Abstract：
:Mastocytosis is a World Health Organization-defined clonal mast cell disorder characterized by significant clinicopathologic heterogeneity. Despite this diversity, a mutation of the KIT gene, most commonly D816V, is found in almost all cases and believed a driver lesion. Peripheral blood allele-specific oligonucleotide polymerase chain reaction can reliably detect KIT D816V and is used for the initial screening of adults with suspected systemic mastocytosis. The discovery of KIT mutations as central to the pathobiology of mastocytosis has prompted development of KIT-targeted agents, including imatinib and midostaurin (approved medications for patients with advanced systemic mastocytosis), and drugs in development, like KIT D816V-specific inhibitor avapritinib.
journal_name
Immunol Allergy Clin North Amjournal_title
Immunology and allergy clinics of North Americaauthors
Falchi L,Verstovsek Sdoi
10.1016/j.iac.2018.04.005subject
Has Abstractpub_date
2018-08-01 00:00:00pages
411-428issue
3eissn
0889-8561issn
1557-8607pii
S0889-8561(18)30031-6journal_volume
38pub_type
杂志文章,评审abstract：:In summary, the major physiologic changes that occur in pregnancy are the increased minute ventilation, which is caused by increased respiratory center sensitivity and drive; a compensated respiratory alkalosis; and a low expiratory reserve volume. The vital capacity and measures of forced expiration are well preserve...
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journal_title：Immunology and allergy clinics of North America
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journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
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journal_title：Immunology and allergy clinics of North America
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journal_title：Immunology and allergy clinics of North America
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journal_title：Immunology and allergy clinics of North America
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journal_title：Immunology and allergy clinics of North America
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journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2008.09.005
更新日期：2009-02-01 00:00:00
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journal_title：Immunology and allergy clinics of North America
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journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
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journal_title：Immunology and allergy clinics of North America
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journal_title：Immunology and allergy clinics of North America
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journal_title：Immunology and allergy clinics of North America
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journal_title：Immunology and allergy clinics of North America
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journal_title：Immunology and allergy clinics of North America
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journal_title：Immunology and allergy clinics of North America
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journal_title：Immunology and allergy clinics of North America
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journal_title：Immunology and allergy clinics of North America
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journal_title：Immunology and allergy clinics of North America
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journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章
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journal_title：Immunology and allergy clinics of North America
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