Abstract:
:The autoinflammatory diseases encompass approximately 30 monogenic disorders in which inborn errors in the innate immune system lead to episodic systemic inflammation. Largely mediated by dysregulation of myeloid cells, interleukin (IL)-1β, type I interferon, and NF-κB, these disorders have rapidly expanded over the past several years, and increasing numbers of patients identified. Crossover disorders, bridging autoinflammation and immunodeficiency, have recently been described. This article focuses on the clinical presentation of IL-1 and interferon-driven autoinflammatory disorders, and discusses novel diseases with features of immunodeficiency. Approaches to the clinical diagnosis, genetic testing, and treatment of these disorders are addressed.
journal_name
Immunol Allergy Clin North Amjournal_title
Immunology and allergy clinics of North Americaauthors
Broderick Ldoi
10.1016/j.iac.2018.08.004subject
Has Abstractpub_date
2019-02-01 00:00:00pages
13-29issue
1eissn
0889-8561issn
1557-8607pii
S0889-8561(18)30074-2journal_volume
39pub_type
杂志文章,评审abstract::Recurrent infections in children are a cause for concern. It is essential to distinguish simple recurrent infections caused by exposures in the day care or school settings from those caused by inherent deficiencies in the immune system or other systemic diseases. Multiple diagnostic tools are available for the evaluat...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2015.07.005
更新日期:2015-11-01 00:00:00
abstract::Excessive dynamic airway collapse is a relatively new diagnosis separate from tracheobronchomalacia that is manifested by functional collapse of the large airways. Most commonly described in patients with underlying obstructive lung disease such as chronic obstructive pulmonary disease and asthma, it may contribute to...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2018.01.006
更新日期:2018-05-01 00:00:00
abstract::Moderate to severe atopic dermatitis (AD) negatively affects patients and their families. Pruritus, scratching, and sleep problems are common complaints linked to disturbed quality of life. Treatment is complex, and nonadherence rates are high. This article reviews the effect of AD on patients and their families and i...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章
doi:10.1016/j.iac.2010.05.003
更新日期:2010-08-01 00:00:00
abstract::A new form of hereditary angioedema (HAE) was identified in the year 2000. Its clinical appearance resembles HAE types I and II, which are caused by mutations that result in a deficiency of C1 inhibitor (C1-INH). In patients with the new form of HAE, C1-INH plasma levels and function values are normal, so it's termed ...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2017.04.004
更新日期:2017-08-01 00:00:00
abstract::Allergic rhinitis affects a large portion of the population. Patients are frequently sensitized to indoor allergens. The most important contributors are house dust mites, pets, and fungi. In very controlled environments where allergen exposure is significantly reduced, individuals have been shown to have clinical impr...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章
doi:10.1016/j.iac.2011.05.005
更新日期:2011-08-01 00:00:00
abstract::Certain medications can generate asthma symptoms, with the potential to cause considerable morbidity. This article focuses on the common drugs that have the potential to cause distinct respiratory reactions in asthmatics: aspirin and other nonsteroidal anti-inflammatory drugs, beta-blockers, and angiotensin-converting...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2004.09.009
更新日期:2005-02-01 00:00:00
abstract::"Nonallergic rhinitis" (NAR) is defined by intermittent or persistent nasal symptoms without evidence of immunoglobulin E-mediated sensitization to relevant aeroallergens. The largest subgroup is idiopathic, and is characterized by nasal hyperreactivity to nonspecific environmental triggers, including temperature, hum...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2015.12.013
更新日期:2016-05-01 00:00:00
abstract::This article reviews the primary immunodeficiencies that result in hypogammaglobulinemia or predominantly antibody deficiency disorders. This group makes up the largest proportion of patients with primary immunodeficiency. Significant advances have been made in understanding the molecular basis and clinical characteri...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2008.06.003
更新日期:2008-11-01 00:00:00
abstract::Asthma exacerbations are a significant cause of health care use and mortality. Home management strategies may be effective in managing many exacerbations before presentation to a health care institution. This article focuses on the variety of options available to patients and providers to choose from as they customize...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2019.07.010
更新日期:2019-11-01 00:00:00
abstract::Evaluation of antibodies produced after immunization is central to immune deficiency diagnosis. This includes assessment of responses to routine immunizations as well as to vaccines administered specifically for diagnosis. Here, we present the basic concepts of the humoral immune response and their relevance for vacci...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2020.03.004
更新日期:2020-08-01 00:00:00
abstract::During the last 2 decades, the continued development and the large-scale production of polyclonal immune serum globulin (ISG) preparations with improved safety and tolerability profiles have allowed treatment to focus on quality of life and long-term freedom from the complications of primary immune deficiency disease,...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2008.01.008
更新日期:2008-05-01 00:00:00
abstract::Childhood asthma and obesity have reached epidemic proportions worldwide, and the latter is also contributing to increasing rates of related metabolic disorders, such as diabetes. However, the relationship between asthma, obesity, and abnormal metabolism is not well understood nor has it been adequately explored in ch...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2014.07.002
更新日期:2014-11-01 00:00:00
abstract::Acute eosinophilic pneumonia, chronic eosinophilia, Churg-Strauss syndrome, and the hypereosinophilic syndrome are pulmonary eosinophilic syndromes characterized by an increased number of eosinophils in peripheral blood, in lung tissue, in sputum, in bronchoalveolar lavage fluid, or in all of these. These pulmonary eo...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2007.07.005
更新日期:2007-08-01 00:00:00
abstract::Asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) defines a subgroup of patients with asthma who have persistent airflow obstruction or patients with COPD who may exhibit variable airflow limitation and/or evidence of type 2 inflammation. Additional investigations are needed to determine whether ACO re...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2020.07.002
更新日期:2020-11-01 00:00:00
abstract::Asthma is characterized by persistent airway inflammation, which is associated with airway hyperresponsiveness and variable airflow obstruction, which accounts for the majority of symptoms experienced by asthmatic patients. Allergen sensitization and inhalation causes airway inflammation, and is likely important in th...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2005.05.005
更新日期:2005-08-01 00:00:00
abstract::Helminth infections may inhibit the development of allergic diseases, including asthma. On the other hand, some helminth species may induce or worsen symptoms of asthma. This article discusses the impact of helminth infections on asthma as well as the potencial of helminth-derived molecules with regulatory characteris...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2019.03.009
更新日期:2019-08-01 00:00:00
abstract::In summary, the major physiologic changes that occur in pregnancy are the increased minute ventilation, which is caused by increased respiratory center sensitivity and drive; a compensated respiratory alkalosis; and a low expiratory reserve volume. The vital capacity and measures of forced expiration are well preserve...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2005.10.004
更新日期:2006-02-01 00:00:00
abstract::Hymenoptera venom allergy is a typical IgE-mediated reaction caused by sensitization to 1 or more allergens of the venom, and accounts for 1.5% to 34% of all cases of anaphylaxis. Patients suffering from mastocytosis are more susceptible to the anaphylactic reactions to an insect sting. This article aims to answer the...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2014.02.004
更新日期:2014-05-01 00:00:00
abstract::The major treatment strategies for DH are gluten restriction or medical treatment with sulfones. Control of the cutaneous manifestations, but not the gastrointestinal changes, is rapid with dapsone. In addition to control of the cutaneous signs and symptoms of DH, dietary gluten restriction also induces improvement of...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2012.04.007
更新日期:2012-05-01 00:00:00
abstract::Food allergy is an emerging epidemic in the United States and the Western world. The determination of factors that make certain foods allergenic is still not clearly understood. Only a tiny fraction of thousands of proteins and other molecules is responsible for inducing food allergy. In this review, the authors prese...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2011.12.003
更新日期:2012-02-01 00:00:00
abstract::Physical urticarias are a unique subgroup of chronic urticaria in which urticarial responses can be reproducibly induced by different specific physical stimuli acting on the skin. These conditions include urticaria factitia/symptomatic dermographism, delayed pressure urticaria, cold contact urticaria, heat contact urt...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2013.09.010
更新日期:2014-02-01 00:00:00
abstract::This article summarizes the guidelines for using replacement therapy in the management of patients who have primary antibody deficiency. ...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,实务指引
doi:10.1016/j.iac.2008.07.003
更新日期:2008-11-01 00:00:00
abstract::Allergic rhinitis and asthma should be considered as organ-specific inflammatory diseases in which the genetic background has determined a local overproduction of Th2-type cytokines and an over-expansion of particular APCs and T cells. Among the latter, a potential pathogenetic role could be assumed for natural killer...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2006.11.004
更新日期:2007-02-01 00:00:00
abstract::There is some evidence to support the use of sublingual immunotherapy (SLIT) in food allergy, although its role is unclear. One randomized, double-blind, placebo-controlled trial supports the safe and efficacious use of dust mite SLIT in children with mild to moderate atopic dermatitis, but these data have not been co...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2019.09.011
更新日期:2020-02-01 00:00:00
abstract::Thus far, the most effective strategy for the prevention of food allergy is early introduction of allergenic solids to at-risk infants. Early skin moisturization may have a role in food allergy prevention. There is insufficient evidence for hydrolyzed formula as a means of allergy prevention. Studies on vitamin D, ome...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2019.06.001
更新日期:2019-11-01 00:00:00
abstract::Mastocytosis is a World Health Organization-defined clonal mast cell disorder characterized by significant clinicopathologic heterogeneity. Despite this diversity, a mutation of the KIT gene, most commonly D816V, is found in almost all cases and believed a driver lesion. Peripheral blood allele-specific oligonucleotid...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2018.04.005
更新日期:2018-08-01 00:00:00
abstract::Biologic agents (BAs) are important therapeutic tools; their use has rapidly expanded and they are used in oncology, immunology, and inflammatory diseases. Their use may be limited, however, by adverse drug reactions. This article reviews the current literature on clinical presentation and pathogenic mechanisms of bot...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2014.04.008
更新日期:2014-08-01 00:00:00
abstract::The symptomatic hypereosinophilic patient must be approached in a stepwise manner, with thorough assessment to determine whether the hypereosinophilia itself is contributing to damage and disease manifestations (thereby defining a hypereosinophilic syndrome), and to identify an eventual cause of hypereosinophilia, fol...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2015.05.006
更新日期:2015-08-01 00:00:00
abstract::The cause of eosinophilic esophagitis remains unknown, but its epidemiology and clinical features provide pieces to the puzzle. Eosinophilic esophagitis probably emerged in the 1950s or early 1960s, has an increasing incidence, occurs in most developed countries, is related to food allergies, affects adults and childr...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2008.09.005
更新日期:2009-02-01 00:00:00
abstract::Aspirin-exacerbated respiratory disease is a clinical syndrome characterized by severe, persistent asthma, hyperplastic eosinophilic sinusitis with nasal polyps, and reactions to aspirin and other nonsteroidal antiinflammatory drugs that preferentially inhibit cyclooxygenase 1. The mechanisms behind the therapeutic ef...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2012.11.003
更新日期:2013-05-01 00:00:00