Abstract:
:This article describes the efficacy, immunogenicity, and safety of CAIV-T. This vaccine has the potential to significantly contribute to the control of influenza infection and influenza-associated illnesses, including febrile otitis media and lower respiratory disease. When compared with inactivated vaccine, CAIV-T has significant advantages in convenience of administration. The high efficacy of CAIV-T and its efficacy in children against a significantly drifted strain of H3N2 (A/Sydney), a strain not contained in the vaccine, are compelling observations for use of the vaccine in children. Effectiveness in adults was demonstrated using the same vaccine strain against the drifted H3N2 strain. The proposed vaccine administration schedule for healthy individuals aged 9 to 49 years is a single dose administered annually before the winter. For children aged 5 to 8 years, two doses are recommended the first year they are immunized with CAIV-T to ensure protection against all strains contained in the vaccine. Thereafter, a single annual revaccination is sufficient.
journal_name
Immunol Allergy Clin North Amjournal_title
Immunology and allergy clinics of North Americaauthors
Belshe RB,Mendelman PMdoi
10.1016/s0889-8561(03)00098-5subject
Has Abstractpub_date
2003-11-01 00:00:00pages
745-67issue
4eissn
0889-8561issn
1557-8607pii
S0889-8561(03)00098-5journal_volume
23pub_type
杂志文章,评审abstract::Asthma is a heterogeneous disease in which various cytokines orchestrate airway inflammation. Tumor necrosis alpha (TNF-alpha) is a proinflammatory cytokine that has been implicated in the modulation of inflammation in various diseases, including asthma. Although TNF-alpha blocking strategies have been an effective th...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2004.06.010
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abstract::Allergic rhinitis affects a large portion of the population. Patients are frequently sensitized to indoor allergens. The most important contributors are house dust mites, pets, and fungi. In very controlled environments where allergen exposure is significantly reduced, individuals have been shown to have clinical impr...
journal_title:Immunology and allergy clinics of North America
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abstract::Eosinophilic gastrointestinal diseases (EGIDs) encompass a variety of disorders including eosinophilic esophagitis (EE), eosinophilic gastroenteritis (EG), and eosinophilic colitis. Although the pathogenesis of EGIDs is still poorly understood, dietary food antigens have been shown to cause EGIDs through several short...
journal_title:Immunology and allergy clinics of North America
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journal_title:Immunology and allergy clinics of North America
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journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2014.02.003
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abstract::Mastocytosis is a World Health Organization-defined clonal mast cell disorder characterized by significant clinicopathologic heterogeneity. Despite this diversity, a mutation of the KIT gene, most commonly D816V, is found in almost all cases and believed a driver lesion. Peripheral blood allele-specific oligonucleotid...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2018.04.005
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journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2013.02.006
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journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2010.02.003
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journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
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journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2015.12.003
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journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2013.07.001
更新日期:2013-11-01 00:00:00
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journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2016.08.009
更新日期:2017-02-01 00:00:00
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journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2015.01.005
更新日期:2015-05-01 00:00:00
abstract::A new form of hereditary angioedema (HAE) was identified in the year 2000. Its clinical appearance resembles HAE types I and II, which are caused by mutations that result in a deficiency of C1 inhibitor (C1-INH). In patients with the new form of HAE, C1-INH plasma levels and function values are normal, so it's termed ...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2017.04.004
更新日期:2017-08-01 00:00:00
abstract::Asthma is a complex heterogeneous disease characterized by reversible airflow obstruction. After appropriate diagnosis, the management in school-aged children centers on 3 broad domains: pharmacologic treatment, treatment of underlying comorbidities, and education of the patient and caregivers. It is important to unde...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2018.12.004
更新日期:2019-05-01 00:00:00
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journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2004.09.009
更新日期:2005-02-01 00:00:00
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journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2010.08.003
更新日期:2010-11-01 00:00:00
abstract::Prevalence of allergic diseases has been increasing due to multiple factors, among which climate change has had the most impact. Climate factors increase production of pollen, which also exhibits increased allergenicity. Also, as a result of climate change, there has been a shift in flowering phenology and pollen init...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2020.09.006
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abstract::Inherited defects in components of the nonhomologous end-joining DNA repair mechanism produce a T-B-NK+ severe combined immunodeficiency disease (SCID) characterized by heightened sensitivity to ionizing radiation. Patients with the radiosensitive form of SCID may also have increased short- and long-term sensitivity t...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章
doi:10.1016/j.iac.2009.10.004
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abstract::Stress reduction interventions can have a positive therapeutic effect in autoimmune disease patients. Physicians and patients must recognize the potential for stress to impact autoimmune diseases and how stress management should be considered in a multidimensional treatment approach. This article evaluates the effects...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2010.09.004
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abstract::The cause of eosinophilic esophagitis remains unknown, but its epidemiology and clinical features provide pieces to the puzzle. Eosinophilic esophagitis probably emerged in the 1950s or early 1960s, has an increasing incidence, occurs in most developed countries, is related to food allergies, affects adults and childr...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2008.09.005
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journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2005.10.004
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journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2019.06.001
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abstract::Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-mediated food allergy that usually presents in infancy. Cow's milk, soy, and grains are the most common food triggers. FPIES can present as a medical emergency with symptoms including delayed persistent emesis or diarrhea that can lead to severe dehydrat...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2017.09.009
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abstract::In the 1970s and 1980s, scientific methods were introduced in the standardization of allergen vaccines and, in combination with improved documentation of the clinical benefits obtained using standardized vaccines, specific allergy treatment as a scientifically based, reproducible, and safe treatment for allergic disea...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2006.02.012
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abstract::Physical urticarias are a unique subgroup of chronic urticaria in which urticarial responses can be reproducibly induced by different specific physical stimuli acting on the skin. These conditions include urticaria factitia/symptomatic dermographism, delayed pressure urticaria, cold contact urticaria, heat contact urt...
journal_title:Immunology and allergy clinics of North America
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doi:10.1016/j.iac.2013.09.010
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abstract::The interplay of geographic, geochemical, and meteorologic factors combines to define distinct floristic zones in North America. Latitude, elevation, Pacific or Atlantic Ocean influence, continental air mass influence, mountains, and hills are contributory geographic factors. Hardiness zones are defined by the nadir o...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/s0889-8561(03)00029-8
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abstract::There is a need for newer therapeutic agents that improve the safety of allergen immunotherapy, provide ease of delivery to patients that fosters compliance and allows access to a greater proportion of the allergic population who could benefit from this disease-modifying treatment, and achieve an acceptable therapeuti...
journal_title:Immunology and allergy clinics of North America
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abstract::This article focuses on issues of safety and monitoring when immunosuppressive pharmacologic therapies are prescribed for the treatment of connective tissue disease (CTD)-associated interstitial pneumonias, vasculitides, and bronchiolitis. Prospective, randomized placebo-controlled clinical trials have yet to be perfo...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2012.07.001
更新日期:2012-11-01 00:00:00
abstract::The symptomatic hypereosinophilic patient must be approached in a stepwise manner, with thorough assessment to determine whether the hypereosinophilia itself is contributing to damage and disease manifestations (thereby defining a hypereosinophilic syndrome), and to identify an eventual cause of hypereosinophilia, fol...
journal_title:Immunology and allergy clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.iac.2015.05.006
更新日期:2015-08-01 00:00:00