Abstract:
:Measurement of urinary leukotriene E(4) (uLTE(4)) is a sensitive and noninvasive method of assaying total body cysteinyl leukotriene production and changes in cysteinyl leukotriene production. Recent studies have reported on novel uLTE(4) receptor interactions, and new applications for uLTE(4), as a biomarker of environmental exposure to tobacco smoke and ambient air pollution, a predictor of risk for asthma exacerbations related to tobacco smoke, and a marker of susceptibility to leukotriene receptor antagonists.
journal_name
Immunol Allergy Clin North Amjournal_title
Immunology and allergy clinics of North Americaauthors
Rabinovitch Ndoi
10.1016/j.iac.2012.06.012subject
Has Abstractpub_date
2012-08-01 00:00:00pages
433-45issue
3eissn
0889-8561issn
1557-8607pii
S0889-8561(12)00062-8journal_volume
32pub_type
杂志文章,评审abstract::Asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) defines a subgroup of patients with asthma who have persistent airflow obstruction or patients with COPD who may exhibit variable airflow limitation and/or evidence of type 2 inflammation. Additional investigations are needed to determine whether ACO re...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2020.07.002
更新日期:2020-11-01 00:00:00
abstract::The interplay of geographic, geochemical, and meteorologic factors combines to define distinct floristic zones in North America. Latitude, elevation, Pacific or Atlantic Ocean influence, continental air mass influence, mountains, and hills are contributory geographic factors. Hardiness zones are defined by the nadir o...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/s0889-8561(03)00029-8
更新日期:2003-08-01 00:00:00
abstract::Excessive dynamic airway collapse is a relatively new diagnosis separate from tracheobronchomalacia that is manifested by functional collapse of the large airways. Most commonly described in patients with underlying obstructive lung disease such as chronic obstructive pulmonary disease and asthma, it may contribute to...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2018.01.006
更新日期:2018-05-01 00:00:00
abstract::Thus far, the most effective strategy for the prevention of food allergy is early introduction of allergenic solids to at-risk infants. Early skin moisturization may have a role in food allergy prevention. There is insufficient evidence for hydrolyzed formula as a means of allergy prevention. Studies on vitamin D, ome...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2019.06.001
更新日期:2019-11-01 00:00:00
abstract::Exercise-induced anaphylaxis is an uncommon disorder in which anaphylaxis occurs in response to physical exertion. Food-dependent exercise-induced anaphylaxis is a disorder with similar symptoms, although symptoms develop only if exercise takes place within a few hours of eating and, in most cases, only if a specific ...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2015.01.005
更新日期:2015-05-01 00:00:00
abstract::Asthma is a complex heterogeneous disease characterized by reversible airflow obstruction. After appropriate diagnosis, the management in school-aged children centers on 3 broad domains: pharmacologic treatment, treatment of underlying comorbidities, and education of the patient and caregivers. It is important to unde...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2018.12.004
更新日期:2019-05-01 00:00:00
abstract::This article summarizes the guidelines for using replacement therapy in the management of patients who have primary antibody deficiency. ...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,实务指引
doi:10.1016/j.iac.2008.07.003
更新日期:2008-11-01 00:00:00
abstract::Childhood asthma and obesity have reached epidemic proportions worldwide, and the latter is also contributing to increasing rates of related metabolic disorders, such as diabetes. However, the relationship between asthma, obesity, and abnormal metabolism is not well understood nor has it been adequately explored in ch...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2014.07.002
更新日期:2014-11-01 00:00:00
abstract::Angioedema usually occurs within the setting of allergic diseases or urticaria, but situations occur in which angioedema itself represents a disease, such as in hereditary angioedema. Evaluation of patients for recurrent angioedema without wheals must take into account both specific clinical signs and symptoms and spe...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2013.07.001
更新日期:2013-11-01 00:00:00
abstract::Heterogeneous presentations of disease pose particular diagnostic and management challenges to the clinician. Progestogen hypersensitivity (PH) classically consists of hypersensitivity symptoms to endogenous progesterone during the luteal phase of the menstrual cycle. However, with the rise of assisted fertility and t...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2017.07.006
更新日期:2017-11-01 00:00:00
abstract::The transient airway narrowing that occurs as a result of exercise is defined as exercise-induced bronchoconstriction (EIB). The prevalence of EIB has been reported to be up to 90% in asthmatic patients, reflecting the level of disease control. However, EIB may develop even in subjects without clinical asthma, particu...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2018.01.007
更新日期:2018-05-01 00:00:00
abstract::Much has been learned from epidemiologic studies conducted in the past 4 decades that can be directly applied to the management of workers affected with occupational asthma. Studies have provided information about host factors, environmental exposure, and occupational agents posing the highest risks for development of...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2011.07.009
更新日期:2011-11-01 00:00:00
abstract::Asthma and allergies continue to be major public health problems in affluent westernized countries. Changes in dietary habits dating from before the increase in asthma prevalence may have a role in the development of asthma and allergies. Many studies have investigated the role of specific nutrients in asthma and alle...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2008.03.005
更新日期:2008-08-01 00:00:00
abstract::Asthma is an inflammatory condition of both the small and large airways. Recently the small airways have gained attention as studies have shown significant inflammation in the small airways in all severities of asthma. This inflammation has correlated with peripheral airway resistance and as a result, noninvasive meth...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2016.03.009
更新日期:2016-08-01 00:00:00
abstract::Helminth infections may inhibit the development of allergic diseases, including asthma. On the other hand, some helminth species may induce or worsen symptoms of asthma. This article discusses the impact of helminth infections on asthma as well as the potencial of helminth-derived molecules with regulatory characteris...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2019.03.009
更新日期:2019-08-01 00:00:00
abstract::Respiratory viruses and allergens synergistically contribute to disease pathogenesis in asthma. Potential mechanisms underlying this clinically relevant association are the subject of intense investigation. This review summarizes current knowledge and recent advances in this area, with an emphasis on potential mechani...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2014.09.012
更新日期:2015-02-01 00:00:00
abstract::There are many conditions that may present with swelling that mimics angioedema. When swelling persists for greater than a few days or is unresponsive to treatment for urticaria/angioedema, other etiologies should be considered. In most instances, a thorough history and physical examination will define other etiologie...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2006.09.006
更新日期:2006-11-01 00:00:00
abstract::Sublingual immunotherapy (SLIT) represents a significant advance and it seems particularly suitable in pediatric patients. There are favorable results for food allergy in controlled trials. For latex allergy, the results of several trials are encouraging. For atopic dermatitis, previous experience with subcutaneous im...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章
doi:10.1016/j.iac.2011.02.011
更新日期:2011-05-01 00:00:00
abstract::Urticaria and angioedema are commonly encountered complaints in children. Although the diagnosis is clear, establishing an etiology, especially with respect to chronic urticaria, can be challenging. A significant proportion of chronic urticarial cases are now considered to have an autoimmune etiology. This article rev...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2005.03.003
更新日期:2005-05-01 00:00:00
abstract::Mastocytosis is characterized by accumulation of pathologic mast cells in tissues. Most patients with mastocytosis experience mast cell activation symptoms in response to various triggers. The diagnosis of mastocytosis should be made from objective pathologic findings. Modern diagnostic criteria and classification of ...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2014.02.003
更新日期:2014-05-01 00:00:00
abstract::During the last 2 decades, the continued development and the large-scale production of polyclonal immune serum globulin (ISG) preparations with improved safety and tolerability profiles have allowed treatment to focus on quality of life and long-term freedom from the complications of primary immune deficiency disease,...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2008.01.008
更新日期:2008-05-01 00:00:00
abstract::Aspirin-exacerbated respiratory disease is a significant endotype of both asthma and chronic rhinosinusitis with nasal polyps. The disease demonstrates what seems to be a unified inflammatory mechanism culminating in highly eosinophilic nasal polyp disease and asthma. The rate of polyp recurrence and morbidity from as...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2016.06.002
更新日期:2016-11-01 00:00:00
abstract::Prevalence of allergic diseases has been increasing due to multiple factors, among which climate change has had the most impact. Climate factors increase production of pollen, which also exhibits increased allergenicity. Also, as a result of climate change, there has been a shift in flowering phenology and pollen init...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2020.09.006
更新日期:2021-02-01 00:00:00
abstract::The first rule of environmental allergen control is that avoidance is appropriate for allergic patients with asthma. Although this rule is obvious to allergists, it frequently is not considered by families and physicians who are not trained in allergy. The next step in environmental avoidance is to determine the speci...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/s0889-8561(03)00003-1
更新日期:2003-08-01 00:00:00
abstract::Asthma is characterized by persistent airway inflammation, which is associated with airway hyperresponsiveness and variable airflow obstruction, which accounts for the majority of symptoms experienced by asthmatic patients. Allergen sensitization and inhalation causes airway inflammation, and is likely important in th...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2005.05.005
更新日期:2005-08-01 00:00:00
abstract::Asthma is a heterogeneous disease with multiple phenotypes. There are no tissue or bronchoalveolar lavage biomarkers that are "specific" for asthma. Markers associated with eosinophilic, neutrophilic, and paucigranulocytic asthma are discussed here, and those for remodeling. Efforts are to compare tissue and lavage bi...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2007.09.003
更新日期:2007-11-01 00:00:00
abstract::Recurrent infections in children are a cause for concern. It is essential to distinguish simple recurrent infections caused by exposures in the day care or school settings from those caused by inherent deficiencies in the immune system or other systemic diseases. Multiple diagnostic tools are available for the evaluat...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2015.07.005
更新日期:2015-11-01 00:00:00
abstract::Respiratory symptoms and asthma control questionnaires are poor predictors of the presence or severity of exercise-induced bronchoconstriction (EIB), and objective measurement is recommended. To optimize the chance of a positive test result, there are several factors to consider when exercising patients for EIB, inclu...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2013.02.006
更新日期:2013-08-01 00:00:00
abstract::There is a need for newer therapeutic agents that improve the safety of allergen immunotherapy, provide ease of delivery to patients that fosters compliance and allows access to a greater proportion of the allergic population who could benefit from this disease-modifying treatment, and achieve an acceptable therapeuti...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2015.08.010
更新日期:2016-02-01 00:00:00
abstract::The autoinflammatory diseases encompass approximately 30 monogenic disorders in which inborn errors in the innate immune system lead to episodic systemic inflammation. Largely mediated by dysregulation of myeloid cells, interleukin (IL)-1β, type I interferon, and NF-κB, these disorders have rapidly expanded over the p...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2018.08.004
更新日期:2019-02-01 00:00:00