Abstract：
:Asthma is a heterogeneous disease in which various cytokines orchestrate airway inflammation. Tumor necrosis alpha (TNF-alpha) is a proinflammatory cytokine that has been implicated in the modulation of inflammation in various diseases, including asthma. Although TNF-alpha blocking strategies have been an effective therapeutic modality in diseases such as rheumatoid arthritis, their role in asthma and the effects of the blockade in asthma is poorly understood. This article examines the role of TNF-alpha in asthma and the effects of blocking TNF-alpha as a possible therapeutic option in patients with severe corticosteroid-dependent asthma.
journal_name
Immunol Allergy Clin North Amjournal_title
Immunology and allergy clinics of North Americaauthors
Babu KS,Davies DE,Holgate STdoi
10.1016/j.iac.2004.06.010subject
Has Abstractpub_date
2004-11-01 00:00:00pages
583-97, v-viissue
4eissn
0889-8561issn
1557-8607pii
S0889-8561(04)00085-2journal_volume
24pub_type
杂志文章,评审abstract：:There are many conditions that may present with swelling that mimics angioedema. When swelling persists for greater than a few days or is unresponsive to treatment for urticaria/angioedema, other etiologies should be considered. In most instances, a thorough history and physical examination will define other etiologie...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2006.09.006
更新日期：2006-11-01 00:00:00
abstract：:Atopic dermatitis (AD) is a heterogeneous disease and many attempts have been made to define subsets of patients based on clinical characteristics. However, the current characterization of patients with AD might not adequately reflect the pathophysiologic diversity within patients with AD. This article reviews current...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2016.08.008
更新日期：2017-02-01 00:00:00
abstract：:Helminth infections may inhibit the development of allergic diseases, including asthma. On the other hand, some helminth species may induce or worsen symptoms of asthma. This article discusses the impact of helminth infections on asthma as well as the potencial of helminth-derived molecules with regulatory characteris...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2019.03.009
更新日期：2019-08-01 00:00:00
abstract：:Excessive dynamic airway collapse is a relatively new diagnosis separate from tracheobronchomalacia that is manifested by functional collapse of the large airways. Most commonly described in patients with underlying obstructive lung disease such as chronic obstructive pulmonary disease and asthma, it may contribute to...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2018.01.006
更新日期：2018-05-01 00:00:00
abstract：:Chronic rhinosinusitis is a complex heterogeneous disease. Infection in the form of biofilm may have an important, if not central, role in the maintenance of the recalcitrant inflammation for this increasingly common chronic disease. Therefore, the importance of understanding the interaction of biofilm disease with th...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2009.07.005
更新日期：2009-11-01 00:00:00
abstract：:Allergic rhinitis (AR) is the most common immunologic disease in industrialized societies and has a significant impact on quality of life. Most asthmatics also have rhinitis. AR may present with comorbidities, including chronic otitis media with effusion, cough, and pollen-food cross-reactivity. AR may occur in isolat...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2015.12.003
更新日期：2016-05-01 00:00:00
abstract：:The study of aging, susceptibility to tumors, and immunity is at an initial stage, and numerous excellent questions challenge immunologists and tumor biologists. Because unpredicted factors contribute to tumor susceptbility in the human population, the authors feel that the development of an animal model is essential ...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/s0889-8561(02)00085-1
更新日期：2003-02-01 00:00:00
abstract：:This article reviews the dermatologic and allergic conditions of the eyelid. Topics include various eyelid dermatitis, inflammatory lesions, infections, benign and malignant tumor, urticaria, vascular lesions, and others. Treatment considerations for these conditions of the eyelid are also discussed. ...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2007.12.004
更新日期：2008-02-01 00:00:00
abstract：:Measurement of urinary leukotriene E(4) (uLTE(4)) is a sensitive and noninvasive method of assaying total body cysteinyl leukotriene production and changes in cysteinyl leukotriene production. Recent studies have reported on novel uLTE(4) receptor interactions, and new applications for uLTE(4), as a biomarker of envir...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2012.06.012
更新日期：2012-08-01 00:00:00
abstract：:Aspirin-exacerbated respiratory disease is a significant endotype of both asthma and chronic rhinosinusitis with nasal polyps. The disease demonstrates what seems to be a unified inflammatory mechanism culminating in highly eosinophilic nasal polyp disease and asthma. The rate of polyp recurrence and morbidity from as...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2016.06.002
更新日期：2016-11-01 00:00:00
abstract：:Urticaria and angioedema are commonly encountered complaints in children. Although the diagnosis is clear, establishing an etiology, especially with respect to chronic urticaria, can be challenging. A significant proportion of chronic urticarial cases are now considered to have an autoimmune etiology. This article rev...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2005.03.003
更新日期：2005-05-01 00:00:00
abstract：:Exercise-induced anaphylaxis is an uncommon disorder in which anaphylaxis occurs in response to physical exertion. Food-dependent exercise-induced anaphylaxis is a disorder with similar symptoms, although symptoms develop only if exercise takes place within a few hours of eating and, in most cases, only if a specific ...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2015.01.005
更新日期：2015-05-01 00:00:00
abstract：:Food allergy is an emerging epidemic in the United States and the Western world. The determination of factors that make certain foods allergenic is still not clearly understood. Only a tiny fraction of thousands of proteins and other molecules is responsible for inducing food allergy. In this review, the authors prese...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2011.12.003
更新日期：2012-02-01 00:00:00
abstract：:Childhood asthma and obesity have reached epidemic proportions worldwide, and the latter is also contributing to increasing rates of related metabolic disorders, such as diabetes. However, the relationship between asthma, obesity, and abnormal metabolism is not well understood nor has it been adequately explored in ch...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2014.07.002
更新日期：2014-11-01 00:00:00
abstract：:Mastocytosis is characterized by accumulation of pathologic mast cells in tissues. Most patients with mastocytosis experience mast cell activation symptoms in response to various triggers. The diagnosis of mastocytosis should be made from objective pathologic findings. Modern diagnostic criteria and classification of ...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2014.02.003
更新日期：2014-05-01 00:00:00
abstract：:The cause of eosinophilic esophagitis remains unknown, but its epidemiology and clinical features provide pieces to the puzzle. Eosinophilic esophagitis probably emerged in the 1950s or early 1960s, has an increasing incidence, occurs in most developed countries, is related to food allergies, affects adults and childr...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2008.09.005
更新日期：2009-02-01 00:00:00
abstract：:Mycoplasma pneumoniae and Chlamydophila pneumoniae are atypical bacteria that are frequently found in patients with asthma. A definitive diagnosis of infection is often difficult to obtain because of limitations with sampling and detection. Numerous animal studies have outlined mechanisms by which these infections may...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2010.08.003
更新日期：2010-11-01 00:00:00
abstract：:Prevalence of allergic diseases has been increasing due to multiple factors, among which climate change has had the most impact. Climate factors increase production of pollen, which also exhibits increased allergenicity. Also, as a result of climate change, there has been a shift in flowering phenology and pollen init...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2020.09.006
更新日期：2021-02-01 00:00:00
abstract：:Delayed pressure urticaria is a mechanical urticaria in which pressure causes whealing. Delayed cutaneous erythema and edema occur in association with marked subcutaneous swelling after the application of a sustained pressure stimulus to the skin. The earliest reports and theories of the pathogenesis of delayed pressu...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2004.01.006
更新日期：2004-05-01 00:00:00
abstract：:Sublingual immunotherapy (SLIT) represents a significant advance and it seems particularly suitable in pediatric patients. There are favorable results for food allergy in controlled trials. For latex allergy, the results of several trials are encouraging. For atopic dermatitis, previous experience with subcutaneous im...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章
doi：10.1016/j.iac.2011.02.011
更新日期：2011-05-01 00:00:00
abstract：:Asthma is an inflammatory condition of both the small and large airways. Recently the small airways have gained attention as studies have shown significant inflammation in the small airways in all severities of asthma. This inflammation has correlated with peripheral airway resistance and as a result, noninvasive meth...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2016.03.009
更新日期：2016-08-01 00:00:00
abstract：:A new form of hereditary angioedema (HAE) was identified in the year 2000. Its clinical appearance resembles HAE types I and II, which are caused by mutations that result in a deficiency of C1 inhibitor (C1-INH). In patients with the new form of HAE, C1-INH plasma levels and function values are normal, so it's termed ...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2017.04.004
更新日期：2017-08-01 00:00:00
abstract：:Recurrent infections in children are a cause for concern. It is essential to distinguish simple recurrent infections caused by exposures in the day care or school settings from those caused by inherent deficiencies in the immune system or other systemic diseases. Multiple diagnostic tools are available for the evaluat...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2015.07.005
更新日期：2015-11-01 00:00:00
abstract：:Biologic agents (BAs) are important therapeutic tools; their use has rapidly expanded and they are used in oncology, immunology, and inflammatory diseases. Their use may be limited, however, by adverse drug reactions. This article reviews the current literature on clinical presentation and pathogenic mechanisms of bot...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2014.04.008
更新日期：2014-08-01 00:00:00
abstract：:There is some evidence to support the use of sublingual immunotherapy (SLIT) in food allergy, although its role is unclear. One randomized, double-blind, placebo-controlled trial supports the safe and efficacious use of dust mite SLIT in children with mild to moderate atopic dermatitis, but these data have not been co...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2019.09.011
更新日期：2020-02-01 00:00:00
abstract：:This article reviews the primary immunodeficiencies that result in hypogammaglobulinemia or predominantly antibody deficiency disorders. This group makes up the largest proportion of patients with primary immunodeficiency. Significant advances have been made in understanding the molecular basis and clinical characteri...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2008.06.003
更新日期：2008-11-01 00:00:00
abstract：:Anaphylaxis occurs frequently in the community, and it can be fatal in community settings. Risk assessment and risk reduction should ideally be coordinated by an allergy/immunology specialist and focus on: (1) prevention of subsequent anaphylaxis episodes, (2) emergency preparedness, and (3) anaphylaxis education. Pre...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2007.03.007
更新日期：2007-05-01 00:00:00
abstract：:Physical urticarias are a unique subgroup of chronic urticaria in which urticarial responses can be reproducibly induced by different specific physical stimuli acting on the skin. These conditions include urticaria factitia/symptomatic dermographism, delayed pressure urticaria, cold contact urticaria, heat contact urt...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2013.09.010
更新日期：2014-02-01 00:00:00
abstract：:Asthma and allergies continue to be major public health problems in affluent westernized countries. Changes in dietary habits dating from before the increase in asthma prevalence may have a role in the development of asthma and allergies. Many studies have investigated the role of specific nutrients in asthma and alle...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2008.03.005
更新日期：2008-08-01 00:00:00
abstract：:In the 1970s and 1980s, scientific methods were introduced in the standardization of allergen vaccines and, in combination with improved documentation of the clinical benefits obtained using standardized vaccines, specific allergy treatment as a scientifically based, reproducible, and safe treatment for allergic disea...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2006.02.012
更新日期：2006-05-01 00:00:00
