limitation and/or evidence of type 2 inflammation. Additional investigations are needed to determine whether ACO re...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2020.07.002
更新日期：2020-11-01 00:00:00
abstract：:Respiratory symptoms and asthma control questionnaires are poor predictors of the presence or severity of exercise-induced bronchoconstriction (EIB), and objective measurement is recommended. To optimize the chance of a positive test result, there are several factors to consider when exercising patients for EIB, inclu...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2013.02.006
更新日期：2013-08-01 00:00:00
abstract：:Physical urticarias are a unique subgroup of chronic urticaria in which urticarial responses can be reproducibly induced by different specific physical stimuli acting on the skin. These conditions include urticaria factitia/symptomatic dermographism, delayed pressure urticaria, cold contact urticaria, heat contact urt...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2013.09.010
更新日期：2014-02-01 00:00:00
abstract：:The symptomatic hypereosinophilic patient must be approached in a stepwise manner, with thorough assessment to determine whether the hypereosinophilia itself is contributing to damage and disease manifestations (thereby defining a hypereosinophilic syndrome), and to identify an eventual cause of hypereosinophilia, fol...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2015.05.006
更新日期：2015-08-01 00:00:00
abstract：:Asthma is characterized by persistent airway inflammation, which is associated with airway hyperresponsiveness and variable airflow obstruction, which accounts for the majority of symptoms experienced by asthmatic patients. Allergen sensitization and inhalation causes airway inflammation, and is likely important in th...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2005.05.005
更新日期：2005-08-01 00:00:00
abstract：:In the 1970s and 1980s, scientific methods were introduced in the standardization of allergen vaccines and, in combination with improved documentation of the clinical benefits obtained using standardized vaccines, specific allergy treatment as a scientifically based, reproducible, and safe treatment for allergic disea...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2006.02.012
更新日期：2006-05-01 00:00:00
abstract：:Mastocytosis is characterized by accumulation of pathologic mast cells in tissues. Most patients with mastocytosis experience mast cell activation symptoms in response to various triggers. The diagnosis of mastocytosis should be made from objective pathologic findings. Modern diagnostic criteria and classification of ...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2014.02.003
更新日期：2014-05-01 00:00:00
abstract：:This article describes the efficacy, immunogenicity, and safety of CAIV-T. This vaccine has the potential to significantly contribute to the control of influenza infection and influenza-associated illnesses, including febrile otitis media and lower respiratory disease. When compared with inactivated vaccine, CAIV-T ha...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/s0889-8561(03)00098-5
更新日期：2003-11-01 00:00:00
abstract：:Atopic dermatitis (AD) is a heterogeneous disease and many attempts have been made to define subsets of patients based on clinical characteristics. However, the current characterization of patients with AD might not adequately reflect the pathophysiologic diversity within patients with AD. This article reviews current...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2016.08.008
更新日期：2017-02-01 00:00:00
abstract：:Angioedema can be associated with many disorders and the presentation can be variable. Subsets of the angioedema syndromes are thought to be cytokine mediated (Table 1). Of these, the best described are the episodic angioedema with eosinophilia syndrome (Gleich's syndrome) and non-episodic angioedema with eosinophilia...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2006.09.001
更新日期：2006-11-01 00:00:00
abstract：:Allergic rhinitis (AR) is the most common immunologic disease in industrialized societies and has a significant impact on quality of life. Most asthmatics also have rhinitis. AR may present with comorbidities, including chronic otitis media with effusion, cough, and pollen-food cross-reactivity. AR may occur in isolat...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2015.12.003
更新日期：2016-05-01 00:00:00
abstract：:Heterogeneous presentations of disease pose particular diagnostic and management challenges to the clinician. Progestogen hypersensitivity (PH) classically consists of hypersensitivity symptoms to endogenous progesterone during the luteal phase of the menstrual cycle. However, with the rise of assisted fertility and t...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2017.07.006
更新日期：2017-11-01 00:00:00
abstract：:The cause of eosinophilic esophagitis remains unknown, but its epidemiology and clinical features provide pieces to the puzzle. Eosinophilic esophagitis probably emerged in the 1950s or early 1960s, has an increasing incidence, occurs in most developed countries, is related to food allergies, affects adults and childr...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2008.09.005
更新日期：2009-02-01 00:00:00
abstract：:The first rule of environmental allergen control is that avoidance is appropriate for allergic patients with asthma. Although this rule is obvious to allergists, it frequently is not considered by families and physicians who are not trained in allergy. The next step in environmental avoidance is to determine the speci...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/s0889-8561(03)00003-1
更新日期：2003-08-01 00:00:00
abstract：:Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-mediated food allergy that usually presents in infancy. Cow's milk, soy, and grains are the most common food triggers. FPIES can present as a medical emergency with symptoms including delayed persistent emesis or diarrhea that can lead to severe dehydrat...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2017.09.009
更新日期：2018-02-01 00:00:00
abstract：:The autoinflammatory diseases encompass approximately 30 monogenic disorders in which inborn errors in the innate immune system lead to episodic systemic inflammation. Largely mediated by dysregulation of myeloid cells, interleukin (IL)-1β, type I interferon, and NF-κB, these disorders have rapidly expanded over the p...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2018.08.004
更新日期：2019-02-01 00:00:00
abstract：:Delayed pressure urticaria is a mechanical urticaria in which pressure causes whealing. Delayed cutaneous erythema and edema occur in association with marked subcutaneous swelling after the application of a sustained pressure stimulus to the skin. The earliest reports and theories of the pathogenesis of delayed pressu...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2004.01.006
更新日期：2004-05-01 00:00:00
abstract：:A new form of hereditary angioedema (HAE) was identified in the year 2000. Its clinical appearance resembles HAE types I and II, which are caused by mutations that result in a deficiency of C1 inhibitor (C1-INH). In patients with the new form of HAE, C1-INH plasma levels and function values are normal, so it's termed ...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2017.04.004
更新日期：2017-08-01 00:00:00
abstract：:Excessive dynamic airway collapse is a relatively new diagnosis separate from tracheobronchomalacia that is manifested by functional collapse of the large airways. Most commonly described in patients with underlying obstructive lung disease such as chronic obstructive pulmonary disease and asthma, it may contribute to...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2018.01.006
更新日期：2018-05-01 00:00:00
abstract：:The psychologic and behavioral components of sickness represent, together with fever response and associated neuroendocrine changes, a highly organized strategy of the organism to fight infection. This strategy, referred to as sickness behavior, is triggered by the proinflammatory cytokines produced by activated cells...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章
doi：10.1016/j.iac.2009.02.002
更新日期：2009-05-01 00:00:00
abstract：:The interplay of geographic, geochemical, and meteorologic factors combines to define distinct floristic zones in North America. Latitude, elevation, Pacific or Atlantic Ocean influence, continental air mass influence, mountains, and hills are contributory geographic factors. Hardiness zones are defined by the nadir o...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/s0889-8561(03)00029-8
更新日期：2003-08-01 00:00:00
abstract：:Helminth infections may inhibit the development of allergic diseases, including asthma. On the other hand, some helminth species may induce or worsen symptoms of asthma. This article discusses the impact of helminth infections on asthma as well as the potencial of helminth-derived molecules with regulatory characteris...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2019.03.009
更新日期：2019-08-01 00:00:00
