Abstract:
:Class I fusion glycoproteins of viruses are involved in the fusion between viral envelope and cell membrane. A region located in the N-terminal domain of these glycoproteins, called the fusion peptide, is essential for fusion. Fusion peptides are able to induce by themselves in vitro membrane fusion. In this paper, we review the properties of those peptides related to their fusogenicity, in particular the correlation existing between their ability to insert obliquely in membranes and fusogenicity. This relation notably allows predicting successfully the minimal region of some fusion peptides sufficient to induce significant in vitro fusion. The notion of obliquity and fusogenicity is discussed in terms of the existing proposed mechanisms for viral fusion.
journal_name
Protein Pept Lettjournal_title
Protein and peptide lettersauthors
Charloteaux B,Lorin A,Brasseur R,Lins Ldoi
10.2174/092986609788681724subject
Has Abstractpub_date
2009-01-01 00:00:00pages
718-25issue
7eissn
0929-8665issn
1875-5305journal_volume
16pub_type
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