Abstract:
:A computer-aided docking study was carried out to quickly clarify the binding structure of the ligand-receptor complex between bisphenol A (BPA), a well-known endocrine disruptor, and estrogen-related receptor gamma (ERRgamma). The resulting complex indicated that BPA binds to the ligand-binding pocket of ERRgamma without any disruptions of the activation conformation.
journal_name
Protein Pept Lettjournal_title
Protein and peptide lettersauthors
Nose T,Shimohigashi Ydoi
10.2174/092986608783744261subject
Has Abstractpub_date
2008-01-01 00:00:00pages
290-6issue
3eissn
0929-8665issn
1875-5305journal_volume
15pub_type
杂志文章abstract::Interaction between S100P and its target protein is an essential step in several cellular functions. The amphipathic mellitin peptide binds tightly to S100P protein in the presence of calcium cation. Since little is known about the recognition sequence, mellitin interaction form a model for S100P. Interaction between ...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986606775338380
更新日期:2006-01-01 00:00:00
abstract::Class I fusion glycoproteins of viruses are involved in the fusion between viral envelope and cell membrane. A region located in the N-terminal domain of these glycoproteins, called the fusion peptide, is essential for fusion. Fusion peptides are able to induce by themselves in vitro membrane fusion. In this paper, we...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/092986609788681724
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Searching the biomarker from complex heterogeneous material for early detection of disease is a challenging task in the field of biomedical sciences. OBJECTIVE:The study has been arranged to explore the proteomics serum derived profiling of the differential expressed and low molecular weight protein in brea...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866527666200110155609
更新日期:2020-01-01 00:00:00
abstract::The aerotolerance of the lactic - fermentative bacterium Streptococcus thermophilus is mainly based on the key antioxidant function of superoxide dismutase (StSOD). In this work, the comparison of recombinant StSOD (rStSOD) forms obtained from two different initiation triplets indicated that the enzyme from S. thermop...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986612799363127
更新日期:2012-03-01 00:00:00
abstract::Classification of newly determined protein structures is important in understanding their function and mechanism of action. Currently available methods employ a global structure alignment strategy and are computationally expensive. We propose a two-step methodology with a quick screen to significantly reduce the numbe...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986607781483877
更新日期:2007-01-01 00:00:00
abstract::Human ankyrin repeat and suppressor of cytokine signaling box protein 9 (hASB9), a subunit of an Elongin C-cullin-SOCS box (ECS) E3 ubiquitin ligase complex, is believed to be involved in specific substrate-recognition for ubiquitination and degradation. In fact, this specific substrate-recognition is determined by th...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986609787601688
更新日期:2009-01-01 00:00:00
abstract::Polymyositis is an inflammatory myopathy characterized by muscle invasion of T-cells penetrating the basal lamina and displacing the plasma membrane of normal muscle fibers. In order to understand the different adhesive mechanisms at the T-cell surface, Schubert randomly selected 19 proteins expressed at the T-cell su...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986612801619534
更新日期:2012-08-01 00:00:00
abstract::Bromelain inhibitor, "bromein", is a proteinase-inhibitor specific to the cysteine proteinase bromelain from pineapple stem. In the stem, eight bromein isoforms are known to exist, and each isoform has a short peptide (light chain) and a long one (heavy chain) with five disulfide bonds. The three-dimensional structure...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/0929866525666180821115432
更新日期:2018-01-01 00:00:00
abstract::Hepatitis C virus and related viruses in the Flaviviridae family (such as dengue virus, yellow fever virus or West Nile virus) are amongst the most important human pathogens, causing substantial morbidity and mortality world-wide. The production of viral progeny in Flaviviridae is orchestrated by the small, multifunct...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/092986610791498911
更新日期:2010-08-01 00:00:00
abstract::DrTI was effective against trypsin-like enzymes from A. kuehniella and C. cephalonica, however an artificial diet was insufficient to affect the survival and body weight of either insect. The inhibitor stimulated chymotrypsin-like enzymes and probably induced the synthesis of enzymes insensitive to TLCK in neonate lar...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986609789839395
更新日期:2009-01-01 00:00:00
abstract::Peptides with more than one biological activity are many a times multifunctional peptides. Two peptides with multifunctional properties from alpha (S2)-casein were stabilized in presence of cosolvents for their biological activities like ACE inhibition activity and antioxidant activity. These bioactive peptides in cos...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986608784246416
更新日期:2008-01-01 00:00:00
abstract::Spermadhesins are a family of secretory proteins expressed in the male genital tract of pig, horse and bull. Their function and structure have been widely studied, especially those isolated from boar. However, there are no data concerning spermadhesins isolated from buck. Buck seminal plasma was collected and subjecte...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866023408670
更新日期:2002-08-01 00:00:00
abstract:BACKGROUND:Microalgae have been suggested as promising feedstocks of significant biotechnological interest due to their enormous potential for the sustainable production of industrially valuable compounds such as lipids/fatty acids, proteins, metabolites, pigments, and biofuels. However, exploitation of algal biomass f...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/0929866525666180122100722
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Uterine Leiomyoma is mainly widespread non-malignant tumor. Around more than 80% woman have these particular tumor among them only 30% of them are detected. Integrin-ᵦ1 is one of the up regulated biomarkers during tumorigenesis which is also associated with structural disordered. Intrinsically disordered pro...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866525666180326114325
更新日期:2018-01-01 00:00:00
abstract::The development of a stable L-BDH chimera was attempted by exchanging whole domains between two native structural analogs, L-BDH and meso-BDH, because the S-configuration specificity of L-BDH is valuable from the standpoint of its application but its activity is unstable, whereas meso-BDH is stable. The domain chimera...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986611795713970
更新日期:2011-08-01 00:00:00
abstract::α-Synuclein forms amyloid deposits in the dopaminergic neurons; a process that is believed to contribute to the Parkinson's disease. An emerging theme in amyloid research is the hypothesis that the toxic species produced during amyloid formation share common physic-chemical features and exert their effects by common m...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866522666150209142649
更新日期:2015-01-01 00:00:00
abstract::We previously described a potent anthrax toxin inhibitor, based on a phage-library-selected peptide sequence, synthesized as a tetra-branched molecule on a lysine core and further modified for improvement of activity [Pini et al., Biochem. J., 2006, 395, 157]. This branched peptide had very low solubility because of s...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986608784966958
更新日期:2008-01-01 00:00:00
abstract::The formation of amyloid-like fibrils was studied by using the well-known serine protease trypsin as a model protein in the presence of ethanol as organic solvent. Trypsin forms amyloid-like fibrils in aqueous ethanol at pH = 7.0. The dye Congo red (CR) was used to detect the presence of amyloid-like fibrils in the sa...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866522666151002154324
更新日期:2015-01-01 00:00:00
abstract::Quantum mechanical fragment molecular orbital calculations have been performed for receptor binding of the hemagglutinin protein of the recently pandemic influenza 2009 H1N1, A/swine/Iowa/1930, and A/Puerto Rico/8/1934 viruses to α2-6 linked sialyloligosaccharides, as analogs of human receptors. The strongest receptor...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986611794927893
更新日期:2011-05-01 00:00:00
abstract::Highly efficient coupling reagents, N-methanesulphonyloxy-2-phenyl benzimidazole and N - p-toluenesulphonyloxy-2-phenyl benzimidazole were designed, synthesized and successfully applied in peptide coupling reactions. Their efficiency was evaluated by synthesizing a number of structurally different amides and peptides ...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986607780090847
更新日期:2007-01-01 00:00:00
abstract::Migraine is a common neurologic condition marked by recurrent episodes of headache. Its pathophysiology is highly complex involving neuronal, inflammatory and vascular mechanisms. The Renin-Angiotensin System (RAS) can modulate all these mechanism, being a potential pharmacological target for migraine treatment. We ca...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866527666200129160136
更新日期:2020-01-01 00:00:00
abstract::We report the stepwise transformation of a linear peptide epitope recognized by the anti-transforming growth factor alpha monoclonal antibody Tab2 into peptomers and finally into peptoid analogs. The key experiment in this study is the substitution analysis in which each position of the peptide is exchanged by a set o...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986606777841299
更新日期:2006-01-01 00:00:00
abstract::DNA fragmentation factor 45 (DFF45) regulates DNase DFF40 as its inhibitor and chaperone. It was reported that the N-terminal domain (NTD) of DFF45 alone is disordered and DFF40 is necessary as a mutual chaperone for the folding of NTD. However, here we reported the crystallization of DFF45 NTD. These crystals diffrac...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866033479068
更新日期:2003-04-01 00:00:00
abstract::Src is a non-receptor protein tyrosine kinase ubiquitously expressed in animals. It is involved in various cellular processes, including the innate immune response in mammals. However, less is known about the function of insect Src. Here we presented a homologue of Src in silkworm (Bombyx mori), named as BmSrc by phyl...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866523666161129114520
更新日期:2017-01-01 00:00:00
abstract::Oblique orientated alpha-helices are highly specialised protein structural elements that penetrate membranes at a shallow angle and are used to promote membrane destabilisation by a number of protein classes. Here, the use of extended hydrophobic moment methodology shows that the amphibian extrudates, aurein 1.2 and c...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866053406039
更新日期:2005-01-01 00:00:00
abstract::The role of interaction between Asn259 (catalytic domain) with Gln821 (C-terminal domain) in PeptidaseN was investigated. The k(cat) of PeptidaseN containing Asn259Asp or Gln821Glu is enhanced whereas it is suppressed in Asn259AspGln821Glu. Structural analysis shows this interaction to change the relative disposition ...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986609787848081
更新日期:2009-01-01 00:00:00
abstract::Hepatitis C virus (HCV) triggers coordinated innate and adaptive response in host cell. HCV genome and proteins of the replicating virus are recognized as non-self-antigens by host cell to activate Toll Like Receptors (TLRs). Activated TLRs ultimately express cytokines, which can clear virus either by activating inter...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866523666160419150136
更新日期:2016-01-01 00:00:00
abstract::In recent years, therapeutic proteins have become an important growing class of drugs in the pharmaceutics industry. The development of recombinant DNA technology has caused to appreciation of therapeutic value of many proteins and peptides in medicine. Currently, approximately 100 therapeutic proteins obtained approv...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/092986652012131112125148
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND:Laminin, a member of the Extracellular Matrix (ECM), is a glycoprotein that is used as a factor that affects cell adhesion, proliferation, survival, and differentiation. Of these, five globular domains (LG domains) of the alpha chain play an important role in influencing the cell by binding to the integrin. ...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866526666190617091155
更新日期:2019-01-01 00:00:00
abstract::We examined the production and secretion of fusion constructs containing alpha-N-acetylglucosaminidase, the enzyme deficient in Sanfilippo B, and either wildtype TAT or modified TAT in cultured Spodoptera frugiperda cells. All constructs exhibited successful expression of active enzyme, suggesting the future possibili...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986606775974456
更新日期:2006-01-01 00:00:00