Abstract：
:Urticaria and angioedema are commonly encountered complaints in children. Although the diagnosis is clear, establishing an etiology, especially with respect to chronic urticaria, can be challenging. A significant proportion of chronic urticarial cases are now considered to have an autoimmune etiology. This article reviews progress in the field of urticaria and angioedema including developments in pathogenesis, description of laboratory testing, and review of medications. Urticaria and angioedema can usually be controlled by avoidance of triggers, a variety of supportive medications, and reassurance.
journal_name
Immunol Allergy Clin North Amjournal_title
Immunology and allergy clinics of North Americaauthors
Baxi S,Dinakar Cdoi
10.1016/j.iac.2005.03.003subject
Has Abstractpub_date
2005-05-01 00:00:00pages
353-67, viiissue
2eissn
0889-8561issn
1557-8607pii
S0889-8561(05)00011-1journal_volume
25pub_type
杂志文章,评审abstract：:Based on the hygiene hypothesis association between atopy and bacillus Calmette-Guerin (BCG), purified protein derivative skin test reaction, mycobacterial disease, and environmental mycobacteria are summarized. The role of mycobacterial species in the activation of the innate immune response through Toll-like recepto...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2006.02.002
更新日期：2006-05-01 00:00:00
abstract：:Allergic rhinitis affects a large portion of the population. Patients are frequently sensitized to indoor allergens. The most important contributors are house dust mites, pets, and fungi. In very controlled environments where allergen exposure is significantly reduced, individuals have been shown to have clinical impr...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章
doi：10.1016/j.iac.2011.05.005
更新日期：2011-08-01 00:00:00
abstract：:Childhood asthma and obesity have reached epidemic proportions worldwide, and the latter is also contributing to increasing rates of related metabolic disorders, such as diabetes. However, the relationship between asthma, obesity, and abnormal metabolism is not well understood nor has it been adequately explored in ch...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2014.07.002
更新日期：2014-11-01 00:00:00
abstract：:This article focuses on issues of safety and monitoring when immunosuppressive pharmacologic therapies are prescribed for the treatment of connective tissue disease (CTD)-associated interstitial pneumonias, vasculitides, and bronchiolitis. Prospective, randomized placebo-controlled clinical trials have yet to be perfo...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2012.07.001
更新日期：2012-11-01 00:00:00
abstract：:Since the initial reports of penicillin and beta-lactam drugs causing allergic reactions, much has been elucidated regarding their pathophysiology and mechanism of action. Despite advances in testing for penicillin allergy, with IgE antibodies and skin tests available for the major and minor determinants of penicillin...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2004.03.004
更新日期：2004-08-01 00:00:00
abstract：:Anaphylaxis occurs frequently in the community, and it can be fatal in community settings. Risk assessment and risk reduction should ideally be coordinated by an allergy/immunology specialist and focus on: (1) prevention of subsequent anaphylaxis episodes, (2) emergency preparedness, and (3) anaphylaxis education. Pre...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2007.03.007
更新日期：2007-05-01 00:00:00
abstract：:This article reviews the primary immunodeficiencies that result in hypogammaglobulinemia or predominantly antibody deficiency disorders. This group makes up the largest proportion of patients with primary immunodeficiency. Significant advances have been made in understanding the molecular basis and clinical characteri...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2008.06.003
更新日期：2008-11-01 00:00:00
abstract：:Mastocytosis is a World Health Organization-defined clonal mast cell disorder characterized by significant clinicopathologic heterogeneity. Despite this diversity, a mutation of the KIT gene, most commonly D816V, is found in almost all cases and believed a driver lesion. Peripheral blood allele-specific oligonucleotid...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2018.04.005
更新日期：2018-08-01 00:00:00
abstract：:Chronic rhinosinusitis is a complex heterogeneous disease. Infection in the form of biofilm may have an important, if not central, role in the maintenance of the recalcitrant inflammation for this increasingly common chronic disease. Therefore, the importance of understanding the interaction of biofilm disease with th...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2009.07.005
更新日期：2009-11-01 00:00:00
abstract：:The interplay of geographic, geochemical, and meteorologic factors combines to define distinct floristic zones in North America. Latitude, elevation, Pacific or Atlantic Ocean influence, continental air mass influence, mountains, and hills are contributory geographic factors. Hardiness zones are defined by the nadir o...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/s0889-8561(03)00029-8
更新日期：2003-08-01 00:00:00
abstract：:There is some evidence to support the use of sublingual immunotherapy (SLIT) in food allergy, although its role is unclear. One randomized, double-blind, placebo-controlled trial supports the safe and efficacious use of dust mite SLIT in children with mild to moderate atopic dermatitis, but these data have not been co...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2019.09.011
更新日期：2020-02-01 00:00:00
abstract：:Although it is not yet known how many genes may contribute to the susceptibility or the severity of asthma and related phenotypes, genome-wide screens and positional cloning techniques have been successful in identifying contributing genes in multiple populations. The results of these studies provide additional insigh...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章
doi：10.1016/j.iac.2005.09.003
更新日期：2005-11-01 00:00:00
abstract：:Aspirin-exacerbated respiratory disease is a significant endotype of both asthma and chronic rhinosinusitis with nasal polyps. The disease demonstrates what seems to be a unified inflammatory mechanism culminating in highly eosinophilic nasal polyp disease and asthma. The rate of polyp recurrence and morbidity from as...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2016.06.002
更新日期：2016-11-01 00:00:00
abstract：:Inherited defects in components of the nonhomologous end-joining DNA repair mechanism produce a T-B-NK+ severe combined immunodeficiency disease (SCID) characterized by heightened sensitivity to ionizing radiation. Patients with the radiosensitive form of SCID may also have increased short- and long-term sensitivity t...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章
doi：10.1016/j.iac.2009.10.004
更新日期：2010-02-01 00:00:00
abstract：:Mast cells produce symptoms by local and remote effects of mediator release and by their presence in increased numbers in normal tissue and bone marrow, where they damage and impair normal organ function. Moreover, mast cells are long-lived and heterogeneous in their response to secretagogues and to inhibitors of medi...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2006.05.006
更新日期：2006-08-01 00:00:00
abstract：:Excessive dynamic airway collapse is a relatively new diagnosis separate from tracheobronchomalacia that is manifested by functional collapse of the large airways. Most commonly described in patients with underlying obstructive lung disease such as chronic obstructive pulmonary disease and asthma, it may contribute to...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2018.01.006
更新日期：2018-05-01 00:00:00
abstract：:Several biologics are currently FDA approved for asthma that target Th2 high patients. Unfortunately, 50% of patients with severe asthma do not fit this phenotype of disease and have fewer effective therapeutic options. In the clinical setting, total IgE, FeNO and peripheral blood eosinophils are important tools in de...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2017.01.007
更新日期：2017-05-01 00:00:00
abstract：:Moderate to severe atopic dermatitis (AD) negatively affects patients and their families. Pruritus, scratching, and sleep problems are common complaints linked to disturbed quality of life. Treatment is complex, and nonadherence rates are high. This article reviews the effect of AD on patients and their families and i...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章
doi：10.1016/j.iac.2010.05.003
更新日期：2010-08-01 00:00:00
abstract：:Stress reduction interventions can have a positive therapeutic effect in autoimmune disease patients. Physicians and patients must recognize the potential for stress to impact autoimmune diseases and how stress management should be considered in a multidimensional treatment approach. This article evaluates the effects...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2010.09.004
更新日期：2011-02-01 00:00:00
abstract：:Prevalence of allergic diseases has been increasing due to multiple factors, among which climate change has had the most impact. Climate factors increase production of pollen, which also exhibits increased allergenicity. Also, as a result of climate change, there has been a shift in flowering phenology and pollen init...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2020.09.006
更新日期：2021-02-01 00:00:00
abstract：:Chronic rhinosinusitis (CRS) has a substantial impact on patients' quality of life (QOL). Among the many metrics available for measuring treatment success in CRS, patient-reported outcome measures that quantify changes in QOL are the most widely used methods. In addition, objective data from imaging, endoscopy, and ol...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2019.12.004
更新日期：2020-05-01 00:00:00
abstract：:The transient airway narrowing that occurs as a result of exercise is defined as exercise-induced bronchoconstriction (EIB). The prevalence of EIB has been reported to be up to 90% in asthmatic patients, reflecting the level of disease control. However, EIB may develop even in subjects without clinical asthma, particu...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2018.01.007
更新日期：2018-05-01 00:00:00
abstract：:In summary, the major physiologic changes that occur in pregnancy are the increased minute ventilation, which is caused by increased respiratory center sensitivity and drive; a compensated respiratory alkalosis; and a low expiratory reserve volume. The vital capacity and measures of forced expiration are well preserve...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2005.10.004
更新日期：2006-02-01 00:00:00
abstract：:Measurement of urinary leukotriene E(4) (uLTE(4)) is a sensitive and noninvasive method of assaying total body cysteinyl leukotriene production and changes in cysteinyl leukotriene production. Recent studies have reported on novel uLTE(4) receptor interactions, and new applications for uLTE(4), as a biomarker of envir...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2012.06.012
更新日期：2012-08-01 00:00:00
abstract：:The autoinflammatory diseases encompass approximately 30 monogenic disorders in which inborn errors in the innate immune system lead to episodic systemic inflammation. Largely mediated by dysregulation of myeloid cells, interleukin (IL)-1β, type I interferon, and NF-κB, these disorders have rapidly expanded over the p...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2018.08.004
更新日期：2019-02-01 00:00:00
abstract：:Acute eosinophilic pneumonia, chronic eosinophilia, Churg-Strauss syndrome, and the hypereosinophilic syndrome are pulmonary eosinophilic syndromes characterized by an increased number of eosinophils in peripheral blood, in lung tissue, in sputum, in bronchoalveolar lavage fluid, or in all of these. These pulmonary eo...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2007.07.005
更新日期：2007-08-01 00:00:00
abstract：:Much has been learned from epidemiologic studies conducted in the past 4 decades that can be directly applied to the management of workers affected with occupational asthma. Studies have provided information about host factors, environmental exposure, and occupational agents posing the highest risks for development of...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2011.07.009
更新日期：2011-11-01 00:00:00
abstract：:Aspirin-exacerbated respiratory disease is a clinical syndrome characterized by severe, persistent asthma, hyperplastic eosinophilic sinusitis with nasal polyps, and reactions to aspirin and other nonsteroidal antiinflammatory drugs that preferentially inhibit cyclooxygenase 1. The mechanisms behind the therapeutic ef...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2012.11.003
更新日期：2013-05-01 00:00:00
abstract：:Asthma is a heterogeneous disease with multiple phenotypes. There are no tissue or bronchoalveolar lavage biomarkers that are "specific" for asthma. Markers associated with eosinophilic, neutrophilic, and paucigranulocytic asthma are discussed here, and those for remodeling. Efforts are to compare tissue and lavage bi...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2007.09.003
更新日期：2007-11-01 00:00:00
abstract：:The first rule of environmental allergen control is that avoidance is appropriate for allergic patients with asthma. Although this rule is obvious to allergists, it frequently is not considered by families and physicians who are not trained in allergy. The next step in environmental avoidance is to determine the speci...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/s0889-8561(03)00003-1
更新日期：2003-08-01 00:00:00
