解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:CsaA is among the few chaperones which are present in both bacteria and archaea, but absent in eukaryotes. There are no reports on interactome analysis of CsaA from archaea, till date. Identification of binding partners of CsaA might be helpful in understanding CsaA-associated processes in Picrophilus torrid...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866527999201126205131
更新日期:2020-11-26 00:00:00
abstract:BACKGROUND:Reversibly glycosylated polypeptide (RGP), a kind of hydrosoluble and plasmodesmal-associated protein found in plants, plays a crucial role in the development of pollen. OBJECTIVE:A novel RGP 2 was isolated and identified from rape (Brassica napus L.) bee pollen. METHOD:RGP2 was isolated and purified by io...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866527666201103161302
更新日期:2020-11-03 00:00:00
abstract:BACKGROUND:Fruit juice clarification is a challenging aspect of beverage industry which needs to be addressed for economical and hygienic production of fruit juices. OBJECTIVE:Current study is focused on the complete purification, characterization and thermodynamic analysis of an efficient mannanase enzyme to analyze ...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866527666200916142305
更新日期:2020-09-16 00:00:00
abstract:BACKGROUND:Chickpea is a widely grown legume in India, Australia, Canada, and Mediterranean regions. Seeds of chickpea are good source of protein for both human and animals. Wild relatives of chickpea (Cicer arietinum) are the potential gene pool for crop improvement; however, very little information is available on th...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866527666200910164118
更新日期:2020-09-10 00:00:00
abstract:BACKGROUND:The O. tesota lectin PF2 is a tetrameric protein with subunits of 33 kDa that recognizes only complex carbohydrates, resistant to proteolytic enzymes and has insecticidal activity against Phaseolus beans pest. OBJECTIVE:To explore PF2 lectin features at different protein structural levels and to evaluate th...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866527666200813204303
更新日期:2020-08-13 00:00:00
abstract:BACKGROUND:OPT3s are involved in the transport of Fe from xylem to phloem, in loading Fe into phloem, and in the transmission of shoot-to-root iron signaling. Yet, apart from Arabidopsis, little is known about these transporters'functions in other plant species. OBJECTIVE:OPT3 proteins of several plant species were ch...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866527666200625202028
更新日期:2020-06-25 00:00:00
abstract:BACKGROUND:The heterologous production of antimicrobial peptides in bacterial models can produce insoluble proteins due to the lack of proper folding. Fusion proteins have been used to increase the expression and solubility of these types of proteins with varying degrees of success. OBJECTIVES:Here, we demonstrate the...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866527666200610133407
更新日期:2020-06-10 00:00:00
abstract:BACKGROUND:Prmt5 plays major role in regulation of gene expression, RNA processing, cell growth and differentiation, signal transduction, germ cell development, etc., in mammals. Prmt5 is also related to cancer. Knowing the proteins interacting with Prmt5 is important to understand Prmt5's function in cells. Although t...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866527666200505213431
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Ciprofloxacin (Cip) is the most commonly used quinolone in clinical practice; however large-scale use has favored the increase of multiresistant pathogenic microorganisms. Antimicrobial peptides (AMPs) appear to be a promising alternative in potentiating these conventional drugs. OBJECTIVE:The aim of this s...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866527666200416145549
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Recently, the small molecule that inhibits the human copper-trafficking proteins Atox1 and CCS was reported, which suggested that small molecule has an effect on the copper regulation system in the cell. The copper chaperones CopC is regarded as a redox switch and possess barrel structure, thus the interacti...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866526666191204124245
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:It is currently believed that protein folding rates are influenced by protein structure, environment and temperature, amino acid sequence and so on. We have been working for long to determine whether and in what ways mRNA affects the protein folding rate. A large number of palindromes aroused our attention i...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866526666191014144015
更新日期:2020-01-01 00:00:00
abstract::Migraine is a common neurologic condition marked by recurrent episodes of headache. Its pathophysiology is highly complex involving neuronal, inflammatory and vascular mechanisms. The Renin-Angiotensin System (RAS) can modulate all these mechanism, being a potential pharmacological target for migraine treatment. We ca...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866527666200129160136
更新日期:2020-01-01 00:00:00
abstract::Supramolecular self-assembled functional materials comprised of cyclic dipeptide building blocks have excellent prospects for biotechnology applications due to their exceptional structural rigidity, morphological flexibility, ease of preparation and modification. Although the pharmacological uses of many natural cycli...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866527666200212123542
更新日期:2020-01-01 00:00:00
abstract::A pivotal feature that underlies the development of neurodegeneration is the accumulation of protein aggregates. In response, eukaryotic cells have evolved sophisticated quality control mechanisms to identify, repair and/or eliminate the misfolded abnormal proteins. Chaperones identify any otherwise abnormal conformat...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866526666191026111951
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Multiple Sequence Alignment (MSA) is a fundamental task in bioinformatics and is required for many biological analysis tasks. The more accurate the alignments are, the more credible the downstream analyses. Most protein MSA algorithms realign an alignment to refine it by dividing it into two groups horizonta...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866526666190806143959
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Microbe-Binding Peptides (MBPs) are currently being investigated to address the problem of antimicrobial resistance. Strategies enhancing their antimicrobial activity have been developed, including peptide dimerization. Here, we present an alternative approach based on peptide polymerization, yielding hapten...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866527666200427212940
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Searching the biomarker from complex heterogeneous material for early detection of disease is a challenging task in the field of biomedical sciences. OBJECTIVE:The study has been arranged to explore the proteomics serum derived profiling of the differential expressed and low molecular weight protein in brea...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866527666200110155609
更新日期:2020-01-01 00:00:00
abstract::Self-Interacting Proteins (SIPs), whose two or more copies can interact with each other, have significant roles in cellular functions and evolution of Protein Interaction Networks (PINs). Knowing whether a protein can act on itself is important to understand its functions. Previous studies on SIPs have focused on thei...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/0929866527666191227141713
更新日期:2020-01-01 00:00:00
abstract::Phage Virion Proteins (PVP) are essential materials of bacteriophage, which participate in a series of biological processes. Accurate identification of phage virion proteins is helpful to understand the mechanism of interaction between the phage and its host bacteria. Since experimental method is labor intensive and t...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866526666190410124642
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Nε-acetyl L-α lysine is an unusual acetylated di-amino acid synthesized and accumulated by certain halophiles under osmotic stress. Osmolytes are generally known to protect proteins and other cellular components under various stress conditions. OBJECTIVE:The structural and functional stability imparted by N...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866526666191105130041
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Protealysin, a zinc metalloprotease of Serratia proteamaculans, is the prototype of a new group within the peptidase family M4. Protealysin-like proteases (PLPs) are widely spread in bacteria but are also found in fungi and archaea. The biological functions of PLPs have not been well studied, but published d...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866526666181212114907
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Laminin, a member of the Extracellular Matrix (ECM), is a glycoprotein that is used as a factor that affects cell adhesion, proliferation, survival, and differentiation. Of these, five globular domains (LG domains) of the alpha chain play an important role in influencing the cell by binding to the integrin. ...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866526666190617091155
更新日期:2019-01-01 00:00:00
abstract::The self-assembly of short peptide building blocks into well-ordered nanostructures is a key direction in bionanotechnology. The formation of β -sheet organizations by short peptides is well explored, leading to the development of a wide range of functional assemblies. Likewise, many natural proteinaceous materials, s...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/0929866525666180917163142
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Paraoxonase (PON; arilesterase, [EC 3.1.8.1]) is an enzyme from the group arilesterases (ARE). This enzyme is capable of hydrolyzing paraoxone which is the active metabolite of parathion, an organic phosphorus insecticide. PON activity was found to be low in individuals prone to development of atherosclerosi...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866526666190124144622
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Cathepsin D is a lysosomal enzyme that is found in all organisms acting in protein turnover, in humans it is present in some types of carcinomas, and it has a high activity in Parkinson's disease and a low activity in Alzheimer disease. In marine organisms, most of the research has been limited to corroborat...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866526666190405124353
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:NMAAP1 plays a role in regulating macrophage differentiation to the M1 type and exerting antitumoral functions. It is not clear what role and mechanism NMAAP1 does play in the reversal of macrophages from M1 to M2. METHODS:We detected the typing of macrophages with high or low expression of NMAAP1 by QPCR a...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866526666190503105343
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:In the last years, Antimicrobial Peptides (AMPs) and lipopeptides have received attention as promising candidates to treat infections caused by resistant microorganisms. OBJECTIVE:The main objective of this study was to investigate the effect of repetitive KLFK motifs and the attachment of aliphatic acids t...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866526666181208144629
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Type VI Secretion System (T6SS) has been found in approximately onequarter of the gram-negative bacterial species, and its structural characteristics appear to slightly differ from species to species. The genes encoding T6SS are designated as type six secretion A-M (tssA-M). The expression of the tss gene cl...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866526666190119121859
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Bursa of Fabricius plays the vital functions on B cell development and antibody production in poultry. The bursal-derived peptide plays the essential roles on avian immature B cell development. OBJECTIVES:Here we explored the functions of the recently reported bursal nonapeptide (BP9) on the antibody produc...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866526666190730101455
更新日期:2019-01-01 00:00:00
abstract::Seminal plasma proteins contributed by secretions of accessory glands plays a copious role in fertilization. Their role is overlooked for decades and even now, as Artificial Reproduction Techniques (ART) excludes the plasma components in the procedures. Recent evidences suggest the importance of these proteins startin...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/0929866526666190208112152
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Radical Probe Mass Spectrometry (RP-MS) describes a pioneering methodology in structural biology that enables the study of protein structures, their interactions, and dynamics on fast timescales (down to sub-milliseconds). Hydroxyl radicals (•OH) generated directly from water within aqueous solutions induce ...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/0929866526666181128124241
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Wheat germ, one of the byproducts of flour milling, contains abundant physiologically active components. Globulins in wheat germ are a class of high-quality functional proteins and have received widespread attention. However, the composition of wheat germ globulin( WGG)and the structure of the typical protei...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866524666171026123054
更新日期:2018-02-08 00:00:00
abstract:BACKGROUND:Breast cancer demands safe adjuvant to overcome the side effects of standard drug tamoxifen. Diet derived bioactive compounds are reported to exhibit modulation of cancer growth leading to cell death. Chickpea is a protein rich edible legume with several bioactive compounds that includes lectin as well. Char...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866525666180406142900
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:A core sequence (the 9 C-terminal residues) of calcification-associated peptide (CAP- 1) isolated from the exoskeleton of the red swamp crayfish was previously shown to control calcium carbonate precipitation with chitin. In addition, a modified core sequence in which the phosphorylated serine at the N termi...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866525666171221114658
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Assisted Reproduction Techniques (ART) have significantly advanced since the first successful In Vitro Fertilization (IVF). However, most in vitro-produced embryos fail to implant. Key steps in ART are the correct infertility diagnosis, in order to manage the individualised treatments, and the assessment of ...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/0929866525666180412164602
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Cysteine S-sulfenylation is a major type of dynamic post-translational modification of the protein that plays an important role in regulating many biological processes in both of prokaryotic and eukaryotic species. To understand the function of S-sulfenylated proteins, identification of S-sulfenylation sites...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/0929866525666180905110619
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Development of proteins and peptides into drugs has been considered as a promising strategy to target certain diseases. However, only few proteins and peptides have been approved as new drugs into the market each year. One major problem is that proteins and peptides often exhibit short plasma half-life times...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/0929866525666180530122835
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Microalgae have been suggested as promising feedstocks of significant biotechnological interest due to their enormous potential for the sustainable production of industrially valuable compounds such as lipids/fatty acids, proteins, metabolites, pigments, and biofuels. However, exploitation of algal biomass f...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/0929866525666180122100722
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Nanosheets of SnO2 which an n-type semiconductor with a rutile-type crystalline structure are predominantly used as gas sensors. SnO2 nanosheets have a tetragonal crystal structure where growth along the c-axis is suppressed to form a sheet. The major exposed facets of SnO2 nanosheets have {110}, {101} and {...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866525666171206114429
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Cryptochrome is a flavin-binding blue-light photoreceptor that functions in growth and development in plants, the circadian clock in animals and navigation in birds. However, a lack of purified cryptochrome has hindered studies of the structure and function of this protein. In this study, we obtained a subst...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866525666181004112308
更新日期:2018-01-01 00:00:00