The folding process of apomyoglobin.

abstract：:In recent years, therapeutic proteins have become an important growing class of drugs in the pharmaceutics industry. The development of recombinant DNA technology has caused to appreciation of therapeutic value of many proteins and peptides in medicine. Currently, approximately 100 therapeutic proteins obtained approv...

journal_title：Protein and peptide letters

authors： Ozgur A,Tutar Y

更新日期：2013-12-01 00:00:00

abstract：:Familial mediterranean fever (FMF) is a systemic disorder characterized by recurrent attacks of fever and polyserositis. In FMF, several pro-inflammatory cytokines have been found to be elevated during the attacks. In recent years, it is shown that some proteins originated from adipose tissue play important role in in...

journal_title：Protein and peptide letters

authors： Keskin G,Inal A,Ozışık L

更新日期：2010-10-01 00:00:00

abstract：:Coiled coils are important structural modules and domains of protein-protein interactions. Further, they provide the required framework to proteins, like kinesins, myosins and SNAREs, which are either structural or involved in transport of biomolecules. We provide an interactive webserver to measure the strength of in...

journal_title：Protein and peptide letters

authors： Alva V,Syamala Devi DP,Sowdhamini R

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Chickpea is a widely grown legume in India, Australia, Canada, and Mediterranean regions. Seeds of chickpea are good source of protein for both human and animals. Wild relatives of chickpea (Cicer arietinum) are the potential gene pool for crop improvement; however, very little information is available on th...

journal_title：Protein and peptide letters

authors： Dhar S,Bhattacharjee M,Acharjee S,Baishya D

更新日期：2020-09-10 00:00:00

abstract：:Quantum mechanical fragment molecular orbital calculations have been performed for receptor binding of the hemagglutinin protein of the recently pandemic influenza 2009 H1N1, A/swine/Iowa/1930, and A/Puerto Rico/8/1934 viruses to α2-6 linked sialyloligosaccharides, as analogs of human receptors. The strongest receptor...

journal_title：Protein and peptide letters

authors： Fukuzawa K,Omagari K,Nakajima K,Nobusawa E,Tanaka S

更新日期：2011-05-01 00:00:00

abstract：:The small heat shock protein SsHSP14.1 from the hyper-thermophilic archeaon, Sulfolobus solfataricus (S. solfataricus) was able to protect proteins from thermal aggregation and prevent enzymes from heat induced inactivation. According to the 3D (dimensional) structural model of SsHSP14.1 developed by us before, the re...

journal_title：Protein and peptide letters

authors： Wen ZZ,Wang YH,Yang B,Xie MQ,Chou KC

更新日期：2011-03-01 00:00:00

abstract：:There is accumulating evidence that proteinuria is not merely a biomarker for the progression of chronic kidney disease (CKD), but also a mediator of this devastating disorder. Indeed, albumin, one of the major components found in proteinuria, causes proinflammatory and profibrotic changes in cultured proximal tubular...

journal_title：Protein and peptide letters

authors： Matsui T,Yamagishi S,Ueda S,Fukami K,Okuda S

更新日期：2010-01-01 00:00:00

abstract：:We report that the plant oncoprotein RolA from Agrobacterium rhizogenes acts to stabilize beta-glucoronidase (Gus) when the two proteins are expressed as a fusion protein in transformed tobacco. The observed 50-fold increase of Gus activity was shown to be related to protein accumulation, with no significant changes i...

journal_title：Protein and peptide letters

authors： Barros LM,Curtis RH,Viana AA,Campos L,Carneiro M

更新日期：2003-06-01 00:00:00

abstract：:Porins are integral membrane proteins found in the outer membrane of bacteria, mitochondria and chloroplasts. Herein, we have reviewed sequence and structural understanding about bacterial porins. The first porin structure from Rhodobacter capsulatus at 1.8 Å resolution in 1991 till the recent structural advancement, ...

journal_title：Protein and peptide letters

authors： Kumar A,Bhandari A,Krishnaswamy S

更新日期：2015-01-01 00:00:00

abstract：:The stability of Merrifield linker in Fmoc deprotection process was quantitatively investigated by establishing working curve of two major decomposition components from two resin bound dipeptide models. By sampling reaction solution and analyzing with RP-HPLC, decomposition rate was determined. The results indicated t...

journal_title：Protein and peptide letters

authors： Yang X,Lin H,Lu W,Wang D

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:Fruit juice clarification is a challenging aspect of beverage industry which needs to be addressed for economical and hygienic production of fruit juices. OBJECTIVE:Current study is focused on the complete purification, characterization and thermodynamic analysis of an efficient mannanase enzyme to analyze ...

journal_title：Protein and peptide letters

authors： Ikram Ul Haq,Shakoor S,Nawaz A,Arshad Y,Mukhtar H

更新日期：2020-09-16 00:00:00

abstract：:The etiology of multiple sclerosis (MS) remains unclear. To determine if autoantibodies to myelin basic protein (MBP) are produced during parvovirus B19 infection, a competitive ELISA was performed using plasma from MS patients exhibiting high IgG titers for parvovirus. Our results showed the addition of MBP decreased...

journal_title：Protein and peptide letters

authors： Thomas G,Rael L,Shimonkevitz R,Melamed I,Bar-Or D

更新日期：2006-01-01 00:00:00

abstract：:Allergy prevalence has increased worldwide over the last 25 years along with industrialization and westernized lifestyles. Indoor allergens are primarily responsible for the sensitization and development of atopic diseases. The main indoor allergens are known to be derived from various arthropods which account for up ...

journal_title：Protein and peptide letters

authors： Jeong KY,Hong CS,Yong TS

更新日期：2007-01-01 00:00:00

abstract：:Nicotinamide adenine dinucleotide (NAD) plays an important role in cellular metabolism and acts as hydrideaccepting and hydride-donating coenzymes in energy production. Identification of NAD protein interacting sites can significantly aid in understanding the NAD dependent metabolism and pathways, and it could further...

journal_title：Protein and peptide letters

authors： Wang X,Wang CC,Zhang YQ,Mi G,Zhang J,Li ML

更新日期：2012-05-01 00:00:00

abstract：:Peptides with more than one biological activity are many a times multifunctional peptides. Two peptides with multifunctional properties from alpha (S2)-casein were stabilized in presence of cosolvents for their biological activities like ACE inhibition activity and antioxidant activity. These bioactive peptides in cos...

journal_title：Protein and peptide letters

authors： Srinivas S,Prakash V

更新日期：2008-01-01 00:00:00

abstract：:A novel cellulase was isolated from the thermoacidophilic bacterium Alicyclobacillus acidocaldarius ATCC27009 grown in medium containing carboxymethylcellulose. The enzyme is a glycosylated monomer of 56.2 kDa, relatively thermostable, with optimal pH and temperature of 4.0 and 65 degrees C, respectively. Enzymatic as...

journal_title：Protein and peptide letters

authors： Morana A,Esposito A,Maurelli L,Ruggiero G,Ionata E,Rossi M,La Cara F

更新日期：2008-01-01 00:00:00

abstract：:A proof-of-principle methodology is presented in which all commercially-available cysteine (Cys) and selenocysteine (Sec) solid phase peptide synthesis (SPPS) derivatives are synthesized in high yield from easily prepared protected dichalcogenide precursors. A Zn-mediated biphasic reduction process applied to a series...

journal_title：Protein and peptide letters

authors： Flemer S

更新日期：2014-01-01 00:00:00

abstract：:G-protein betagamma dimers are prime regulators transmitting extracellular signals to wide-ranging cellular effectors including phosphoinositide 3-kinase (PI3K) isoforms beta and gamma. Recombinant Gbetagamma purified from Sf9 cells via metal-affinity and anion exchange chromatography exhibited a wortmannin-insensitiv...

journal_title：Protein and peptide letters

authors： Shymanets A,Ahmadian MR,Nürnberg B

更新日期：2009-01-01 00:00:00

abstract：:In this paper(1) we present a novel framework for protein secondary structure prediction. In this prediction framework, firstly we propose a novel parameterized semi-probability profile, which combines single sequence with evolutionary information effectively. Secondly, different semi-probability profiles are respecti...

journal_title：Protein and peptide letters

authors： Huang DS,Huang X

更新日期：2006-01-01 00:00:00

abstract：:Increasing antibiotic resistance has led to an urgent need for new therapeutic approaches. Host defense peptides are known to be antimicrobial and have revealed broad immunomodulatory functions for both innate and adaptive immunity. This review will focus on the role of host defense peptides in infection and immune re...

journal_title：Protein and peptide letters

authors： Hirsch T,Jacobsen F,Steinau HU,Steinstraesser L

更新日期：2008-01-01 00:00:00

abstract：:Nucleobindin-2 is a 420 amino acid EF-hand Ca²⁺ binding protein that can be further processed to generate an 82 amino terminal peptide termed Nesfatin-1. To examine the function of secreted Nucleobindin-2 in adipocyte differentiation, cultured 3T3-L1 cells were incubated with either 0 or 100 nM of GST, GST-Nucleobindi...

journal_title：Protein and peptide letters

authors： Tagaya Y,Osaki A,Miura A,Okada S,Ohshima K,Hashimoto K,Yamada M,Satoh T,Shimizu H,Mori M

更新日期：2012-09-01 00:00:00

abstract：:BmK ITa1 cDNA was cloned and highly expressed in E. coli and insect cell. SDS-PAGE and western blot analysis revealed that subunit molecular weight of expression products is about 40 kDa and 10 kDa respectively. The expression product purified by a Ni(2+)-IDA-sepharose 6B column was toxic for insect, which indicated t...

journal_title：Protein and peptide letters

authors： Liu Z,Yang GZ,Chi CW,Wu XF

更新日期：2002-10-01 00:00:00

abstract：:Galanin is a neuropeptide that is widely distributed in the central and peripheral nervous systems. Some small cell lung carcinoma (SCLC) cell lines such as SBC-3A release only the high-molecular-mass form, with lower molecular mass forms being undetectable. To investigate the mechanism of processing of progalanin to ...

journal_title：Protein and peptide letters

authors： Yamamoto H,Iguchi K,Ohno S,Yokogawa T,Nishikawa K,Hoshino M

更新日期：2011-10-01 00:00:00

abstract：:The superoxide anion radical is a highly reactive toxic species produced during the metabolic processes. A number of copper (II) complexes with amino acids and peptides are known to show superoxide dismutase (SOD) like activity. The design and application of synthetic low molecular weight metal complexes as SOD mimics...

journal_title：Protein and peptide letters

authors： Singh RK,Srivastava VC,Singh UP

更新日期：2011-12-01 00:00:00

abstract：:Alpha-gliadins isolated by carboxymethylcellulose chromatography contain noncovalently bound glucose probably due to contaminating proteoglycans and to material shed from the column. Traces of carbohydrate remain strongly bound to alpha-gliadins even after harsh denaturation, but our results indicate alpha-gliadins ar...

journal_title：Protein and peptide letters

authors： Turner JB,Garner GV,Gordon DB,Brookes SJ,Smith CA

更新日期：2002-02-01 00:00:00

abstract：:Human histatins are histidine-rich, low molecular weight salivary proteins that contribute to the immune system of the oral cavity. In this work, nucleotide sequences of the HIS1 (coding for histatin 1) and HIS2 (coding for histatin 3) genes, homologous to the human ones, have been sequenced and analysed in five prima...

journal_title：Protein and peptide letters

authors： Padovan L,Segat L,Pontillo A,Antcheva N,Tossi A,Crovella S

更新日期：2010-07-01 00:00:00

abstract：:Identifying protein complexes in protein-protein interaction (PPI) networks is a fundamental problem in computational biology. High-throughput experimental techniques have generated large, experimentally detected PPI datasets. These interactions represent a rich source of data that can be used to detect protein comple...

journal_title：Protein and peptide letters

authors： Liao B,Fu X,Cai L,Chen H

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:Uterine Leiomyoma is mainly widespread non-malignant tumor. Around more than 80% woman have these particular tumor among them only 30% of them are detected. Integrin-ᵦ1 is one of the up regulated biomarkers during tumorigenesis which is also associated with structural disordered. Intrinsically disordered pro...

journal_title：Protein and peptide letters

authors： Maulik U,Uversky VN,Sen S

更新日期：2018-01-01 00:00:00

abstract：:We examined the production and secretion of fusion constructs containing alpha-N-acetylglucosaminidase, the enzyme deficient in Sanfilippo B, and either wildtype TAT or modified TAT in cultured Spodoptera frugiperda cells. All constructs exhibited successful expression of active enzyme, suggesting the future possibili...

journal_title：Protein and peptide letters

authors： Bandsmer JC,Campbell TN,Cheyne I,Choy FY

更新日期：2006-01-01 00:00:00

abstract：:The cytotoxicity of hPrP[173-195] prion peptide against a neuroblastoma cell model was found independent of its tendency to aggregate over time. Cytosolic and nuclear inclusions of peptide were highlighted by confocal microscopy, suggesting a role as a transcription factor in activating signal transduction pathways in...

journal_title：Protein and peptide letters

authors： Urso E,Acierno R,Lionetto MG,Rizzello A,Papa A,Schettino T,Maffia M

更新日期：2009-01-01 00:00:00