abstract：:Prevalence of allergic diseases has been increasing due to multiple factors, among which climate change has had the most impact. Climate factors increase production of pollen, which also exhibits increased allergenicity. Also, as a result of climate change, there has been a shift in flowering phenology and pollen init...

journal_title：Immunology and allergy clinics of North America

authors： Seth D,Bielory L

更新日期：2021-02-01 00:00:00

abstract：:Asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) defines a subgroup of patients with asthma who have persistent airflow obstruction or patients with COPD who may exhibit variable airflow limitation and/or evidence of type 2 inflammation. Additional investigations are needed to determine whether ACO re...

journal_title：Immunology and allergy clinics of North America

authors： Sharma S,Khurana S,Federman AD,Wisnivesky J,Holguin F

更新日期：2020-11-01 00:00:00

abstract：:Evaluation of antibodies produced after immunization is central to immune deficiency diagnosis. This includes assessment of responses to routine immunizations as well as to vaccines administered specifically for diagnosis. Here, we present the basic concepts of the humoral immune response and their relevance for vacci...

journal_title：Immunology and allergy clinics of North America

authors： Bonilla FA

更新日期：2020-08-01 00:00:00

abstract：:Chronic rhinosinusitis (CRS) has a substantial impact on patients' quality of life (QOL). Among the many metrics available for measuring treatment success in CRS, patient-reported outcome measures that quantify changes in QOL are the most widely used methods. In addition, objective data from imaging, endoscopy, and ol...

journal_title：Immunology and allergy clinics of North America

authors： Chowdhury N,Smith TL,Beswick DM

更新日期：2020-05-01 00:00:00

abstract：:There is some evidence to support the use of sublingual immunotherapy (SLIT) in food allergy, although its role is unclear. One randomized, double-blind, placebo-controlled trial supports the safe and efficacious use of dust mite SLIT in children with mild to moderate atopic dermatitis, but these data have not been co...

journal_title：Immunology and allergy clinics of North America

authors： Smith DM,Freeman TM

更新日期：2020-02-01 00:00:00

abstract：:Thus far, the most effective strategy for the prevention of food allergy is early introduction of allergenic solids to at-risk infants. Early skin moisturization may have a role in food allergy prevention. There is insufficient evidence for hydrolyzed formula as a means of allergy prevention. Studies on vitamin D, ome...

journal_title：Immunology and allergy clinics of North America

authors： Abrams EM,Chan ES

更新日期：2019-11-01 00:00:00

abstract：:Asthma exacerbations are a significant cause of health care use and mortality. Home management strategies may be effective in managing many exacerbations before presentation to a health care institution. This article focuses on the variety of options available to patients and providers to choose from as they customize...

journal_title：Immunology and allergy clinics of North America

authors： Ulrich L,Palacios S

更新日期：2019-11-01 00:00:00

abstract：:Helminth infections may inhibit the development of allergic diseases, including asthma. On the other hand, some helminth species may induce or worsen symptoms of asthma. This article discusses the impact of helminth infections on asthma as well as the potencial of helminth-derived molecules with regulatory characteris...

journal_title：Immunology and allergy clinics of North America

authors： Fernandes JS,Cardoso LS,Pitrez PM,Cruz ÁA

更新日期：2019-08-01 00:00:00

abstract：:Asthma is a complex heterogeneous disease characterized by reversible airflow obstruction. After appropriate diagnosis, the management in school-aged children centers on 3 broad domains: pharmacologic treatment, treatment of underlying comorbidities, and education of the patient and caregivers. It is important to unde...

journal_title：Immunology and allergy clinics of North America

authors： Kercsmar CM,Shipp C

更新日期：2019-05-01 00:00:00

abstract：:The autoinflammatory diseases encompass approximately 30 monogenic disorders in which inborn errors in the innate immune system lead to episodic systemic inflammation. Largely mediated by dysregulation of myeloid cells, interleukin (IL)-1β, type I interferon, and NF-κB, these disorders have rapidly expanded over the p...

journal_title：Immunology and allergy clinics of North America

authors： Broderick L

更新日期：2019-02-01 00:00:00

abstract：:Fractional concentration of exhaled nitric oxide (FENO) is a biomarker used to identify allergic airway inflammation. Because it is noninvasive and easy to obtain, its utility has been studied in the diagnosis and management of several respiratory diseases. Much of the research has been done in asthma, and many studie...

journal_title：Immunology and allergy clinics of North America

authors： Hoyte FCL,Gross LM,Katial RK

更新日期：2018-11-01 00:00:00

abstract：:Mastocytosis is a World Health Organization-defined clonal mast cell disorder characterized by significant clinicopathologic heterogeneity. Despite this diversity, a mutation of the KIT gene, most commonly D816V, is found in almost all cases and believed a driver lesion. Peripheral blood allele-specific oligonucleotid...

journal_title：Immunology and allergy clinics of North America

authors： Falchi L,Verstovsek S

更新日期：2018-08-01 00:00:00

abstract：:The transient airway narrowing that occurs as a result of exercise is defined as exercise-induced bronchoconstriction (EIB). The prevalence of EIB has been reported to be up to 90% in asthmatic patients, reflecting the level of disease control. However, EIB may develop even in subjects without clinical asthma, particu...

journal_title：Immunology and allergy clinics of North America

authors： Bonini M,Silvers W

更新日期：2018-05-01 00:00:00

abstract：:Excessive dynamic airway collapse is a relatively new diagnosis separate from tracheobronchomalacia that is manifested by functional collapse of the large airways. Most commonly described in patients with underlying obstructive lung disease such as chronic obstructive pulmonary disease and asthma, it may contribute to...

journal_title：Immunology and allergy clinics of North America

authors： Morris MJ,Woods JT,McLaughlin CW

更新日期：2018-05-01 00:00:00

abstract：:Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-mediated food allergy that usually presents in infancy. Cow's milk, soy, and grains are the most common food triggers. FPIES can present as a medical emergency with symptoms including delayed persistent emesis or diarrhea that can lead to severe dehydrat...

journal_title：Immunology and allergy clinics of North America

authors： Bingemann TA,Sood P,Järvinen KM

更新日期：2018-02-01 00:00:00

abstract：:Heterogeneous presentations of disease pose particular diagnostic and management challenges to the clinician. Progestogen hypersensitivity (PH) classically consists of hypersensitivity symptoms to endogenous progesterone during the luteal phase of the menstrual cycle. However, with the rise of assisted fertility and t...

journal_title：Immunology and allergy clinics of North America

authors： Foer D,Buchheit KM

更新日期：2017-11-01 00:00:00

abstract：:A new form of hereditary angioedema (HAE) was identified in the year 2000. Its clinical appearance resembles HAE types I and II, which are caused by mutations that result in a deficiency of C1 inhibitor (C1-INH). In patients with the new form of HAE, C1-INH plasma levels and function values are normal, so it's termed ...

journal_title：Immunology and allergy clinics of North America

authors： Magerl M,Germenis AE,Maas C,Maurer M

更新日期：2017-08-01 00:00:00

abstract：:Several biologics are currently FDA approved for asthma that target Th2 high patients. Unfortunately, 50% of patients with severe asthma do not fit this phenotype of disease and have fewer effective therapeutic options. In the clinical setting, total IgE, FeNO and peripheral blood eosinophils are important tools in de...

journal_title：Immunology and allergy clinics of North America

authors： Tabatabaian F,Ledford DK,Casale TB

更新日期：2017-05-01 00:00:00

abstract：:Atopic dermatitis (AD) is a common inflammatory condition of the skin that is usually seen in childhood, but can onset or persist into adulthood. The characteristic distribution and morphology based on age, chronic relapsing course, and pruritus comprise the clinical criteria used in the diagnosis of AD. However, the ...

journal_title：Immunology and allergy clinics of North America

authors： Barrett M,Luu M

更新日期：2017-02-01 00:00:00

abstract：:Atopic dermatitis (AD) is a heterogeneous disease and many attempts have been made to define subsets of patients based on clinical characteristics. However, the current characterization of patients with AD might not adequately reflect the pathophysiologic diversity within patients with AD. This article reviews current...

journal_title：Immunology and allergy clinics of North America

authors： Thijs JL,de Bruin-Weller MS,Hijnen D

更新日期：2017-02-01 00:00:00

abstract：:Aspirin-exacerbated respiratory disease is a significant endotype of both asthma and chronic rhinosinusitis with nasal polyps. The disease demonstrates what seems to be a unified inflammatory mechanism culminating in highly eosinophilic nasal polyp disease and asthma. The rate of polyp recurrence and morbidity from as...

journal_title：Immunology and allergy clinics of North America

authors： Stevenson DD,White AA

更新日期：2016-11-01 00:00:00

abstract：:Asthma is an inflammatory condition of both the small and large airways. Recently the small airways have gained attention as studies have shown significant inflammation in the small airways in all severities of asthma. This inflammation has correlated with peripheral airway resistance and as a result, noninvasive meth...

journal_title：Immunology and allergy clinics of North America

authors： Finkas LK,Martin R

更新日期：2016-08-01 00:00:00

abstract：:Allergic rhinitis (AR) is the most common immunologic disease in industrialized societies and has a significant impact on quality of life. Most asthmatics also have rhinitis. AR may present with comorbidities, including chronic otitis media with effusion, cough, and pollen-food cross-reactivity. AR may occur in isolat...

journal_title：Immunology and allergy clinics of North America

authors： Scadding GK,Scadding GW

更新日期：2016-05-01 00:00:00

abstract：:"Nonallergic rhinitis" (NAR) is defined by intermittent or persistent nasal symptoms without evidence of immunoglobulin E-mediated sensitization to relevant aeroallergens. The largest subgroup is idiopathic, and is characterized by nasal hyperreactivity to nonspecific environmental triggers, including temperature, hum...

journal_title：Immunology and allergy clinics of North America

authors： Shusterman D

更新日期：2016-05-01 00:00:00

abstract：:There is a need for newer therapeutic agents that improve the safety of allergen immunotherapy, provide ease of delivery to patients that fosters compliance and allows access to a greater proportion of the allergic population who could benefit from this disease-modifying treatment, and achieve an acceptable therapeuti...

journal_title：Immunology and allergy clinics of North America

authors： Creticos PS

更新日期：2016-02-01 00:00:00

abstract：:Recurrent infections in children are a cause for concern. It is essential to distinguish simple recurrent infections caused by exposures in the day care or school settings from those caused by inherent deficiencies in the immune system or other systemic diseases. Multiple diagnostic tools are available for the evaluat...

journal_title：Immunology and allergy clinics of North America

authors： Hernandez-Trujillo VP

更新日期：2015-11-01 00:00:00

abstract：:The symptomatic hypereosinophilic patient must be approached in a stepwise manner, with thorough assessment to determine whether the hypereosinophilia itself is contributing to damage and disease manifestations (thereby defining a hypereosinophilic syndrome), and to identify an eventual cause of hypereosinophilia, fol...

journal_title：Immunology and allergy clinics of North America

authors： Roufosse F

更新日期：2015-08-01 00:00:00

abstract：:Exercise-induced anaphylaxis is an uncommon disorder in which anaphylaxis occurs in response to physical exertion. Food-dependent exercise-induced anaphylaxis is a disorder with similar symptoms, although symptoms develop only if exercise takes place within a few hours of eating and, in most cases, only if a specific ...

journal_title：Immunology and allergy clinics of North America

authors： Feldweg AM

更新日期：2015-05-01 00:00:00

abstract：:Respiratory viruses and allergens synergistically contribute to disease pathogenesis in asthma. Potential mechanisms underlying this clinically relevant association are the subject of intense investigation. This review summarizes current knowledge and recent advances in this area, with an emphasis on potential mechani...

journal_title：Immunology and allergy clinics of North America

authors： Rowe RK,Gill MA

更新日期：2015-02-01 00:00:00

abstract：:Childhood asthma and obesity have reached epidemic proportions worldwide, and the latter is also contributing to increasing rates of related metabolic disorders, such as diabetes. However, the relationship between asthma, obesity, and abnormal metabolism is not well understood nor has it been adequately explored in ch...

journal_title：Immunology and allergy clinics of North America

authors： Perez MK,Piedimonte G

更新日期：2014-11-01 00:00:00

abstract：:Biologic agents (BAs) are important therapeutic tools; their use has rapidly expanded and they are used in oncology, immunology, and inflammatory diseases. Their use may be limited, however, by adverse drug reactions. This article reviews the current literature on clinical presentation and pathogenic mechanisms of bot...

journal_title：Immunology and allergy clinics of North America

authors： Vultaggio A,Castells MC

更新日期：2014-08-01 00:00:00

abstract：:Mastocytosis is characterized by accumulation of pathologic mast cells in tissues. Most patients with mastocytosis experience mast cell activation symptoms in response to various triggers. The diagnosis of mastocytosis should be made from objective pathologic findings. Modern diagnostic criteria and classification of ...

journal_title：Immunology and allergy clinics of North America

authors： Akin C,Valent P

更新日期：2014-05-01 00:00:00

abstract：:Hymenoptera venom allergy is a typical IgE-mediated reaction caused by sensitization to 1 or more allergens of the venom, and accounts for 1.5% to 34% of all cases of anaphylaxis. Patients suffering from mastocytosis are more susceptible to the anaphylactic reactions to an insect sting. This article aims to answer the...

journal_title：Immunology and allergy clinics of North America

authors： Niedoszytko M,Bonadonna P,Oude Elberink JN,Golden DB

更新日期：2014-05-01 00:00:00

abstract：:Physical urticarias are a unique subgroup of chronic urticaria in which urticarial responses can be reproducibly induced by different specific physical stimuli acting on the skin. These conditions include urticaria factitia/symptomatic dermographism, delayed pressure urticaria, cold contact urticaria, heat contact urt...

journal_title：Immunology and allergy clinics of North America

authors： Abajian M,Schoepke N,Altrichter S,Zuberbier T,Maurer M

更新日期：2014-02-01 00:00:00

abstract：:Angioedema usually occurs within the setting of allergic diseases or urticaria, but situations occur in which angioedema itself represents a disease, such as in hereditary angioedema. Evaluation of patients for recurrent angioedema without wheals must take into account both specific clinical signs and symptoms and spe...

journal_title：Immunology and allergy clinics of North America

authors： Cicardi M,Zanichelli A

更新日期：2013-11-01 00:00:00

abstract：:Respiratory symptoms and asthma control questionnaires are poor predictors of the presence or severity of exercise-induced bronchoconstriction (EIB), and objective measurement is recommended. To optimize the chance of a positive test result, there are several factors to consider when exercising patients for EIB, inclu...

journal_title：Immunology and allergy clinics of North America

authors： Anderson SD,Kippelen P

更新日期：2013-08-01 00:00:00

abstract：:Aspirin-exacerbated respiratory disease is a clinical syndrome characterized by severe, persistent asthma, hyperplastic eosinophilic sinusitis with nasal polyps, and reactions to aspirin and other nonsteroidal antiinflammatory drugs that preferentially inhibit cyclooxygenase 1. The mechanisms behind the therapeutic ef...

journal_title：Immunology and allergy clinics of North America

authors： Burnett T,Katial R,Alam R

更新日期：2013-05-01 00:00:00

abstract：:This article focuses on issues of safety and monitoring when immunosuppressive pharmacologic therapies are prescribed for the treatment of connective tissue disease (CTD)-associated interstitial pneumonias, vasculitides, and bronchiolitis. Prospective, randomized placebo-controlled clinical trials have yet to be perfo...

journal_title：Immunology and allergy clinics of North America

authors： Meyer KC,Bierach J

更新日期：2012-11-01 00:00:00

abstract：:Measurement of urinary leukotriene E(4) (uLTE(4)) is a sensitive and noninvasive method of assaying total body cysteinyl leukotriene production and changes in cysteinyl leukotriene production. Recent studies have reported on novel uLTE(4) receptor interactions, and new applications for uLTE(4), as a biomarker of envir...

journal_title：Immunology and allergy clinics of North America

authors： Rabinovitch N

更新日期：2012-08-01 00:00:00

abstract：:The major treatment strategies for DH are gluten restriction or medical treatment with sulfones. Control of the cutaneous manifestations, but not the gastrointestinal changes, is rapid with dapsone. In addition to control of the cutaneous signs and symptoms of DH, dietary gluten restriction also induces improvement of...

journal_title：Immunology and allergy clinics of North America

authors： Cardones AR,Hall RP 3rd

更新日期：2012-05-01 00:00:00