Abstract：
:This article reviews the primary immunodeficiencies that result in hypogammaglobulinemia or predominantly antibody deficiency disorders. This group makes up the largest proportion of patients with primary immunodeficiency. Significant advances have been made in understanding the molecular basis and clinical characteristics of patients with the more severe forms of antibody deficiency in the last 6 years. Recognition of these disorders remains poor with significant diagnostic delay. The milder forms of antibody deficiency disorders, especially those with normal total serum immunoglobulin G levels, remain poorly characterized and understood. Further work remains to be done in understanding and recognizing these syndromes to benefit patient care and foster further knowledge of the immune system.
journal_name
Immunol Allergy Clin North Amjournal_title
Immunology and allergy clinics of North Americaauthors
Yong PF,Chee R,Grimbacher Bdoi
10.1016/j.iac.2008.06.003subject
Has Abstractpub_date
2008-11-01 00:00:00pages
691-713, viiissue
4eissn
0889-8561issn
1557-8607pii
S0889-8561(08)00071-4journal_volume
28pub_type
杂志文章,评审abstract：:Prevalence of allergic diseases has been increasing due to multiple factors, among which climate change has had the most impact. Climate factors increase production of pollen, which also exhibits increased allergenicity. Also, as a result of climate change, there has been a shift in flowering phenology and pollen init...
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journal_title：Immunology and allergy clinics of North America
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journal_title：Immunology and allergy clinics of North America
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journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
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journal_title：Immunology and allergy clinics of North America
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journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
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journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
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journal_title：Immunology and allergy clinics of North America
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journal_title：Immunology and allergy clinics of North America
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journal_title：Immunology and allergy clinics of North America
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journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
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journal_title：Immunology and allergy clinics of North America
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journal_title：Immunology and allergy clinics of North America
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journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
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journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
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journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
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journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,实务指引
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abstract：:Sublingual immunotherapy (SLIT) represents a significant advance and it seems particularly suitable in pediatric patients. There are favorable results for food allergy in controlled trials. For latex allergy, the results of several trials are encouraging. For atopic dermatitis, previous experience with subcutaneous im...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章
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journal_title：Immunology and allergy clinics of North America
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journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
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journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
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journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2019.12.004
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