Abstract:
:Asthma is characterized by persistent airway inflammation, which is associated with airway hyperresponsiveness and variable airflow obstruction, which accounts for the majority of symptoms experienced by asthmatic patients. Allergen sensitization and inhalation causes airway inflammation, and is likely important in the initiation and persistence of asthma in more than 50% of patients, and while allergen avoidance (or avoidance of other initiating factors, such as occupational sensitizers) can help some patients, it is often difficult to achieve. For this reason, pharmacologic treatment to reduce airway inflammation is currently the cornerstone of therapy for most individuals who have asthma.
journal_name
Immunol Allergy Clin North Amjournal_title
Immunology and allergy clinics of North Americaauthors
O'Byrne PMdoi
10.1016/j.iac.2005.05.005subject
Has Abstractpub_date
2005-08-01 00:00:00pages
511-21, viissue
3eissn
0889-8561issn
1557-8607pii
S0889-8561(05)00036-6journal_volume
25pub_type
杂志文章,评审abstract::The transient airway narrowing that occurs as a result of exercise is defined as exercise-induced bronchoconstriction (EIB). The prevalence of EIB has been reported to be up to 90% in asthmatic patients, reflecting the level of disease control. However, EIB may develop even in subjects without clinical asthma, particu...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2018.01.007
更新日期:2018-05-01 00:00:00
abstract::This article reviews the dermatologic and allergic conditions of the eyelid. Topics include various eyelid dermatitis, inflammatory lesions, infections, benign and malignant tumor, urticaria, vascular lesions, and others. Treatment considerations for these conditions of the eyelid are also discussed. ...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2007.12.004
更新日期:2008-02-01 00:00:00
abstract::Food allergy is an emerging epidemic in the United States and the Western world. The determination of factors that make certain foods allergenic is still not clearly understood. Only a tiny fraction of thousands of proteins and other molecules is responsible for inducing food allergy. In this review, the authors prese...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2011.12.003
更新日期:2012-02-01 00:00:00
abstract::Respiratory symptoms and asthma control questionnaires are poor predictors of the presence or severity of exercise-induced bronchoconstriction (EIB), and objective measurement is recommended. To optimize the chance of a positive test result, there are several factors to consider when exercising patients for EIB, inclu...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2013.02.006
更新日期:2013-08-01 00:00:00
abstract::Asthma is a complex heterogeneous disease characterized by reversible airflow obstruction. After appropriate diagnosis, the management in school-aged children centers on 3 broad domains: pharmacologic treatment, treatment of underlying comorbidities, and education of the patient and caregivers. It is important to unde...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2018.12.004
更新日期:2019-05-01 00:00:00
abstract::The incidence of immune-mediated anaphylaxis during anesthesia ranges from 1 in 10,000 to 1 in 20,000. Neuromuscular blocking agents represent the most frequently involved substances, followed by latex and antibiotics, but every drug or substance used may be involved. Diagnosis relies on tryptase measurements at the t...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章
doi:10.1016/j.iac.2009.04.004
更新日期:2009-08-01 00:00:00
abstract::Fractional concentration of exhaled nitric oxide (FENO) is a biomarker used to identify allergic airway inflammation. Because it is noninvasive and easy to obtain, its utility has been studied in the diagnosis and management of several respiratory diseases. Much of the research has been done in asthma, and many studie...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2018.06.001
更新日期:2018-11-01 00:00:00
abstract::This article summarizes the guidelines for using replacement therapy in the management of patients who have primary antibody deficiency. ...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,实务指引
doi:10.1016/j.iac.2008.07.003
更新日期:2008-11-01 00:00:00
abstract::Respiratory viruses and allergens synergistically contribute to disease pathogenesis in asthma. Potential mechanisms underlying this clinically relevant association are the subject of intense investigation. This review summarizes current knowledge and recent advances in this area, with an emphasis on potential mechani...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2014.09.012
更新日期:2015-02-01 00:00:00
abstract::Atopic dermatitis (AD) is a heterogeneous disease and many attempts have been made to define subsets of patients based on clinical characteristics. However, the current characterization of patients with AD might not adequately reflect the pathophysiologic diversity within patients with AD. This article reviews current...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2016.08.008
更新日期:2017-02-01 00:00:00
abstract::The study of aging, susceptibility to tumors, and immunity is at an initial stage, and numerous excellent questions challenge immunologists and tumor biologists. Because unpredicted factors contribute to tumor susceptbility in the human population, the authors feel that the development of an animal model is essential ...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/s0889-8561(02)00085-1
更新日期:2003-02-01 00:00:00
abstract::Recurrent infections in children are a cause for concern. It is essential to distinguish simple recurrent infections caused by exposures in the day care or school settings from those caused by inherent deficiencies in the immune system or other systemic diseases. Multiple diagnostic tools are available for the evaluat...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2015.07.005
更新日期:2015-11-01 00:00:00
abstract::Allergic rhinitis and asthma should be considered as organ-specific inflammatory diseases in which the genetic background has determined a local overproduction of Th2-type cytokines and an over-expansion of particular APCs and T cells. Among the latter, a potential pathogenetic role could be assumed for natural killer...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2006.11.004
更新日期:2007-02-01 00:00:00
abstract::Since the initial reports of penicillin and beta-lactam drugs causing allergic reactions, much has been elucidated regarding their pathophysiology and mechanism of action. Despite advances in testing for penicillin allergy, with IgE antibodies and skin tests available for the major and minor determinants of penicillin...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2004.03.004
更新日期:2004-08-01 00:00:00
abstract::Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-mediated food allergy that usually presents in infancy. Cow's milk, soy, and grains are the most common food triggers. FPIES can present as a medical emergency with symptoms including delayed persistent emesis or diarrhea that can lead to severe dehydrat...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2017.09.009
更新日期:2018-02-01 00:00:00
abstract::Biologic agents (BAs) are important therapeutic tools; their use has rapidly expanded and they are used in oncology, immunology, and inflammatory diseases. Their use may be limited, however, by adverse drug reactions. This article reviews the current literature on clinical presentation and pathogenic mechanisms of bot...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2014.04.008
更新日期:2014-08-01 00:00:00
abstract::Inherited defects in components of the nonhomologous end-joining DNA repair mechanism produce a T-B-NK+ severe combined immunodeficiency disease (SCID) characterized by heightened sensitivity to ionizing radiation. Patients with the radiosensitive form of SCID may also have increased short- and long-term sensitivity t...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章
doi:10.1016/j.iac.2009.10.004
更新日期:2010-02-01 00:00:00
abstract::Exercise-induced anaphylaxis is an uncommon disorder in which anaphylaxis occurs in response to physical exertion. Food-dependent exercise-induced anaphylaxis is a disorder with similar symptoms, although symptoms develop only if exercise takes place within a few hours of eating and, in most cases, only if a specific ...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2015.01.005
更新日期:2015-05-01 00:00:00
abstract::Much has been learned from epidemiologic studies conducted in the past 4 decades that can be directly applied to the management of workers affected with occupational asthma. Studies have provided information about host factors, environmental exposure, and occupational agents posing the highest risks for development of...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2011.07.009
更新日期:2011-11-01 00:00:00
abstract::Asthma is an inflammatory condition of both the small and large airways. Recently the small airways have gained attention as studies have shown significant inflammation in the small airways in all severities of asthma. This inflammation has correlated with peripheral airway resistance and as a result, noninvasive meth...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2016.03.009
更新日期:2016-08-01 00:00:00
abstract::The major treatment strategies for DH are gluten restriction or medical treatment with sulfones. Control of the cutaneous manifestations, but not the gastrointestinal changes, is rapid with dapsone. In addition to control of the cutaneous signs and symptoms of DH, dietary gluten restriction also induces improvement of...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2012.04.007
更新日期:2012-05-01 00:00:00
abstract::In the 1970s and 1980s, scientific methods were introduced in the standardization of allergen vaccines and, in combination with improved documentation of the clinical benefits obtained using standardized vaccines, specific allergy treatment as a scientifically based, reproducible, and safe treatment for allergic disea...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2006.02.012
更新日期:2006-05-01 00:00:00
abstract::Mastocytosis is a World Health Organization-defined clonal mast cell disorder characterized by significant clinicopathologic heterogeneity. Despite this diversity, a mutation of the KIT gene, most commonly D816V, is found in almost all cases and believed a driver lesion. Peripheral blood allele-specific oligonucleotid...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2018.04.005
更新日期:2018-08-01 00:00:00
abstract::Prevalence of allergic diseases has been increasing due to multiple factors, among which climate change has had the most impact. Climate factors increase production of pollen, which also exhibits increased allergenicity. Also, as a result of climate change, there has been a shift in flowering phenology and pollen init...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2020.09.006
更新日期:2021-02-01 00:00:00
abstract::Mast cells produce symptoms by local and remote effects of mediator release and by their presence in increased numbers in normal tissue and bone marrow, where they damage and impair normal organ function. Moreover, mast cells are long-lived and heterogeneous in their response to secretagogues and to inhibitors of medi...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2006.05.006
更新日期:2006-08-01 00:00:00
abstract::Mastocytosis is characterized by accumulation of pathologic mast cells in tissues. Most patients with mastocytosis experience mast cell activation symptoms in response to various triggers. The diagnosis of mastocytosis should be made from objective pathologic findings. Modern diagnostic criteria and classification of ...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2014.02.003
更新日期:2014-05-01 00:00:00
abstract::Sublingual immunotherapy (SLIT) represents a significant advance and it seems particularly suitable in pediatric patients. There are favorable results for food allergy in controlled trials. For latex allergy, the results of several trials are encouraging. For atopic dermatitis, previous experience with subcutaneous im...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章
doi:10.1016/j.iac.2011.02.011
更新日期:2011-05-01 00:00:00
abstract::Heterogeneous presentations of disease pose particular diagnostic and management challenges to the clinician. Progestogen hypersensitivity (PH) classically consists of hypersensitivity symptoms to endogenous progesterone during the luteal phase of the menstrual cycle. However, with the rise of assisted fertility and t...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2017.07.006
更新日期:2017-11-01 00:00:00
abstract::This article describes the efficacy, immunogenicity, and safety of CAIV-T. This vaccine has the potential to significantly contribute to the control of influenza infection and influenza-associated illnesses, including febrile otitis media and lower respiratory disease. When compared with inactivated vaccine, CAIV-T ha...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/s0889-8561(03)00098-5
更新日期:2003-11-01 00:00:00
abstract::Measurement of urinary leukotriene E(4) (uLTE(4)) is a sensitive and noninvasive method of assaying total body cysteinyl leukotriene production and changes in cysteinyl leukotriene production. Recent studies have reported on novel uLTE(4) receptor interactions, and new applications for uLTE(4), as a biomarker of envir...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2012.06.012
更新日期:2012-08-01 00:00:00